Original Publications & Reviews

Departments of Biotechnology and Medical Biotechnology

2024

• Zuo, F., Cao, Y. R., Sun, R., Wang, Q., Simonelli, L., Du, L., Bertoglio, F., Schubert, M., Guerra, C., Cavalli, A., Hust, M., Robbiani, D.F., Varani, L., Abolhassani, H., Xie, X., Hammarström, L., Marcotte, H. & Pan-Hammarström, Q. (accepted). Ultrapotent IgA dimeric antibodies neutralize emerging Omicron variants. Journal of Virology
• Lampinen, V., Gröhn, S., Lehmler, N., Jartti, M., Hytönen, V.P., Schubert, M. # & Hankaniemi, M.M. #  (2024). Production of norovirus-, rotavirus-, and enterovirus-like particles in insect cells is simplified by plasmid-based expression. Scientific Reports 14:14874
• Metzdorf, K., Jacobsen, H., Kim, Y., Teixeira Alves, L.G., Kulkarni, U., Brdovčak, M.C., Materljan, J., Eschke, K., Chaudhry, M.Z., Hoffmann, M., Bertoglio, F., Ruschig, M., Hust, M., Šustić, M., Krmpotic, A., Jonjic, S., Widera, M., Ciesek, S., Pöhlmann, S., Landthaler, M. & Čičin-Šain, L. (2024). A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants. Frontiers Immunology 15: 1383086
• Ruschig, M., Nerlich, J., Becker, M., Meier, D., Polten, S., Cervantes-Luevano, K., Kuhn, P., Licea Navarro, A.F., Hallermann S., Dübel, S., Schubert M., Brown, J. & Hust, M. (2024). Human antibodies neutralizing the alpha-latrotoxin of the European black widow. Frontiers Immunology 15: 1407398
• Marcotte, H., Cao, Y., Zuo, F., Simonelli, L., Sammartino, J.C., Pedoti, M., Sun, R., Cassaniti, I., Hagbom, M., Piralla, A., Yang, J., Du, L., Percivalle, E., Bertoglio, F., Schubert, M., Abolhassani, H., Sherina, N., Guerra, C., Borte, S., Rezaei, N., Kumagai-Braesch, M., Xue, Y., Su, C., Yan, Q., He, P., Grönwall, C., Klareskog, L., Calzolai, L., Cavalli, A., Wang, Q., Robbiani, D., Hust, M., Shi, Z., Feng, L., Svensson, L., Chen, L., Bao, L., Baldanti, F., Xiao, J., Qin, C., Hammarström, L., Yang, Y., Varani, L., Xie, X.S. & Pan-Hammarström, Q. (2024). Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages. PNAS 121(3):e2315354120 doi: 10.1073/pnas.2315354120
• Zuo, F., Cao, Y., Sun, R., Yisimayi, A., Du, L., Bertoglio. F., Schubert, M., Guerra, C., Cavalli, A., Hust, M., Robbiani, D.F., Abolhassani, H., Xie, X.S., Hammarström, L., Marcotte, H. & Pan-Hammarström, Q. (2024). Neutralisation activity of mucosal IgA is more sustainable than serum IgG against XBB sublineages and BA.2.86. Lancet Infectious Diseases 24(19): e7-e9
• Dübel, S. (2024) Can antibodies be "vegan"? A guide through the maze of today's antibody generation methods. Mabs,16(1) DOI: 10.1080/19420862.2024.2343499.

2023

• Abassi, L., Bertoglio, F., Mačak-Šafranko, Ž., Schirrmann, T., Grewling-Pils, M., Seifert, O., Khan, F., Katzmarzyk, M., Jacobsen, H., Gödecke, N., Heine, P.A., Frenzel, A., Nowack, H., Dübel, S., Kurolt, I.-C., Kontermann, R.E., Markotić, A., Schubert, M., Hust, M. & Čičin-Šain, L. (2023). Evaluation of the neutralizing antibody STE90-C11 against SARS-CoV-2 Delta infection and its recognition of other variants of concern. Viruses 15: 2153 https://doi.org/10.3390/v15112153

• Lutz, S., Klaus, K., Albici, A.-M., Ebinger, L., Sellmer, L., Teipel, H., Frenzel, A., Langner, A., Winterberg, D., Krohn, S., Hust, M., Schirrmann, T., Dübel, S., Scherließ, R., Humpe, A., Gramatzki, M., Kellner, C.& Peipp, M. (2023). Novel NKG2D-Directed Bispecific Antibodies Enhance Antibody-Mediated Killing of Malignant B Cells by NK Cells and T Cells. Frontiers Immunology 14: 1227572, doi: 10.3389/fimmu.2023.1227572

• Dragon, A.C., Beermann, L.M., Umland, M., Bonifacius, A., Ruhl, L., Kehler, P., Gellert, J., Weiß, L., Mayer-Hain, S., Zimmermann, K., Riese, S., Thol, F., Beutel, G., Maecker-Kolhoff, B., Yamamoto, F., Blasczyk, R., Schambach, A., Hust, M., Hudecek, M. & Eiz-Vesper, B. (2023). CAR-Ts redirected against the Thomsen-Friedenreich antigen CD176 mediate specific elimination of malignant cells from leukemia and solid tumors. Frontiers Immunology 14: 1219165

• Bertoglio, F., Ko, Y.-P., Thomas, S., Giordano, L., Romana, Scommegna, F.R., Meier, D., Polten, S., Becker, M., Arora, S., Hust, M., Höök, M. & Visai, L. (2023). Antibodies to Coagulase of Staphylococcus aureus crossreact to Efb and reveal different binding of shared Fibrinogen binding repeats. Frontiers Immunology 14: 1221108

• Steinke, S., Roth, K.D.R., Englick, R., Langreder, N., Ballmann, R., Fühner, V., Zilkens, K.J.K., Moreira, G.M.S.G., Koch, A., Russo, G., Schubert, M., Bertoglio, F., Heine, P.A. & Hust, M. (2023). Mapping Epitopes by Phage Display. Methods Molecular Biology 2702, 563-585

• Heine, P.A., Ballmann, R., Thevarajah, P., Russo, G., Moreira, G.M.S.G. & Hust, M. (2023). Biomarker Discovery by ORFeome Phage Display. Methods Molecular Biology 2702, 543-561

• Ballmann, R., Schneider, K.-T., Roth, K.D.R. & Dübel, S. (2023). Antibody Batch Cloning. Methods Molecular Biology 2702, 411-417

• Langreder, N., Schäckermann, D., Unkauf, T., Schubert, M., Frenzel, A., Bertoglio, F. & Hust, M. (203). Antibody Affinity and Stability Maturation by Error-Prone PCR. Methods Molecular Biology 2702, 395-410

• Heine, P.A., Ruschig, M., Langreder, Wenzel, E.V., Schubert, M., Bertoglio, F. & Hust, M. (2023). Antibody Selection in Solution Using Magnetic Beads. Methods Molecular Biology 2702, 261-274

• Steinke, S., Roth, K.D.R., Ruschig, Langreder, N., Polten, S., Schneider, K.-T., Ballmann, R., Russo, G., Zilkens, K.J.K., Schubert, M., Bertoglio, F. & Hust, M. (2023). Antibody Selection via Phage Display in Microtiter Plates. Methods Molecular Biology 2702, 247-260

• Ruschig, M., Heine, P.A., Fühner, V., Zilkens, K.J.K., Steinke, S., Schubert, M., Bertoglio, F. & Hust, M. (2023). Construction of Human Immune and Naive scFv Phage Display Libraries. Methods Molecular Biology 2702, 15-37

• Nur, A., Schubert, M., Lai, J.Y., Hust, M., Choong, Y.S., Isa, W.Y.H.W. & Lim TS. (2023). Antibody Phage Display. Methods Molecular Biology 2702, 3-12

• Rojas, G., Relova-Hernández, E., Pérez-Riverón, A., Castro-Martínez, C., Diaz-Bravo, O., Cabrera Infante, Y., Gómez, T., Solozábal, J., Beatriz DíazBravo, A., Schubert, M., Becker, M., Pérez-Massón, B., Pérez-Martínez, D., Alvarez-Arzola, R., Guirola, O., Chinea, G., Graca, L., Dübel, S., León, K., Carmenate, T. (2023) Molecular reshaping of phage-displayed Interleukin- at beta chain receptor interface to obtain potent super-agonists with improved developability profiles. Communic. Biol. 6:828
• Pieper, T, Roth, K.D.R., Glaser, V., Riet, T., Buitrago-Molina, L.E., Hagedorn, M., Lieber, M., Hust, M., Noyan, F., Jaeckel, E., Hardtke-Wolenski, M. (2023). Generation of Chimeric Antigen Receptors against Beta Cell Antigen Tetraspanin 7.  Cells 12: 1453
• Liu, D., Bai, X., Samaddar, M., Helmick, H.D.B., Tenguria, S., Drolia, R., Amalaradjou, M.A.R, Li, X., Gallina, N.L.F, Aryal, U.K., Moreira, G.M.S.G., Hust, M., Seleem, M., Cox, A., Ostafe, R., Klimek, J.F., Kokini, J.L., Noinaj, N., & Bhunia, A.K. (2023). Cell Surface Anchoring of Listeria Adhesion Protein on L. monocytogenes is Fastened by Internalin B. Cell Reports 42: 112515
• Chung, H.-Y., Wickel, J., Hahn, N., Mein, N., Schwarzbrunn, M., Koch, P., Ceanga, M., Haselmann, H., Baade-Büttner, C., von Stackelberg, N., Hempel, N., Schmidl, L., Groth, M., Andreas, N., Götze, J., Coldewey, S.M., Bauer, M., Mawrin, C., Dargbvainiene, J., Leypoldt, F., Steinke, S., Wang, Z.-Q., Hust, M. & Geis, C. (2023). Microglia mediate neurocognitive deficits by eliminating C1q tagged synapses in sepsis-associated encephalopathy. Science Advances 9:eabq7806
• Zuo, F., Sun, R., Abolhassani, H., Du, L., Wang, Y., Vlachiotis, S., Bertoglio, F., Schubert, M., Rezaei, N., Chavoshzadeh, Z., Guerra, C., Cavalli, A., Andrell, J., Kumagai-Braesch, M., Xue, Y., Cao, Y., Hust, M., Robbiani, D.F., Xie, X., Hammarström, L., Marcotte, H., Pan-Hammarstrom. Q. (2023). Heterologous inactivated virus/mRNA vaccination response to BF.7, BQ.1.1, and XBB.1. The Lancet Regional Health - Western Pacific  33:100762
• Steinke, S., Kirmann, T., Loi, E.A., Nerlich, J., Weichard, I., Kuhn, P., Bullmann, T., Ritzau-Jost. A., Sila Rizalar, F., Prüss, H., Haucke, V., Geis, C., Hust, M. & Hallermann, S. (2023). NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies. Brain 146:1812-1820
• Ruschig, M., Marschall, A.L.J. (2023) Targeting the Inside of Cells with Biologicals: Toxin Routes in a Therapeutic Context. BioDrugs. https://doi.org/10.1007/s40259-023-00580-y
• Langreder, N., Schäckermann, D., Meier, D., Becker, M., Schubert, M., Dübel, S., Reinard, T., Figge-Wegener, S., Roßbach, C., Bäumer, W., Ladel, S. & Hust, M. (2023). Development of an inhibiting antibody against equine interleukin 5 to treat insect bite hypersensitivity of horses. Scientific Reports 13:4029

2022

• Jaron, M., Lehky, M., Zarà, M., Zaydowicz, C.N., Lak, A., Ballmann, R., Heine, P.A., Wenzel, E.V., Schneider, K.-T., Bertoglio, F., Kempter,  S., Köster, R.W., Barbieri, S.S., Van den Heuvel, J., Hust, M., Dübel, S., & Schubert, M. (2022). Baculovirus-Free SARS-CoV-2 Virus Like Particle Production in Insect Cells for Rapid Neutralization Assessment. Viruses 14: 2087
• Brlić, P.K., Pavletić, M., Lerga, M., Krstanović, F., Matešić, M.P., Miklić, K., Malić, S., Mikša, L, Pajcur, M., Peruć, D., Schubert, M., Bertoglio, F., Arapović, J., Protić, A., Šustić, A., Milošević, M., Šain, L.C., Jonjić, S., Lisnić, V.J. & Brizić, I. (2022). SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study. Viruses 14:1966
• Geisen, U.M., Rose, R., Neumann, F., Ciripoi, M., Vullriede, L., Reid, H.M., Berner, D.K., Bertoglio, F., Hoff, P., Hust, M., Longardt, A.C., Lorentz, T., Martini, G.R., Saggau. C. ,Schirmer, J.H., Schubert, M., Sümbül, M., Tran, F., Voß. M., Zeuner. R., Morrison, P.J., Bacher, P., Fickenscher, H., Gerdes. S., Peipp, M., Schreiber, S., Krumbholz, A. & Hoyer, B.F.  (2022). The long term vaccine-induced anti-SARS-CoV-2 immune response is impaired in quantity and quality under TNFα blockade. J Med Virol 94: 5780-5789
• Cokarić Brdovčak, M., Materljan, J., Šustić, M., Ravlić, S. , Ružić, T., Lisnić, B., Miklić, K., Brizić, I., Pribanić Matešić, M., Juranić Lisnić, V., Halassy, B., Rončević, D., Knežević, Z., Štefan, L., Bertoglio, F., Schubert, M., Čičin-Šain, L., Markotić, A., Jonjić, S. & Krmpotić, A. (2022). ChAdOx1-S adenoviral vector vaccine applied intranasally elicits superior mucosal immunity compared to the intramuscular route of vaccination. Eur J Immunol 52:936-945
• Menzler, M.; Ganskow, C.S.G.; Ruschig, M.; Moustafa, E.; Sittinger, V.; Lachmann, K.; Wenzel, E.V.; Russo, G.; Klahn, P.; Gäbler, J. (2022) Testing of Diamond Electrodes as Biosensor for Antibody-Based Detection of Immunoglobulin Protein with Electrochemical Impedance Spectroscopy. C 8, 74. DOI: 10.3390/c8040074
• Ch'ng, A.C.W, Schepergerdes, L., Choong, Y.S., Hust, M. & Lim, T.S. (2022). Antimicrobial antibodies by phage display: Identification of antibody-based inhibitor against mycobacterium tuberculosis isocitrate lyase. Mol Immunol 155: 47-57
• Lang, S., Rau, U., Behrendt, C., Syldatk, C., Hust, M. & Dübel, S. (2022) Vom Gen zum Produkt. Nachr. Chemie 70, 7/8, 24-26 DOI: 10.1002/nadc.20224129350
• Ballmann, R., Hotop, S.-K., Bertoglio, F., Steinke, S., Heine, P.A., Chaudhry, M.-Z, Jahn, D., Pucker, B., Baldanti, F., Piralla, A., Schubert, M., Čičin-Šain, L., Brönstrup, M., Hust, M. & Dübel, S. (2022). ORFeome phage display reveals a major immunogenic epitope on the S2 subdomain of SARS-CoV-2 Spike protein. Viruses, 14(6), 1326; https://doi.org/10.3390/v14061326
• Zuo, F., Abolhassani, H., Du, L., Piralla, A., Bertoglio, F., de Campos-Mata, L., Wan, H., Schubert, M., Wang, Y., Sun, R., Cassaniti, I., Vlachiotis, S., Kumagai-Braesch, M., Andréll, J., Zhang, Z., Xue, Y., Wenzel, E.V., Calzolai, L., Varani, L., Rezaei, N., Chavoshzadeh, Z., Baldanti F., Hust, M., Hammarström, L., Marcotte, H. & Pan-Hammarström, Q. (2022). Heterologous immunization with inactivated vaccine followed by mRNA booster elicits strong humoral and cellular immune responses against the SARS-CoV-2 Omicron variant. Nature Communications 13:2670
• Paladines, L., Hassen, W.M., Chawich, J., Dübel, S., Lévesque, S., Dubowski, J.J., Frost, E.H. (2022). Investigation of Conditions for Capture of Live Legionella pneumophila with Polyclonal and Recombinant Antibodies. Biosensors  12, 380. https://doi.org/10.3390/bios12060380
• Jakob, V., Zoller, B.G.E., Rinkes, J., Wu, Y., Kiefer, A.F., Hust, M., Polten, S., White, A.M., Harvey, P.J., Durek, T., Craik, D.J, Siebert, A., Kazmaier, U. & Empting, M. (2022). Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA. European Journal Medical Chemistry 231:114148

