Brandt, W., Backenköhler, A., Schulze, E., Plock, A., Herberg, T., Roese, E., Wittstock, U. (2014) Molecular models and mutational analyses of plant specifier proteins suggest active site residues and reaction mechanism Plant Molecular Biology 84:173-188
Chizzali, C., Liu, B., Richter, K., Flachowsky, H., Peil, A., Hanke, M.V., Beerhues, L. (2014) Biphenyls and dibenzofurans - fire blight-induced phytoalexins of pear Acta Hort. 1056:181-185
Cramer,L., Fleck,G., Horn,G., Beuerle,T. (2014) Process Development of Lappula squarrosa Oil Refinement: Monitoring of Pyrrolizidine Alkaloids in Boraginaceae Seed Oils Journal of the American Oil Chemists' Society 91:721-731
Beuerle,T., Mädge,I., Cramer,L. (2014) Pyrrolizidinalkaloide in Lebensmitteln Deutsche Lebensmittelrundschau 110:242-246
Muszyńska, B., Ekiert, H., Kwiecień, I., Maślanka, A., Zodi, R., Beerhues, L. (2014) Comparative analysis of therapeutically important indole compounds in in vitro cultures of Hypericum perforatum cultivars by HPLC and TLC analysis coupled with densitometric detection Nat. Prod. Commun. 9:1437-1440
Beuerle,T. (2014) Summenparametermethode zur Bestimmung von Pyrrolizidinalkaloiden Deutsche Lebensmittel-Rundschau 110:454-459
Reckwell, D., Hänsch, R., Schulze, J., Beerhues, L. (2014) Immunolocalization of biphenyl synthase in elicitor-treated cell cultures of Sorbus aucuparia Acta Hort. 1056:307-311
Langer,N., Lindigkeit,R., Schiebel,H.-M., Ernst,L., Beuerle,T. (2014) Identification and quantification of synthetic cannabinoids in ‘spice-like‘ herbal mixtures: snapshot of the German situation in the fall of 2012 Drug Testing and Analysis 6:59 – 71
Ji, Y., Xiao, J., Shen, Y., Ma, D., Li, Z., Pu, G., Li, X., Huang, L., Liu, B., Ye, H., Wang, H. (2014) Cloning and characterization of AabHLH1, a bHLH transcription factor that positively regulates artemisinin biosynthesis in Artemisia annua Plant Cell Physiol. 55:1592-1604
Coyne, S., Litomska, A., Chizzali, C., Khalil, M., Richter, K., Beerhues, L., Hertweck, C. (2014) Control of plant defense mechanisms and fire blight pathogenesis through the regulation of 6-thioguanine biosynthesis in Erwinia amylovora ChemBioChem 15:373-376
Tsai, Y.C., Chiang, S.Y., El-Shazly, M., Wu, C.C., Beerhues, L., Lai, W.C., Wu, S.F., Yen, M.H., Wu, Y.C., Chang, F.R. (2013) The oestrogenic and anti-platelet activities of dihydrobenzofuroisocoumarins and homoisoflavonoids from Liriope platyphylla roots Food Chemistry 140:305-314
Menzel,F., Blüthgen,N., Tolasch,T., Conrad,J., Beifuß,U., Beuerle,T., Schmitt,T. (2013) Crematoenones - a novel substance class exhibited by ants functions as appeasement signal Frontiers in Zoology 10:Doi: 10.1186/1742-9994-10-32
Coyne, S., Chizzali, C., Khalil, M.N.A., Litomska, A., Richter, K., Beerhues, L., Hertweck, C. (2013) Biosynthesis of the antimetabolite 6-thioguanine in Erwinia amylovora plays a key role in fire blight pathogenesis Angewandte Chemie Int. Ed. 52:10564-10568
Benford,D., Beuerle,T., Brimer,L., Cottrill,B., Doerge,D., Dusemund,B., Farmer,P., Fürst,P., Humpf, H.-U., Mulder,P. (2013) Scientific Opinion on Tropane alkaloids in food and feed EFSA Journal 11:3386
Abdel-Rahman, I.A.M., Beuerle, T., Ernst, L., Abdel-Baky, A.M., Desoky, E.K., Ahmed, A.S., Beerhues, L. (2013) In vitro formation of the anthranoid scaffold by cell-free extracts from yeast-extract-treated Cassia bicapsularis cell cultures Phytochemistry 88:15-24
Khalil, M.N.A., Beuerle, T., Müller, A., Ernst, L., Bhavanam, V.B.R., Liu, B., Beerhues, L. (2013) Biosynthesis of the biphenyl phytoalexin aucuparin in Sorbus aucuparia cell cultures treated with Venturia inaequalis Phytochemistry 96:101-109
Cramer,L., Schiebel,H.-M., Ernst,L., Beuerle,T. (2013) Pyrrolizidine Alkaloids in the Food Chain: Development, Validation, and Application of a New HPLC-ESI-MS/MS Sum Parameter Method Journal of Agriculture and Food Chemistry 61:11382-11391
Abdel-Rahman, I.A.M., Abdel-Baky, A.M., Desoky, E.E.K., Ahmed, A.S., Beerhues, L. (2013) Establishment of callus and cell suspension cultures of Cassia bicapsularis L. Bull. Pharm. Sci., Assiut University 36:23-30
Jiratchariyakul, W., Beerhues, L., Mahady, G.B., Kummalue, T., Vongsakul, M. (2013) Botanicals in dietary supplements (Editorial) Evidence-Based Complementary and Alternative Medicine ID 465313:1-2 (http://dx.doi.org/10.1155/2013/465313)
Chizzali, C., Gaid, M.M., Belkheir, A.K., Beuerle, T., Hänsch, R., Richter, K., Flachowsky, H., Peil, A., Hanke, M.V., Liu, B., Beerhues, L. (2013) Phytoalexin formation in fire blight-infected apple Trees 27:477-484
Oetken,J., Beuerle,T., Knapp,H., Giesecke,T., Winterhalter,P., Jerz,G. (2013) Preparative mass-spectrometry profiling of genotoxic pyrrolizidine alkaloids in Jacobaea vulgaris (syn. Senecio jacobaea) by spiral-coil countercurrent chromatography and ESI-MS/MS off-line continuous injection Planta Med 79-PH8:Doi: 10.1055/s-0033-1352085
Kuchernig, J.-C., Burow, M., Wittstock, U. (2012) Evolution of specifier proteins in glucosinolate-containing plants BMC Evolutionary Biology 12:127
Gershenzon, J., Fontana, A., Burow, M., Wittstock, U., Degenhardt, J. (2012) Mixtures of plant secondary metabolites: metabolic origins and ecological benefits In: The Ecology of Plant secondary Metabolites: From Genes to Global Processes. Iason GR, Dicke M, Hartley SE (eds.). Cambridge University Press. British Ecological Society. :56-77
Stauber, E.J., Kuczka, P., van Ohlen, M., Vogt, B., Janowitz, T., Piotrowski, M., Beuerle, T., Wittstock, U. (2012) Turning the ''mustard oil bomb'' into a ''cyanide bomb'': aromatic glucosinolate metabolism in a specialist insect herbivore PloS ONE 7 (4):e35545
Schramm, K., Vassao, D.G., Reichelt, M., Gershenzon, J., Wittstock, U. (2012) Metabolism of glucosinolate-derived isothiocyanates to glutathione conjugates in generalist lepidopteran herbivores Insect Biochemistry and Molecular Biology 42:174-182
Ernst,L., Krueger,K., Lindigkeit,R., Schiebel,H.-M., Beuerle,T. (2012) Synthetic cannabinoids in “spice-like” herbal blends: first appearance of JWH-307 and recurrence of JWH-018 on the German market Forensic Science International 222:216-222
Philippe N. Okusa, Till Beuerle, Caroline Stévigny and Pierre Duez (2012) Absence of pyrrolizidine alkaloids in Cordia gilletii de wild (boraginaceae) Biochemical Systematics and Ecology 41:1-2
Simolka,K., Lindigkeit,R., Schiebel,H.-M., Papke,U., Ernst,L., Beuerle,T. (2012) Analysis of synthetic cannabinoids in ‘spice-like‘ herbal highs: Snapshot of the German market in summer 2011 Analytical and Bioanalytical Chemistry 404:157-171
Chizzali, C., Khalil, M., Beuerle, T., Schuehly, W., Richter, K., Flachowsky, H., Peil, A., Hanke, M.V., Liu, B., Beerhues, L. (2012) Formation of biphenyl and dibenzofuran phytoalexins in the transition zones of fire blight-infected stems of Malus domestica cv. ''Holsteiner Cox'' and Pyrus communis cv. ''Conference'' Phytochemistry 77:179-185
Wang,L., Beuerle,T., Timbilla,J., Ober,D. (2012) Independent Recruitment of a Flavin-Dependent Monooxygenase for Safe Accumulation of Sequestered Pyrrolizidine Alkaloids in Grasshoppers and Moths PLoS ONE 7:e31796 (1-7)
Qiu, X., Lei, C., Huang, L., Li, X., Hao, H., Du, Z., Wang, H., Ye, H., Beerhues, L., Liu, B. (2012) Endogenous hydrogen peroxide is a key factor in the yeast extract-induced activation of biphenyl biosynthesis in cell cultures of Sorbus aucuparia Planta 235:217-223
Fellenberg, C., van Ohlen, M., Handrick, V., Vogt, T. (2012) The role of CCoAOMT1 and COMT1 in Arabidopsis anthers. Planta 236:51-61
Chizzali, C., Beerhues, L. (2012) Phytoalexins of the Pyrinae: biphenyls and dibenzofurans Beilstein J. Org. Chem. 8:613-620
Cramer,L., Beuerle, T. (2012) Detection and Quantification of Pyrrolizidine Alkaloids in Antibacterial Medical Honeys Planta Medica 78:1976-1982
Huang, L., Wang, H., Ye, H., Du, Z., Zhang, Y., Beerhues, L., Liu, B. (2012) Differential expression of benzophenone synthase and chalcone synthase in Hypericum sampsonii Natural Product Communications 7:1615-1618
Huang, L., Li, J., Ye, H., Li, C., Wang, H., Liu, B., Zhang, Y. (2012) Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus Planta 236:1571-1581
Li, X., Ma, D., Chen, J., Pu, G., Ji, Y., Lei, C., Du, Z., Liu, B., Ye, H., Wang, H. (2012) Biochemical characterization and identification of a cinnamyl alcohol dehydrogenase from Artemisia annua Plant Sciences 193-194:85-95
Chizzali, C., Gaid, M.M., Belkheir, A.K., Hänsch, R., Richter, K., Flachowsky, H., Peil, A., Hanke, M.V., Liu, B., Beerhues, L. (2012) Differential expression of biphenyl synthase gene family members in fire-blight-infected apple "Holsteiner Cox" Plant Physiology 158:864-875
Alexander,J., Benford,D., Boobis,A., Ceccatelli,S., Cottrill,B., Cravedi,J.-P, Di Domenico,A., Doerge,D., Dogliotti, E., Edler,L., Farmer,P., Filipic,M., Fink-Gremmels, J., Fürst,P., Guerin,T., Knutsen,H.K., Machala,M., Mutti,A., Rose,M., Schlatter,J., van Leeuwen,R., Beuerle,T., Brimer,L., Dusemund,B., Humpf,H.-U., Mulder,P., Binaglia,M., Carletti,A., Cioacata,G., Ruiz,J.AG., EFSA Panel on Contaminants in the Food Chain CONTAM (2012) Scientific Opinion on ergot alkaloids in food and feed EFSA Journal 10:2798
Büttner, M., Barleben, L. (2012) One-pot fusion polymerase chain reaction for combinatorial synthesis of DNA from several cassettes. Anal. Biochem. 421:797-798
Abdelhady, M.I.S., Kamal, A.M., Tawfik, N.F., Abdelkhalik, S.M., Motaal, A.A., Beerhues, L. (2012) Induction of callus and cell suspension cultures of three Callistemon species BioTechnology: An Indian Journal 6:295-298
Gaid, M.M., Sircar, D., Müller, A., Beuerle, T., Liu, B., Ernst, L., Hänsch, R., Beerhues, L. (2012) Cinnamate:CoA ligase initiates biosynthesis of a benzoate-derived xanthone phytoalexin in Hypericum calycinum cell cultures Plant Physiology 160:1267-1280
Kuchernig, J.-C., Backenköhler, A., Lübbecke, M., Burow, M., Wittstock, U. (2011) A thiocyanate-forming protein generates multiple products upon allylglucosinolate breakdown in Thlaspi arvense. Phytochemistry 72:1699-1709
