Publikationen des IPB

• Orth, N., Krueger, J., Liu, B., Mahmoud, F.M., Benning, S., Beerhues, L., Schloter, M., Boy, J., Guggenberger, G., Winkelmann, T. (2024)
  Linking soil characteristics, rhizosphere microbiome composition, and plant defence reaction to apple replant disease severity
  Plant and Soil, in press
• Busnena, B.A., Beerhues, L., Liu, B. (2024)
  Biphenyl and dibenzofuran phytoalexins differentially inhibit root-associated microbiota in apple, including fungal and oomycetal replant disease pathogens
  Phytopathology, in press (DOI: 10.1094/PHYTO-03-24-0088-R)
• Unger, K.; Raza. S. A. K.; Mayer, T.; Reichelt, M.; Stuttmann, J.; Hielscher, A.; Wittstock, U.; Gershenzon, J.; Agler, M. T. (2024)
  Glucosinolate structural diversity shapes recruitment of a metabolic network of leaf-associated bacteria
  Nature Communications 15: 8496 (DOI: 10.1038/s41467-024-52679-7)
• Lyu, H., Ernst, L., Nakamura, Y., Okamura, Y., Koellner, T., Luck, K., Liu, B., Chen, Y., Beerhues, L., Gershenzon, J., Paetz, C. (2024)
  Phenylphenalenones and Linear Diarylheptanoid Derivatives are Biosynthesized via Parallel Routes in Musella lasiocarpa, the Chinese Dwarf Banana
  Organic Letters 26: 5522
• Hauschild, K., Orth, N., Liu, B., Giongo, A., Gschwendtner, S., Beerhues, L., Schloter, M., Vetterlein, D., Winkelmann, T., Smalla, K. (2024)
  Rhizosphere competent inoculants modulate the apple root-associated microbiome and plant phytoalexins
  Applied Microbiology and Biotechnology 108: 344
• Ernst, L., Lyu, H., Liu, P., Paetz, C., Sayed, H.M.B., Meents, T., Ma, H., Beerhues, L., El-Awaad, I., Liu, B. (2024)
  Regiodivergent biosynthesis of bridged bicyclononanes
  Nature Communications 15: 4525
• Schimmel, J., Gentsch, N., Boy, J., Uteau, D., Rohr, A.D., Winkelmann, T., Busnena, B., Liu, B., Krueger, J., Kaufhold, S., Rammelmair, D., Dultz, S., Maurischat, P., Beerhues, L., Guggenberger, G. (2024)
  Alleviation of apple replant disease in sandy soils by clay amendments
  Silicon  16: 4343
• Chroston, E.C.M., Bziuk, N., Stauber, E.J., Ravindran, B.M., Hielscher, A., Smalla, K., Wittstock, U. (2024)
  Plant glucosinolate biosynthesis and breakdown pathways shape the rhizosphere bacterial/archaeal community
  Plant, Cell & Environment 47:2127–2145. DOI: 10.1111/pce.14870
• Siefen, N., Staudt, J., Busnena, B.A., Orth, N., Beuerle, T., Lankes, C., Baab, G., Beerhues, L., Winkelmann, T., Schmitz, M., Liu, B. (2024)
  Differential accumulation of phenolics and phytoalexins in seven Malus genotypes cultivated in apple replant disease-affected soil
  Scientia Horticulturae 328: 112902

• Busnena, B., Beerhues, L., Liu, B. (2023)
  Biphenyls and dibenzofurans of the rosaceous subtribe Malinae and their role as phytoalexins
  Planta 258: 78

• Hashemi Haeri, H., Schneegans, N., Eisenschmidt-Bönn, D., Brandt, W., Wittstock, U., Hinderberger, D. (2023)
  Characterization of the active site in the thiocyanate-forming protein from Thlaspi arvense (TaTFP) using EPR spectroscopy
  Biological Chemistry: in press; doi.org/10.1515/hsz-2023-0187

• Sayed, H.M.B., Nassar, S., Kaufholdt, D., Beerhues, L., Liu, B., El-Awaad, I. (2023)
  Biosynthesis of polyprenylated xanthones in Hypericum perforatum roots involves 4-prenyltransferase
  Plant Physiology 192:2971-2988

