In the context of the production of pharmaceutical drugs, this project deals with the modelling and simulation of the production of solid particulate products using the example of tablets. Product quality is influenced by the interlinking of production process steps that affect the structures and properties of the intermediate and final products. In addition to fluctuating ambient conditions, the applied process parameters have a varying influence on the distributed properties of the materials, which can also be of varying degrees. Knowledge of the existing product quality of the intermediate and end products is of central importance in pharmaceutical production. The aim of the project is an agent-based simulation of product structures across the interlinked process steps. The project focuses on the process step of (continuous) granulation, for whose sub-processes process models are developed and extended so that distributed product properties can be processed and mapped. The individual process models are then integrated into a process chain model with the already existing process models. The aim of the simulation is to increase the transparency of the process and improve the traceability of the product properties within the process. A related optimized forward and backward process control is investigated within the project. The project is funded by the DFG and is carried out in cooperation with the Institute for Particle Technology.
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