Winde, I., Wittstock, U. (2011) Insect herbivore counteradaptations to the plant glucosinolate-myrosinase system Phytochemistry 72:1566-1575
Opitz, S.E.W., Mix, A., Winde, I.B., Müller, C. (2011) Desulfation Followed by Sulfation: Metabolism of Benzylglucosinolate in Athalia rosae (Hymenoptera: Tenthredinidae) ChemBioChem 12:1252-1257
Sircar, D., Mukherjee, C., Beuerle, T., Beerhues, L., Mitra, A. (2011) Characterization of p-hydroxybenzaldehyde dehydrogenase, the final enzyme of p-hydroxybenzoic acid biosynthesis in hairy roots of Daucus carota Acta Physiol. Plant. 33:2019-2024
Gaid, M.M., Scharnhop, H., Ramadan, H., Beuerle, T., Beerhues, L. (2011) 4-Coumarate:CoA ligase family members from elicitor-treated Sorbus aucuparia cell cultures J. Plant Physiol. 168:944-951
Lei, C., Ma, D., Pu, G., Qiu, X., Du, Z., Wang, H., Li, G., Ye, H., Liu, B. (2011) Foliar application of chitosan activates artemisinin biosynthesis in Artemisia annua L. Industrial Crops and Products 33:176-182
Liu, B., Wang, H., Du, Z., Li, G., Ye, H. (2011) Metabolic engineering of artemisinin biosynthesis in Artemisia annua L. Plant Cell Rep. 30:689-694
Kempf,M., Wittig,M., Reinhard,A., von der Ohe,K., Blacquière,T., Raezke,K.-P., Michel,R., Schreier,P., Beuerle,T. (2011) Pyrrolizidine Alkaloids in Honey: Comparison of two current analytical methods Food Additives and Contaminants 28:332-347
Abd El-Mawla,A.M.A, Farag,S.F., Beuerle,T. (2011) Cinnamyl alcohols and methyl esters of fatty acids from Wedelia prostrata callus cultures Natural Product Research 25:45-52
Kempf,M., Wittig,M., Schönfeld,K., Cramer,L., Schreier,P., Beuerle,T. (2011) Pyrrolizidine alkaloids in food: Downstream contamination in the food chain caused by honey and pollen Food Additives and Contaminants: Part A 28:325-331
Ernst,L., Schiebel,H.-M., Theuring,C., Lindigkeit,R., Beuerle,T. (2011) Identification and characterization of JWH-122 used as new ingredient in "spice-like" herbal incenses Forensic Science International 208:e31-35
Beerhues, L. (2011) Biosynthesis of the active Hypericum perforatum constituents Medicinal and Aromatic Plant Science and Biotechnology 5: Special Issue 1: Hypericum (Odabas, M.S., Cirak, C., eds.): 70-77
Hüttner, C., Beuerle, T., Liu, B., Beerhues, L., Richter, K., Flachowsky, H., Peil, A., Hanke, M.V. (2011) Biphenyl and dibenzofuran formation in fire blight-infected Malus domestica cultivars Acta Hort. (ISHS) 896:547-553
Alexander,J., Benford,D., Boobis,A., Ceccatelli,S., Cottrill,B., Cravedi,J.-P., Di Domenico,A., Doerge,D., Dogliotti,E., Edler,L., Farmer,P., Filipic,M., Fink-Gremmels,J., Furst,P., Guerin,T., Knutsen,H.K., Machala,M., Mutti,A., Rose,M., Schlatter,J., van Leeuwen,R., Beuerle,T., Brimer,L., Dusemund,B., Humpf,H.-U., Mulder,P., Cioacata,G., Binaglia,M., Fabiansson,S., EFSA Panel Contaminants in the Food Chain CONTAM (2011) Scientific opinion on pyrrolizidine alkaloids in food and feed EFSA Journal 9:2406
Beuerle,T., Blacquière,T., von der Ohe,W. (2011) Pyrrolizidin Alkaloide; Giftige (Bienen)-Weiden; Was bedeutet dies für Bienen, Honig und Pollen Allgemeine Deutsche Imkerzeitung ADIZ 10:12-15
Abdelhady, M.I.S., Abdel Motaal, A., Beerhues, L. (2011) Total phenolic content and antioxidant activity of standardized extracts from leaves and cell cultures of three Callistemon species Am. J. Plant Sci. 2:847-850
Guo, Y., Ma, L., Ji, Y., Pu, G., Liu, B., Du, Z., Li, G., Ye, H., Wang, H. (2011) Isolation of the 5''''-end of plant genes from genomic DNA by TATA-box-based degenerateprimers Mol Biotechnol. 47:152-156
Wittstock, U., Burow, M. (2010) Glucosinolate breakdown in Arabidopsis: mechanism, regulation and biological significance The Arabidopsis Book (Last, R., Chang,C., Jander, G., Kliebenstein, D.J., McClung, R. Millar, H., Torii, K., Wagner, D., eds.) :doi: 10.1199/tab.0134 (http://www.aspb.org/publications/arabidopsis/)
Müller, R., De Vos, M., Sun, J.Y., Soenderby I.E., Halkier, B.A., Wittstock, U. Jander, G. (2010) Differential effects of indole and aliphatic glucosinolates on lepidopteran herbivores Journal of Chemical Ecology 36:905-913
Sarosh, B., Wittstock, U., Halkier, B.A., Ekbom, B. (2010) The influence of metabolically engineered glucosinolates profiles in Arabidopsis thaliana on Plutella xylostella preference and performance Chemoecology 20:1-9
Kempf,M., Reinhard,A., Beuerle,T. (2010) Pyrrolizidine alkaloids (PAs) in honey and pollen - legal regulation of PA levels in food and animal feed required Molecular Nutrition & Food Research 54:158-168
Kempf,M., Heil,S., Haßlauer,I., Schmidt,L., von der Ohe,K., Theuring,C., Reinhard,A., Schreier,P., Beuerle,T. (2010) Pyrrolizidine alkaloids in pollen and pollen products Molecular Nutrition & Food Research 54:292-300
Liu, B., Raeth, T., Beuerle, T., Beerhues, L. (2010) A novel 4-hydroxycoumarin biosynthetic pathway Plant Mol. Biol. 72:17-25
Schramek, N., Wang, H., Römisch-Margl, W., Keil, B., Radykewicz, T., Winzenhörlein, B., Beerhues, L., Bacher, A., Rohdich, F., Gershenzon, J., Liu, B., Eisenreich, W. (2010) Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study Phytochemistry 71:179-187
Hüttner, C., Beuerle, T., Scharnhop, H., Ernst, L., Beerhues, L. (2010) Differential effect of elicitors on biphenyl and dibenzofuran formation in Sorbus aucuparia cell cultures J. Agric. Food Chem. 58:11977-11984
Kempf,M., Schreier,P., Reinhard,A., Beuerle,T. (2010) Pyrrolizidinalkaloide in Honig und Pollen Journal für Verbraucherschutz und Lebensmittelsicherheit 5:393–406
Ma, L., Shi, G., Ye, H., Liu, B., Wang, Y. (2010) Plant-specific type III polyketide synthase superfamily: gene structure, function and metabolites Sheng Wu Gong Cheng Xue Bao 26:1482-1492
Wang, H., Ma, C., Li, Z., Ma, L., Wang, H., Ye, H., Xu, G., Liu, B. (2010) Effects of exogenous methyl jasmonate on artemisinin biosynthesis and secondary metabolites in Artemisia annua L Industrial Crops and Products 31:214-218
Reinhard,A., Janke,M., von der Ohe, W., Beuerle, T. (2010) Einfluss von Pyrrolizidinalkaloiden auf Honigbienen Bienenjournal 8:336
Burow, M., Wittstock, U. (2009) Regulation and function of specifier proteins in plants Phytochem. Rev. 8:87-99
Burow, M., Losansky, A., Müller, R., Plock, A., Kliebenstein, D., Wittstock, U. (2009) The genetic basis of constitutive and herbivore-induced ESP-independent nitrile formation in Arabidopsis. Plant Physiology 149:561-574
Klundt, T., Bocola, M., Lütge, M., Beuerle, T., Liu, B., Beerhues, L. (2009) A single amino acid substitution converts benzophenone synthase in phenylpyrone synthase J. Biol. Chem. 284:30957-30964
Lindigkeit,R., Boehme,A., Eiserloh,I., Luebbecke,M., Wiggermann,M., Ernst,L., Beuerle,T. (2009) Spice: A never ending story? Forensic Science International 191:58-63
Beerhues, L., Liu, B. (2009) Biosynthesis of biphenyls and benzophenones - Evolution of benzoic acid-specific type III polyketide synthases in plants Phytochemistry 70:1719-1727
Schwarz, H., Liu, B., Peters, S., Barillas, W., Beerhues, L. (2009) Purification, cDNA cloning and functional expression of NADPH-cytochrome P450 reductase from Centaurium erythraea cell cultures Plant Biology 11:300-306
Reinhard,A., Janke,M., von der Ohe,W., Kempf,M., Theuring,C., Hartmann,T., Schreier,P., Beuerle, T. (2009) Feeding Deterrence and Detrimental Effects of Pyrrolizidine Alkaloids Fed to Honey Bees (Apis mellifera) Journal of Chemical Ecology 35:1086-1095
Ma, L.Q., Guo, Y.W., Gao, D.Y., Ma, D.M., Wang, Y.N., Li, G.F., Liu, B.Y., Wang, H., Ye, H.C. (2009) Identification of a Polygonum cuspidatum three-intron gene encoding a type III polyketide synthase producing both naringenin and p-hydroxybenzalacetone Planta 229:1077-1086
Gaid, M.M., Sircar, D., Beuerle, T., Mitra, A., Beerhues, L. (2009) Benzaldehyde dehydrogenase from chitosan-treated Sorbus aucuparia cell cultures J. Plant Physiol. 166:1343-1349
Abdelhady,M.I.S., Beuerle,T., Ober,D. (2009) Homospermidine in transgenic tobacco results in considerably reduced spermidine levels but is not converted to pyrrolizidine alkaloid precursors. Plant Molecular Biology 71:145-155
Ma, D., Pu, G., Lei, C., Ma, L., Wang, H., Guo, Y., Chen, J., Du, Z., Li, G., Ye, H., Liu, B. (2009) Isolation and characterization of AaWRKY1, an Artemisia annua transcription factor that regulates the amorpha-4,11-diene synthase gene, a key gene of artemisinin biosynthesis Plant Cell Physiol 50:2146-2161
Hartmann,T. (2009) Pyrrolizidine alkaloids: The successful adoption of a plant chemical defense In: W.E.Conner (ed.) Tiger Moths and Woolly Bears: pp. 55-81, Oxford University Press: Oxford, New York :
Wang, H., Ma, C., Ma, L., Du, Z., Ye, H., Li, G., Liu, B., Xu, G. (2009) Secondary metabolic profiling and artemisinin biosynthesis of two genotypes of Artemisia annua Planta Med 75:1625-1633
Pu, G.B., Ma, D.M., Chen, J.L., Ma, L.Q., Wang, H., Li, G.F., Ye, H.C., Liu, B.Y. (2009) Salicylic acid activates artemisinin biosynthesis in Artemisia annua L Plant Cell Rep 28:1127-1135
Ma, C., Wang, H.H., Lu, X., Wang, H., Xu, G., Liu, B. (2009) Terpenoid metabolic profiling analysis of transgenic Artemisia annua L. by comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry Metabolomics 5:497-506
Burow, M., Wittstock, U., Gershenzon, J. (2008) Sulfur-containing secondary metabolites and their role in plant defense In: Hell, R. et al. (eds.) Advances in Photosynthesis and Respriation, Vol. 27: Sulfur metabolism in phototrophic organisms, Springer, Dordrecht :201-222
Burow, M., Zhang, Z.Y., Ober, J.A., Lambrix, V.M., Wittstock, U., Gershenzon, J., Kliebenstein, D.J. (2008) ESP and ESM1 mediate indol-3-acetonitrile production from indol-3-ylmethyl glucosinolate in Arabidopsis Phytochemistry 69:663-671
Hartmann,T., Ober,D. (2008) Defense by pyrrolizidine alkaloids: developed by plants and recruited by insects. In: A. Schaller (ed.) Induced Plant Resistance to Herbivory :pp. 213-231, Springer