• Wrede, A., Kanfra, X., Heuer, H., Liu, B., Beerhues, L. (2023)
  Bodenmüdigkeit Teil 6 - Die Rolle von Nematoden und Mikroorganismen
  Deutsche Baumschule 09/2023:40-44

• Wrede, A., Busnena, B., Schröpfer, S., Baader, L., Rohr, A.D., Grunewaldt-Stöcker, G., Winkelmann, T., Liu, B., Beerhues, L. (2023)
  Bodenmüdigkeit Teil 4 - Reaktion von Apfelpflanzen auf die Bodenmüdigkeit
  Deutsche Baumschule 07/2023:40-43

• Kwiecień, I., Miceli, N., Kędzia, E., Cavò, E., Taviano, M.F., Beerhues, L., Ekiert, H. (2023)
  Different types of Hypericum perforatum cvs. (Elixir, Helos, Topas) in vitro cultures: a rich source of bioactive metabolites and biological activities of biomass extracts
  Molecules 28:2376

Chroston, E.C.M., Hielscher, A., Strieker, M., Wittstock, U. (2022)
The impact of nitrile-specifier proteins on indolic carbinol and nitrile formation in homogenates of Arabidopsis thaliana.
Molecules 27:8042 (https://doi.org/10.3390/molecules27228042)

Bitchagno, G.T.M., Nchiozem-Ngnitedem, VA., Melchert, D., Fobofou, S.A. (2022)
Demystifying racemic natural products in the homochiral world. 
Nature Reviews Chemistry 6:806-822 (https://doi.org/10.1038/s41570-022-00431-4)

Kurzbach, E., Strieker, M., Wittstock, U. (2022)
Production of benzylglucosinolate in genetically engineered carrot suspension cultures.
Plant Biotechnology 39:241-250 (doi: 10.5511/plantbiotechnology.22.0509a)

• Busnena, B., Beuerle, T., Mahnkopp-Dirks, F., Winkelmann, T., Beerhues, L., Liu, B. (2021)
  Formation and exudation of biphenyl and dibenzofuran phytoalexins by roots of the apple rootstock M26 grown in apple replant disease soil
  Phytochemistry 192:112972

• Adss, S., Liu, B., Beerhues, L., Hahn, V., Heuer, H., Elhady, A. (2021)
  Priming soybean cv. Primus leads to successful systemic defence against the root-lesion nematode, Pratylenchus penetrans
  Frontiers in Plant Science 12: 651943

• Guo, Y., Nassar, S., Ma, L., Feng, G., Li, X., Chen, M., Chai, T., Abdel-Rahman, I., Beuerle, T., Beerhues, L., Wang, H., Liu, B. (2021)
  Octaketide synthase from Polygonum cuspidatum implements emodin biosynthesis in Arabidopsis thaliana
  Plant and Cell Physiology 62: 424-435

• Balbín-Suárez, A., Jacquiod, S., Rohr, A.D., Liu, B., Flachowsky, H., Winkelmann, T., Beerhues, L., Nesme, J., Sørensen, S.J., Vetterlein, D., Smalla, K. (2021)
  Root exposure to apple replant disease soil triggers local defense response and rhizoplane microbiome dysbiosis
  FEMS Microbiology Ecology 97(4): fiab031
• Singh, P., Kaufholdt, D., Awadalah, M., Hänsch, R., Beerhues, L., Gaid, M. (2021)
  Cytosolic aromatic aldehyde dehydrogenase provides benzoic acid for xanthone biosynthesis in Hypericum
  Plant Physiology and Biochemistry 160: 82-93

