Studentische Arbeiten

Thin elastic films out of transparent silicone material (e. g. PDMS, [1]) are widely used in organ-on-chip systems. It is important to have control over the elastic properties of these thin films, as biological cells sense and react to substrate stiffness. A study from 2009 suggests that spin coating, the fabrication process for such thin films, has an impact on the microstructure and thus also on the stiffness of the PDMS when very thin films (below 200 µm thickness) are manufactured [2]. On top of that, the PDMS film could increase its stiffness dependent on its storage duration.

Responsible: David Jaworski

For gut cell cultures in infection studies to be representative, there is the wish to mimic the biomechanical in-vivo conditions of the cells. Epithelial gut cells in a living body are permanently stimulated by fluid-flow-induced shear stress and mechanical strain. 

Responsible: David Jaworski

Epithelial gut cells in a living body are permanently stimulated by fluid-flow-induced shear stress and mechanical strain. In the EpiStretch project, we develop a device that will contribute to infection studies on cells with in-vivo-like biomechanical conditions.

Responsible: David Jaworski

Epithelial gut cells in a living body are permanently stimulated by fluid-flow-induced shear stress and mechanical strain. In the EpiStretch project, we develop a device that will contribute to infection studies on cells with in-vivo-like biomechanical conditions.

Responsible: David Jaworski

The aim of this project is to fabricate PDMS microfluidic for in vivo whole-brain imaging of zebrafish larvae. Such a device needs to accomplish several goals, including integration with the chip with light-sheet microscope. Technical challenges in fabricating with high precision out of PDMS exhibiting a sufficient optical quality and sidewalls that can accommodate the incoming excitation laser is required.

Responsible: Dominika Schrödter

Das Ziel dieser Arbeit ist die Entwicklung der hochautomatisierten Arbeitsabläufe von modellen, welche Simulationen und Auswertung Algorithmen kombinieren, um die Simulationen beschleunigen zu können.

Responsible: Songtago Cai

Der am IMT vorgeschlagene und gefertigte Point-of-Care Prototyp wird als kostengünstiger, empfindlicher Point-of-Care Biosensor zur Überwachung und Detektion von Viren dienen. Das Ziel dieser Arbeit ist die Erstellung eines Simulationsmodells zum Vorhersagen des Fließverhaltens in den porösen Medien.

Responsible: Songtago Cai

Oxidative and nitrosative stress are directly linked to a wide range of disorders, from Alzheimer’s to schizophrenia. A sensor to measure these stressors could find applications from point-of-care diagnostic aids (labs-on-chips) to functioning as a new research tool in miniaturized disease models (organs-on-chips). The aim of this project is to take a previously-developed optical assay based on a soluble chemical and develop it into a sensor platform by immobilizing or otherwise integrating this chemical compound into microfluidic devices.

Responsible: Dr. Thomas Winkler

Biomedical research largely relies on culture of cells in standardized arrays of culture wells (e.g. 96-plate). The aim of this project is to design a robotic gantry system that can operate inside a cell culture incubator to measure metabolic function and dispense/exchange liquids from such culture plates. The goal is to use standard, low-cost components and provide an open-source design to make it accessible to academic laboratories worldwide.

Responsible: Dr. Thomas Winkler

Lipid nanoparticles (LNPs) is a carrier for medical agents in the human body. Many modern active pharmaceutical ingredients have poor water solubility and strong lipophilic properties. As a result, the need for alternative dosage forms in order to apply these drugs appropriately is increasing. However, the dosage form can be improved by reducing the size of the drug particles, which results in fundamentally different biophysical properties compared to systems with macroparticles, and increases the specific surface area relevant for mass transfer.

Responsible: Ebrahim TaiediNejad

This thesis deals with the fabrication of microfluidic channel with IP-Q photoresist in different shape and sizes. IP-Q photoresist is used for High-speed fabrication of millimetre-sized microfluidic chip using Nanoscribe’s high-precision 3D printing technology. The 3D printing of the channel system is achieved with a 2PP system equipped with a near infrared femtosecond laser source.

Responsible: Ebrahim TaiediNejad

Hi! We are MinkTec, a spin-off of the IMT and we want to be the very first company to find and successfully target the causes of non-specific back pain. Our unique sensor shirt is the first easy-to-use technology in the world to track the exact shape of the spine 24/7 and display a personalized 3D-avatar of the user in their mobile app. Using machine learning algorithms, we want to analyze motion patterns of back pain patients to find the causes of their pain. Our app provides tips and tricks for better posture as well as targeted vibration alerts and includes an individualized training plan that is covered by all German Health Insurances.

Ansprechpartner: Benjamin Holmer (benjamin.holmer@minktec.com or +49 176 6122 8869)

Dear Students / Liebe Studierende,

In this project you can do any kind of work to create flexible/stretchable sensor systems! From sensor design/fabrication, over electronics development/fabrication to exciting software development tasks. You can expect interesting tasks at a competent and pleasant working atmosphere!

Just have a look at my website: www.ib-ekoch.de

Die Arbeit kann sowohl in deutscher als auch in englischer Sprache durchgeführt werden.

Feel free to contact me at any time :)

Ansprechpartner: Eugen Koch