Dr. Wei He

Interactions between cellular metabolism and macrophage function, and how these interactions are associated with physiologic and pathophysiologic conditions.

05.2019 - now
postdoc fellow in Department of Bioinformatics & Biochemistry, BRICS, TU Braunschweig.

10.2017 - 03.2019
postdoctoral fellow in Centre for Biomolecular Interactions, University of Bremen.

2012-2017
PhD student in Centre for Biomolecular Interactions, University of Bremen.

2010-2011
research assistant in Wuhan Institute of Virology at Chinese Academy of Sciences, Wuhan, China.

2006-2010
master program in biochemistry and molecular biology in Graduate University of Chinese Academy of Sciences; master thesis in Wuhan Institute of Virology at Chinese Academy of Sciences, Wuhan, China.

• Henne A, Vigh A, Märtens A, Nonnenmacher Y, Ohm M, Hosseini S, More TH, Lauterbach MA, Garritsen H, Korte M, He W, Hiller K. SiMeEx, a simplified method for metabolite extraction of adherent mammalian cells. Front Mol Biosci. 2022 Dec 21;9:1084060.

• Francois L, Boskovic P, Knerr J, He W, Sigismondo G, Schwan C, More TH, Schlotter M, Krijgsveld J, Hiller K, Grosse R, Lichter P, Radlwimmer B. BCAT1 redox function maintains mitotic fidelity. Cell Rep. 2022 Oct 18;41(3):111524.

• Heinz A, Nonnenmacher Y, Henne A, Khalil MA, Bejkollari K, Dostert C, Hosseini S, Goldmann O, He W, Palorini R, Verschueren C, Korte M, Chiaradonna F, Medina E, Brenner D, Hiller K. Itaconate controls its own synthesis via feedback-inhibition of reverse TCA cycle activity at IDH2.   Biochim Biophys Acta Mol Basis Dis. 2022 Aug 26:166530.
• He W, Henne A,  Lauterbach M, Geißmar E, Nikolka F, Kho C, Heinz A, Dostert C, Grusdat  M, Cordes T, Härm J, Goldmann O, Ewen A, Verschueren C, Blay-Cadanet J,  Geffers R, Garritsen H, Kneiling M, Holm CK, Metallo CM, Medina E,  Abdullah Z, Latz E, Brenner D, Hiller K. Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages. Nat Metab. 2022 May;4(5):524-533.
• Lupse B, Annamalai K, Ibrahim H, Kaur S, Geravandi S, Sarma B, Pal A, Awal S, Joshi A, Rafizadeh S, Madduri MK, Khazaei M, Liu H, Yuan T, He W, Gorrepati KDD, Azizi Z, Qi Q, Ye K, Oberholzer J, Maedler K, Ardestani A. Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes. Cell Rep. 2021 Aug 3;36(5):109490.
• He W, Rebello OD, Henne A, Nikolka F, Klein T, Maedler K. GLP-2 Is Locally Produced From Human Islets and Balances Inflammation Through an Inter-Islet-Immune Cell Crosstalk. Front Endocrinol. 2021 Jul 5;12:697120.
• He W, Heinz A, Jahn D, Hiller K. Complexity of macrophage metabolism in infection. Curr Opin Biotechnol. 2021 Apr;68:231-239.
• Mirastschijski U, Schwab I, Coger V, Zier U, Rianna C, He W, Maedler K, Kelm S, Radtke A, Belge G, Lindner P, Stahl F, Scharpenberg M, Lasota L, Timm J.  Topical lung surfactant accelerates skin wound healing in vitro and in vivo: a translational study from bench to clinical phase I study. Sci Rep. 2020 Feb 13;10(1):2581.
• He W, Annamalai K, Yuan T, Maedler K. Macrophage-associated pro-inflammatory state in human islets from obese individuals. Nutrition & Diabetes. 2019 Dec 2;9(1):36. (selected as Readers' Choice: The Best of Nutrition and Diabetes 2019)
• He W, Rebello O, Savino R, Terracciano R, Schuster-Klein C, Guardiola B, Maedler K. TLR4 triggered complex inflammation in human pancreatic islets. Biochim Biophys Acta. (BBA) - Molecular Basis of Disease. 2019 Jan;1865(1):86-97.
• Gorrepati KDD, He W, Lupse B, Yuan T, Maedler K, Ardestani A. An SCFFBXO28 E3 Ligase Protects Pancreatic β-Cells from Apoptosis. Int J Mol Sci. 2018 Mar 24;19(4).
• He W, Yuan T, Choezom D, Hunkler H, Annamalai K, Lupse B, Maedler K. Ageing potentiates diet-induced glucose intolerance, β-cell failure and tissue inflammation through TLR4. Sci Rep. 2018 Feb 9;8(1):2767.
• Nackiewicz D, Dan M, He W, Kim R, Salmi A, Rütti S, Westwell-Roper C, Cunningham A, Speck M, Schuster-Klein C, Guardiola B, Maedler K, Ehses JA. TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6. Diabetologia. 2014 Aug;57(8):1645-54.
• He W, Li LX, Liao QJ, Liu CL, Chen XL. Epigallocatechin gallate inhibits hepatitis B virus DNA synthesis in a viral replication-inducible cell. World J Gastroenterol. 2011 Mar 21;17(11):1507-14.