• Gaid, M., Grosch, J.H., Möller, S., Beerhues, L., Krull, R. (2019)
  Toward enhanced hyperforin production in St. John’s wort root cultures
  Engineering in Life Sciences 19:916-930
• Sarkate, A., Saini, S.S., Gaid, M., Teotia, D., Mir, J.I., Agrawa, P.K., Beerhues, L., Sircar, D. (2019)
  Molecular cloning and functional analysis of a biphenyl phytoalexin‑specific O‑methyltransferase from apple cell suspension cultures
  Planta 249:677-691
• Shakya, P., Marslin, G., Siram, K., Beerhues, L., Franklin, G. (2019)
  Elicitation as a tool to improve the profiles of high value secondary metabolites and pharmacological properties of Hypericum perforatum
  Journal of Pharmacy and Pharmacology 71:70-82
• Ernst,L., Langer,N., Bockelmann,A., Salkhordeh,E., Beuerle,T. (2019)
  Identification and quantification of synthetic cannabinoids in ‛spice-like’ herbal mixtures: Update of the German situation in summer 2018
  Forensic Science International 294:96-102
• Nagia, M., Gaid, M., Biedermann, E., Fiesel, T., El-Awaad, I., Hänsch, R., Wittstock, U., Beerhues, L. (2019)
  Sequential regiospecific gem-diprenylation of tetrahydroxyxanthone by prenyltransferases from Hypericum sp.
  New Phytologist 222:318-334
• Eisenschmidt-Bönn, D., Schneegans, N., Backenköhler, A., Wittstock, U., Brandt, W. (2019)
  Structural diversification during glucosinolate breakdown: Mechanisms of thiocyanate, epithionitrile and simple nitrile formation
  Plant Journal 99:329-343
• Glindemann, C.P., Backenköhler, A., Strieker, M., Wittstock, U., Klahn, P. (2019)
  Synthesis and biochemical evaluation of an artificial, fluorescent glucosinolate (GSL)
  ChemBioChem 20:1-6
• Gaid, M., Füller, J., Müller-Goymann, C. (2019)
  The petroleum ether extract from Hypericum perforatum root cultures exhibits potent antiproliferative activity in human keratinocytes and fibroblasts
  Planta Medica 85:591-598
• Chmit,M.S., Wahrig,B., Beuerle,T. (2019)
  Quantitative and qualitative analysis of pyrrolizidine alkaloids in liqueurs, elixirs and herbal juices
  Fitoterapia 136:104172
• Tomar,V., Beuerle,T., Sircar, D. (2019)
  A validated HPTLC method for the simultaneous quantifications of three Phenolic acids and three withanolides from Withania somnifera plants and its herbal products
  Journal of Chromatography B 1124:154-160
• Hartke,J., Sprenger,P.P., Sahm,J., Winterberg,H., Orivel,J., Baur,H., Beuerle,T., Schmitt,T., Feldmeyer,B., Menzel,F. (2019)
  Cuticular hydrocarbons as potential mediators of cryptic species divergence in a mutualistic ant association
  Ecology and Evolution 9:9160-9176
• Teotia, D., Gaid, M., Saini, S., Verma, A., Yennamalli, R., Khare, S., Ambatipudi, K., Mir, J., Beuerle, T., Hänsch, R., Roy, P., Agrawal, P., Beerhues, L., Sircar, D. (2019)
  Cinnamate:CoA-ligase is involved in benzoate-derived biphenyl phytoalexin biosynthesis in Malus × domestica Golden Delicious cell cultures
  Plant Journal 100:1176-1192
• Liu, B., Gaid, M., Chizzali, C., Khalil, M.N.A., Sircar, D., Reckwell, D., Beuerle, T., Richter, K., Hänsch, R., Flachowsky, H., Beerhues, L. (2019)
  Biphenyls and dibenzofurans are the phytoalexins of apple
  Acta Horticulturae 1261:259-264
• Saini SS, Teotia D, Gaid M, Sircar D (2019)
  A new enzymatic activity from elicitor-treated pear cell cultures converting trans-cinnamic acid to benzaldehyde.
  Physiologia Plantarum 167:64-74
• Meier, K., Ehbrecht, M.D., Wittstock, U. (2019)
  Glucosinolate content in dormant and germinating Arabidopsis thaliana seeds is affected by non-functional alleles of classical myrosinase and nitrile-specifier protein genes
  Frontiers in Plant Science 10:Article 1549
• Tipke,I., Bücker,L., Middelstaedt,J., Winterhalter,P., Lubienski,M., Beuerle,T. (2019)
  HILIC HPLC-ESI-MS/MS identification and quantification of the alkaloids from the genus Equisetum
  Phytochemical Analysis 30:669–678