Marín-Loaiza, J.C., Ernst, L., Beuerle, T., Theuring, C., Céspedes, C.L., Hartmann, T. (2008) Pyrrolizidine alkaloids of the endemic Mexican genus Pittocaulon and assignment of stereoisomeric 1,2-saturated necine bases Phytochemistry 69:154-167
Hartmann, T. (2008) The lost origin of chemical ecology in the late nineteenth century Proc. Natl. Acad. Sci. U.S.A. 105:4541-4546
Kempf,M., Beuerle,T., Bühringer,M., Denner,M., Trost,D., von der Ohe,K., Bhavanam,V.B.R., Schreier,P. (2008) Pyrrolizidine alkaloids in honey: Risk analysis by gas chromatography-mass spectrometry Molecular Nutrition & Food Research 52:1193-2000
Ma, C., Wang, H.H., Lu, X., Xu, G., Liu, B. (2008) Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry J Chromatogr A 1186:412-419
Ma, L.Q., Pang, X.B., Shen, H.Y., Pu, G.B., Wang, H.H., Lei, C.Y., Wang, H., Li, G.F., Liu, B.Y., Ye, H.C. (2008) A novel type III polyketide synthase encoded by a three-intron gene from Polygonum cuspidatum Planta 229:457-469
Kempf,M., Beuerle,T., Bühringer,M., Denner,M., Trost,D., Schreier,P. Analysis of pyrrolizidine alkaloids in honey. (2008) Analysis of pyrrolizidine alkaloids in honey Lebensmittelchemie 62:126
Wheat, C.W., Vogel, H., Wittstock, U., Braby, M.F., Underwood, D., Mitchell-Olds, T. (2007) The genetic basis of a plant-insect coevolutionary key innovation Proc. Natl. Acad. Sci. USA 104:20427-20431
Wittstock, U., Burow, M. (2007) Tipping the scales - specifier proteins in glucosinolate hydrolysis IUBMB Life 59:744-751
Burow, M., Rice, M., Hause, B., Gershenzon, J., Wittstock, U. (2007) Cell- and tissue-specific localization and regulation of the epithiospecifier protein in Arabidopsis thaliana Plant Molecular Biology 64:173-185
Burow, M., Bergner, A., Gershenzon, J., Wittstock, U. (2007) Glucosinolate hydrolysis in Lepidium sativum - identification of the thiocyanate-forming protein Plant Molecular Biology 63:49-61
Hartmann, T. (2007) From waste products to ecochemicals: fifty years research of plant secondary metabolism Phytochemistry 68:2831-2846
Liu, B., Raeth, T., Beuerle, T., Beerhues, L. (2007) Biphenyl synthase, a novel type III polyketide synthase Planta 225:1495-1503
Beerhues, L., Liu, B., Raeth, T., Klundt, T., Beuerle, T., Bocola, M. (2007) Benzoic acid-specific type III polyketide synthases American Chemical Society Symposium Series 955 (Rimando, A.M., Baerson, S.R., eds.) :97-108
Brehm, G., Hartmann, T., Willmott, K. (2007) Pyrrolizidine alkaloids and pharmacophagous Lepidoptera visitors of Prestonia amabilis (Apocynaceae) in a montane rain forest in Ecuador Annales of the Missouri Botanical Garden 94:463-473
Marín Loaiza, J.C., Céspedes, C.L., Beuerle, T., Theuring, C., Hartmann, T. (2007) Ceroplastes albolineatus, the first scale insect shown to sequester pyrrolizidine alkaloids from its host-plant Pittocaulon praecox Chemoecology 17:109-115
Frölich, C., Ober, D., Hartmann, T. (2007) Tissue distribution, core biosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three Boraginaceae species Phytochemistry 68:1026-1037
Charchoglyan, A., Abrahamyan, A., Fujii, I., Boubakir, Z., Gulder, T.A.M., Kutchan, T.M., Vardapetyan, H., Bringmann, G., Ebizuka, Y., Beerhues, L. (2007) Differential accumulation of hyperforin and secohyperforin in Hypericum perforatum tissue cultures Phytochemistry 68:2670-2677
Beerhues, L. (2007) Hyperforin, garcinol and related compounds - Biosynthesis of complex plant polyketide derivatives Proceedings of the 5th Indochina Conference on Pharmaceutical Sciences (Puttipipatkhachorn, S. et al., eds.) : 5-10
Ma, C., Wang, H., Lu, X., Li, H., Liu, B., Xu, G. (2007) Analysis of Artemisia annua L. volatile oil by comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry J. Chromatogr. A 1150:50-53
Han, J.L., Li, Z.Q., Liu, B.Y., Wang, H., Li, G.F., Ye, H.C. (2007) Metabolic engineering of terpenoids in plants Sheng Wu Gong Cheng Xue Bao 23:56-569
Beerhues, L., Liu, B. (2007) Polyketide metabolism in Hypericum perforatum and related species Biotechnology and sustainable agriculture 2006 and beyond (Xu, Z., Li, J., Xue, Y., Yang, W., eds.) Springer :345-348
Beuerle,T., Theuring,C., Klewer,N., Schulz,S., Hartmann,T. (2007) Absolute configuration of the creatonotines and callimorphines, two classes of arctiid-specific pyrrolizidine alkaloids Insect Biochem. Mol. Biol. 37:80-89
Wang, H., Liu, Y., Chong, K., Liu, B.Y., Ye, H.C., Li, Z.Q., Yan, F., Li, G.F., (2007) Earlier flowering induced by over-expression of CO gene does not accompany increase of artemisinin biosynthesis in Artemisia annua Plant Biol (Stuttg) 9:442-446
Vergara, F., Svatos, A., Schneider, B., Reichelt, M., Gershenzon, J., Wittstock, U. (2006) Glycine conjugates in a lepidopteran insect herbivore - the metabolism of benzylglucosinolate in the cabbage white butterfly, Pieris rapae ChemBioChem 7:1982-1989
Burow, M., Markert, J., Gershenzon, J., Wittstock, U. (2006) Comparative biochemical characterization of nitrile-forming proteins from plants and insects that alter myrosinase-catalyzed hydrolysis of glucosinolates. FEBS J. 273:2432-2446
Burow, M., Müller, R., Gershenzon, J., Wittstock, U. (2006) Altered glucosinolate hydrolysis in genetically engineered Arabidopsis thaliana and its influence on the larval development of Spodoptera littoralis Journal of Chemical Ecology 32:2333-2349
Beerhues, L. (2006) Hyperforin Phytochemistry 67:2201-2207
Hänsch R, Lang C, Riebeseel E, Lindigkeit R, Gessler A, Rennenberg H, Mendel RR (2006) Plant sulfite oxidase as novel producer of H2O2: combination of enzyme catalysis with a subsequent non-enzymatic reaction step. J Biol Chem 281(10):6884-8
Frölich, C., Hartmann, T., Ober, D. (2006) Tissue distribution and biosynthesis of 1,2-saturated pyrrolizidine alkaloids in Phalaenopsis hybrids (Orchidaceae) Phytochemistry 67:1493-1502
Ober, D. (2005) Seeing Double – Gene Duplication and Diversification in Plant Secondary Metabolism Trends in Plant Science 10:444-449
Nurhayati, N., Ober, D. (2005) Recruitment of alkaloid-specific homospermidine synthase (HSS) from ubiquitous deoxyhypusine synthase: does Crotalaria possess a functional HSS that still has DHS activity? Phytochemistry 66:1346-1357
Müller, C., Wittstock, U. (2005) Uptake and turn-over of glucosinolates sequestered in the sawfly Athalia rosae. Insect Biochem. Mol. Biol. 35:1189-1198
Hartmann, T., Theuring, C., Beuerle, T., Bernays, E. A., and Singer, M. S. (2005) Acquisition, transformation and maintenance of plant pyrrolizidine alkaloids by the polyphagous arctiid Grammia geneura Insect Biochem. Mol. Biol. 35:1083-1099
Pelser, P. B., de Vos, H., Theuring, C., Beuerle, T., Vrieling, K., Hartmann, T. (2005) Frequent gain and loss of pyrrolizidine alkaloids in the evolution of Senecio section Jacobaea (Asteraceae) Phytochemistry 66,:1285-1295
Hartmann, T., Theuring, C., Beuerle, T., Klewer, N., Schulz, S., Singer, M.S., Bernays, E.A. (2005) Specific recognition, detoxification and metabolism of pyrrolizidine alkaloids by the polyphagous arctiid Estigmene acrea Insect Biochem. Mol. Biol. 35:391-411
Beerhues, L. (2005) Gifte der Natur - Pflanzen und Tiere Lateinamerikas die waage (Kulturmagazin der Grünenthal GMBH) 44:86-93
Beerhues, L., Abd El-Mawla, A., Beuerle, T., Boubakir, Z., Klingauf, P., Liu, B. (2005) Biosynthesis of active plant polyketide derivatives Proceedings of the 9th International Congress "Phytopharm 2005" and the PSE Young Scientists Meeting on "Plants and Health" (Makarov, V.G., ed.) :39-46
Boubakir, Z., Beuerle, T., Liu, B., Beerhues, L. (2005) The first prenylation step in hyperforin biosynthesis Phytochemistry 66:51-57
Jenett-Siems, K., Ott, S.C., Schimming, T., Siems, K., Müller, F., Hilker, M., Witte, L., Hartmann, T., Austin, D. F., Eich, E. (2005) Ipangulines and minalobines, chemotaxonomic markers of the infrageneric Ipomoea taxon subgenus Quamoclit, section Mina Phytochemistry 66:223-231
Klingauf, P., Beuerle, T., Mellenthin, A., El-Moghazy, S.A.M., Boubakir, Z., Beerhues, L. (2005) Biosynthesis of the hyperforin skeleton in Hypericum calycinum cell cultures Phytochemistry 66:139-145
Anke, S., Niemüller, D., Moll, S., Hänsch, R., Ober, D. (2004) Polyphyletic origin of pyrrolizidine alkaloids within the Asteraceae: Evidence from differential tissue expression of homospermidine synthase Plant Physiology 136:4037-4047
Reimann, A., Nurhayati, N., Backenköhler, A., and Ober, D. (2004) Repeated evolution of the pyrrolizidine-mediated defense system in separate angiosperm lineages. The Plant Cell 16:2772-2784
Wittstock, U., Agerbirk, N., Stauber, E.J., Olsen, C.E., Hippler, M., Mitchell-Olds, T., Gershenzon, J., Vogel, H. (2004) Successful herbivore attack due to metabolic diversion of a plant chemical defense. Proc. Natl. Acad. Sci. U.S.A. 101:4859-4864
Narberhaus, I., Papke, U., Theuring, C., Beuerle, T., Hartmann, T., Dobler, S. (2004) Direct evidence for membrane transport of host plant derived pyrrolizidine alkaloid N-oxides in two leaf beetle genera J. Chem. Ecol. 30:2003-2022
Singer, M.S., Carriere, Y., Theuring, C., Hartmann, T. (2004) Disentangling food quality from resistance against parasitoids: diet choice by a generalist caterpillar The American Naturalist 164:423-429
Hartmann, T., Theuring, C., Beuerle, T., Bernays, E. A. (2004) Phenological fate of plant-acquired pyrrolizidine alkaloids in the polyphagous arctiid Estigmene acrea Chemoecology 14:207-216
Pasteels, J. M., Hartmann, T. (2004) Sequestration of pyrrolizidine alkaloids in Oreina and Platyphora leaf beetles: Physiological, ecological and evolutionary aspects In: New Contributions to the Biology of Chrysomelidae (eds. Jolivet, P. H., Santiago-Blay, J. A., Schmitt, M.), pp. 677-691. :SPB Academic Publishing bv, The Hague, The Netherlands
Hartmann, T. (2004) Plant-derived secondary metabolites as defensive chemicals in herbivorous insects: a case-study in chemical ecology Planta 219:1-4
Narberhaus, I., Theuring, C., Hartmann, T., Dobler, S. (2004) Time course of pyrrolizidine alkaloid sequestration in Longitarsus flea beetles (Coleoptera, Chrysomelidae) Chemoecology 14:17-23