• LIm, T.S., Hust, M., Visai, L. (2022). Editorial: Recent Advances in Recombinant Antibody Therapeutics and Diagnostics For Infectious Diseases. Frontiers Public Health 10:876889

• Russo, G., Unkauf, T., Meier, D., Wenzel, E.V., Langreder, N., Schneider, K.T., Wiesner, R,. Bischoff, R., Stadler, V. & Dübel, S. (2022) In vitro evolution of myc-tag antibodies: in depth specificity and affinity analysis of Myc1-9E10 and Hyper-Myc. Biol. Chem. 403 (5/6), 479-494. DOI: 10.1515/hsz-2021-0405 (open access)
• Pribanić, Matešić M., Kučan, Brlić P., Lenac, Roviš T., Mačak, Šafranko Ž., Chaouat, A.E., Miklić, K., Malić, S., Ivanković, N., Schubert, M., Bertoglio, F., Markotić, A., Mandelboim, O., Jonjić, S. & Brizić ,I. (2022) Collection of Monoclonal Antibodies Targeting SARS-CoV-2 Proteins. Viruses. 14(2):443. DOI: 10.3390/v14020443
• Schubert, M., Bertoglio, F., Steinke, S., Heine, P.A., Ynga-Durand, M.A., Maass, H., Sammartino, J.C., Cassaniti, I., Zuo, F., Du, L., Korn, J., Milošević, M., Wenzel, E.V., Krstanović, F., Polten, S., Pribanić-Matešić, M., Brizić, I., Baldanti, F., Hammarström, L., Dübel, S., Šustić, A., Marcotte, H., Strengert, M., Protić, A., Piralla, A., Pan-Hammarström, Q., Čičin-Šain, L. & Hust, M. (2022). Human serum from SARS-CoV-2 vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant. BMC Medicine 20:102
• Moreira, G.M.S.G, Gronow, S., Dübel, S., Mendonça, M., Moreira, A. N., Conceição, F. R., & Hust, M. (2022). Phage display-derived monoclonal antibodies against internalins A and B allow specific detection of Listeria monocytogenes. Frontiers in Public Health 10:712657 , DOI: 10.3389/fpubh.2022.712657

• Sevenich, M., Thul, E., Lakomek, N.-A., Klünemann, T., Schubert, M., Bertoglio, F., van den Heuvel, J., Petzsch, P., Mohrlüder, J., & Willbold, D. (2022) Phage Display-Derived Compounds Displace hACE2 from Its Complex with SARS-CoV-2 Spike Protein. Biomedicines 10: 441. DOI: 10.3390/biomedicines10020441

• Pribanić Matešić, M., Kučan Brlić, P., Lenac Roviš, T., Mačak Šafranko, Ž., Chaouat, A.E., Miklić, K., Malić, S., Ivanković, N., Schubert, M., Bertoglio, F., Markotić, A., Mandelboim, O., Jonjić, S., Brizić, I., (2022). Collection of Monoclonal Antibodies Targeting SARS-CoV-2 Proteins. Viruses 14: 443. DOI: 10.3390/v14020443

• Kim, Y. , Zheng, X., Eschke, K., Chaudhry, M.Z., Bertoglio, F., Tomić, A., Krmpotić, A., Hoffmann, M., Bar-On, Y., Boehme, J., Bruder, D., Ebensen, T.,  Brunotte, L, Ludwig, S., Messerle, M., Guzman, C., Mandelboim, O, Hust, M., Pöhlmann, S., Jonjić, S., & Čičin-Šain, L. (2022). MCMV based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination. Cellular & Molecular Immunology 19: 234-244
• Assou, J, Zhang, D, Roth, K.D.R., Steinke, S., Hust, M., Reinard, T., Winkelmann, T. & Boch, J. (2022). Removing the major allergen Bra j I from brown mustard (Brassica juncea) by CRISPR/Cas9. The Plant Journal 109:649-663, DOI: 10.1111/tpj.15584
• Marcotte, H., Piralla, A., Zuo, F., Du, L., Cassaniti, I., Wan, H., Kumagai-Braesh, M., Andréll, J., Percivalle, E., Sammartino, J.C., Wang, Y., Vlachiotis, S., Attevall, J., Bergami, F., Ferrari, A., Colaneri. M., Vecchia, M., Sambo, M., Zuccaro, V., Asperges, E., Bruno, R., Oggionni, T., Meloni, F., Abolhassanni, H., Bertoglio, F., Schubert, M., Calzolai, L., Varani, L., Hust, M., Xue, Y., Hammarström, L., Baldanti. F. & Pan-Hammarström, Q. (2022). Immunity to SARS-CoV-2 up to 15 months after infection. iScience 25:103743, DOI: 10.1016/j.isci.2022.103743
• Taubert, R., Engel, B., Diestelhorst, J., Hupa-Breier, K.L., Behrendt, P., Baerlecken, N.T., Sühs, K.W., Janik, M.K., Zachou, K., Sebode, M., Schramm, C., Londoño, M.C., Habes, S., UK-AIH Consortium, Oo, Y.H., Lalanne, C., Pape, S., Schubert, M., Hust, M., Dübel, S., Thevis, M., Jonigk, D., Beimdiek, J., Buettner, F.F.R., Drenth, J.P., Muratori, L., Adams, D.H., Dyson, J.K., Renand, A., Graupera, I., Lohse, A.W., Dalekos, G.N., Milkiewicz, P., Stangel, M., Maasoumy, B., Witte, T., Wedemeyer, H., Manns, M.P. & Jaeckel E. (2022). Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis. Hepatology 75:13-27 https://doi.org/10.1002/hep.32134

2021

• Malik, K., Duru, C., Stickings, P., Wenzel, E.V., Hust, M. & Matejtschuk, P. (2021). Investigating Alternative Container Formats for Lyophilization of Biological Materials Using Diphtheria Antitoxin Monoclonal Antibody as a Model Molecule. Pharmaceutics 13: 1948
• Marschall, A.L.J. (2021) Targeting the Inside of Cells with Biologicals: Chemicals as a Delivery Strategy. BioDrugs doi.org/10.1007/s40259-021-00500-y
• Schneider, K.-T., Kirmann, T., Wenzel E.V., Grosch, J.-H., Helmsing, S., Meier, D., Becker, M., Matejtschuk, P., Hust, M., Russo, G. & Dübel, S. (2021) Shelf-life extension of Fc-fused single chain fragment variable (scFv-Fc) antibodies by lyophilization. Frontiers Cell. Infect. Microbiol. 11:717689 doi: 10.3389/fcimb.2021.717689
• Gilbride, B, Moreira, G.M.S.G, Hust, M., Cao, C. & Steward, L. (2021). Catalytic ferromagnetic gold nanoparticle immunoassay for the detection and differentiation of Mycobacterium tuberculosis and Mycobacterium bovis. Analytica Chimica Acta 1184: 339037
• Bertoglio, F., Fühner. V., Ruschig, M., Heine, P.A., Abasi, L., Klünemann, T., Rand, U., Meier, D., Langreder, N., Steinke, S., Ballmann, R., Schneider, K.-T., Roth, K.D.R., Kuhn, P., Riese, P., Schäckermann, D., Korn, J., Koch, A., Chaudhry, M.Z., Eschke, K., Kim, Y., Zock-Emmenthal, S., Becker, M., Scholz, M., Moreira, G.M.S.G., Wenzel, E.V., Russo, G., Garritsen, H.S.P., Casu, S., Gerstner, A., Roth, G., Adler, J., Trimpert, J., Hermann, A., Schirrmann, T., Dübel, S., Frenzel, A., Van den Heuvel, J., Čičin-Šain, L., Schubert, M. & Hust, M. (2021). A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients is binding to the ACE2-RBD interface and is tolerant to most known RBD mutations. Cell Reports 36: 109433 DOI:10.1016/j.celrep.2021.109433

      More info on this story of the generation of COVID-19 therapeutic antibody COR-101:  
      →   Link to CORAT Therapeutics website
      →   Corona Antibody Team @ TU Braunschweig
      →   PDB database entry (7B3O) of COR-101 in complex with SARS-CoV-2 RBD (DOI: 10.2210/pdb7B3O/pdb)
      →   3d animation of the virus binding site
      →   Video about the antibody therapy using COR-101 by ARD Magazin Visite or Deutsche Herszstiftung (in german)

• Bradbury, A. R.M. ,  Dübel, S.,  Knappik, A. & Plückthun, A. (2021). Animal- versus in vitro-derived antibodies: avoiding the extremes. mAbs, 13:1, DOI: 10.1080/19420862.2021.1950265

• Brondino, N., Bertoglio, F., Forneris, F., Faravelli, S., Borghesi, A., Damiani, S., Provenzani, U., Nola, M., Olivola, M., Caviglia, M., Politi, P., Fusar-Poli, L. & Fusar-Poli, P. A (2021). A pilot Study on Covid and Autism: Prevalence, Clinical Presentation and Vaccine Side Effects. Brain Sci. 11(7):860. doi: 10.3390/brainsci11070860

• Magalhães. C.G., Moreira, G.M.S.G., Ferreira, M.R.A., Santos, L.M.D., Finger, P.F., Ramos, D.F., Silva, P.E.A.D., Hust, M. & Conceição, F.R. (2021). Novel phage display-derived recombinant antibodies recognizing both MPT64 native and mutant (63-bp deletion) are promising tools for tuberculosis diagnosis. Biologicals 72: 54-57

• Roth, K.D.R., Wenzel, E.V., Ruschig, M., Steinke, S., Langreder, N., Heine, P.A., Schneider, K.-T., Ballmann, R., Fühner, V., Kuhn, P., Schirmann, T., Frenzel, A., Dübel. S., Schubert, M., Moreira, G.M.S.M., Bertoglio, F., Russo, G. & Hust, M. (2021). Developing recombinant antibodies by phage display against infectious diseases and toxins for diagnostics and therapy. Frontiers Cellular and Infection Microbiology 11:697876 DOI: 10.3389/fcimb.2021.697876

• Sell, J., Haselmann, H., Hallermann, S., Hust, M. & Geis, C. (2021). Autoimmune encephalitis: novel therapeutic targets at the preclinical level. Expert Opin Ther Targets 25, 37-47

• Elter, A., Bock, T., Spiehl, D., Russo, G., Hinz, S. C., Bitsch, S., Baum, E., Langhans, M., Meckel, T., Dörsam, E., Kolmar, H., & Schwall, G. (2021). Carbohydrate binding module-fused antibodies improve the performance of cellulose-based lateral flow immunoassays. Scientific reports 11(1), 7880. https://doi.org/10.1038/s41598-021-87072-7
  
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• Bertoglio, F., Meier, D., Langreder, N., Steinke, S., Rand, U., Simonelli, L., Heine, P. A., Ballmann, R., Schneider, K.-T., Roth, K. D. R., Ruschig, M., Riese, P., Eschke, K., Kim, Y., Schaeckermann, D., Pedotti, M., Kuhn, P., Zock-Emmenthal, S., Wöhrle, J., Becker, M., Grashoff, M., Wenzel, E. V., Russo, G., Kröger, A., Brunotte, L., Ludwig, S., Fühner, V., Krämer, S. D., Dübel, S., Varani, L., Roth, G., Cicin-Sain, L., Schubert, M. & Hust, M. (2021) SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface.   Nature communications 12, 1577 (2021) (open access)
  
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• Nosenko, T., Hanke-Uhe, M., Heine, P.A., Shahid, A., Dübel, S., Rennenberg, H., Schumacher,  J., Winkler. J.B., Schnitzler, J.-P., Hänsch, R., Kaufholdt, D. (2021) Plant defense proteins as potential markers for early detection of forest damage and diseases. Frontiers Forests Glob. Change, doi: 10.3389/ffgc.2021.654032
• Moreira, G. & Dübel, S. (2021) Recombinant Antibodies and Phage Display. In: An Introduction to Molecular Biotechnology, 3rd ed., Ed.: Wink, M. Wiley-VCH, ISBN:9783527344147, p.341-362
• Valldorf, B., Hinz., S.C., Russo, G., Pekar, L., Mohr, L., Klemm, J., Doerner, A., Krah, S., Hust, M. & Zielonka, S. (2021). Antibody Display Technologies – Selecting the cream of the crop. Biological Chemistry 403, 455-477
• Dübel, S., Hermann, A., Schirrmann, T., Frenzel, A., Hust, M. (2021). COR-101, ein menschlicher Antikörper gegen COVID-19. BIOspektrum 27, 46–48, DOI: 10.1007/s12268-021-1512-x
• Sherina, N., Piralla, A., Du, L., Wan, H., Kumagai-Braesh, M., Andréll, J., Braesch-Andersen, S., Cassaniti, I., Percivalle, E., Sarasini, A., Bergami, F., Di Martino, R., Colaneri, M., Vecchia, M., Sambo, M., Zuccaro, V., Bruno, R., Oggionni, T., Meloni, F., Abolhassani, H., Bertoglio, F., Schubert, M., Byrne-Steele, M., Han, J., Hust, M., Xue, Y., Hammarström, L., Baldanti, F., Marcotte, H. & Pan-Hammarström, Q. (2021) Persistence of SARS-CoV-2 specific B-and T-cell responses in convalescent COVID-19 patients 6-8 months after the infection. Med 2: 281-295, DOI: 10.1016/j.medj.2021.02.001
• Schubert, M., Nimtz, M., Bertoglio, F., Schmelz, S., Lukat, P. & van den Heuvel J. (2021). Reproducible and Easy Production of Mammalian Proteins by Transient Gene Expression in High Five Insect Cells. Methods Mol Biol Clifton NJ 2305: 129–140.
• König, J, Hust, M. and Van den Heuvel, J. (2021). Validation of the Production of Antibodies in Different Formats in the HEK 293 Transient Gene Expression System. Methods Molecular Biology 2247: 56-76

2020

• J. Korn, D. Schäckermann, T. Kirmann, F. Bertoglio, S. Steinke, J. Heisig, M. Ruschig, G. Rojas, N. Langreder, E. Wenzel, K. Roth, M. Becker, D. Meier, J. van den Heuvel, M. Hust, S. Dübel & M. Schubert (2020) Baculovirus- free insect cell expression system for high yield antibody and antigen production. Scientific Reports,  7;10(1):21393. doi: 10.1038/s41598-020-78425-9

• Laureano, A.F.S., Zani, M.B., Sant'Ana, A.M., Tognato, R.C., Lombello, C.B., do Nascimento, M.H.M., Helmsing, S., Fühner, V., Hust, M. & Puzer, L. (2020). Generation of recombinant antibodies for human tissue kallikrein 7 to address skin diseases. Bioorganic & Medicinal Chemistry Letters 30: 127626

• Moreira, G. M.S, Köllner, S.M.S., Helmsing, S., Jänsch, L., Meier, A., Gronow, S.,  Boedeker, C.,  Dübel, S,  Mendonça, M.,  Moreira, A. N., Conceição, F. R. & Hust, M. (2020) Pyruvate dehydrogenase complex - enzyme 2, a new target for Listeria spp. detection identified using combined phage display technologies. Scientific Reports 10, 15267 https://doi.org/10.1038/s41598-020-72159-4

• Gray, A., Bradbury, A.R.M., Knappik, A., Plückthun, A., Borrebaeck, C.A.K. & Dübel, S. (2020) Animal free alternatives and the antibody iceberg. Nature Biotechnol. 38, 1234–1239 http://dx.doi.org/10.1038/s41587-020-0687-9.