• Kwiecien, J., Smolin, J., Beerhues, L., Ekiert, H. (2018)
  The impact of media composition on production of flavonoids in agitated shoot cultures of the three Hypericum perforatum L. cultivars Elixir, Helos and Topas
  In Vitro Cell. Dev. Biol. Plant 54:332-340
• Füller, J., Kellner, T., Gaid, M., Beerhues, L., Müller-Goymann, CC. (2018)
  Stabilization of hyperforin dicyclohexylammonium salt with dissolved albumin and albumin nanoparticles for studying hyperforin effects on 2D cultivation of keratinocytes in vitro
  Eur. J. Pharm. Biopharm. 126:115-122
• Gaid, M., Biedermann, E., Füller, J., Haas, P., Behrends, S., Krull, R., Scholl, S., Wittstock, U., Müller-Goymann, C., Beerhues, L. (2018)
  Biotechnological production of hyperforin for pharmaceutical formulation
  Eur. J. Pharm. Biopharm. 126:10-26
• Haas, P., Gaid, M., Zarinwall, A., Beerhues, L., Scholl, S. (2018)
  Downstream processing of hyperforin from Hypericum perforatum root cultures
  Eur. J. Pharm. Biopharm. 126:104-107
• Steiner, A.-M., Busching, C., Vogel, H., Wittstock, U. (2018)
  Molecular identification and characterization of rhodaneses from the insect herbivore Pieris rapae
  Scientific Reports 8:10819, doi:10.1038/s41598-018-29148-5
• Elgahme, N.F.A., Wittstock, U. (2018)
  Quantitative profiling of polyacetylenes in tissue cultures and plant parts of three species of the Asteraceae
  Plant Cell, Tissue, and Organ Culture (PCTOC) 134:251-265
• Sarkate, A., Saini, S.S., Teotia, D., Gaid, M., Mir, J.I., Roy, P., Agrawal, P.K., Sircar, D. (2018)
  Comparative metabolomics of scab-resistant and susceptible apple cell cultures in response to scab fungus elicitor treatment
  Scientific Reports 8:17844
• Backenköhler, A., Eisenschmidt, D., Schneegans, N., Strieker, M., Brandt, W., Wittstock, U. (2018)
  Iron is a centrally bound cofactor of specifier proteins involved in glucosinolate breakdown
  PLOS ONE 13:e0205755
• Kanfra, X., Liu, B., Beerhues, L., Sorensen, S., Heuer, H. (2018)
  Free-living nematodes together with associated microbes play an essential role in apple replant disease
  Frontiers in Plant Science 9:1666
• Tocci, N., Gaid, M., Kaftan, F., Belkheir, A.K., Belhadj, I., Liu, B., Svatoš, A., Hänsch, R., Pasqua, G., Beerhues, L. (2018)
  Exodermis and endodermis are the sites of xanthone biosynthesis in Hypericum perforatum roots
  New Phytologist 217:1099-1112
• Gottschalk,C., Huckauf,A., Dübecke,A., Kaltner,F., Zimmermann,M., Rahaus,I., Beuerle,T. (2018)
  Uncertainties in the determination of pyrrolizidine alkaloid levels in naturally contaminated honeys and comparison of results obtained by different analytical approaches
  Food Additives & Contaminants: Part A 35:1366-1383

• Ohlen, M. v., Herfurth, A.-M., Wittstock, U. (2017)
  Herbivore adaptations to plant cyanide defenses
  In: Herbviores (Shields, V. (ed.)), Intech Open, Rijeka (Croatia) :29-57, dx.doi.org/10.5772/66277
• Letsyo,E., Jerz,G., Winterhalter,P., Beuerle,T. (2017)
  Toxic pyrrolizidine alkaloids in herbal medicines commonly used in Ghana
  Journal of Ethnopharmacology 202:154-161
• Ernst,L., Brandhorst,K., Papke,U., Altrogge,A., Zodel,S., Langer,N., Beuerle,T. (2017)
  Identification and quantification of synthetic cannabinoids in ‛spice-like’ herbal mixtures: update of the German situation in early 2017
  Forensic Science International 277:51-58
• Herfurth, A.-M., Ohlen, M.v., Wittstock, U. (2017)
  β-Cyanoalanine synthases and their possible role in Pierid host plant adaptation
  Insects 8:62, doi:10.3390/insects8020062
• Letsyo,E., Jerz,G., Winterhalter,P., Dübecke,A., von der Ohe,W., von der Ohe,K., Beuerle,T. (2017)
  Pyrrolizidine alkaloids in floral honeys of tropical Ghana: a health risk assessment
  Food Additives & Contaminants: Part B 10:300-310
• Letsyo,E., Jerz,G., Winterhalter,P., Lindigkeit,R., Beuerle, T. (2017)
  Incidence of Pyrrolizidine Alkaloids in Herbal Medicines from German Retail Markets: Risk Assessments and Implications to Consumers
  Phytotherapy Research 31:1903-1909
• Saini, S.S., Teotia, D., Gaid, M., Thakur, A., Beerhues, L., Sircar, D. (2017)
  Benzaldehyde dehydrogenase-driven phytoalexin biosynthesis in elicitor-treated Pyrus pyrifolia cell cultures
  J. Plant Physiol. 215:154-162
• Juneja, K., Saini, S.S., Gaid, M., Beerhues, L., Sircar, D. (2017)
  Production of life-saving drugs from Himalayan herbs
  Sustainable Utilization of Natural Resources (Mondal, P., Dalai, A.K., eds.), CRC Press, Boca Raton, USA Chapter 11:333-352
• Bog,M., Elmer,M., Doppel,M., Ehrnsberger,H.F., Beuerle,T., Heilmann,J., Oberprieler,C. (2017)
  Phytochemical investigations and food-choice experiments with two mollusc species in three central European Senecio L. (Asteraceae, Senecioneae) species and their hybrids
  Chemoecology 27:155-169