Hartmann,T., Theuring,C., Beuerle,T., Ernst,L., Singer, M.S., Bernays, E.A. (2004) Acquired and partially de novo synthesized pyrrolizidine alkaloids in two polyphagous arctiids and the alkaloid profiles of their larval food-plants J. Chem. Ecol. 30:229-254
Bernays, E.A., Hartmann, T., Chapman, R.F. (2004) Gustatory sensitivity to pyrrolizidine alkaloids in the Senecio specialist, Tyria jacobaeae (Lepidoptera, Arctiidae) Physiol. Entomol. 29:67-72
Liu, B., Beuerle, T., Klundt, T., Beerhues, L. (2004) Biphenyl synthase from yeast-extract-treated cell cultures of Sorbus aucuparia Planta 218:492-496
Ober, D. (2003) Chemical ecology of alkaloids exemplified with the pyrrolizidines. Recent Advances in Phytochemistry (J. T. Romeo et al., eds.) 37, Pergamon, Amsterdam:203-230
Wittstock, U., Kliebenstein, D.J., Lambrix, G., Reichelt, M., Gershenzon, J. (2003) Glucosinolate hydrolysis and its impact on generalist and specialist insect herbivores. ed. Romeo J.T., Recent Advances in Phytochemistry: Integrative phytochemistry: from ethnobotany to molecular ecology. Vol. 37, Elsevier, Amsterdam:101-125
Ober, D., Harms, R., Witte, L., Hartmann, T. (2003) Molecular evolution by change of function: Alkaloid-specific homospermidine synthase retained all properties of deoxyhypusine synthase except binding the eIF5A precursor protein. J. Biol. Chem. 278:12805-12812
Ober, D., Gibas, L., Witte, L., Hartmann, T. (2003) Evidence for general occurrence of homospermidine in plants and its supposed origin as by-product of deoxyhypusine synthase Phytochemistry 62:339-344
Weinig, S., Hecht, H.-J., Mahmud, T., and Müller, R. (2003) Further insights into Myxobacterial PKS/NRPS systems and evidence for a new subclass of methyl transferases Chem. Biol. 10:939-952
Weinig, S., Mahmud, T., and Müller, R. (2003) Markerless mutations in the myxothiazol biosynthetic gene cluster: A delicate megasynthetase with a superfluous nonribosomal peptide synthetase domain Chem. Biol. 10:953-960
Bode, H.B., Irschik, H., Wenzel, S.C., Reichenbach, H., Müller, R., and Höfle, G. (2003) The Leupyrrins: A Structurally Unique Family of Secondary Metabolites from the Myxobacterium Sorangium cellulosum J. Nat. Prod. 66:1203-1206
Hartmann, T. Theuring, C., Bernays, E.A. (2003) Are insect-synthesized retronecine esters (creatonotines) the precursors of the male courtship pheromone in the arctiid moth Estigmene acrea? J. Chem. Ecol. 29:2603-2609
Hartmann,T., Ober,D. (2003) Der pflanzliche Sekundärstoffwechsel: Biologische Notwendigkeit und pharmazeutischer Nutzen. Carolo-Wilhelmina: Forschungsmagazin der Technischen Universität Braunschweig 38:26-32
Gerth, K., Pradella, S., Perlova, O., Beyer, S. and Müller, R. (2003) Myxobacteria: Proficient producers of novel natural products with various biological activities past and future biotechnological aspects with the focus on the genus Sorangium J. Biotechnol. :in press
Bernays, E.A., Rodrigues, D., Chapman, R.F., Singer, M.R., Hartmann, T. (2003) Loss of gustatory responses to pyrrolizidine alkaloids after their extensive ingestion in the polyphagous caterpillar, Estigmene acrea J. Exp. Biol. 206:4487-4496
Halusková, J., Liu, B., Beerhues, L. (2003) rDNA methylation in Hypericum perforatum diploids and tetraploids Z. Naturforsch. 58c:895-897
Kopp, M., Irschik, H., Gross, F., Perlova, O., Sandmann, S., Gerth, K., and Müller, R. (2003) Critical variations of conjugational DNA transfer into secondary metabolite multiproducing Sorangium cellulosum strains So ce12 and So ce56 development of a mariner-based transposon mutagenesis system J. Biotechnol. :in press
Chapman, R. F., Bernays, E. A., Singer, M. S., Hartmann, T. (2003) Experience influences gustatory responsiveness to pyrrolizidine alkaloids in the polyphagous caterpillar, Estigmene acrea J. Comp. Physiol. A 189:833-841
Franke, D., Lorbach, V., Dose, C., Eßer, S.. Halfar, M., Thömmes, J., Müller, R., Takors, R., Sprenger, G.A and Müller, M. (2003) 5S,6S)-Dihydroxy-cyclohexa-1,3-dienecarboxylic acid: microbial access with engineered cells of Escherichia coli and applicability as starting material in natural product synthesis Chemistry – A European Journal 9:4188-4196
Narberhaus, I., Theuring, C., Hartmann, T., Dobler, S. (2003) Uptake and metabolism of pyrrolizidine alkaloids in Longitarsus flea beetles (Coleoptera: Chrysomelidae) adapted and non-adapted to alkaloid-containing host plants. J. Comp. Physiol. B 173:483-491
Liu, B., Falkenstein-Paul, H., Schmidt, W., Beerhues, L. (2003) Benzophenone synthase and chalcone synthase from Hypericum androsaemum cell cultures: cDNA cloning, functional expression, and site-directed mutagenesis of two polyketide synthases. Plant J. 34:847-855
Hartmann, T., Häggström, H., Theuring, C., Lindigkeit, L., Rahier, M. (2003) Detoxification of pyrrolizidine alkaloids by the harvestman Mitopus morio (Phalangidae) a predator of alkaloid defended leaf beetles Chemoecology 13:123-127
Bernays, E. A., Chapman, R. F., LaMunyon, C. W., Hartmann, T. (2003) Taste receptors for pyrrolizidine alkaloids in a monophagous caterpillar. J. Chem. Ecol. 29:1709-1722
Bode, H. B., and Müller, R. (2003) Possibility of bacterial recruitment of plant genes associated with the biosynthesis of secondary metabolites Plant. Physiol. 132:1153-1161
Pasteels, J. M.,Theuring, C.,Witte, L.,Hartmann, T. (2003) Sequestration and metabolism of protoxic pyrrolizidine alkaloids by larvae of the leaf beetle Platyphora boucardi and their transfer via pupae into defensive secretions of adults J. Chem. Ecol. 29:337-355
Bode, H.B., Zeggel, B., Silakowski, B., Wenzel, S. C., Reichenbach, H. and Müller, R. (2003) Steroid biosynthesis in procaryotes: Identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)-oxidosqualen cyclase from the myxobacterium Stigmatella aurantiaca Mol. Microbiol. 47:471-481
Pasteels, J. M., Theuring, C., Windsor, D. M., Hartmann, T. (2003) Uptake and metabolism of [14C]rinderine and [14C]retronecine in leaf-beetles of the genus Platyphora and alkaloid accumulation in the exocrine defensive secretions. Chemoecology 13:55-62
Hartmann, T., Theuring, C., Witte, L., Schulz, S., Pasteels, J. M. (2003) Biochemical processing of plant acquired pyrrolizidine alkaloids by the alkaloid sequestering neotropical leaf-beetle Platyphora boucardi. Insect Biochem. Mol. Biol. 33:515-524
Halkier, B.A., Hansen, C.H., Mikkelsen, M.D., Naur, P., Wittstock, U. (2002) The role of cytochromes P450 in biosynthesis and evolution of glucosinolates. eds. Romeo, J.T., Dixon, R.A., Recent Advances in Phytochemistry: Phytochemistry in the post-genomics eras. Vol. 36, Elsevier, Amsterdam:223-248
Wittstock, U., Gershenzon J. (2002) Constitutive plant toxins and their role in defense against herbivores and pathogens. Curr. Opin. Plant Biol. 5:300-307
Moll, S. ,Anke, S., Kahmann, U., Hansch, R., Hartmann, T., Ober, D. (2002) Cell-specific expression of homospermidine synthase, the entry enzyme of the pyrrolizidine alkaloid pathway in Senecio vernalis, in comparison with its ancestor, deoxyhypusine synthase Plant Physiol. 130:47-57
Wittstock, U., Halkier, B.A. (2002) Glucosinolate research in the Arabidopsis era. Trends Plant Sci. 7:263-270
Naumann, C., Hartmann, T., Ober, D. (2002) Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids in the alkaloid-defended arctiid moth Tyria jacobaeae Proc. Natl. Acad. Sci. U. S. A. 99:6085-90
Beuerle,T., Pichersky, E. (2002) Enzymatic Synthesis and Purification of Aromatic Coenzyme A Esters Analytical Biochemistry 302:305-312
Beuerle,T., Pichersky,E. (2002) Purification and Characterization of Benzoate: Coenzyme A ligase from Clarkia breweri Archives of Biochemistry and Biophysics 400:258-264
Lavid,N., Wang,J., Shalit,M., Guterman,I., Bar,E., Beuerle,T., Menda,N., Shafir,S., Zamir,D., Adam,Z., Vainstein,A., Weiss,D., Pichersky,E., Lewinsohn,E. (2002) O-methyltransferases involved in the biosynthesis of volatile phenolic derivatives in rose petals. Plant Physiology 129:1899-1907
Gang,D.R., Lavid,N., Zubieta,C., Cheng,F., Beuerle,T., Lewinsohn,E., Noel,J.P., Pichersky, E. (2002) Characterization of Phenylpropene O-Methyltransferases from Sweet Basil: Facile Change of Substrate Specificity and Convergent Evolution within a Plant OMT Family Plant Cell 14:505-519
Arakawa, K., Müller, R., Mahmud, T., Yu, T.-W. and Floss, H. G. (2002) Characterization of the Early Stage Aminoshikimate Pathway in the Formation of 3-Amino-5-hydroxybenzoic Acid (AHBA): The RifN Protein Specifically Converts Kanosamine into Kanosamine 6-Phosphate J. Amer. Chem. Soc. 124:10644-10655
Bernays, E. A., Chapman, R. F., Hartmann, T. (2002) A highly sensitive taste receptor cell for pyrrolizidine alkaloids in the lateral galeal sensillum of a polyphagous caterpillar, Estigmene acraea J. Comp. Physiol. [A] 188:715-23
Haberer, W., Witte, L., Hartmann, T., Dobler, S. (2002) Pyrrolizidine alkaloids in Pulmonaria obscura Planta Med. 68:480-482
Bernays, E. A., Chapman, R. F., Hartmann, T. (2002) A taste receptor neurone dedicated to the perception of pyrrolizidine alkaloids in the medial galeal sensillum of two polyphagous arctiid caterpillars Physiol. Entomol. 27:312-321
Brückmann, M., Termonia, A., Pasteels, J. M., Hartmann, T. (2002) Characterization of an extracellular salicyl alcohol oxidase from larval defensive secretions of Chrysomela populi and Phratora vitellinae (Chrysomelina) Insect Biochem. Mol. Biol. 32:1517-23
Gaitatzis, N., Silakowski, B., Kunze, B., Nordsiek, G., Blöcker, H., Höfle, G. and Müller, R. (2002) The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase J. Biol. Chem. 277:13082-13090
Abd El-Mawla, A.M.A., Beerhues, L. (2002) Benzoic acid biosynthesis in cell cultures of Hypericum androsaemum. Planta 214:727-733
Mahmud, T., Bode, H. B., Silakowski, B., Kroppenstedt, R. M., Xu, M., Nordhoff, S., Höfle, G. and Müller, R. (2002) A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria J. Biol. Chem. 277:32768-32774