• Gray, A.C., Bradbury, A., Dübel, S., Knappik, A., Plückthun, A. & Borrebaeck, C.A.K. (2020) Reproducibility: bypass animals for antibody production. Nature 581, 262  DOI: 10.1038/d41586-020-01474-7
• Gray, A., Bradbury, A.R.M., Knappik, A., Plückthun, A., Borrebaeck, C.A.K. & Dübel, S. (2020) Animal-derived-antibody generation faces strict reform in accordance with EU policy on animal use. Nature Meth. 17, 755–756 https://doi.org/10.1038/s41592-020-0906-9
• Wenzel, V.E., Russo, G. & Dübel, S. (2020) Multiklonale Antikörper als tierversuchsfreier Ersatz für Zweitantikörper aus Seren, BIOSpektrum (Springer-Verlag , Heidelberg) 26(4), 416-417. DOI: 10.1007/s12268-020-1401-7
  
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• Dübel, S., Hust, M., Frenzel, A. & Schirrmann, T. (2020) Rekombinante, vollständig menschliche Antikörper zur Behandlung akuter COVID-19. BIOSpektrum (Springer-Verlag, Heidelberg), 26(4), 444-446.  DOI: 10.1007/s12268-020-1404-4
  
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• Eskes, C., Alves, P.M., Clewell, R., Corsini, E., Cotgreave, I., Kopp-Schneider, A., Antón, J.M.A. Piersma, A., Westmoreland, C., Borrebaeck, C., Bradbury, A., Dübel, S., Gray, A., Knappik, H.-J., Plückthun, A. (2020) ESAC opinion on the scientific validity of replacements for animal-derived antibodies. In: Viegas Barroso, J., Halder, M. and Whelan, M., EURL ECVAM Recommendation on Non-Animal-Derived Antibodies, EUR 30185 EN, Publications Office of the European Union, Luxembourg, ISBN 978-92-76-18346-4  p. 12-70.
• Sehnert, B., Burkhardt, H., Dübel, S., Voll, R.E. (2020) Cell-Type Targeted NF-kappaB Inhibition for the Treatment of  Inflammatory Diseases. Cells, 9(7), 1627; doi.org/10.3390/cells9071627
• Zhang, C., Ötjengerdes, R.M., Roewe, J., Mejias, R., Marschall A.L.J. (2020) Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology. BioDrugs Aug;34(4):435-462 doi: 10.1007/s40259-020-00419-w.
• Sellmann, C., Pekar, L., Bauer, C., Ciesielski, E., Krah, S., Becker, S., Toleikis, L., Kügler, J., Frenzel, A., Valldorf,. B., Hust, M. and Zielonka S. (2020). A One-Step Process for the Construction of Phage Display scFv and VHH Libraries. Molecular Biotechnology 64, 228-229
• Tundidor, Y., Ponce, L., Chao, L., Solozabal, J., Hust, M., Dübel, S. and Rojas, G. (2020). Affinity-matured variants derived from nimotuzumab keep the original fine specificity and exhibit superior biological activity. Scientific. Reports 10, 1194. doi: 10.1038/s41598-019-57279-w.
• Behring, S., Hänsch, R., Helmsing, S., Schirrmann, T. and Schubert, M. (2020). Screening for scFv- fragments that are stable and active in the cytosol. Hum. Antibod. doi:10.3233/HAB-200402
• Wenzel, E.V., Bosnak, M., Tierney, R., Schubert, M., Brown, J., Dübel, S., Efstratiou, A., Sesardic, D., Stickings, P. & Hust, M. (2020). Human antibodies neutralizing diphtheria toxin in vitro and in vivo. Sci. Rep. 10, 571 (2020) - Read comment on this paper in SCIENCE
• Wenzel, E.V., Roth, K.D.R., Russo, G., Fühner, V., Helmsing, S., Frenzel, A. and Hust, M. (2020). Antibody Phage Display: Antibody Selection in Solution Using Biotinylated Antigens. Methods Molecular Biology 2070,143-155
• Jakob, V., Helmsing, S., Hust, M. and Empting, M. (2020). Restriction-Free Construction of a Phage-Presented Very Short Macrocyclic Peptide Library. Methods Molecular Biology 2070, 95-113

2019

• Allen J, Najjar K, Erazo-Oliveras A, Kondow-McConaghy HM, Brock DJ, Graham K, Hager EC, Marschall ALJ, Dübel S, Juliano RL, Pellois JP (2019) Cytosolic Delivery of Macromolecules in Live Human Cells Using the Combined Endosomal Escape Activities of a Small Molecule and Cell Penetrating Peptides. J. ACS Chem Biol. doi: 10.1021/acschembio.9b00585.
• Russo, G., Fühner, V., Frenzel, A., Hust, M., Dübel, S. (2019) Parallelized Microscale Expression of Soluble scFv. J. Meth. Mol. Biol. 2025, 203-211

• de Groot, C., Müsken,. M., Bleckmann, M., Ebensen, T., Guzman, C.A. & Müller-Goymann, C.C. (2019). Novel colloidal associations of soyasaponins and lipid components (DPPC, cholesterol) as potential adjuvants for vaccines. Vaccine 2019; 37: 4975–4986.
• Tenspolde, M., Zimmermann, K., Weber, L.C., Hapke, M., Lieber, M., Dywicki, J., Frenzel, A., Hust, M., Galla, M., Buitrago-Molina, L.E., Manns, M.P., Jaeckel, E. and Hardtke-Wolenski, M. (2019). Regulatory T cells engineered with a novel insulin-specific chimeric antigen receptor as a candidate immunotherapy for type 1 diabetes. J Autoimmun. 103, 102289. doi: 10.1016/j.jaut.2019.05.017

• Chauvin, D., Hust, M., Schütte, M., Chesnay, A., Parent, C., Moreira, G.M.S.G, Arroyo, J., Sanz, A.B., Pugnière, M., Martineau, P., Chandenier, J., Heuzé-Vourc’h, N.  and Desoubeaux, G. (2019). Targeting Aspergillus fumigatus Crf Transglycosylases With Neutralizing Antibody Is Relevant but Not Sufficient to Erase Fungal Burden in a Neutropenic Rat Model. Frontiers in Microbiology 10, 600

• Namikawa, K., Dorigo, A., Zagrebelsky, M., Russo, G., Kirmann, T., Fahr, W., Dübel, S., Korte, M. and Köster, R. (2019) Modeling neurodegenerative Spinocerebellar Ataxia type 13 in zebrafish using a Purkinje neuron specific tunable co-expression system. J. Neurosci. 39, 3948-3969, DOI: https://doi.org/10.1523/JNEUROSCI.1862-18.2019

• Kopertekh, L., Meyer, T., Freyer, C. and Hust M. (2019). Transient plant production of Salmonella Typhimurium diagnostic antibodies. Biotechnology Reports 21, e00314

• Rojas, G., Carmenate, T., Santo-Tomás, J.F., Valiente, P.A., Becker, M., Riverón, A., Yaima Tundidor, Y., Yaquelín Ortíz, Y., de Cossío- Díaz, J.F., Graça, L., Dübel, S. and León, K. (2019) Engineering phage-displayed human Interleukin-2 for better developability: directed evolution of super-secreted variants. Scientific Reports 9, 800

• Ramli, R.S., Moreira, G.M.S.G., Zantow, J., Goris, M.G.A., Nguyen, V.K., Novoselova, N., Pessler, F. and Hust, M. (2019). Discovery of Leptospira spp. seroreactive peptides using ORFeome Phage Display. PLOS Neglected Tropical Diseases 13, e0007131

• Fühner, V., Heine, P.A., Zilkens, K., Meier, D., Roth, K.D.R., Moreira, G.M.S.G., Hust, M. and Russo, G. (2019). Epitope Mapping via Phage Display from single gene libraries. Methods Molecular Biology 1904, 353-375

2018

• Fühner, V., Heine, P.A., Helmsing, S., Goy, S., Heidepriem, J., Loeffler, F.F., Dübel, S., Gerhard, R. and Hust, M. (2018). Development of Neutralizing and Non-neutralizing Antibodies Targeting Known and Novel Epitopes of TcdB of Clostridioides difficile. Frontiers in Microbiology 9: 2908

• Chung, S.Y., Schöttelndreier, D., Tatge, H., Fühner, V., Hust, M., Beer, L.A. and Gerhard, R. (2018). The conserved Cys-2232 in Clostridioides difficile toxin B modulates oligomerization and receptor binding. Frontiers in Microbiology 9: 2314 doi.org/10.3389/fmicb.2018.02314

• Sung, K.H., Josewski, J., Dübel, S., Blankenfeldt, W. & Rau, U. (2018) Structural insights into antigen recognition of an anti-beta-(1,6)-beta-(1,3)-D-glucan antibody. Scientific Reports 8,13652
  
  PDB structure annotations: 6EV1 , 6EV2

• Bala, G., Crauwels, M., Blykers, A., Remory, I., Marschall, A.L.J., Dübel, S., Dumas, L., Broisat, A., Martin, C., Ballet, S., Cosyns, B., Caveliers, V., Devoogdt, N., Xavier, C. and Hernot, S. (2018) Radiometal-Labeled Anti-VCAM-1 Nanobodies as Molecular Tracers for Atherosclerosis – Impact of Radiochemistry on Pharmacokinetics. Biol. Chem. doi: 10.1515/hsz-2018-0330

• Russo, G., Lehne, F., Pose Mendez, S.M., Dübel, S., Köster R.W. and Sassen, W.A. (2018) Culture and Transfection of Zebrafish Primary Cells (video article) JOVE 138, e57872 doi: 10.3791/57872

• Beer, L.A., Tatge, H., Schneider, C., Ruschig, M., Hust, M., Barton, J., Thiemann, S,. Fühner, V., Russo G. & Gerhard, R. (2018) The Binary Toxin CDT of Clostridium difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains. Toxins 10, 225, https://doi.org/10.3390/toxins10060225

• Froude, J.W., Herbert, A.S., Pelat, T., Miethe, S., Zak, S.E., Brannan, J.M., Bakken, R.R., Steiner, A.R., Yin, G., Hallam, T.J., Sato, A.K., Hust, M., Thullier, P. and Dye, J.M. (2018). Post-Exposure Protection in Mice against Sudan Virus by a Two Antibody Cocktail. Viruses 10: 286

• Burke, C.W., Froude, J.W., Miethe, S., Hülseweh, B., Hust, M. and Glass, P.J. (2018). Human-Like Neutralizing Antibodies Protect Mice from Aerosol Exposure with Western Equine Encephalitis Virus. Viruses 10: 147
• Wezler, X., Dübel, S. and Schirrmann, T. (2018) Antibody fusion proteins with human ribonucleases 1 to 8. Human Antibodies 26(4):177-192 doi: 10.3233/HAB-180337

• Sadana, P., Geyer, R., Pezoldt, J., Helmsing, S., Huehn, J., Hust, M., Dersch, P. and Scrima, A. (2018). The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine. Journal of Biological Chemistry 293: 8672-8690

• Dübel, S. (2018) Viele monoklonale Antikörper sind nicht monospezifisch. BioSpektrum 4.2018, p.395-399
• Dübel, S., Hust, M., Kügler, J., Kuhn, P., Frenzel, A., Krah, S. and Zielonka, S. (2018). Trendbericht Biochemie 2018: Menschliche Antikörper für Medikamente. Nachrichten aus der Chemie 66: 284-290
• Bradbury, A.R.M., Trinklein, N.D., Thie, H., Wilkinson, I.C., Tandon, A.K., Anderson, S., Bladen, C.L., Jones, S., Force Aldred, S., Bestagno, M., Burrone, O., Maynard, J., Ferrara, F., Trimmer, J.S., Görnemann, J., Glanville, J., Wolf, P., Frenzel, A., Wong. J., Yu, X., Eng, H.-Y., Lane, D, Lefranc, M.-P., Clark, M., & Dübel, S. (2018) When monoclonal antibodies are not monospecific: hybridomas frequently express additional functional variable regions. mAbs 10, 539–546 https://doi.org/10.1080/19420862.2018.1445456
  
  [ download PDF ]

• Russo, G., Theisen, U., Fahr, W., Helmsing, S., Hust, M., Köster R.W., and Dübel, S. (2018) Sequence defined antibodies improve the detection of Cadherin 2 (N-Cadherin) during Zebrafish development. N. Biotechnology 45, 98-112 https://doi.org/10.1016/j.nbt.2017.12.008

• Moreira, G.M.S.G., Fühner, V. and Hust, M. (2018). Epitope Mapping by Phage Display. Phage display, Ed: Lim, T.S. and Hust, M., Methods Molecular Biology 1701: 497-518

• Zantow, J., Moreira, G.M.S.G., Dübel, S. and Hust, M. (2018). ORFeome Phage Display. Phage display, Ed: Lim, T.S. and Hust, M., Methods Molecular Biology 1701: 477-495

• Unkauf, T., Hust, M. and Frenzel, A. (2018). Antibody Affinity and Stability Maturation by Error-Prone PCR. Phage display, Ed: Lim, T.S. and Hust, M., Methods Molecular Biology 1701: 393-407

• Fahr, W. and Frenzel, A. (2018). Phage Display and Selections on Cells. Phage display, Ed: Lim, T.S. and Hust, M., Methods Molecular Biology 1701: 321-330
• Russo, G., Meier, D., Helmsing, S., Wenzel, E., Oberle, F., Frenzel, A. and Hust, M. (2018). Parallelized antibody selection in microtiter plates. Phage display, Ed: Lim, T.S. and Hust, M., Methods Molecular Biology 1701: 273-284
• Avril, A., Miethe, S., Hust, M. and Pelat, T. (2018). Construction of macaque immune libraries. Phage display, Ed: Lim, T.S. and Hust, M., Methods Molecular Biology 1701: 83-112

• Kügler, J., Tomszak, F., Frenzel, A. and Hust, M. (2018). Construction of Human Immune and Naive scFv Libraries. Phage display, Ed: Lim, T.S. and Hust, M., Methods Molecular Biology 1701: 3-24

2017

• Sehnert, B., Burkhardt, H., Finzel, S., Dübel, S., Voll, R.E. (2017) The sneaking ligand approach for cell type-specific modulation of intracellular signalling pathways. Clin Immunol. S1521-6616(17)30636-8. doi: 10.1016/j.clim.2017.08.018.