• Wittstock, U., Meier, K., Dörr, F. Beena, M.R. (2016)
  NSP-dependent simple nitrile formation dominates upon breakdown of major aliphatic glucosinolates in roots, seeds, and seedlings of Arabidopsis thaliana Columbia-0
  Frontiers in Plant Science 7:1821 (10.3389/fpls.2016.01821)
• Wittstock, U., Kurzbach, E., Herfurth, A.M., Stauber, E.J. (2016)
  Glucosinolate breakdown
  Advances in Botanical Research, Vol. 80: Glucosinolates (E. Kopriva, ed.) :125-169
• Ohlen, M. van, Herfurth, A.-M., Kerbstadt, H., Wittstock, U. (2016)
  Cyanide detoxification in an insect herbivore: Molecular identification of beta-cyanoalanine synthases from Pieris rapae
  Insect Biochem. Mol. Biol. 70:99-110
• Langer,N., Lindigkeit,R., Schiebel,H.-M., Papke,U., Ernst,L., Beuerle,T. (2016)
  Identification and quantification of synthetic cannabinoids in “spice-like” herbal mixtures: update of the German situation for the spring of 2015
  Forensic Toxicology 34:94-107
• Gaid, M., Haas, P., Beuerle, T., Scholl, S., Beerhues, L. (2016)
  Hyperforin production in Hypericum perforatum root cultures
  J. Biotechnol. 222:47-55
• Hsu, Y.M., Wu, T.Y., El-Shazly, M., Beerhues, L., Du, Y.C., Thang, T.D., Luu, H.V., Hwang, T.L., Chang, F.R., Wu, Y.C. (2016)
  3-Methyl-4,5-dihydrooxepine, polyoxygenated seco-cyclohexenes and cyclohexenes from Uvaria flexuosa and their anti-inflammatory activity
  Phytochemistry 122:184-192
• Teotia, D., Saini, S.S., Gaid, M., Beuerle, T., Beerhues, L., Sircar, D. (2016)
  Development and validation of a new HPLC method for the determination of biphenyl and dibenzofuran phytoalexins in Rosaceae
  J. Chromatogr. Sci. 54:918-922
• Letsyo,E., Jerz,G., Winterhalter,P., Horn,G., Beuerle,T. (2016)
  Survey of pyrrolizidine alkaloids in seven varieties of Lappula squarrosa: An alternative source of heart-healthy vegetable oil
  Phytochemical Analalysis 27:133-139
• El-Awaad, I., Bocola, M., Beuerle, T., Liu, B., Beerhues, L. (2016)
  Bifunctional CYP81AA proteins catalyze identical hydroxylations but alternative regioselective phenol couplings in plant xanthone biosynthesis
  Nature Communications 7:11472
• Chizzali, C., Swiddan, A.K., Abdelaziz, S., Gaid, M., Richter, K., Fischer, T.C., Liu, B., Beerhues, L. (2016)
  Expression of biphenyl synthase genes and formation of phytoalexin compounds in three fire blight-infected Pyrus communis cultivars
  PLoS ONE 11(7):e0158713
• Belkheir, A.K., Gaid, M., Liu, B., Hänsch, R., Beerhues, L. (2016)
  Benzophenone synthase and chalcone synthase accumulate in the mesophyll of Hypericum perforatum leaves at different developmental stages
  Frontiers Plant Science 7:921
• Franklin, G., Beerhues, L., Cellarova, E. (2016)
  Editorial: Molecular and biotechnological advancements in Hypericum species
  Frontiers Plant Science 7:1687
• Langer,N., Lindigkeit,R., Schiebel,H.-M., Papke,U., Ernst,L., Beuerle, T. (2016)
  Identification and quantification of synthetic cannabinoids in “spice-like“ herbal mixtures: update of the German situation for the spring of 2016
  Forensic Science International 269:31-41
• Gaid, M., Wucherpfennig, T., Scholl, S., Beerhues, L., Krull, R. (2016)
  Challenges for the cultivation of plant cells on the example of Hypericum perforatum and Taxus chinensis
  Bioprocessing of plant in vitro systems (Pavlov, A., Bley, T., eds.), Reference Series in Phytochemistry Springer:1-26