Hansen, C.H., Wittstock, U., Olsen, C.E., Hick, A.J., Pickett, J.A., Halkier, B.A. (2001) Cytochrome P450 CYP79F1 from Arabidopsis catalyzes the conversion of dihomomethionine and trihomomethionine to the corresponding aldoximes in the biosynthesis of aliphatic glucosinolates. J. Biol. Chem. 276:11078-11085
Ober, D. (2001) Warum gibt es Gift- und Arzneipflanzen? Die Evolution des pflanzlichen Sekundärstoffwechsels am Beispiel der Pyrrolizidin-Alkaloide Deutsche Apotheker Zeitung 141:2127-2131
Buss, K., Müller, R., Dahm, C., Gaitatzis, N., Skrypczak-Pietrszek, E., Lohmann, S., Gassen, M. and Leistner, E. (2001) Clustering of isochorismate synthase genes menF and entC and channeling of isochorismate in Escherichia coli Biochim. Biophys. Acta 1522:151-157
Silakowski, B., Kunze, B. and Müller, R. (2001) Multiple hybrid polyketide synthase/non-ribosomal peptide synthetase gene clusters the myxobacterium Stigmatella aurantiaca Gene 275:233-240
Gaitatzis, N., Kunze, B. and Müller, R. (2001) In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterisation of a reductive release mechanism from non-ribosomal peptide synthetases Proc. Nat. Acad. Sci. (USA) 98:11136-11141
Pasteels, J. M., Termonia, A., Windsor, D. M., Witte, L., Theuring, C., Hartmann, T. (2001) Pyrrolizidine alkaloids and pentacyclic triterpene saponins in the defensive secretions of Platyphora leaf beetles Chemoecology 11:113-120
Abd El-Mawla, A.M.A., Schmidt, W., Beerhues, L. (2001) Cinnamic acid is a precursor of benzoic acids in cell cultures of Hypericum androsaemum L. but not in cell cultures of Centaurium erythraea RAFN. Planta 212:288-293
Beerhues, L. (2001) Jagdgift und Arznei. Gifte aus tropischen Pflanzen und Tieren als Herzglykoside, Muskelrelaxanzien und Analgetika. Deutsche Apotheker Zeitung 141:163-173
Silakowski, B., Nordsiek, G., Kunze, B., Blöcker, H. and Müller, R. (2001) Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: The myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sg a15 Chem. & Biol. 8:59-69
Hartmann, T., Theuring, C., Witte, L., Pasteels, J. M. (2001) Sequestration, metabolism and partial synthesis of tertiary pyrrolizidine alkaloids by the neotropical leaf-beetle Platyphora boucardi Insect Biochem. Mol. Biol. 31:1041-56
Gaitatzis, N., Hans, A., Müller, R. and Beyer, S. (2001) The mtaA gene of the myxothiazol biosynthetic gene clusterfrom Stigmatella aurantiaca DW4/3-1 encodes a phosphopantetheinyl transferase that activates polyketide synthases and polypeptide synthetases J. Biochemistry 129:119-124
Yu, T., Müller, R., Müller, M., Zhang, X., Dräger, G., Kim, C-G., Leistner, E. and Floss, H.G. (2001) Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in Amycolatopsis mediterranei J. Biol. Chem. 276:12546-12555
Mikkelsen, M.D., Hansen, C.H Wittstock, U., Halkier, B.A. (2000) Cytochrome P450 CYP79B2 from Arabidopsis catalyzes the conversion of tryptophan to indole-3-acetaldoxime, a precursor of indole glucosinolates and indole-3-acetic acid. J. Biol. Chem. 275:33712-33717
Ober, D., Hartmann, T. (2000) Phylogenetic origin of a secondary pathway: The case of pyrrolizidine alkaloids Plant Mol. Biol. 44:445-450
Wittstock, U., Halkier, B.A. (2000) Cytochrome P450 CYP79A2 from Arabidopsis thaliana L. catalyzes the conversion of L-phenylalanine to phenylacetaldoxime in the biosynthesis of benzylglucosinolate. J. Biol. Chem. 275:14659-14666
Ober, D., Harms, R., Hartmann, T. (2000) Cloning and expression of homospermidine synthase from Senecio vulgaris: A revision Phytochemistry 55:305-309
Wittstock, U., Chen, S., Halkier, B.A. (2000) A method for expression cloning of transporter genes by screening yeast for uptake of radiolabelled substrate. J. Exp. Bot. 51:955-960
Hartmann, T., Ober, D. (2000) Biosynthesis and metabolism of pyrrolizidine alkaloids in plants and specialized insect herbivores Top. Curr. Chem. Springer, Berlin [u.a.], 209:207-244
Wittstock, U., Fischer, M., Svendsen, I., Halkier, B.A. (2000) Cloning and characterization of two cDNAs encoding sulfatases in the Roman snail Helix pomatia. IUBMB Life 49:71-76
Silakowski, B., Kunze, B. and Müller, R. (2000) Stigmatella aurantiaca Sg a15 contains genes encoding type I and type II 3-deoxy-D-arabino-heptulosonate-7-phosphate synthases: involvement of a type II synthase in aurachin biosynthesis Arch. Microbiol. 173:403-411
Schmidt, W., Abd El-Mawla, A.M.A., Wolfender, J.L., Hostettmann, K., Beerhues, L. (2000) Xanthones in cell cultures of Hypericum androsaemum. Planta Med. 66:380-381
Barillas, W., Beerhues, L. (2000) 3-Hydroxybenzoate:coenzyme A ligase from cell cultures of Centaurium erythraea: Isolation and characterization. Biol. Chem. 381:155-160
Schmidt, W., Peters, S., Beerhues, L. (2000) Xanthone 6-hydroxylase from cell cultures of Centaurium erythraea RAFN and Hypericum androsaemum L. Phytochemistry 53:427-431
Müller, R., Gerth, K., Brand, P., Blöcker, H. and Beyer, S. (2000) Identification of an L-dopa decarboxylase gene from Sorangium cellulosum So ce90 Arch. Microbiol. 173:303-306
Dobler, S., Haberer, W. ,Witte, L., Hartmann, T. (2000) Selective sequestration of pyrrolizidine alkaloids from diverse host plants by Longitarsus flea beetles J. Chem. Ecol. 26:1281-1298
Graser, G., Hartmann, T. (2000) Biosynthesis of spermidine, a direct precursor of pyrrolizidine alkaloids in root cultures of Senecio vulgaris L Planta 211:239-245
Silakowski, B., Kunze, B., Nordsiek, G., Blöcker, H., Höfle, G. and Müller, R. (2000) The myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sg a15 Eur. J. Biochem. 267:6476-6485
Brückmann, M., Trigo, J. R., Foglio, M. A., Hartmann, T. (2000) Storage and metabolism and radioactively labeled pyrrolizidine alkaloids by butterflys and larvae of Mechanitis polymnia (Lepidoptera: Nymphalidae, Ithomiinae) Chemoecology 10:25-32
Ober, D., Hartmann, T. (1999) Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase Proc. Natl. Acad. Sci. U. S. A. 96:14777-14782
Ober, D., Hartmann, T. (1999) Deoxyhypusine synthase from tobacco: cDNA isolation, characterization, and bacterial expression of an enzyme with extended substrate specificity J. Biol. Chem. 274:32040-32047
Beuerle,T., Engelhard,S., Bicchi, C., Schwab,W. (1999) Isolation, identification, and enantioselective synthesis of octane-1,3,7-triol: Determination of its absolute configuration Journal of Natural Products 62:35-40
Beuerle,T., Schwab, W. (1999) Metabolic profile of linoleic acid in stored apples: Formation of 13(R)-hydroxy-9(Z),11(E)-octadecadienoic acid Lipids 34:375-380
Beuerle,T., Schwab,W. (1999) Biosynthesis of R-(+)-octane-1,3-diol. Crucial role of beta-oxidation in the enantioselective generation of 1,3-diols in stored apples. Lipids 34:617-625
Kavvadias,D., Beuerle,T., Wein,M., Boss,B., König,T., Schwab,W. (1999) Novel 1,3-dioxanes from apple juice and cider Journal of Agriculture and Food Chemistry 47:5178-5183
Silakowski, B., Schairer, H. U., Ehret, H., Kunze, B., Weinig, S., Norsiek, G., Blöcker, H., Höfle, G., Beyer, S. and Müller, R. (1999) New lessons for combinatorial biosynthesis from Myxobacteria: The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1 J. Biol. Chem. 274:37391-37399
Beyer, S., Kunze, B., Silakowski, B. and Müller, R. (1999) Metabolic diversity in myxobacteria – identification of the myxalamid and the stigmatellin biosynthetic gene cluster of Stigmatella aurantiaca Sg a15 and a combined polyketide-(poly)peptide gene cluster from the epothilon producing strain Sorangium cellulosum So ce90 Biochim. Biophys. Acta 1445:185-195
Weber, S.,Eisenreich, W.,Bacher, A.,Hartmann, T. (1999) Pyrrolizidine alkaloids of the lycopsamine type: Biosynthesis of trachelanthic acid Phytochemistry 50:1005-1014
Chen, S., von Bamberg, D., Hale, V., Breuer, M., Hardt, B., Müller, R., Floss, H.G., Reynolds, K.A. and Leistner, E. (1999) Biosynthesis of ansatrienin (mycotrienin) and naphtomycin: Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus TÜ 1892. 261, 98- Eur. J. Biochem. 261:98-107
Ehmke, A.,Rahier, M.,Pasteels, J. M.,Theuring, C.,Hartmann, T. (1999) Sequestration, maintenance, and tissue distribution of pyrrolizidine alkaloid N-oxides in larvae of two Oreina species J. Chem. Ecol. 25:2385-2395
Beerhues, L., Barillas, W., Peters, S., Schmidt, W. (1999) Biosynthesis of plant xanthones. Bioorganic Chemistry. Highlights and New Aspects (Diederichsen, U., Lindhorst, T.K., Wessjohann, L., Westermann, B.) Wiley-VCH, Weinheim:322-328
Hartmann, T. (1999) Chemical ecology of pyrrolizidine alkaloids Planta 207:483-495
Tofern, B.,Kaloga, M.,Witte, L.,Hartmann, T.,Eich, E. (1999) Occurrence of loline alkaloids in Argyreia mollis (Convolvulaceae) Phytochemistry 51:1177-1180
Gomez, N. E.,Witte, L.,Hartmann, T. (1999) Chemical defense in larval tortoise beetles: Essential oil composition of fecal shields of Eurypedus nigrosignata and foliage of its host plant, Cordia curassavica J. Chem. Ecol. 25:1007-1027
Hartmann, T.,Theuring, C.,Schmidt, J.,Rahier, M.,Pasteels, J. M. (1999) Biochemical strategy of sequestration of pyrrolizidine alkaloids by adults and larvae of chrysomelid leaf beetles J. Insect Physiol. 45:1085-1095
Brunerie,P., Beuerle,T., Schreier,P., Schwab, W. (1998) C8-Diols as Precursors of New Flavouring Acetals in Apples Natural Product Analysis, Eds., Schreier,P., Herderich,M., Humpf,H.-U., Schwab,W. Vieweg, Braunschweig :345-351
Schwab,W., Beuerle,T., Roscher,R. (1998) Radiotracer Techniques in Biosynthetic Studies of Flavour Compounds Natural Product Analysis, Eds. Schreier,P., Herderich,M., Humpf,H.-U. and Schwab ,W. Vieweg, Braunschweig:289-297
Tinney, G.,Theuring, C.,Paul, N.,Hartmann, T. (1998) Effects of rust infection with Puccinia lagenophorae on pyrrolizidine alkaloids in Senecio vulgaris Phytochemistry 49:1589-1592
Jenett-Siems, K.,Schimming, T.,Kaloga, M.,Eich, E.,Siems, K.,Gupta, M. P.,Witte, L.,Hartmann, T. (1998) Phytochemistry and chemotaxonomy of the Convolvulaceae: Pyrrolizidine alkaloids of Ipomoea hederifolia and related species Phytochemistry 47:1551-1560