• Rasetti-Escargueil , C., Avril, A., Miethe, S., Mazuet, C., Derman, Y., Selby, K., Thullier, P., Pelat, T., Urbain, R., Fontayne, A., Korkeala, H., Sesardic, D., Hust, M. and Popoff, M.R. (2017) The European AntibotABE Framework Program and Its Update: Development of Innovative Botulinum Antibodies. Toxins 9: 309

• Stech, M., Nikolaeva, O., Thoring, L., Stöcklein, W.F.M., Wüstenhagen, D.A., Hust, M., Dübel, S. and Kubick, S. (2017) Cell-free synthesis of functional antibodies using a coupled in vitro transcription-translation system based on CHO cell lysates. Sci Rep. Sep 20;7(1):12030

• Josewski, J., Buchmeier, S., Frenzel, A., Tinnefeld, P., Dübel, S. and Rau, U. (2017) Generation of recombinant antibodies against the beta-(1,6)-branched beta-(1,3)-D-glucan schizophyllan from immunized mice via phage display. Biotec Res Intl. 2017, 8791359, 8 pp, doi.org/10.1155/2017/8791359

• Sassen, W.A, Lehne, F., Russo, G., Wargenau, S., Dübel, S. & Köster, R.W. (2017) Embryonic zebrafish primary cell culture for transfection and live cellular and subcellular imaging Devel. Biol. 430, 18-31

• Beißner, S., Thies, J.W., Bechthold, C., Kuhn, P., Dübel. S., Thürmann, B., & Dietzel, A. (2017) Low-cost, in-liquid measuring system using novel compact oscillation circuit and quartz-crystal microbalances (QCM) as versatile biosensor platform. J. Sensors & Sensor Syst 6, 341-350

• Frenzel, A., Kügler, J., Helmsing, S., Meier, D., Schirrmann, T., Hust, M. and Dübel, S. (2017). Designing human antibodies by phage display. Tranfusion Medicine and Hemotherapy 44: 312-318
• Schmitt, L.C., Rau, A., Seifert, O., Honer, J., Schmid, S., Hutt, M., Zantow, J., Hust, M., Dübel, S., Olayioye, M.A. and Kontermann, R.E. (2017). Inhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IV. mAbs 9: 831-843
• Froude, J.W., Pelat, T., Miethe, S., Zak, S.E., Wec, A.Z., Chandran, K., Brannan, J.M., Bakken, R.R., Hust, M., Thullier, P. and Dye, J.M. (2017). Generation and characterization of protective antibodies to Marburg virus. mAbs 9: 696-703

• Kuhn, P., Thiem, S., Steinert, M., Purvis, D., Lugmayr, V., Treutlein, U., Plobner, L. , Leiser, R.-M., Hust, M. and Dübel, S. (2017). Human Anti-Lipopolysaccharid (LPS) antibodies against Legionella with high species specificity. Human Antibodies 26: 29-38

• Thies, J.-W., Kuhn, P., Thürmann, B., Dübel, S., Dietzel, A. (2017) Microfluidic quartz-crystal-microbalance (QCM) sensors with specialized immunoassays for extended measurement range and improved reusability. Microelectronic Engineering 179, 25–30. doi:10.1016/j.mee.2017.04.023

• Kellmann, S., Dübel, S. and Thie, H. (2017) A strategy to identify linker-based modules for the allosteric regulation of antibody-antigen binding affinities of different scFvs. mAbs 9: 404-418

• Noyan, F., Zimmermann, K., Hardtke-Wolenski, M., Knoefel, A., Schulde, E., Geffers, R., Hust, M., Huehn, J., Galla, M., Morgan, M., Jokuszies, A., Manns, M.P., Jaeckel, E. (2017). Prevention of allograft rejection by use of regulatory T cells with a MHC-specific chimeric antigen receptor. American Journal of Transplantation 17: 917-930

• Weber, L.K., Palermo, A., Kügler, J., Armant, O., Isse, A., Rentschler, S., Jaenisch, T.,Hubbuch, J., Dübel, S., Nesterov-Mueller, A., Breitling, F. and Loeffler, F.F. (2017) Single amino acid fingerprinting of the human antibody repertoire with high density peptide arrays. J Immunol Methods 443:45-54

• Marschall, A.L.J., Zhang, C., Dübel, S. (2017) Evaluating the Delivery of Proteins to the Cytosol of Mammalian Cells. Methods Mol Biol. 1513: 201-208

2016

• Postel, S., Deredge, D., Bonsor, D.A., Yu, X., Diederichs, K., Helmsing, S., Vromen, A., Friedler, A., Hust, M., Egelman, E.H., Beckett, D., Wintrode, P.L., and Sundberg, E.J. (2016). Bacterial flagellar capping proteins adopt diverse oligomeric states. eLIFE 5:e18857

• Zantow, J., Just, S., Lagkouvardos, I., Kisling, S., Dübel, S., Lepage, P., Clavel, T. and Hust, M. (2016). Mining gut microbiome oligopeptides by functional metaproteome display. Scientific Reports 6:34337
• Hahn T., Zayed A., Kovacheva M., Stadtmüller R., Lang S., Muffler K., Ulber R. (2016). Dye affinity chromatography for fast and simple purification of fucoidan from marine brown algae. Eng. Life Sci. 16, 78-87

• Derman, Y., Selby, K., Miethe, S., Frenzel, A., Liu, Y., Rasetti-Escargueil, C., Avril, A., Pelat, T., Urbain, R., Fontayne, A., Thullier, P., Sesardic, D., Lindström, M., Hust, M. and Korkeala, H. (2016). Neutralization of Botulinum Neurotoxin Type E by a Humanized Antibody. Toxins 8: 25

• Miethe, S., Mazuet, C., Liu, Y., Tierney, R., Rasetti-Escargueil, C., Avril, A., Frenzel, A., Thullier, P., Pelat, T., Urbain, R., Fontayne, A., Sesardic, D., Hust, M. and Popoff, M.-R. (2016). Development of Germline-Humanized Antibodies Neutralizing Botulinum Neurotoxin A and B. PLoS ONE 11: e0161446

• Marschall, A.L.J., Dübel, S. (2016). Antibodies inside of a cell can change its outside: can intrabodies provide a new therapeutic paradigm? Comput. Struct. Biotech. J. 14: 304-308

• Mendonça, M., Moreira, G.M., Conceição, F.R., Hust, M., Mendonça, K.S., Moreira, Â.N., França, R.C., da Silva, W.P., Bhunia, A.K. and Aleixo, J.A.. (2016). Fructose 1,6-Bisphosphate Aldolase, a Novel Immunogenic Surface Protein on Listeria Species. PLoS ONE 11(8): e0160544

• Frenzel, A., Schirrmann, T. and Hust, M. (2016). Phage display-derived human antibodies in clinical development and therapy. mAbs 8: 1177-1194

• Kuhn, P., Fühner, V., Moreira, G.M.S.G., Frenzel, A., Miethe, S. and Hust, M. (2016). Recombinant Antibodies for Diagnostics and Therapy against Pathogens and Toxins generated by Phage Display.  Proteomics - Clinical Applications 10: 922-948

• Zantow, J., Dübel, S. and Hust, M. (2016). Funktionales Proteom-Display zur Identifikation von Biomarkern. Biospektrum 22: 256-259
   
• Schieferdecker, A., Oberle, A., Thiele, B., Hofmann, F., Göthel, M, Miethe, S., Hust, M., Braig, F., Voigt, M., Koch-Nolte, F., Haag, F., Alawi, M., Indenbirken, D., Grundhoff, A., Bokemeyer, C., Bacher, U., Kröger, N. and Binder, M. (2016). A transplant immunome deep sequencing and screening platform defines a unique targetable epitope fingerprint of multiple myeloma. Blood 127: 3202-3214
   
• Rohrbeck, A., Fühner, V., Schröder, A., Hagemann, S., Vu, X.-H., Berndt, S., Hust, M., Pich, A. and Just, I. (2016). Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody. Toxins 8:100
   
• Blokzijl, A., Zieba, A., Hust, M., Schirrmann, T., Helmsing, S., Grannas, K., Hertz, E., Moren, A., Chen, L., Soderberg, O., Moustakas, A., Dübel, S. and Landegren, U. (2016). Single chain antibodies as tools to study TGF-β regulated SMAD proteins in proximity ligation-based pharmacological screens. Molecular&Cellular Proteomics 15:1848-1856

• Connor, D.O., Zantow, J., Hust, M., Bier, F.F. and von Nickisch-Rosenegk, M. (2016). Identification of Novel Immunogenic Proteins of Neisseria gonorrhoeae by Phage Display. PLoS ONE 11(2): e0148986

• Kibat, J., Schirrmann, T., Knape, M.J., Helmsing, S., Meier, D., Hust, M., Schröder, C., Bertinetti, D., Pardes, K., Funk, M., Lages, A., Giese, N., Herberg, F. W., Dübel, S. and Hoheisel, J.D.  (2016). Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality. New Biotechnology 33: 574-581

• Jones, T.D., Carter, P.J., Plückthun, A., Vásquez, M., Holgate, R.G.E., Hötzel, I., Popplewell, A.G., Parren, P.W.H.I., Enzelberger, M., Rademaker, H.J., Clark, M.R., Lowe, D.C., Dahiyat, B.I., Smith, V., Lambert, J.M., Wu, H., Reilly, M., Haurum, J.S., Dübel, S., Huston, J.S., Schirrmann, T., Janssen, R.A.J., Steegmaier, M., Gross, J.A., Bradbury, A.R.M., Burton, D.R., Dimitrov, D.S., Chester, K.A., Glennie, M.J., Davies, J., Walker, A., Martin, S., McCafferty, J. and Baker, M.P. (2016). The INNs and outs of antibody nonproprietary names. mAbs 8: 1-9

• Tomszak, F., Weber, S., Zantow, J., Schirrmann, T., Hust, M. and Frenzel, A. (2016). Selection of recombinant human antibodies. Advances in Experimental Medicine and Biology 917: 23-54

• Unkauf, T., Miethe, S. Fühner, V., Schirrmann, T., Frenzel, A. and Hust, M. (2016). Generation of recombinant antibodies against toxins and viruses by phage display for Diagnostics and Therapy.  Advances in Experimental Medicine and Biology 917: 55-76

2015

• Thies, J. W., Kuhn, P., Masthoff, I.-C., Schulze, T, Rustenbeck, I., Garnweitner, G., Dübel, S. and Dietzel, A. (2015). Proteindetection by Quartz-Crystal-Microbalances. Tagungsband Mikro System Technik Kongress 2015, VDE Verlag Berlin, ISBN 978-3-8007-4100-7, S. 800-803

• Rasetti-Escargueil, C., Avril, A., Tierney, R., Bak, N., Miethe, S., Chahboun, S., Mazuet, C., Popoff, M., Thullier, P., Hust, M., Pelat, T. and Sesardic, D. (2015). Development of human-like scFv-Fc neutralising Botulinum toxin type B. mAbs 6: 1161-1177

• Marschall, A., Dübel, S. and Böldicke, T. (2015). Specific in vitro knockdown of protein function by intrabodies. mAbs 6: 1010-1035 ( download)
• Pöhnlein M., Hausmann R., Lang S., Syldatk C. (2015). Enzymatic synthesis and modification of surface-active glycolipids. Eur. J. Lipid Sci. Technol. 117, 145-155.

• Miethe, S., Rasetti-Escargueil, C., Avril, A., Liu, Y., Chahboun, S., Korkeala, H., Mazuet, C., Popoff, M.-R., Pelat, T., Thullier. P., Sesardic, D. and Hust, M. (2015).  Development of human-like scFv-Fc neutralizing botulinum neurotoxin E. PLoS ONE 10: e0139905

• Avril, A., Miethe, S., Popoff, M., Mazuet, C., Chahboun, S., Rassetti-Escargueil, C., Sesardic, D., Thullier, P., Hust, M. and Pelat, T. (2015). Isolation of nanomolar scFvs of non-human primate origin, cross-neutralizing botulinum neurotoxins A1 and A2 by targeting their heavy chain. BMC Biotechnology 15: 86

• Wirsing, L., Klawonn, F., Sassen, W., Lünsdorf, H., Probst, C., Hust, M., Mendel, R., Kruse, T. and Jänsch, L. (2015). Linear discriminant analysis identifies mitochondrially localized proteins in Neurospora crassa. Journal of Proteome Research 14: 3900-3911

• Zehner, M., Marschall, A.L., Bos, E., Schloetel, J.G., Kreer, C., Fehrenschild, D., Limmer, A., Ossendorp, F., Lang, T., Koster, A.J., Dübel, S. and Burgdorf S. (2015). The translocon protein sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells. Immunity 42: 850-863

• Droste, P., Frenzel, A., Steinwand, M., Pelat, T., Thullier, P., Hust, M., Lashuel, H. and Dübel, S. (2015). Structural differences of amyloid-β fibrils revealed by antibodies from phage display. BMC Biotechnology 15: 57

• Becker, M., Felsberger, A., Frenzel, A., Shattuck, W.M.C, Dyer, M., Kügler, J., Zantow, J., Mather, T. and Hust, M. (2015). Application of M13 Phage Display for Identifying Immunogenic Proteins from Tick (Ixodes scapularis) Saliva. BMC Biotechnology 15: 43

• Kügler, J., Wilke, S. Meier, D., Tomszak, F.,  Frenzel, A. , Schirrmann, T., Dübel, S.,  Garritsen, H.,  Hock, B., Toleikis, L., Schütte, M. and Hust, M. (2015). Generation and analysis of the improved human HAL9/10 antibody phage display libraries. BMC Biotechnology 15: 10

2014

• Bacher, P., Kniemeyer, O., Teutschbein, J., Thön, M., Vödisch, M., Wartenberg, D., Scharf, D.H., Koester-Eiserfunke, N., Schütte, M., Dübel, S., Assenmacher, M., Brakhage, A.A., and Scheffold, A. (2014). Identification of immunogenic antigens from Aspergillus fumigatus by direct multiparameter characterization of specific conventional and regulatory CD4+ T cells. J. Imunol 193: 3332-3343

• Froude, J.W., Pelat, T., Miethe, S., Zak, S., Bakken, R., Hust, M., Thullier, P. and Dye, J.M. (2014). A Multinational Consortium for the Development of Therapeutic Antibodies to Tier 1 Bioterrorism Agents: Protective scFv-Fc Antibody against Marburg Virus derived from Macaque Immune Library. STO Scientific Publications, STO-MP-HFM239-18