• Gumz, F., Krausze, J., Eisenschmidt, D., Backenköhler, A., Barleben, L., Brandt, W., and Wittstock, U. (2015)
  The crystal structure of the thiocyanate-forming protein from Thlaspi arvense, a kelch protein involved in glucosinolate breakdown
  Plant Mol. Biol. 89:67-81
• Sievert,C., Beuerle,T., Hollmann,J., Ober,D. (2015)
  Single cell subtractive transcriptomics for identification of cell-specifically expressed candidate genes of pyrrolizidine alkaloid biosynthesis
  Phytochemistry 117:17-24
• Cramer,L., Ernst,L., Lubienski,M., Papke,U., Schiebel,H.-M., Jerz,G., Beuerle,T. (2015)
  Structural and quantitative analysis of Equisetum alkaloids
  Phytochemistry 116:269-282
• Mädge,I., Cramer,L., Rahaus,I., Jerz,G., Winterhalter,P., Beuerle,T. (2015)
  Pyrrolizidine Alkaloids in Herbal Teas for Infants, Pregnant or Lactating Women
  Food Chemistry 187:491-498
• Sircar, D., Gaid, M.M., Chizzali, C., Reckwell, D., Kaufholdt, D., Beuerle, T., Broggini, G.A.L., Flachowsky, H., Liu, B., Hänsch, R., Beerhues, L. (2015)
  Biphenyl 4-hydroxylases involved in aucuparin biosynthesis in rowan and apple are cytochrome P450 736A proteins
  Plant Physiology 168:428-442
• Khalil, M.N.A., Brandt, W., Beuerle, T., Reckwell, D., Groeneveld, J., Hänsch, R., Gaid, M., Liu, B., Beerhues, L. (2015)
  O-Methyltransferases involved in biphenyl and dibenzofuran biosynthesis
  Plant Journal 83:263-276
• Kwiecień, I., Szydłowska, A., Kawka, B., Beerhues, L., Ekiert, H. (2015)
  Accumulation of biologically active phenolic acids in agitated shoot cultures of three Hypericum perforatum cultivars: ‘Elixir’, ‘Helos’ and ‘Topas’
  Plant Cell Tiss Organ Cult 123:273-281
• Fiesel, T., Gaid, M., Müller, A., Bartels, J., El-Awaad, I., Beuerle, T., Ernst, L., Behrends, S., Beerhues, L. (2015)
  Molecular cloning and characterization of a xanthone prenyltransferase from Hypericum calycinum cell cultures
  Molecules 20:15616-15630
• Moon, U.R., Sircar, D., Barthwal, R., Sen, S.K., Beuerle, T., Beerhues, L., Mitra, A. (2015)
  Shoot cultures of Hoppea fastigiata (Griseb.) C.B. Clarke as potential source of neuroprotective xanthones
  J Nat Med 69:375-386
• Cheng, Y.B., Tsai, Y.H., Lo, I.W., Haung, C.C., Tsai, Y.C., Beerhues, L., El-Shazly, M., Hou, M.F., Yuan, S.S., Wu, C.C., Chang, F.R., Wu, Y.C. (2015)
  Pandalisines A and B, novel indolizidine alkaloids from the leaves of Pandanus utilis
  Bioorg Med Chem Lett 25:4333-4336