Peters, S., Schmidt, W., Beerhues, L. (1998) Regioselective oxidative phenol couplings of 2,3’,4,6-tetrahydroxybenzophenone in cell cultures of Centaurium erythraea RAFN and Hypericum androsaemum L. Planta 204:64-69
August, P. R., Tang, L., Yoon, Y.J., Ning, S., Müller, R., Yu, T., Taylor, M., Hoffmann, D., Kim, C-G., Zhang, X., Hutchinson, C.R. and Floss, H.G. (1998) Biosynthesis of the ansamycin antibiotic rifamycin: Deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699 Chem. Biol. 5:69-79
Müller, M., Müller, R., Yu, T. and Floss, H.G. (1998) Synthesis of (-)-3-amino-3-deoxyquinic acid J. Org. Chem. 63:9753-9755
Dahm, C., Müller, R., Schulte, G., Schmidt, K. and Leistner, E. (1998) The role of isochorismate hydroxymutase genes entC aned menF in enterobactin and menaquinone biosynthesis in Escherichia coli Biochim. Biophys. Acta 1425:377-386
Chang, A.,Hartmann, T. (1998) Solubilization and characterization of a senecionine N-oxygenase from Crotalaria scassellatii seedlings Phytochemistry 49:1859-1866
Graser, G.,Witte, L.,Robins, D. J.,Hartmann, T. (1998) Incorporation of chirally deuterated putrescines into pyrrolizidine alkaloids: A reinvestigation Phytochemistry 47:1017-1024
Hartmann, T.,Dierich, B. (1998) Chemical diversity and variation of pyrrolizidine alkaloids of the senecionine type: Biological need or coincidence? Planta 206:443-451
Wittstock, U., Lichtnow, K.H., Teuscher, E. (1997) Effects of cicutoxin and related polyacetylenes from Cicuta virosa on neuronal action potentials: a comparative study on the mechanism of the convulsive action Planta Med. 63:120-124
Beuerle,T., Schwab,W. (1997) Biosynthesis and Metabolism of C8-Diols in Apples 5th Wartburg-Symposium Flavour Perception Aroma Evaluation, H.-P. Kruse and M. Rothe (Eds.) Eigenverlag Universität Potsdam:381-390
Beuerle,T., Schwab,W. (1997) Octane-1,3-diol and its derivatives from pear fruits Zeitschrift fur Lebensmittel-Untersuchung und-Forschung A -food research and technology 205:215-217
Dietrich,C., Beuerle,T., Withopf,B., Schreier,P., Brunerie,P., Bicchi,C., Schwab,W. (1997) Absolute configuration and conformation of 1,3-dioxanes from cider Journal of Agriculture and Food Chemistry 45:3178-3182
Verhoeven,H., Beuerle,T., Schwab,W. (1997) Solid-phase microextraction: Artefact formation and its avoidance Chromatgraphia 46: 63-66
Beuerle,T., Schwab,W. (1997) Biosynthesis of octane-1,3-diol in apple fruit Phytochemistry 45:1153-1155
Beuerle,T., Withopf,B., Schwab,W. (1997) Evaporative Light Scattering Detector (ELSD): Versatile Tool for the Analysis of Flavour Precursors 5th Wartburg Symposium Flavour Perception Aroma Evaluation, H.-P. Kruse and M. Rothe (Eds.) Eigenverlag Universität Potsdam:487-491
Lindigkeit, R.,Biller, A.,Buch, M.,Schiebel, H. M.,Boppre, M.,Hartmann, T. (1997) The two faces of pyrrolizidine alkaloids: The role of the tertiary amine and its N-oxide in chemical defense of insects with acquired plant alkaloids Eur. J. Biochem. 245:626-636
Graser, G.,Hartmann, T. (1997) Biosynthetic incorporation of the aminobutyl group of spermidine into pyrrolizidine alkaloids Phytochemistry 45:1591-1595
Hartmann, T.,Witte, L.,Ehmke, A.,Theuring, C.,Rowell-Rahier, M.,Pasteels, J. M. (1997) Selective sequestration and metabolism of plant derived pyrrolizidine alkaloids by chrysomelid leaf beetles Phytochemistry 45:489-497
Justus, M.,Witte, L.,Hartmann, T. (1997) Levels and tissue distribution of loline alkaloids in endophyte-infected Festuca pratensis Phytochemistry 44:51-57
Beerhues, L., Barillas, W., Peters, S., Schmidt, W. (1997) Xanthone biosynthesis in plant cell cultures. Recent research developments in phytochemistry (Pandalai, D.) Research Signpost, Trivandrum:69-76
Ledüc, C., Birgel, I., Müller, R. and Leistner, E. (1997) Isochorismate hydroxymutase from a cell-suspension culture of Galium mollugo L. Planta Planta 202:206-210
Barillas, W., Beerhues, L. (1997) 3-Hydroxybenzoate:coenzyme A ligase and 4-coumarate:coenzyme A ligase from cultured cells of Centaurium erythraea. Planta 202:112-116
Schmidt, W., Beerhues, L. (1997) Alternative pathways of xanthone biosynthesis in cell cultures of Hypericum androsaemum L. FEBS Lett. 420:143-146
Tholl, D., Ober, D., Martin, W., Kellermann, J., Hartmann, T. (1996) Purification, molecular cloning and expression in Escherichia coli of homospermidine synthase from Rhodopseudomonas viridis Eur. J. Biochem. 240:373-379
Miller, T., Wittstock, U., Teuscher, E. (1996) Effects of some compounds of the essential oil of chamomile, Chamomilla recutita (L.) RAUSCHERT, on histamine release from rat mast cells Planta Med. 62:60-61
Strauß, U., Wittstock, U., Teuscher, E., Jung, S., Mix, E. (1996) Cicutoxin from Cicuta virosa - a new and potent potassium channel blocker in T lymphocytes. Biochem. Biophys. Res. Commun. 219:332-336
Ober, D.,Tholl, D.,Martin, W.,Hartmann, T. (1996) Homospermidine synthase of Rhodopseudomonas viridis: Substrate specificity and effects of the heterologously expressed enzyme on polyamine metabolism of Escherichia coli J. Gen. Appl. Microbiol. 42:411-419
Beuerle,T., Schreier,P., Brunerie,P., Bicchi,C., Schwab,W. (1996) Absolute configuration of octanol derivatives in apple fruits. Phytochemistry 43:145-149
Orr, A. G.,Trigo, J. R.,Witte, L.,Hartmann, T. (1996) Sequestration of pyrrolizidine alkaloids by larvae of Tellervo zoilus (Lepidoptera: Ithomiinae) and their role in the chemical protection of adults against the spider Nephila maculata (Araneidae) Chemoecology 7:68-73
Freitas, A. V. L.,Trigo, J. R.,Brown, K. S.,Witte, L.,Hartmann, T.,Barata, L. E. S. (1996) Tropane and pyrrolizidine alkaloids in the ithomiines Placidula euryanassa and Miraleria cymothoe (Lepidoptera: Nymphalidae) Chemoecology 7:61-67
Trigo, J. R.,Brown, K. S., Jr.,Witte, L.,Hartmann, T.,Ernst, L.,Barata, L. E. S. (1996) Pyrrolizidine alkaloids: Different acquisition and use patterns in Apocynaceae and Solanaceae feeding ithomiine butterflies (Lepidoptera: Nymphalidae) Bot. J. Linn. Soc. 58:99-123
Pasteels, J. M., Rowell-Rahier, M., Ehmke, A., Hartmann, T. (1996) Host-derived pyrrolizidine alkaloids in Oreina leaf beetles: Physiological, ecological and evolutionary aspects Chrysomelidae Biology, (eds. P. Jolivet, M. L. Cox) :213-225, Academic Publishing, Amsterdam
Hartmann, T. (1996) Diversity and variability of plant secondary metabolism: A mechanistic view Entomol. Exp. Appl. 80:177-188
Beerhues, L. (1996) Benzophenone synthase from cultured cells of Centaurium erythraea. FEBS Lett. 383:264-266
Müller, R., Dahm, C., Schulte, G. and Leistner, E. (1996) An isochorismate hydroxymutase isogene in Escherichia coli FEBS Letters 378:131-134
Müller, R., Kuttler, E., Lanz, C., Drewke, C. and Schmidt, K. (1996) Isolation of a gene encoding cysteine synthase from Flavobacterium K3-15 FEMS Microbiol. Letters 136:305-308
Müller, R., Breuer, M., Wagener, A., Schmidt, K. and Leistner, E. (1996) Bacterial production of trans-dihydroxycyclohexadiene carboxylates by metabolic pathway engineering Microbiology 142:1005-1012
Drewke, C., Klein, M., Clade, D., Arenz, A., Müller, R. and Leistner, E. (1996) 4-O-Phosphoryl-L-threonine, a substrate of the pdxC (serC) gene product involved in vitamin B6 biosynthesis FEBS Letters 390:179-182
Wittstock, U., Hadacek, F., Wurz, G., Teuscher, E., Greger, H. (1995) Polyacetylenes from water hemlock, Cicuta virosa L. Planta Med. 61:439-445
Pasteels, J. M.,Dobler, S.,Rowell-Rahier, M.,Ehmke, A.,Hartmann, T. (1995) Distribution of autogenous and host-derived chemical defenses in Oreina leaf beetles (Coleoptera: Chrysomelidae) J. Chem. Ecol. 21:1163-1179
Van Dam, N. M.,Witte, L.,Theuring, C.,Hartmann, T. (1995) Distribution, biosynthesis and turnover of pyrrolizidine alkaloids in Cynoglossum officinale Phytochemistry 39:287-292
Hartmann, T.,Witte, L. (1995) Pyrrolizidine alkaloids: Chemical, biological and chemoecological aspects In: Alkaloids: Chemical and Biological Perspectives (ed. S. W. Pelletier) vol. 9:155-233, Pergamon Press, Oxford
Hartmann, T. (1995) Pyrrolizidine alkaloids between plants and insects: A new chapter of an old story Chemoecology 5/6:139-146
Schöpker, H., Kneisel, M., Beerhues, L., Robenek, H., Wiermann, R. (1995) Phenylalanine ammonia-lyase and chalcone synthase in glands of Primula kewensis (W. Wats): immunofluorescence and immunogold localization. Planta 196:712-719
Müller, R., Wagener, A., Schmidt, K. and Leistner, E. (1995) Microbial production of specifically ring-13C-labelled 4-hydroxybenzoic acid Appl. Microbiol. Biotechnol. 43:985-988
Beerhues, L., Berger, U. (1995) Differential accumulation of xanthones in methyl-jasmonate- and yeast-extract-treated cell cultures of Centaurium erythraea and C. littorale. Planta 197:608-612
Böttcher, F., Ober, D., Hartmann, T. (1994) Biosynthesis of pyrrolizidine alkaloids: Putrescine and spermidine are essentail substrates of enzymatic homospermidine formation Can. J. Chem. 72:80-85
Beerhues, L. (1994) Constitutive and elicitor-induced xanthones in cell cultures of Centaurium erythraea and Centaurium littorale. Acta Horticulturae 381:250-256
Hartmann, T. (1994) Pyrrolizidine alkaloids as defensive molecules of plants and adapted insects. In: Proceedings BIO JAPAN '94 OSAKA, Int. Conf. Biotechnology : 62-69
Biller, A.,Boppre, M.,Witte, L.,Hartmann, T. (1994) Pyrrolizidine alkaloids in Chromolaena odorata: Chemical and chemoecological aspects Phytochemistry 35:615-619
Hartmann, T. (1994) Senecio spp.: Biochemistry of the formation of pyrrolizidine alkaloids in root cultures In: Biotechnology in Agriculture and Forestry, Medicinal and Aromatic Plants VI, (ed. Y. P. S. Bajaj) vol. 26:339-355, Springer, Berlin, Heidelberg
Beerhues, L., Kombrink, E. (1994) Primary structure and expression of mRNAs encoding basic chitinase and 1,3-ß-glucanase in potato. Plant Mol. Biol. 24:353-367
Beerhues, L., Berger, U. (1994) Xanthones in cell suspension cultures of two Centaurium species. Phytochemistry 35:1227-1231