• Miethe, S. , Pelat, T., Avril, A., Popoff, M., Molgo, J., Rasetti‑Escargueil, C., Fontayne, A., Korkeala, H., Thullier, P., Sesardic, D. and Hust, M. (2014). Development of recombinant antibodies for biodefense using phage display. STO Scientific Publications, STO-MP-HFM239-16

• Dübel, S. and Reichert, J.M. (2014). Therapeutic Antibodies – From Past to Future. In: Handbook of therapeutic antibodies, 2nd ed., Ed. Dübel, S. and Reichert. J.M., Wiley-VCH, Weinheim, 1-13, ISBN 978-3-527-32937-3

• Cingoz, O., Dübel, S. and Reichert, J.M. (2014). Ustekinumab (Stelara). In: Handbook of therapeutic antibodies, 2nd ed., Ed. Dübel, S. and Reichert. J.M., Wiley-VCH, Weinheim, 2069-2086, ISBN 978-3-527-32937-3

• Dübel, S. (2014). Itolizumab (Alzumab), Mogamulizumab (Poteligeo) and Tositumomab (Bexxar). In: Handbook of therapeutic antibodies, 2nd ed., Ed. Dübel, S. and Reichert. J.M., Wiley-VCH, Weinheim, 2113-2120, ISBN 978-3-527-32937-3

• Meyer, T. (2014). Denosumab (Prolia). In: Handbook of therapeutic antibodies, 2nd ed., Ed. Dübel, S. and Reichert. J.M., Wiley-VCH, Weinheim, 1521-1530, ISBN 978-3-527-32937-3

• Kügler, J. (2014). Panitumumab (Vectibix) - A Treatment for Metastatic Colorectal Cancer. In: Handbook of therapeutic antibodies, 2nd ed., Ed. Dübel, S. and Reichert. J.M., Wiley-VCH, Weinheim, 1855-1870 ISBN 978-3-527-32937-3

• Sommer, B., Laux, H., Frenzel, A. and Jostock, T. (2014). Emerging Alternative Production Systems. In: Handbook of therapeutic antibodies, 2nd ed., Ed. Dübel, S. and Reichert. J.M., Wiley-VCH, Weinheim, 561-599, ISBN 978-3-527-32937-3

• Schirrmann, T. and Petrausch, U. (2014). Chimeric Antigene Receptors (CARs). In: Handbook of therapeutic antibodies, 2nd ed., Ed. Dübel, S. and Reichert. J.M., Wiley-VCH, Weinheim, 519-560, ISBN 978-3-527-32937-3

• Hust, M., Frenzel, A., Tomszak, F., Kügler, J. and Dübel, S. (2014). Antibody Phage Display. In: Handbook of therapeutic antibodies, 2nd ed., Ed. Dübel, S. and Reichert. J.M., Wiley-VCH, Weinheim, 43-76, ISBN 978-3-527-32937-3

• Wilke, S. and Hust, M. (2014). Cetuximab (Erbitux). In: Handbook of therapeutic antibodies, 2nd ed., Ed. Dübel, S. and Reichert. J.M., Wiley-VCH, Weinheim, 1501-1520, ISBN 978-3-527-32937-3

• Marschall, A.L.J., Single, F.N., Schlarmann, K., Bosio, A., Strebe, N., van den Heuvel, J., Frenzel, A., Dübel, S. (2014). Functional knock down of VCAM1 in mice mediated by endoplasmatic reticulum retained intrabodies. mAbs 6: 1394-1401

• Stech, M., Hust, M., Schulze, C., Dübel, S. and Kubick, S. (2014). Cell-free eukaryotic systems for the production, engineering and modification of scFv antibody fragments. Engineering in Life Sciences 14: 387-398

• Fuchs, M., Kämpfer, S., Helmsing, S., Spallek, R., Oehlmann, W., Prilop, W., Frank, R., Dübel, S., Mahavir, S. and Hust, M. (2014). Novel human recombinant antibodies against Mycobacterium tuberculosis antigen 85B. BMC-Biotechnology 14:68

• Marschall, A.L.J., Zhang, C., Frenzel, A., Schirrmann, T., Hust, M., Perez, F. and Dübel, S (2014). Delivery of antibodies to the cytosol - debunking the myths. mAbs 6: 943-956

• Schirrmann, T., Steinwand, M., Wezler, X., Ten Haaf, A., Tur M.K. and Barth S. (2014). CD30 as a therapeutic target for lymphoma. Biodrugs 28: 181-209

• Trott, M., Weiß, S., Antoni, S., Koch, J., von Briesen, H., Hust, M. and Dietrich, U. (2014).  Functional characterization of two scFv-Fc antibodies from an HIV controller selected on soluble HIV-1 Env complexes: a neutralizing V3- and a trimer-specific gp41 antibody. PLoS ONE 9:  e97478

• Hülseweh, B., Rülker, T., Pelat, T., Langermann, C., Frenzel, A., Schirrmann, T., Dübel, S., Thullier, P. and Hust, M. (2014). Human-like antibodies neutralizing Western equine encephalitis virus. mAbs 6: 717-726

• Miethe, S., Rasetti-Escargueil, C., Liu, Y., Chahboun, S., Pelat, T., Avril, A., Frenzel, A., Schirrmann, T., Thullier, P., Sesardic, D. and Hust, M. (2014). Development of neutralizing scFv-Fc against botulinum neurotoxin A light chain from a macaque immune library. mAbs 6: 446-459

• Frenzel, A., Kügler, J., Wilke, S., Schirrmann, T. and Hust, M. (2014). Construction of human antibody gene libraries and selection of antibodies by phage display. Human Monoclonal Antibodies: Methods and Protocols, Ed: Steinitz, M., Methods Molecular Biology 1060: 215-243

• Steinwand, M., Droste, P., Frenzel A., Hust, M., Dübel, S. and Schirrmann, T. (2014). The influence of antibody fragment format on phage display based affinity maturation of IgG. mAbs 6: 204-218

• Hust, M., Frenzel, A., Schirrmann, T. and Dübel, S. (2014). Selection of recombinant antibodies from antibody gene libraries. Gene Function Analysis, Ed: Ochs, M.F., Methods Molecular Biology 1101: 305-320

2013

• Kügler, J., Zantow, J., Meyer, T., and Hust, M. (2013). Oligopeptide M13 Phage Display in Pathogen Research.  Viruses 5:2531-2545

• Sehnert, B., Burkhardt, H., Wessels, J.T., Schröder, A., May, M.J., Vestweber, D., Zwerina, J.., Warnatz, K., Nimmerjahn, F., Schett, G., Dübel, S. and Voll, E.R. (2013). NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases. PNAS 110:16556-16561

• Frenzel, A., Hust, M. and Schirrmann, T. (2013). Expression of recombinant Antibodies. Frontiers in Immunology 4:217

• Jäger, V.,  Büssow, K., Wagner, A., Weber, S., Hust, M., Frenzel, A. and Schirrmann, T. (2013). High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells. BMC-Biotechnology 13:52

• Zhou, M., Meyer, T., Koch, S., Koch, J., Brill, B., von Briesen, H., Benito, J.M., Soriano, V., Haberl, A., Bickel, M., Dübel, S., Hust, M. and Dietrich, U. (2013). Identification of an epitope in the membrane proximal external region of gp41 targeted by neutralizing antibodies in plasma from an elite controller using an Env-tailored phage display library. Eur J immunol 43: 499-509

• Dübel, S. (2013) Recombinant antibodies for everyone. in: International Innovation: Healthcare, February 2013 (Research Media, UK): 82-83 (Download pdf)

• Miethe, S., Meyer, T., Wöhl-Bruhn, S.,  Frenzel. A., Schirrmann, T., Dübel, S. and Hust, M. (2013). Production of Single Chain Fragment Variable (scFv) Antibodies in Escherichia coli Using the LEX Bioreactor.  Journal of Biotechnology 163: 105-111

• Bertz, A., Wöhl-Bruhn, S., Miethe, S., Tiersch, B., Koetz, J., Hust, M., Bunjes, H. and Menzel, H. (2013). Encapsulation of Proteins in Hydrogel Carrier Systems for Controlled Drug Delivery: Influence of Network Structure and Drug Size on Release Rate. Journal of Biotechnology 163: 243-249

• Al-Halabi, L., Balck, A., Michalzik, M., Fröde, D., Büttgenbach, S., Hust, M., Schirrmann, T. and Dübel, S. (2013). Recombinant antibody fragments allow repeated measurements of C-reactive protein with a quartz crystal microbalance immunosensor. mAbs 5: 140-149

2012

• Hust, M., Frenzel, A., Meyer, T., Schirrmann, T. and Dübel, S. (2012). Construction of human naive antibody gene libraries. Antibody Engineering: Methods and Protocols, Ed: Chames, P.,  Methods Molecular Biology 907: 85-107

• Geyer, C.R., McCafferty, J., Dübel, S., Bradbury, A.R. and Sidhu, S.S. (2012). Recombinant antibodies and in vitro selection technologies. Methods Mol Biol. 901: 11-32

• Wezler, X., Hust, M., Helmsing, S., Schirrmann, T. and Dübel, S. (2012). Human antibodies targeting CD30+ lymphomas. Human Antibodies 21:13-28

• Pohl, S.C., Schwarz, S., Frenzel, A., and Schirrmann, T. (2012). A Cassette Vector System for the Rapid Cloning and Production of Bispecific Tetravalent Antibodies. Antibodies 1: 19-38

• Meyer, T.,  Schirrmann, T., Frenzel, A., Miethe, S., Stratmann-Selke, J., Gerlach, G.F., Strutzberg-Minder, K., Dübel, S., and Hust, M. (2012). Identification of immunogenic proteins and generation of antibodies against Salmonella Typhimurium using phage display. BMC-Biotechnology 12:29

• Rülker, T., Voß, L., Thullier, P., O'Brien, L.M., Pelat, T., Perkins, S.D., Langemann, C., Schirrmann, T., Dübel, S., Marschall, H.-J., Hust, M. and Hülseweh, B. (2012). Isolation and characterisation of a human-like antibody fragment (scFv) that inactivates VEEV in vitro and in vivo. PLoS ONE 7: e37242

• Frenzel, A., Fröde, D., Meyer, T., Schirrmann, T. and Hust, M. (2012). Generating recombinant antibodies for research, diagnostics and therapy using phage display. Current Biotechnology 1:33-41

• Zhang, C., Helmsing, S., Zagrebelsky, M., Schirrmann, T., Marschall, A.L.J., Schüngel, M., Korte, M., Hust, M. and Dübel, S. (2012). Suppression of p75 Neurotrophin Receptor Surface Expression with Intrabodies Influences Bcl-xL mRNA Expression and Neurite Outgrowth in PC12 Cells. PLoS ONE 7: e30684

2011

• David, F., Steinwand, M., Hust, M., Bohle, K., Ross, A., Dübel, S. and Franco-Lara, E. (2011). Antibody production in Bacillus megaterium: strategies and physiological implications of scaling from micro titer plates to industrial bioreactors. Biotechnology Journal 6:1516-1531

• Thullier, P., Hülseweh, B., Pelat, T., Rülker, T., Miethe, S., Dübel, S. and Hust, M. (2011). Development of human and macaque antibodies using antibody phage display for the detection of equine encephalitis viruses. In: Encephalitis / Book 3, Ed: Hayasaka, D. Intech 309-322

• Chahboun, S., Hust, M., Liu, Y., Pelat, T., Miethe, S., Helmsing, S., Jones ,R.G., Sesardic, D. and Thullier, P. (2011). Isolation of a nanomolar scFv inhibiting the endopeptidase activity of botulinum toxin A, by single-round panning of an immune phage-displayed library of macaque origin. BMC-Biotechnology 11:113

• Colwill, K., Persson, H., Jarvik, N.E., Wyrzucki, A., Wojcik, J., Koide, A., Kossiakoff, A.A., Koide, S., Sidhu, S., Dyson, M.R., Pershad, K., Pavlovic, J.D., Karatt-Vellat, A., Schofield, D.J., Kay, B.K., McCafferty, J., Mersmann, M., Meier, D., Mersmann, J., Helmsing, S., Hust, M., Dübel, S., Berkowicz, S., Freemantle, A., Spiegel, M., Sawyer, A., Layton, D., Nice, E., Dai, A., Rocks, O., Williton, K., Fellhouse, F.A., Hersi, K., Pawson, T., Nilsson, P., Sundberg, M., Sjöberg, R., Sivertsson, A., Schwenk, J.M., Takanen, J.O., Hober, S., Uhlén, M., Dahlgren, L.G., Flores, A. Johansson, I, Weigelt, J., Crombet, L., Loppnau, P., Kozieradzki, I., Cossar, D., Arrowsmith, C.H., Edwards, A.M. and Gräslund, S. (2011). A roadmap to generate renewable protein binders to the human proteome. Nature Methods 8, 551-558

• Lüders, S., David, F., Steinwand, M., Jordan, E., Hust, M., Dübel, S. and Franco-Lara, E. (2011). Influence of the hydromechanical stress and temperature on growth and antibody fragment production with Bacillus megaterium. Applied Microbiology and Biotechnology 91, 81-90

• Balck, A., Michalzik, M., Al-Halabi, L., Dübel, S. and Büttgenbach, S. (2011). Design and Fabrication of a Lab-on-a-chip for Point-of-care Diagnostics. Sensors & Transducers Journal 127, 102-111

• Hust, M., Meyer, T., Voedisch, B., Rülker, T., Thie, H., El-Ghezal, A., Kirsch, M.I., Schütte, M., Helmsing, S., Meier, D., Schirrmann, T. and Dübel, S. (2011). A human scFv antibody generation pipeline for proteome research. Journal of Biotechnology 152, 159-170

• Bradbury, A., Sidhu, S., Dübel, S. and McCafferty, J. (2011) Beyond natural antibodies: the power of in vitro display technologies. Nature Biotechnology 29, 245-254

• Dammeyer, T., Steinwand, M., Krüger, S.C., Dübel, S., Hust, M. and Timmis, K.N. (2011). Efficient production of soluble recombinant single chain Fv fragments by a Pseudomonas putida strain KT2440 cell factory. Microbial Cell Factories 10: 11

• Thie, H., Toleikis, L., Li, J., von Wasielewski, R., Bastert, G., Schirrmann, T., Esteves, I. T., Behrens, C. K.,  Fournes, B., Fournier, N., de Romeuf, C., Hust, M. and Dübel, S. (2011). Rise and fall of an anti-MUC1 specific antibody. PLoS ONE 6: e15921

• Schirrmann, T., Meyer, T., Schütte, M., Frenzel, A., and Hust, M. (2011). Phage display for the generation of antibodies for proteome research, diagnostics and therapy. Molecules 16, 412-426

• Marschall, A.L., Frenzel, A., Schirrmann, T., Schüngel, M. and Dübel S. (2011). Targeting antibodies to the cytoplasm. mAbs 3, 2-15

• Meyer, T.,  Stratmann-Selke, J., Meens, J., Schirrmann, T., Gerlach G.F., Frank, R., Dübel, S., Strutzberg-Minder, K. and Hust, M (2011). Isolation of scFv fragments specific to OmpD of Salmonella Typhimurium. Veterinary Microbiology 147, 162-169

2010

• Bourbeillon, J., Orchard, S., Benhar, I., Borrebaeck, C., de Daruvar, A., Dübel, S., Frank, R., Gibson, F., Gloriam, D., Haslam, N., Hiltker, T., Humphrey-Smith, I., Hust, M., Juncker, D., Koegl, M., Konthur, Z., Korn, B., Krobitsch, S., Muyldermans, S., Nygren, P.-A., Palcy, S., Polic, B., Rodriguez, H., Sawyer, A., Schlapshy, M., Snyder, M.,Stoevesandt, O., Taussig, M.J., Templin, M., Uhlen, M., van der Maarel, S., Wingren, C., Hermjakob, H. and Sherman, D. (2010). Minimum Information about a Protein Affinity Reagent (MIAPAR). Nature Biotechnology 28, 650-653

• Schirrmann, T. and Hust, M. (2010). Construction of human antibody gene libraries and selection of antibodies by phage display. Immunotherapy of Cancer: Methods and Protocols, Ed. Yotnda, P.,  Methods Molecular Biology 651, 177-209
• Bartek T., Zönnchen E., Klein B., Gerstmeir R., Makus P., Lang S., Oldiges M. (2010). Analysing overexpression of L-valine biosynthesis genes in pyruvate-dehydrogenase -deficient Corynebacterium glutamicum. J. Industrial Microbiol. Biotechnol. 37, 263-270

• Dübel, S., Stoevesandt, O., Taussig, M.J. and Hust, M. (2010). Generating recombinant antibodies to the complete human proteome. Trends in Biotechnology 28, 333-339

• Palme O., Comanescu G., Stoineva I., Radel S., Benes E., Develter D., Wray V., Lang S. (2010). Sophorolipids from Candida bombicola: Cell separation by ultrasonic particle manipulation. Eur. J. Lipid Sci. Technol. 112, 663-673.

• Willke T., Hartwich T., Reershemius H., Jurchescu I., Lang S., Vorlop K. (2010). Ökologisch produziertes Methionin aus Mikroorganismen. In: Landbauforschung vTI Agriculture and Forestry Research, Sonderheft 341 (G. Rahmann and U. Schumacher, eds.), pp. 125-135.

• Schirrmann, T. and Büssow, K. (2010). Transient production of scFv-Fc fusion proteins in mammalian cells. In: Antibody engineering Vol 2, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 387-400

• Steinwand, M., Jordan, S. and Hust, M. (2010). Production of Antibody Fragments in the Gram-positive bacterium B. megaterium. In: Antibody engineering Vol 2, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 293-299

• Al-Halabi, L. and Meyer, T. (2010). In vivo biotinylated scFv fragments. In: Antibody engineering Vol 2, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 219-226

• Strebe, N. and Schüngel, M. (2010). Phenotypic knockdown with intrabodies. In: Antibody engineering Vol 2, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 173-180

• Mollova, S., Retter, I., Hust, M., Dübel, S. and Müller, W. (2010). Analysis of single chain antibody sequences using the VBASE2 Fab Analysis Tool. In: Antibody engineering Vol 2, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 3-10

• Schirrmann, T. (2010). Binding studies with flow cytometry. In: Antibody engineering Vol 1, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 765-780

• Rülker, T., Meier, D. and Schirrmann, T. (2010). Quantification of human IgG and related Fc fusion proteins by a human IgG/Fc capture ELISA. In: Antibody engineering Vol 1, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 743-748

• Meyer, T. (2010). Competitive ELISA. In: Antibody engineering Vol 1, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 739-742

• Voedisch, B. and Thie, H. (2010). Size exclusion chromatography. In: Antibody engineering Vol 1, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 607-612

• Liang, M. and Dübel, S. (2010). Production of Recombinant HUman IgG Antibodies in the Baculovirus Expression System. In: Antibody engineering Vol 1, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 453-470

• Thie, H. (2010). Affinity maturation by random mutagenesis and phage display. In: Antibody engineering Vol 1, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 397-410

• Breitling, F., Broders, O., Helmsing, S., Hust, M. and Dübel, S. (2010). Improving phage display throughput by using Hyperphage, miniaturized titration and pVIII (g8p) ELISA. In: Antibody engineering Vol 1, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 197-206

• Hust, M. and Mersmann, M. (2010). Phage Display and selection in microtitre plates. In: Antibody engineering Vol 1, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 139-150

• Pelat, T., Hust, M. and Thullier, P. (2010). Immune libraries from non-human primates (NHP). In: Antibody engineering, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 99-114

• Hust, M. and Dübel, S. (2010). Human antibody gene libraries. In: Antibody engineering Vol 1, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 65-84

• Strebe, N., Breitling, F., Moosmayer, D., Brocks, D., Dübel, S. (2010). Cloning of variable domains from mouse hybridoma by PCR. In: Antibody engineering Vol 1, Ed: Kontermann, R. and Dübel, S., Springer-Verlag, 3-14

• Dübel, S. (2010). Antibody Production: Human, Recombinant. In: Flickinger, M.C. (ed.) Encyclopedia of Industrial Biotechnology, Vol.1. Wiley VCH. ISBN 978-0-471- 79930-6 p.351-365

• Lim, T.S, Mollova, S., Rubelt, F., Sievert, V., Dübel, S., Lehrach, H. and Konthur, Z. (2010). V–gene amplification revisited – An optimised procedure for amplification of rearranged human antibody genes of different isotypes. New Biotechnology

• Naseem, S., Meens, J., Jores, J., Heller, M., Dübel, S., Hust, M. and Gerlach, G.F. (2010). Phage display-based identification and potential diagnostic application of novel antigens from Mycoplasma mycoides subsp. mycoides small colony type. Veterinary Microbiology 142, 285-292

• Mersmann, M., Meier, D., Mersmann, J., Helmsing, S., Nilsson, P., Gräslund S.,  Structural Genomics Consortium, Colwill, K., Hust, M. and Dübel, S. (2010). Towards "proteome scale" antibody selections using phage display. New Biotechnology 27, 118-128

• Schirrmann, T., Menzel, C., Hust, M., Prilop, J., Jostock, T. and Dübel, S. (2010). Oligomeric forms of single chain immunoglobulin (scIgG).  mAbs 2, 1-4

2009

• Pelat, T., Hust., M. and Thullier, P. (2009). Obtention and engineering of non-human primate (NHP) antibodies for therapeutics. Mini Reviews in Medicinal Chemistry 14, 1633-1638

• Moutel, S., El Marjou, A., Vielemeyer, O., Nizak, C., Benaroch, P., Dübel, S. and Perez F. (2009). A multi-Fc-species system for recombinant antibody production. BMC Biotechnology 2009, 9:14

• Thie, H., Binius, S., Schirrmann, T., Hust, M. and Dübel, S. (2009). Multimerization domains for antibody phage display and antibody production. New Biotechnology 26, 314-321

• Rybak, S.M., Arndt, M.A., Schirrmann, T., Dübel, S. and Krauss, J (2009). Ribonucleases and immunoRNases as anticancer drugs. Curr Pharm Des 15, 2665-2675
• Holtkamp A.D., Kelly S., Ulber R., Lang S. (2009). Fucoidans and fucoidanases – focus on techniques for molecular structure elucidation and modification of marine polysaccharides. Appl. Microbiol. Biotechnol. 82, 1-11.

• Gloriam, D.E., Orchard, S., Bertinetti, D., Bjorling, E., Bongcam-Rudloff, E., Bourbeillon, J., Bradbury, A.R., de Daruvar, A., Dübel, S., Frank, R., Gibson, T.J., Haslam, N., Herberg, F.W., Hiltke, T., Hoheisel, J.D., Kerrien, S., Koegl, M., Konthur, Z., Korn, B., Landegren, U., van der Maarel, S., Montecchi-Palazzi, L., Palcy, S., Rodriguez, H., Schweinsberg, S., Sievert, V., Stoevesandt, O., Taussig, M.J., Uhlen, M., Wingren, C., Gold, L., Woollard, P., Sherman, D.J., Hermjakob, H. (2009). A community standard format for the representation of protein affinity reagents. Mol Cell Proteomics

• Hust, M., Steinwand, M., Al-Halabi, L., Helmsing, S., Schirrmann, T. and Dübel, S. (2009). Improved microtitre plate production of single chain Fv fragments in Escherichia coli. New Biotechnology 25, 424-428

• Schütte, M., Thullier, P., Pelat, T., Wezler, X., Rosenstock, P., Hinz, D., Kirsch, M.I.., Hasenberg, M., Frank, R., Schirrmann, T., Gunzer, M., Hust, M. and Dübel, S. (2009). Identification of a putative Crf splice variant and generation of recombinant antibodies for the specific detection of Aspergillus fumigatus. PLoS ONE 4:e6625

• Pelat, T., Hust, M., Hale, M., Lefranc, M.-P., Dübel, S. and Thullier, P. (2009). Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity. BMC-Biotechnology 8:66

• Hust, M., Thie, H., Schirrmann, T. and Dübel, S. (2009). Antibody Phage Display. In: An, Z. and Strohl, W. (ed.) Handbook of Therapeutic Monoclonal Antibodies: From Bench to Clinic, Wiley-VCH 191-21

• Thie, H., Voedisch, B., Dübel, S., Hust, M. and Schirrmann, T. (2009). Affinity maturation by phage display. Therapeutic Antibodies, Ed: Dimitrov, A.S.,  Meth. Mol. Biol.  525, 309-322

• Schirrmann, T., Krauss, J., Arndt, M.A., Ryback, S.M. and Dübel, S. (2009). Targeted therapeutic RNases (ImmunoRNases).  Expert Opin Biol Ther . 9, 79-96

• Strebe, N., Guse, A., Schüngel, M., Schirrmann, T., Haffner, M., Jostock, T., Hust, M., Müller, W. and Dübel, S. (2009). Fuctional knockdown of VCAM-1 at the posttranslational level with ER retained antibodies. Journal of immunological Methods 341, 30-40

2008

• Thie, H., Meyer, T., Schirrmann, T., Hust, M. and Dübel, S. (2008). Phage display derived therapeutic antibodies. Current Pharmaceutical Biotechnology 9, 439-446

• Krauss, J., Arndt, M., Dübel, S. and Rybak, S.M. (2008) Antibody-targeted RNase-fusion proteins (ImmunoRNases) for Cancer Therapy. Curr. Pharm. Biot. 9,:231-234

• Kirsch, M.I., Hülseweh, B., Nacke, C., Rülker, T., Schirrmann, T., Marschall, H.-J., Hust, M. and Dübel, S. (2008). Development of human antibody fragments using antibody phage display for the detection and diagnosis of Venezuelan equine encephalitis virus (VEEV).  BMC-Biotechnology 8:66

• Kügler, J., Nieswandt, S., Gerlach, G.F., Meens, J., Schirrmann, T. and Hust, M. (2008). Identification of immunogenic polypeptides from a Mycoplasma hyopneumoniae genome library by phage display. Applied Microbiology and Biotechnology 80, 447- 458

• Thie, H., Schirrmann, T., Paschke, M., Dübel, S., Hust, M. (2008). SRP and Sec pathway leader peptides for antibody phage display and antibody fragment production in E. coli. New Biotechnology 25, 49-54   

• Schirrmann, T., Al-Halabi, L., Dübel, S., Hust, M. (2008). Production systems for recombinant antibodies. Frontiers in Bioscience 13, 4576-4594  

• Menzel, C., Schirrmann, T., Konthur, Z., Jostock, T., Dübel, S. (2008). Human antibodies RNase fusion protein targeting CD30+ lymphomas. Blood 111, 3830-3837

2007

• Michalzik, M., Balck, A., Al-Halabi, L., Hust, M., Dübel, S. and Büttgenbach, S. (2007). Massenfließsystem zur CRP-Diagnostik. Proc.  Mikrosystemtechnikkongress 2007

• Schirrmann, T., Hust, M., Dübel, S. (2007). Die Antikörperfabrik: Antikörper für jedes Protein. Biologie in unserer Zeit 37, 348-351

• Jordan, E., Al-Halabi, L., Schirrmann, T., Hust, M., Dübel, S. (2007). Production of single chain Fab (scFab) in Bacillus megaterium.  Microbial Cell Factories 6:38

• Li, J., Zhang, C., Jostock, T., Dübel, S. (2007). Analysis of IgG heavy chain to light chain ratio with mutant Encephalomyocarditis virus internal ribosome entry site. Prot. Eng. Des. Sel. 20, 491-496

• Coelho, V., Dernedde, J., Petrausch, U., Panjideh, H., Fuchs, H., Menzel, C., Dübel, S., Keilholz, U., Thiel, E., Deckert, P.M. (2007). Design, construction, and in vitro analysis of A33scFv::CDy, a recombinant fusion protein for antibody-directed enzyme prodrug therapy in colon cancer. Int. J. Oncol. 31, 951-957

• Braschoss, S., Hirsch, B., Dübel, S., Stein, H. and Dürkop H. (2007). New anti-CD30 human pancreatic ribonuclease-based immunotoxin reveals strong and specific cytotoxicity in vivo. Leuk. Lymphoma 48, 1179-1186

• Hust, M., Dübel, S. and Schirrmann, T. (2007). Selection of recombinant antibodies from antibody gene libraries. Gene Function Analysis, Ed: Ochs, M.F.,  Meth. Mol. Biol. 408, 241-254

• Pelat, T., Hust, M., Laffly. E.,  Condemine, F., Bottex, C., Vidal, D., Lefranc, M.P., Dübel, S. and Thullier, P. (2007). A high affinity, human like antibody fragment (scFv) neutralising lethal factor (LF) of Bacillus anthracis by inhibiting the PA-LF complex formation. Antimicrobial agents and chemotherapy 51, 2758-2764

• Schirrmann, T., Hust, M., Konthur, Z., Frank, R., Toleikis, L. and Dübel, S. (2007). Schlüsselreagenzien für die Proteomforschung im Hochdurchsatz. Laborwelt 2/2007, 9-12

• Hust, M., Jostock, T., Menzel, C., Voedisch, B., Mohr, A., Brenneis, M., Kirsch, M.I., Meier, D., Dübel, S. (2007). Single chain (scFab) fragment. BMC-Biotechnology 7:14

• Dübel, S. (2007) Recombinant therapeutic antibodies. App. Microbiol. Biotechnol. 74, 723-729

• Li, J., Menzel, C., Meier, D., Zhang, C., Dübel, S. and Jostock, T (2007). A comparative study of different vector designs for the mammalianexpression. J Immunol Methods 318, 113-124

• Jordan, E., Hust, M., Roth, A., Biedendieck, R., Schirrmann, T., Jahn, D., Dübel, S. (2007). Production of recombinant antibody fragments in Bacillus megaterium. Microbial Cell Factories 6:2

• Taussig, M.J., Stoevesandt, O., Borrebaeck, C., Bradbury, A., Dübel, S., Frank, R., Gibson, T., Gold, L., Herberg, F., Hermjakob, H., Hoheisel, J., Joos, T., Konthur, Z., Landegren, U., Plückthun, A., Ueffing, M. and Uhlen, M. (2007) ProteomeBinders: Planning a European Resource of Affinity Reagents for Analysis of the Human Proteome. Nature Methods 4, 13-17

• Hust, M., Toleikis, L. and Dübel, S. (2007). Antibody phage display. Handbook of therapeutic antibodies, Ed. Dübel, S., Willey-VCH, 45-68

• Soltes, G., Hust, M., Ng, K.K.Y., Bansal, A., Field, J., Stewart, D.I.H., Dübel, S., Cha, S. and Wiersma, E. (2007). On the influence of vector design on antibody phage display. Journal Biotechnology 127, 626-237

2006

• Schmiedl, A., Zimmermann, J., Scherberich, J.E., Fischer, P. and Dübel, S. (2006). Recombinant variants of antibody 138H11 against human gamma-glutamyltransferase for targeting renal cell carcinoma. Human antibodies 15, 81-94

• Michalzik, M., Balck, A., Büttgenbach, S., Al-Halabi, L., Hust, M. and Dübel, S. (2006). Microsensor System for Biochemical and Medical Analysis. Proc. XX Eurosensors, 420-421

• Hust, M., Meysing, M, Schirrmann, T., Selke, M., Meens, J., Gerlach, G.-F. and Dübel, S. (2006). Enrichment of open reading frames presented on bacteriophage M13 using Hyperphage. Biotechniques 41, 335-342

• Dübel, S. (2006) Recombinant Antibodies and Phage Display. In: Wink, M. (ed.) An Introduction to Molecular Biotechnology. Wiley VCH Weinheim, Germany. ISBN 3-527-31412-1, pp. 479-509

• Oumard, A., Qiao, J., Jostock, T., Li, J. and Bode, J. (2006). Recommended method for chromosom exploitation: RMCE-based cassette exchange in animal cell biotechology. Cytotechnology 

• Bitzer J., Große T., Wang L., Lang S., Beil W., Zeeck A. (2006). New amino-phenoxazinones from marine Halomonas sp.: fermentation, structure elucidation, and biological activity. J. Antibiotics, 59, 86-92.