Karwatzki, B., Herget, A., Beerhues, L., Wiermann, R. (1993) In situ localization of chalcone synthase in tannin-containing plants. Phytochemistry 32:585-590
Kombrink, E., Beerhues, L., Garcia-Garcia, F., Hahlbrock, K., Müller, M., Schröder, M., Witte, B., Schmelzer, E. (1993) Expression patterns of defense-related genes in infected and uninfected plants. Mechanisms of plant defense responses (Fritig, B., Legrand, M.) Kluwer Academic Publishers:236-249
Trigo, J. R.,Witte, L.,Brown, K. S., Jr.,Hartmann, T.,Barata, L. E. S. (1993) Pyrrolizidine alkaloids in the arctiid moth Hyalurga syma J. Chem. Ecol. 19:669-679
Witte, L.,Rubiolo, P.,Bicchi, C.,Hartmann, T. (1993) Comparative analysis of pyrrolizidine alkaloids from natural sources by gas chromatography-mass spectrometry Phytochemistry 32:187-196
Böttcher, F.,Adolph, R. D.,Hartmann, T. (1993) Homospermidine synthase, the first pathway-specific enzyme in pyrrolizidine alkaloid biosynthesis Phytochemistry 32:679-689
Beerhues, L., Rittscher, M., Schöpker, H., Schwerdtfeger, C., Wiermann, R. (1993) The significance of the anther tapetum in the biochemistry of pollen pigmentation - an overview. Pl. Syst. Evol. [Suppl.] 7:117-125
Kombrink, E., Beerhues, L., Hahlbrock, K., Müller, M., Schröder, M., Witte, B. (1993) Differential activation of defense-related genes in potato following infection by Phytophthora infestans. Proceedings of the 10th international symposium on systemic fungicides and antifungal compounds (Lyr, H., Polter, C.) Eugen Ulmer:251-257
Proksch, P.,Witte, L.,Wray, V.,Hartmann, T. (1993) Ontogenetic variation of defensive alkaloids in the Mexican bean beetle Epilachna varivestis (Coleoptera: Coccinellidae) Entomol. Gener. 18:1-7
Witte, L.,Ernst, L.,Wray, V.,Hartmann, T. (1992) Revised structure of the main alkaloid of Senecio adonidifolius Phytochemistry 31:1027-1028
Rommeswinkel, M., Karwatzki, B., Beerhues, L., Wiermann, R. (1992) Immunofluorescence localization of chalcone synthase in roots of Pisum sativum L. and Phaseolus vulgaris L. and comparable immunochemical analysis of chalcone synthase from pea leaves. Protoplasma 166:115-121
Hartmann, T. (1992) Alkaloids: biochemistry, physiology and chemical ecology by example of the pyrrolizidine alkaloids In:Frontiers and new horizont in amino acid reserach (ed. Takai, K) Proc. 1st Biennial Int. Conf. on Amino Acid Research :pp. 65-76, Elsevier Science Publishers, Amsterdam
Pasteels, J. M.,Eggenberger, F.,Rowell-Rahier, M.,Ehmke, A.,Hartmann, T. (1992) Chemical defense in chrysomelid leaf beetles. Storage of host-derived pyrrolizidine alkaloids versus de novo synthesized cardenolides Naturwissenschaften 79:521-523
Beerhues, L. (1992) Pflanzliche Strategien der Pathogenabwehr - Biochemische und molekulargenetische Grundlagen. Deutsche Apotheker Zeitung 132:2486-2491
Witte, L.,Ernst, L.,Adam, H.,Hartmann, T. (1992) Chemotypes of two pyrrolizidine alkaloid-containing Senecio spp Phytochemistry 31:559-566
Ehmke, A.,Rowell-Rahier, M.,Pasteels, J. M.,Hartmann, T. (1991) Sequestration of ingested [14C]senecionine N-oxide in the exocrine defensive secretions of chrysomelid beetles J. Chem. Ecol. 17:2367-2380
Kombrink, E., Beerhues, L., Hahlbrock, K., Witte, B. (1991) Differential patterns of expression and cellular localization of chitinases and 1,3-ß-glucanases in potato. Proceedings of the 14th annual Riverside symposium in plant physiology (Huang, A.H.C., Taiz, L.) American Society of Plant Physiologists, Rockville:243-244
Hartmann, T. (1991) Pharmazeutische Biologie In: Angewandte Biologie (Eds. D. Klämbt, H. Kreiskott, B. Streit) :pp. 221-237, VCH Verlagsgesellschaft, Weinheim
Sumaryono, W.,Proksch, P.,Wray, V.,Witte, L.,Hartmann, T. (1991) Qualitative and quantitative analysis of the phenolic constituents from Orthosiphon aristatus Planta Med. 57:176-180
Sumaryono, W.,Proksch, P.,Hartmann, T.,Nimtz, M.,Wray, V. (1991) Induction of rosmarinic acid accumulation in cell suspension cultures of Orthosiphon aristatus after treatment with yeast extract Phytochemistry 30:3267-3272
Hartmann, T. (1991) Alkaloids In: Herbivores: Their Interactions with Secondary Plant Metabolites. (eds. G.A. Rosenthal, M. R. Berenbaum) vol. 1:pp. 79-121, Academic Press, San Diego
Rowell-Rahier, M.,Witte, L.,Ehmke, A.,Hartmann, T.,Pasteels, J. M. (1991) Sequestration of plant pyrrolizidine alkaloids by chrysomelid beetles and selective transfer into the defensive secretions Chemoecology 2:41-48
Ehmke, A.,Witte, L.,Biller, A.,Hartmann, T. (1990) Sequestration, N-oxidation and transformation of plant pyrrolizidine alkaloids by the arctiid moth Tyria jacobaeae L Z. Naturforsch. 45c:1185-1192
Witte, L.,Ehmke, A.,Hartmann, T. (1990) Interspecific flow of pyrrolizidine alkaloids from plants via aphids to ladybirds Naturwissenschaften 77:540-543
Hartmann, T.,Biller, A.,Witte, L.,Ernst, L.,Boppre, M. (1990) Transformation of plant pyrrolizidine alkaloids into novel insect alkaloids by arctiid moths (Lepidoptera) Biochem. Syst. Ecol. 18:549-554
Pieters, L. A.,Hartmann, T.,Janssens, J.,Vlietinck, A. J. (1989) Comparison of capillary gas chromatography with 1H and 13C nuclear magnetic resonance spectroscopy for the quantitation of pyrrolizidine alkaloids from Senecio vernalis J. Chromatogr. 462:387-91
Beerhues, L., Forkmann, G., Schöpker, H., Stotz, G., Wiermann, R. (1989) Flavanone 3-hydroxylase and dihydroflavonol oxygenase activities in anthers of Tulipa. The significance of the tapetum fraction in flavonoid metabolism. J. Plant Physiol. 133:743-746
Lembach, A., Beerhues, L., Wiermann, R. (1989) In situ localization of chalcone synthase in Larix needles by indirect immunofluorescence. Protoplasma 153:58-61
Sander, H.,Hartmann, T. (1989) Site of synthesis, metabolism and translocation of senecionine N-oxide in cultured roots of Senecio erucifolius Plant Cell Tissue Organ Cult. 18:19-32
von Borstel, K.,Witte, L.,Hartmann, T. (1989) Pyrrolizidine alkaloid patterns in populations of Senecio vulgaris, Senecio vernalis and their hybrids Phytochemistry 28:1635-1638
Ehmke, A., Proksch, P.,Witte, L., Hartmann, T., Ismann, M.B. (1989) Fate of ingested pyrrolizidine alkaloid N-oxide in the grasshopper Melanoplus sanguinipes Naturwissenschaften 76:27-29
Hartmann, T.,Ehmke, A.,Eilert, U.,von Borstel, K.,Theuring, C. (1989) Sites of synthesis, translocation and accumulation of pyrrolizidine alkaloid N-oxides in Senecio vulgaris L Planta 177:98-107
Hartmann, T. (1988) Quinolizidines and Pyrrolizidines Cell Cultures and Somatic Cell Genetics of Plants, (eds. Constabel, F., Vasil, I.K.) vol. 5:277-288, Academic Press, New York
Beerhues, L., Wiermann, R. (1988) Chalcone synthases from spinach (Spinacia oleracea L.). I. Purification, peptide patterns, and immunological properties of different forms. Planta 173:532-543
Beerhues, L., Robenek, H., Wiermann, R. (1988) Chalcone synthases from spinach (Spinacia oleracea L.). II. Immunofluorescence and immunogold localization. Planta 173:544-553
Beerhues, L., Robenek, H., Wiermann, R. (1988) Chalcone synthase forms from spinach: In situ localization by immunofluorescence and immunogold labeling. Proceedings of the 14th international conference of Groupe Polyphenols Groupe Polyphenols, Narbonne:57-60
Ehmke, A.,von Borstel, K.,Hartmann, T. (1988) Alkaloid N-oxides as transport and vacuolar storage compounds of pyrrolizidine alkaloids in Senecio vulgaris L Planta 176:83-90
Toppel, G.,Witte, L.,Hartmann, T. (1988) N-oxidation and degradation of pyrrolizidine alkaloids during germination of Crotalaria scassellatii Phytochemistry 27:3757-3760
Hartmann, T. (1988) Secondary metabolism of lupins: Biosynthesis, translocation and accumulation of the quinolizidine alkaloids Proc. 5th Int. Lupin Conf. (Poznan, July 5-8, 1988) :pp. 64-78, PWRiL, Poznan
Hartmann, T.,Sander, H.,Adolph, R. D.,Toppel, G. (1988) Metabolic links between the biosynthesis of pyrrolizidine alkaloids and polyamines in root cultures of Senecio vulgaris Planta 175:82-90
Ehmke, A.,von Borstel, K.,Hartmann, T. (1987) Specific uptake of the N-oxides of pyrrolizidine alkaloids by cells, protoplasts and vacuoles from Senecio cell cultures In: Plant vacuoles, their importance in solute compartment in cells and their appl in plant biotech. (ed. Marine, B) :pp. 301-304, Plenum Press, New York
Hartmann, T.,Toppel, G. (1987) Senecionine N-oxide, the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris Phytochemistry 26:1639-1644
Toppel, G.,Witte, L.,Riebesehl, B.,von Borstel, K.,Hartmann, T. (1987) Alkaloid patterns and biosynthetic capacity of root cultures from some pyrrolizidine alkaloid producing Senecio spp Plant Cell Rep. 6:466-469
Proksch, P.,Isman, M. B.,Witte, L.,Hartmann, T. (1987) Metabolites of insecticidal chromenes from the migratory grasshopper Melanoplus sanguinipes Phytochemistry 26:2227-2230
Hartmann, T. (1987) Warum gibt es so viele Arzneipflanzen? Zur Rolle des pflanzlichen Sekundärstoffwechsels Deutsche Apotheker Zeitung 127:2523-2527
Hartmann, T.,Zimmer, M. (1986) Organ-specific distribution and accumulation of pyrrolizidine alkaloids during the life history of two annual Senecio species J. Plant Physiol. 122:67-80
von Borstel, K.,Hartmann, T. (1986) Selective uptake of pyrrolizidine N-oxides by cell suspension cultures from pyrrolizidine alkaloid producing plants Plant Cell Rep. 5:39-42
Hartmann, T.,Witte, L.,Oprach, F.,Toppel, G. (1986) Reinvestigation of the alkaloid composition of Atropa belladonna plants root cultures and cell suspension cultures Planta Med. 5:390-395
Oprach, F.,Hartmann, T. (1986) Zur Rolle des Tropanols als Reinheitskriterium der Solanaceen-Drogen nach Ph. Eur. Deutsche Apotheker Zeitung 126:643-644
Proksch, P.,Palmer, J.,Hartmann, T. (1986) Metabolism and bioconversion of chromene derivatives in Ageratina adenophora (Asteraceae) Planta 169:130-134
Hartmann, T.,Ehmke, A. (1986) Metabolism of organic N-compounds Progress in Botany 48:124-132