• Langer O., Palme O., Wray V., Tokuda H., Lang S. (2006). Production and modification of bioactive biosufactants. Process Biochem., 41, 2138-2145.

• Niescher S., Wray V., Lang S., Kaschabek S.R., Schlömann M. (2006). Identification and structural characterisation of novel trehalose dinocardiomycolates from n-alkane-grown Rhodococcus opacus 1CP. Appl. Microbiol. Biotechnol., 70, 605-611.

• Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T., Brecht M., Buhrmester J.,  Chernikova T.N., Denaro R., Ferrer M., Gertler C., Goesmann A., Golyshina O.V.,  Kaminski F., Khachane A.N., Lang S., Linke B., McHardy A.C., Meyer F., Nechitaylo T.,  Pühler A., Regenhardt T., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M., Timmis K.N., Vorhölter F.-J., Weidner S., Kaiser O., Golyshin P.N. (2006). Genome sequence of the ubiquitous hydrocarbon degrading marine bacterium Alcanivorax borkumensis. Nature Biotechnol., 24, 997-1004.

• Wang L., Große T., Stevens H., Brinkhoff T., Simon M., Liang L., Bitzer J., Bach G., Zeeck A., Tokuda H., Lang S. (2006). Bioactive hydroxyphenylpyrrole-dicarboxylic acids from a new marine Halomonas sp.: production and structure elucidation. Appl. Microbiol. Biotechnol., 72, 816-822.

• Lange S. A., Roth G., Wittemann S., Lacoste T., Vetter A., Grässle J., Kopta S., Kolleck M., Breitinger B., Wick M., Dübel S. and Bernard A. (2006) Measuring Biomolecular Binding Events with a Compact Disc Player Device. Angew. Chem. 118, 276-279 / Angew. Chem. Intl. Ed. 45, 270-273

2005

• Konthur, Z., Hust, M. and Dübel, S. (2005). Perspectives for systematic in vitro antibody generation. Gene 364, 19-29

• Hust, M., Toleikis, L. and Dübel, S. (2005). Antibody Phage Display. Mod. Asp. Immunobiol. 15, 47-49

• Lang S., Hüners M., Lurtz V. (2005). Bioprocess engineering data on the cultivation of marine procaryotes and fungi. Adv. Biochem. Eng. Biotechnol. 97, 29-62.

• Rau U., Nguyen L. A., Schulz S., Wray V., Nimtz M., Roeper H.,  Koch H., Lang S. (2005) Formation and analysis of mannosylerythritol lipids secreted by Pseudozyma aphidis. Appl. Microbiol. Biotechnol., 66, 551-559

• Rau U., Nguyen L. A., Roeper H.,  Koch H., Lang S. (2005) Fed-batch bioreactor production of mannosylerythritol lipids secreted by Pseudozyma aphidis. Appl. Microbiol. Biotechnol., 68, 607-613

• Rau, U., Nguyen, L. A., Roeper, H., Koch, H., Lang, S. (2005)  Downstream processing of mannosylerythritol lipids produced by Pseudozyma aphidis. Eur J Lipid Sci Technol, 107, 373-380.

• Kirsch, M., Zaman, M., Meier, D., Dübel, S. and Hust, M. (2005). Parameters affecting the display of antibodies on phage. Journal of Immunological Methods 301, 173-185

• Jostock, T. and Dübel, S. (2005) Screening of Molecular Repertoires by Microbial Surface Display. Comb. Chem. High Throughput Screen 8,127-133

• Hust, M. and Dübel, S. (2005). Phage display vectors for the in vitro generation of human antibody fragments in: Immunochemical Protocols, 3rd ed., Ed: Burns, R., Meth. Mol. Biol. 295, 71-95

2004

• Sui, J., He, Y., Jiang, X., Dübel, S., Han, Z., and Song, Z. (2004) A single chain antibody obtained by cell panning of antibody phage inhibits homoaggregation of human leukemia cells. Hum. Antibodies. 13,111-118

• Asolkar R.N., Schröder D., Heckmann R., Lang S., Wagner-Döbler I., Laatsch H. (2004). Helquinoline, a new tetrahydroquinoline antibiotic from Janibacter limosus Hel1. J. Antibiot., 57, 17-23.

• Cohen R., Exerowa D., Pigov I., Heckmann R., Lang S. (2004). DLVO and non-DLVO forces in thin liquid films from rhamnolipids. J. Adhesion, 80, 875-894.

• Lang S., Beil W., Tokuda H., Wicke C., Lurtz V. (2004). Improved production of bioactive glucosylmannosyl-glycerolipid by a sponge-associated Microbacterium spec. Mar. Biotechnol., 6, 152-156.

• Ramm W., Schatton W., Wagner-Döbler I., Wray V., Nimtz M., Tokuda H., Enjyo F., Nishino H., Beil W., Heckmann R., Lurtz V., Lang S. (2004). Diglucosyl-glycerolipids from the marine sponge-associated Bacillus pumilus strain AAS3: their production, enzymatic modification and properties. Appl. Microbiol. Biotechnol., 64, 497-504

• Rau U. (2004) Glucans secreted by fungi. Turkish Electronic Journal of Biotechnology. 2, 30-36.

• Rau U. (2004) Schizophyllan. In: Biotechnology of Biopolymers, From Synthesis to Patents (Vol. 1), Steinbüchel A., Doi Y. (eds), pp 703-735, Wiley-VCH, Weinheim.

• Rau, U., Lang, S., Nguyen, L., Röper, H. (2004) Process for producing and recovering mannosylerythritol lipids from culture medium containing the same. WO 2004020647

• Vollhardt D., Weidemann G., Lang S. (2004). Structure features and phase behavior of 1-(12-hydroxy)stearoyl-rac-glycerol monolayers. J. Phys. Chem. B, 108, 3781-3788.

• Wagner-Döbler I., Rheims H., Felske A., El-Ghezal A., Flade-Schröder D., Laatsch H.,  Lang S., Pukall R., Tindall B.J. (2004). Oceanibulbus indoliflex gen. nov., a North Sea alphaproteobacterium that produces bioactive metabolites. Int. J. Syst. Evolut. Microbiol., 54, 1177-1184.

• Dübel, S., Rohrbach, P. and Schmiedl, A. (2004) Rekombinante Antikörper. Biologie in unserer Zeit 34(6/2004), 372-379.

• Dübel, S. (2004) Antikörper für die Proteomforschung. BIOForum 10/2004

• Schmiedl, A. and Dübel, S. (2004) Rekombinante Antikörper & Phagen-Display. In: Molekulare Biotechnologie, Ed.: Wink, M. Wiley-VCH, p. 511-542

• Frank, R. and Dübel, S. (2004) Analysis of protein interactions with immobilized peptide arrays synthesized on membrane supports. In: Protein Interactions: A Laboratory Manual, 2nd ed., E. Golemis and I. Serebriiskii, eds. (Cold Spring Harbor Laboratory Press, New York)

• Hust, M. and Dübel, S. (2004) Mating antibody phage display to proteomics. Trends in Biotechnol. 22(1), 8-14

2003

• Szardenings M. (2003): Phage display of random peptide libraries: applications, limits, and potential. J. Recept. Signal. Transduct. Res. 23, 307-349.

• Li, Z., Koch, H. and Dübel, S. (2003) Mutations in the N-Terminus of the Major Coat Protein (pVIII, gp8) of Filamentous Bacteriophage Affect Infectivity. J. Mol. Microbiol. Biotechnol.6:57–66

• Usener D, Schadendorf D, Koch J, Dübel S, Eichmüller S (2003): cTAGE: a cutaneous T-cell lymphoma associated antigen family with tumor-specific splicing. J Invest. Dermatol. 121:198-206, 2003

• Rohrbach, P., Broders, O., Toleikis, L., and Dübel, S. (2003). Therapeutic antibodies and antibody fusion proteins. Biotechnology/Genetic Engineering Reviews 20, 129 - 155

• Toleikis, L., Broders, O., and Dübel, S. (2003). Cloning single chain antibody fragments (scFv) from hybridoma clones. In Molecular Diagnosis of Infectious Diseases, 2nd ed in the Series "Methods in Molecular Medicine", D. J and U. Reischl, eds. (Humana Press Inc//Totowa, NY)

• Broders, O., Breitling, F., and Dübel, S. (2003). Hyperphage - Improving Antibody Presentation in Phage Display. Methods Mol Biol 205, 295-302.

• Maier, T., Rau, U., Dieringer, A., (2003) Process for the production of scleroglucan. WO/2003/016545

before 2003

• Rohrbach, P., and Dübel, S. (2002). Antibodies Phage Display Libraries and Therapeutic Gene Targeting. In Vector Targeting for Therapeutic Gene Delivery, D. Curiel and J. Douglas, eds. (John Wiley and Sons, New York), pp. 581-596.

•  Lang S. (2002). Biological amphiphiles (microbial biosurfactants). Current Opinion Colloid Interface Sci., 7, 12-20.

• Lang S. (2002). Surfactants produced by microorganisms. In: Novel Surfactants, 2nd ed. (ed. K. Holmberg), Marcel Dekker, INC., New York, Basel, pp. 279-315.

• Lang S., Trowitzsch-Kienast W. (2002). Biotenside. B.G. Teubner Verlag, Stuttgart, Leipzig, Wiesbaden. ISBN 3-519-03615-0.

• Philp J.C., Kuyukina M.S., Ivshina I.B., Dunbar S.A., Christofi N., Lang S., Wray V. (2002). Alkanotrophic Rhodococcus ruber as a biosurfactant producer. Appl. Microbiol. Biotechnol., 59, 318-324.

• Wagner-Döbler I., Beil W., Lang S., Meiners M., Laatsch H. (2002). Integrated approach to explore the potential of marine microorganisms for the production of bioactive metabolites. Adv. Biochem. Eng. Biotechnol., 74, 208-238.

• Groves MR, Mant A, Kuhn A, Koch J, Dübel S, Robinson C, Sinning IJ (2001) Functional Characterization of Recombinant Chloroplast Signal Recognition Particle. Biol Chem 276:27778-27786

• Rau U., Hammen S., Heckmann R., Wray V., Lang S. (2001) Sophorolipids: A source for novel compounds. Industrial Crops and Products 13, 85-92 .

• Rondot, S., Koch, J., Breitling, F. & Dübel, S. (2001) A helperphage to improve single chain antibody presentation in phage display. Nature Biotechnol., 19; 75-78

• Biermann U., Friedt W., Lang S., Lühs W., Machmüller G., Metzger J.O., Rüsch gen. Klaas M., Schäfer H.-J., Schneider M. (2000). New syntheses with oils and fats as renewable raw materials for the chemical industry. Angew. Chem. Int. Ed., 39, 2206-2224.

• Lang S., Brakemeier A., Heckmann R., Spöckner S., Rau U. (2000). Production of native and modified sophorose lipids. Chimica Oggi/Chemistry Today, October 2000, 76-79.

• Lang S., Syldatk C., Rau U. (2000). Enzymatic synthesis and modification of glycolipids. In: Enzymes in Lipid Modification (ed. U.T. Bornscheuer), Wiley-VCH, Weinheim, New York, Chichester, Brisbane, Singapore, Toronto, pp. 364-393.

• Schilling B.M., Henning A., Rau U. (2000) Repression of oxalic acid biosynthesis in the unsterile scleroglucan production process with Sclerotium rolfsii ATCC 15205. Bioprocess Eng. 22, 51-55 .

• Wicke C., Hüners M., Wray V., Nimtz M., Bilitewski U., Lang S. (2000). Production and structure elucidation of glycoglycerolipids from a marine sponge-associated Microbacterium spec. nov. J. Nat. Prod., 63, 621-626.

• Lang S. (1999). Production of microbial glycolipids. In: Carbohydrate Biotechnology, Protocols (ed. C. Bucke), in: Methods in Biotechnology (ed. J.M. Walker), Humana Press, Totowa, New Jersey, pp. 103-118.

• Lang S., Brakemeier A., Wullbrandt D., Seiffert-Störiko A. (1999) Neuartige Sophoroselipide, Verfahren zu deren Herstellung und Verwendung. Offenlegungsschrift DE 19749413 A1.

• Lang S., Fischer L. (1999). Microbial and enzymatic production of biosurfactants. In: Design and selection of performance surfactants (ed. D. Karsa), in: Annual Surfactants Review, Vol. 2, Sheffield Academic Press, Sheffield, pp. 51-103.

• Lang S., Rau U. (1999). Biokonversion nachwachsender Rohstoffe mit Mikroorganismen. BIOForum 7-8/99, 430-432.

• Lang S., Wullbrandt D. (1999). Rhamnose lipids - Biosynthesis, microbial production and application potential [Minireview]. Appl. Microbiol. Biotechnol. 51, 22-32.

• Rau U., Heckmann R., Wray V., Lang S. (1999). Enzymatic conversion of a sophorose lipid into a glucose lipid. Biotechnol. Letters, 21, 973-977.

• Spöckner S., Wray V., Nimtz M., Lang S. (1999). Glycolipids of the smut fungus Ustilago maydis from cultivation on renewable resources. Appl. Microbiol. Biotechnol. 51, 33-39.