Hartmann, T., Bax, K., Scholz, R. (1984) Aliphatic L-amino acid decarboxylase from ferns (Filicopsida). Z. Naturforsch. 39c:24-30
Hartmann,T., Ehmke, A. (1984) Metabolism of organic N-compounds. Ammonium assimilation and amino acid metabolism. Progress in Botany 46:104-118
Ehmke, A., Scheid, H.-W., Hartmann, T. (1984) Glutamate dehydrogenase of Pisum sativum: Heat-dependent interconversion of multiple forms. Z. Naturforsch. 39c:227-260
Hatzold, T., Elmadfa, I., Gross, R., Wink, M., Hartmann, T., Witte, L. (1983) Quinolizidine alkaloids in seeds of Lupinus mutabilis. J. Agric. Food Chem. 31:934-938
Wink, M., Witte, L., Hartmann, T., Theuring, C., Volz, V. (1983) Accumulation of quinolizidine alkaloids in plants and cell suspension cultures: Genera Lupinus, Cytisus, Baptisia, Genista, Laburnum, and Sophora. Planta Med. 48:253-257
Schoofs, G., Teichmann, S., Hartmann, T., Wink, M. (1983) Lysine decarboxylase in plants and its integration in quinolizidine alkaloid biosynthesis. Phytochemistry 22:65-69
Hartmann, T., Löhr, E. (1983) Decarboxylation of environmental L-leucine by marine red algae. Mar. Biol. 78:7-12
Wink, M., Schiebel, H.-M., Witte, L., Hartmann, T. (1982) Quinolizidine alkaloids from plants and their cell suspension cultures. Ester alkaloids of Lupinus polyphyllus. Planta Med. 44:15-20
Wink, M., Hartmann, T., Witte, L., Rheinheimer, J. (1982) Interrelationship between quinolizidine alkaloid producing legumes and infesting insects: Exploitation of the alkaloid- containing phloem sap of Cytisus scoparius by the broom aphid Aphis cytisorum. Z. Naturforsch. 37c:1081-1086
Wink, M., Hartmann, T. (1982) Enzymatic synthesis of quinolizidine alkaloid esters: A tigloyl-CoA: 13-hydroxylupanine O-tigloyltransferase from Lupinus albus L. Planta 156:560-565
Hartmann, T. (1982) Metabolism of organic N-compounds: Ammonium assimilation and nitrogen partitioning. Progress in Botany 44:154-164
Wink, M., Hartmann, T. (1982) Physiological and biochemical aspects of quinolizidine alkaloid formation in cell suspension cultures. Proc. 5th Int. Congr. Plant Tissue Cell Cult. (Tokyo) :pp. 333-334
Wink, M., Hartmann, T. (1982) Diurnal fluctuation of quinolizidine alkaloid accumulation in legume plants and photomixotrophic cell suspension cultures. Z. Naturforsch. 37c:369-375
Wink, M., Hartmann, T. (1982) Localization of the enzymes of quinolizidine alkaloid biosynthesis in leaf chloroplasts of Lupinus polyphyllus. Plant Physiol. 70:74-77
Hartmann, T. (1982) Die Ammonium-Assimilation im Stickstoffstoffwechsel der Pflanze. Biologie in unserer Zeit 12:9-19
Wink, M., Hartmann, T. (1981) Sites of enzymatic synthesis of quinolizidine alkaloids and their accumulation in Lupinus polyphyllus. Z. Pflanzenphysiol. 102:337-344
Wink, M., Hartmann, T. (1981) Activation of chloroplast-localized enzymes of quinolizidine alkaloid biosynthesis by reduced thioredoxin. Plant Cell Reports 1:6-9
Wink, M., Hartmann, T., Witte, L., Schiebel, H.-M. (1981) The alkaloid patterns of cell suspension cultures and differentiated plants of Baptisia australis and their biogenetical implications. J. Nat. Prod. 44:14-20
Wink, M., Witte, L., Hartmann, T. (1981) Quinolizidine alkaloids of plants and photomixotrophic cell suspension cultures of Sarothamnus scoparius and Orobanche rapum-genistae. Planta Med. 43:342-352
Wink, C., Hartmann, T. (1981) Properties and subcellular localization of L-alanine: aldehyde aminotransferase: Concept of an ubiquitous plant enzyme involved in secondary metabolism. Z. Naturforsch. 36c:625-632
Hartmann, T., Ehmke, A. (1980) Role of mitochondrial glutamate dehydrogenase in the reassimilation of ammonia produced by glycine serine transformation. Planta 149:207-208
Hartmann, T., Schoofs, G., Wink, M. (1980) A chloroplast-localized lysine decarboxylase of Lupinus polyphyllus: The first enzyme in the biosynthetic pathway of quinolizidine alkaloids. FEBS Let. 115:35-38
Nagel, M., Hartmann, T. (1980) Glutamate dehydrogenase from Medicago sativa L.. Purification and comparative kinetic studies of the organ-specific multiple forms. Z. Naturforsch. 35c:406-415
Scheid, H.-W., Ehmke, A., Hartmann, T. (1980) Plant NAD-dependent glutamate dehydrogenase. Purification, molecular properties and metal ion activation of the enzymes from Lemna minor and Pisum sativum. 35c, 213-221 (1980). Z. Naturforsch. 35c:213-221
Scheid, H.-W., Ehmke, A., Hartmann, T. (1980) Plant NAD-dependent glutamate dehydrogenase. Purification, molecular properties and metal ion activation of the enzymes from Lemna minor and Pisum sativum. Z. Naturforsch. 35c:213-221
Nauen, W., Hartmann, T. (1980) Glutamate dehydrogenase from Pisum sativum L.: Localization of the multiple forms and of glutamate formation in isolated mitochondria. Planta 148:7-16
Wink, M., Witte, L., Schiebel, H.-M., Hartmann, T. (1980) Alkaloid pattern of cell suspension cultures and differentiated plants of Lupinus polyphyllus Lindl. analyzed by glas capillary gas-liquid chromatography/mass spectrometry. Planta Med. 38:238-245
Wink, M., Hartmann, T., Witte, L. (1980) Enzymatic synthesis of quinolizidine alkaloids in lupin chloroplasts. Z. Naturforsch. 35c:93-97
Wink, M., Hartmann, T., Witte, L. (1980) Biotransformation of cadaverine and potential biogenetic intermediates of lupanine biosynthesis by plant cell suspension cultures. Planta Med. 40:31-39
Wink, M., Hartmann, T. (1980) Production of quinolizidine alkaloids by photomixotrophic cell suspension cultures: Biochemical and biogenetical aspects. Planta Med. 40:149-155
Wink, M., Hartmann, T. (1979) Cadaverine-pyruvate transamination: The principal step of enzymatic quinolizidine alkaloid biosynthesis in Lupinus polyphyllus cell suspension cultures. FEBS Lett. 101:343-346
Hartmann, T. (1979) Physiologie und Biochemie stickstoffhaltiger sekundärer Pflanzenstoffe. Mitt. TU Carolo-Wilhelmina zu Braunschweig XIV:26-34
Wink, M., Hartmann, T., Schiebel, H.-M. (1979) A model mechanism for the enzymatic synthesis of lupin alkaloids. Z. Naturforsch. 34c:704-708
Hartmann, T. (1979) Metabolism of organic N-compounds. Ammonium assimilation and amino acid metabolism. Progress in Botany 41:83-92
Hartmann, T. (1976) Metabolism of organic N-compounds. Ammonium assimilation in microorganisms and plants. Progress in Botany 38:118-128
Ehmke, A., Hartmann, T. (1976) Properties of glutamate dehydrogenase from Lemna minor. Phytochemistry 15:1611-1617
Unger, W., Hartmann, T. (1976) Biosynthese aliphatischer Monoamine in Blütenpflanzen durch Nebenaktivität einer Glutamat-Oxalacetat-Aminotransferase? Z. Pflanzenphysiol. 77:255-267
Hartmann, T., Aufermann, B. (1973) Zur Physiologie der Aminbildung bei der marinen Rotalge Polysiphonia urceolata. Mar. Biol. 21:70-74
Hartmann, T. (1973) Endogen und exogen ausgelöste Änderungen des Isoenzymspektrums der NAD-spezifischen Glutamatdehydrogenase im Sproß von Pisum sativum. 111, 129-136 (1973). Planta 111:129-136
Hartmann, T., Nagel, M., Ilert, H.-I. (1973) Organspezifische multiple Formen der Glutamatdehydrogenase in Medicago sativa. Planta 111:119-128
Hartmann, T. (1972) Leucin-Carboxylyase aus marinen Rhodophyceae: 3. Coenzymspezifität und Aktivierung durch Carbonylverbindungen. Biochem. Physiol. Pflanzen 163:14-29
Hartmann, T. (1972) Leucin-Carboxylyase aus marinen Rhodophyceae: 2. Eigenschaften des Enzyms aus Polysiphonia urceolata. Biochem. Physiol. Pflanzen 163:1-13
Ilert, H.-I., Hartmann, T. (1972) Dünnschichtchromatographie der 2,4-Dinitrophenylderivate wasserdampfflüchtiger Amine und ihre Anwendung auf die Trennung pflanzlicher Amine. J. Chromatogr. 71:119-125
Hartmann, T, Ilert, H.-I., Steiner, M. (1972) Aldehydaminierung, der bevorzugte Biosyntheseweg für primäre, aliphatische Monoamine in Blütenpflanzen. Z. Pflanzenphysiol. 68:11-18
Hartmann, T. (1972) Stoffwechsel organischer N-Verbindungen. Fortschritte der Botanik 34:155-164
Hartmann, T. (1972) Leucin-Carboxylyase aus marinen Rhodophyceae: Vorkommen, Verbreitung und einige Eigenschaften. Phytochemistry 11:1327-1336
Hartmann, T., Dönges, D., Steiner, M. (1972) Biosynthese aliphatischer Monoamine in Mercurialis perennis durch Aldehyd-Aminosäure-Transaminierung. Z. Pflanzenphysiol. 67:404-417
Hartmann, T. (1970) Biogenesis of aliphatic monoamines in plants. Proc. Phytochem. Soc. 9:921-922
Hartmann, T. (1970) Stoffwechsel organischer N-Verbindungen. Regulation des Aminosäurenstoffwechsels. Fortschritte der Botanik 32, 81-92 (1970). Stoffwechsel organischer N-Verbindungen. Regulation des Aminosäurenstoffwechsels. Fortschritte der Botanik 32:81-92
Dönges, D., Steiner, M., Glombitza, K.-W., Hartmann, T. (1969) Abtrennung des Ammoniaks bei der quantitativen Bestimmung primärer Amine. Pharmazie 24:672-673
Eschrich, W., Hartmann, T. (1969) Translokation und biochemisches Verhalten von D- und L-Phenylalanin in Vicia faba. Planta 85:213-227
Hartmann, T., Eschrich, W. (1969) Stofftransport in Rotalgen. Planta 85:303-312
Hartmann, T., Bast, E. (1969) Decarboxylierung von L-Methionin durch Proteus vulgaris und Bacillus sphaericus. Arch. Mikrobiol. 64:239-243
Steiner, M., Hartmann, T., Dönges, D., Bast, E. (1967) Biosynthese flüchtiger Amine durch eine Amin-Transaminase in Blütenpflanzen. Naturwissenschaften 54:370-371
Hartmann, T. (1967) Nachweis von n-Butylamin in Äpfeln. Experientia 23:680
Hartmann, T. (1967) Biosynthese flüchtiger Amine in Äpfeln durch Aldehyd-Aminierung. Z. Pflanzenphysiol. 57:368-375
Hartmann, T., Glombitza, K.-W. (1967) Der Tryptophanabbau bei Rhizobium leguminosarum. Arch. Mikrobiol. 56:1-8
Hartmann, T. (1967) Über eine Leucindecarboxylase aus Meeresalgen. Ber. Dtsch. Bot. Ges. 80:738-740
Hartmann, T. (1965) Zur Biosynthese flüchtiger Amine beim Mutterkornpilz Claviceps purpurea. Planta 66:191-206
Hartmann, T. (1965) Über das zeitliche Auftreten flüchtiger Amine und freier Aminosäuren in wachsenden, saprophytischen Kulturen von Claviceps purpurea. Planta 66:27-43
Hartmann, T. (1965) Methoden zur quantitativen Trennung und Bestimmung flüchtiger pflanzlicher Amine. 65, (1965). Planta 65:315-333