• Brakemeier A., Wullbrandt D., Lang S. (1998). Microbial alkyl-sophorosides based on 1-dodecanol or 2-,3- and 4-dodecanones. Biotechnol. Letters 20, 215-218.

• Brakemeier A., Wullbrandt D., Lang S. (1998). Candida bombicola: production of novel alkyl-glycosides based on glucose / 2-dodecanol. Appl. Microbiol. Biotechnol. 50, 161-166.

• Lang S., Philp J. (1998). Surface-active lipids in rhodococci. Antonie van Leeuwenhoek 74, 59-70.

• Vollbrecht E., Heckmann R., Wray V., Nimtz M., Lang S. (1998). Production and structure elucidation of di- and oligosaccharide lipids (biosurfactants) from Tsukamurella spec. nov. Appl. Microbiol. Biotechnol. 50, 530-537.

• Yakimov M.M., Golyshin P.N., Lang S., Moore E.R.B., Abraham W.-R., Lünsdorf H., Timmis K.N. (1998). Alcanivorax borkumensis gen. nov., sp. nov., a new hydrocarbon-degrading and surfactant-producing marine bacterium. Int. J. Syst. Bacteriol. 48, 339-348.

• Fiehler K., Albrecht A., Rasch D., Rau U. (1997). Kontinuierliche Produktion von Sophoroselipiden mit Candida bombicola. Fett/Lipid 99, 19-24.

• Fischer L., Lang S., Rau U., Wagner T. (1997) Biotechnologische Herstellung von Produkten für den Pharma-, Lebensmittel- und Kosmetikbereich. Mitteilungen der TU Braunschweig, 32, 18-24.

• Rau U. (1997). Biosynthese, Produktion und Eigenschaften von extrazellulären Pilz-Glucanen. ISBN 3-8265-2929-4, Shaker Verlag, Aachen.

• Rau U., Spöckner S., Fiehler K., Lang S. (1997). Mikrobielle Tenside aus Pflanzenölen. In: 5. Symposium Nachwachsende Rohstoffe-Perspektiven für die Chemie, Bundesministerium für Ernährung, Landwirtschaft und Forsten ed., ISBN 3-88579-314-8, Köllen Druck und Verlag GmbH, Bonn, S. 218-222.

• Albrecht A., Rau U., Wagner F. (1996) Initial steps of sophoroselipid biosynthesis by Candida bombicola ATCC 22214 grown on glucose. Appl. Microbiol. Biotechnol. 46, 67-73 .

• Lang S., Brakemeier A., Schlotterbeck A., Wagner F. (1996). Biotechnological synthesis of surface-active glycolipids. Euro Cosmetics  4 (4/96), 41-45.

• Lokotsch W., Lang S., Möbius D., Wagner F. (1996). Biocatalytical synthesis and monolayer studies of multiple hydroxylated wax esters. J. Amer. Oil Chem. Soc. 73, 1459-1464.

• Rau U., Manzke C., Wagner F. (1996). Influence of substrate supply on the production of sophorose lipids by Candida bombicola ATCC 22214. Biotechnol. Letters 18, 149-154.

• Wullbrandt D., Giani C., Brakemeier A., Lang S., Wagner F. (1996) Neuartige Glucose- und Sophoroselipide, ein Verfahren zu deren Herstellung und deren Verwendung. Offenlegungsschrift DE 19518982 A1.

• Brakemeier A., Lang S., Wullbrandt D., Merschel L., Benninghoven A., Buschmann N.,  Wagner F. (1995). Novel sophorose lipids from microbial conversion of 2-alkanols. Biotechnol. Letters 17, 1183-1188.

• Katsivela E., Kleppe F., Lang S., Wagner F. (1995). Ustilago maydis lipase I. Hydrolysis and ester-synthesis activities of crude enzyme preparation. Enzyme Microbial Technol. 17. 739-745.

• Lang S., Wagner F. (1995). Mikrobielle und enzymatische Synthese von Biotensiden auf der Basis nachwachsender Rohstoffe. Fat Sci. Technol. 97, 69-77.

• Lang S., Ziemann-Nöthe A., Steffen B., Lokotsch W., Multzsch R., Wagner F. (1995). Ungewöhnliche Wachsester - Enzymatische Synthesen und Eigenschaften. Fat Sci. Technol. 97, 105-112.

• Markweg-Hanke M., Lang S., Wagner F. (1995). Dodecanoic acid inhibition of a lipase from Acinetobacter sp. OPA 55. Enzyme Microbial Technol. 17, 512-516.

• Papendorf O., Steffen B., Lang S., Wagner F. (1995). Monoacylglycerols: (Bio)Chemical production and interfacial properties. Chimica Oggi/Chemistry Today 13 (10), 17-20.

• Scheckermann C., Schlotterbeck A., Schmidt M., Wray V., Lang S. (1995). Enzymatic monoacylation of fructose by two procedures. Enzyme Microbial Technol. 17, 157-162.

• Steffen B., Lang S., Hamann D., Schneider P., Cammenga H.K., Wagner F. (1995). Enzymatic formation and physico-chemical behaviour of uncommon monoglycerides. Fat. Sci. Technol. 97, 132-136.

• Albrecht A., Rau U. (1994). Acetylation of a ß-1,6-branched ß-1,3-glucan yielding Schizophyllan acetate. Carbohydr. Polym. 24, 193-197.

• Ishigami Y., Gama Y., Sano Y., Lang S., Wagner F. (1994). Interfacial and micellar behavior of glucose lipid. Biotechnol. Letters, 16 (6), 593-598.

• Multzsch R., Lokotsch W., Steffen B., Lang S., Metzger J.O., Schäfer H.-J., Warwel S., Wagner F. (1994). Enzymatic production and physicochemical characterization of uncommon wax esters and monoglycerides. J. Am. Oil Chem. Soc. 71 (7), 721-725.

• Rau U., Brandt C. (1994). Oxygen controlled batch cultivation of Schizophyllum commune for enhanced production of branched ß-1,3-glucans. Bioprocess Eng. 11, 161-165 .

• Gura E. and Rau U. (1993). Comparison of agitators for the production of branched ß-1,3-D-glucans by Schizophyllum commune. J. Biotechnol. 27, 193-201.

• Haarstrick A. und Rau U. (1993). Strömungscharakteristik pseudoplastischer Polysaccharidlösungen von Schizophyllum commune ATCC 38548. Chem.Ing.Tech. 65, 556-559.

• Lang S., Wagner F. (1993). Bioconversion of oils and sugars to glycolipids. In: Biosurfactants (N. Kosaric, ed.), in: Surfactant Science Series, Vol. 48, Marcel Dekker Inc., New York, Basel, pp. 205-230.

• Lang S., Wagner F. (1993). Biological activities of biosurfactants. In: Biosurfactants (N.Kosaric, ed.) .), in: Surfactant Science Series, Vol. 48, Marcel Dekker Inc., New York, Basel, pp. 251-268.

• Lang S., Wagner F. (1993). Biosurfactants from marine microorganisms. In: Biosurfactants (N.Kosaric, ed.), in: Surfactant Science Series, Vol. 48, Marcel Dekker Inc., New York, Basel, pp.391-418.

• Schlotterbeck A., Lang S., Wray V., Wagner F. (1993). Lipase-catalyzed monoacylation of fructose. Biotechnol. Letters 15, 61-64.

• Dünhaupt A., Lang S., Wagner F. (1992). Pseudomonas cepacia lipase: Studies on aggregation, purification and the cleavage of olive oil. Biotechnol. Letters 14, 953-958.

• Passeri A., Schmidt M., Haffner T., Wray V., Lang S., Wagner F. (1992). Marine biosurfactants, IV. Production, characterization and biosynthesis of an anionic glucoselipid from the marine bacterial strain MM1. Appl. Microbiol. Biotechnol. 37, 281-286.

• Steffen B., Ziemann A., Lang S., Wagner F. (1992). Enzymatic monoacylation of trihydroxy compounds. Biotechnol. Letters 14, 773-778.

• Wagner F., Kleppe F., Lokotsch W., Ziemann A., Lang S. (1992). Synthesis of uncommon wax esters with immobilized lipases. Ann. N.Y. Acad. Sci. 672, 484-491.

• Haarstrick A., Rau U., Wagner F. (1991). Cross-flow filtration as a method of separating fungal cells and purifying the polysaccharide produced. Bioprocess Eng. 6, 79-186.

• Lang S., Multzsch R., Passeri A., Schmeichel A., Steffen B., Wagner F., Hammann D., Cammenga H.K. (1991). Unusual wax esters and glycolipids: Biocatalytical formation and physico-chemical characterization. Acta Biotechnol. 11, 379-386.

• Passeri A., Schmidt M., Lang S., Wagner F., Wray V., Gunkel W. (1991). Formation of glycolipids by n-alkanes utilizing marine bacteria. Kieler Meeresforsch.,Sonderheft 8, 331-334.

• Passeri A., Lang S., Wagner F., Wray V. (1991). Marine biosurfactants, II. Production and characterization of an anionic trehalose tetraester from the marine bacterium Arthrobacter sp. EK 1. Z. Naturforsch. 46c, 204-209.

• Poremba K., Gunkel W., Lang S., Wagner F. (1991). Marine biosurfactants, III. Toxicity testing with marine microorganisms and comparison with synthetic surfactants. Z. Naturforsch. 46c, 210-216.

• Poremba K., Gunkel W., Lang S., Wagner F. (1991). Toxicity testing of synthetic and biogenic surfactants on marine microorganisms. Environ. Toxicol. Chem. 6, 157-163.

• Schulz D., Passeri A., Schmidt M., Lang S., Wagner F., Wray V., Poremba K., Gunkel W. (1991). Screening for biosurfactants among crude oil degrading marine microorganisms. Kieler Meeresforsch.,Sonderheft 8, 322-326.

• Schulz D., Passeri A., Schmidt M., Lang S., Wagner F., Wray V., Gunkel W. (1991). Marine biosurfactants, I. Screening for biosurfactants among crude oil degrading marine microorganisms from the North Sea. Z. Naturforsch. 46c, 197-203.

• Kim J.-S., Powalla M., Lang S., Wagner F., Lünsdorf H., Wray V. (1990). Microbial glycolipid production under nitrogen limitation and resting cell conditions. J. Biotechnol. 13, 257-266.

• Rau U., Müller R.-J., Cordes K., Klein J. (1990). Process and molecular data of branched 1,3-ß-D-glucans in comparison with Xanthan. Bioprocess Eng. 5, 89-93.

• Lang S., Katsiwela E., Wagner F. (1989). Antimicrobial effects of biosurfactants. Fat Sci. Technol. 91, 363-363.

• Poremba K., Gunkel W., Lang S., Wagner F. (1989). Mikrobieller Ölabbau im Meer. Biologie in unserer Zeit 5, 145-148.

• Powalla M., Lang  S., Wray V. (1989). Penta- and disaccharide lipid formation by Nocardia corynebacteroides grown on n-alkanes. Appl. Microbiol. Biotechnol. 31, 473-479.

• Asmer H.-J., Lang S., Wagner F., Wray V. (1988). Microbial production, structure and elucidation and bioconversion of sophorose lipids. J. Am. Oil Chem. Soc. 65, 1460-1466.

• Göbbert U., Schmeichel A., Lang S., Wagner F. (1988). Microbial transesterification of sugar-corynomycolates. J. Am. Oil Chem. Soc. 65, 1519-1525.

• Lang S., Wagner F. (1987). Structure and properties of biosurfactants. In: Biosurfactants and Bioengineering (N.Kosaric, L.W.Cairns, N.C.C.Gray, eds.), in: Surfactant Science Series, Vol. 25, Marcel Dekker Incorp., New York, pp. 21-45.

• Rau U., Wagner F. (1987). Non-newtonian flow behaviour of colloid-dispers glucan solutions. Biotechnol. Letters, 9, 95-100.

• Wagner F., Ristau E., Li Z.-Y., Lang S., Schulz W., Hofmann H.-J., Sewe K.-U.,Lindörfer W. (1987) Gemische aus Trehaloselipid-2,2’,3,4-tetraestern und Verfahren zu deren Herstellung. Patentschrift DE 3248167 C2.

• Wagner F., Ristau E., Lang S., Hofmann H.-J., Sewe K.-U., Lindörfer W. (1987) Verfahren zur Herstellung von Trehaloseestern. Patentschrift DE 3405371 C2.

• Frautz B., Lang S., Wagner F. (1986). Formation of cellobiose lipids by growing and resting cells of Ustilago maydis. Biotechnol. Letters 8 (11), 757-762.

• Syldatk C., Lang S., Matulovic U., Wagner F. (1985). Production of four interfacial-active rhamnolipids from n-alkanes or glycerol by resting cells of Pseudomonas spec. DSM 2874. Z. Naturforsch. 40c, 61-67.

• Göbbert U., Lang S., Wagner F. (1984). Sophorose lipid formation by resting cells of Torulopsis bombicola. Biotechnology Letters 6 (4), 225-230.

• Li Z.-Y., Lang S., Wagner F., Witte L., Wray V. (1984). Formation and identification of interfacial-active glycolipids from resting microbial cells. Appl. Environ. Microbiol. 48 (3), 610-617.

• Bang W.G., Lang S., Sahm H., Wagner F. (1983). Production of L-tryptophan by Escherichia coli cells. Biotechnol. Bioeng. XXV, 999-1011.

• Bang W.G., Behrendt U., Lang S., Wagner F. (1983). Continuous production of L-tryptophan from indole and L-serine by immobilized Escherichia coli cells. Biotechnol. Bioeng. XXV, 1013-1025.

• Lang S., Beyer H., Sistig P., Wagner F., Trowitzsch W., Wray V. (1983). A new red dipyrromethene pigment from Candida boidinii. Z. Naturforsch. 38 c, 7-12.

• Wagner F., Klein J., Bang W.-G., Lang S., Sahm H. (1983) Verfahren zur mikrobiellen Herstellung von L-Tryptophan. Patentschrift DE 2841642 C2.

• Lang S., Wagner F. (1979). Immobilized whole cells: microbial characterization. In: Dechema Monographien 84, 315-335.

• Kreiser W., Lang S. (1976). Zur mikrobiologischen Hydroxylierung eines Pseudo-steroidbutenolids. Chem. Ber. 109, 3318-3322.

• Wagner F., Lang S., Kreiser W. (1976). Zur mikrobiologischen Hydroxylierung von 14a-H-Cardenoliden. Chem. Ber. 109, 3304-3317.

• Lang S., Lincoln D.N., Wray V. (1975). Fourier transform 13C nuclear magnetic resonance studies of steroids. Part I. Some substituted 17ß-(2,5-Dihydro-5-oxo-3-furyl) steroids. J. Chem. Soc. Perkin II  1975, 344-350.

• Wray V., Lang S. (1975). Fourier transform 13C nuclear magnetic resonance studies of steroids. II. Derivatives of 17ß-(2,5-Dihydro-5-oxo-3-furyl)-3ß,5a,6-tri-hydroxy-androstane. Tetrahedron 31, 2815-2819

for publications of S. Dübel before 2003 see ORCID