Doctoral candidate
Pharmacist
Contact
Institut für Pharmazeutische Technologie und Biopharmazie
Technische Universität Braunschweig
Mendelssohnstraße 1
38106 Braunschweig
E-Mail: l.klintz(at)tu-braunschweig.de
Room: 137
Telephone: +49 531 391-5640
PVZ / Dep. 4
Room: 360
Telephone: +49 531 391-65656
Field of work
Development and characterization of an in-vitro model of the nasal mucosa
In preclinical studies on active ingredients and formulations for nasal application, animal experiments are carried out that can be reduced using In-vitro models of the nasal mucosa in accordance with the 3R principle (Replace, Reduce, Refine). Our research focuses on the development of a new in -vitromodel that mimics the physiological properties, in particular permeability and mucociliary clearance, of the human nasal mucosa. A particular focus is on the detailed characterization of this model with regard to mucus quality and quantity as well as cilia expression.
References
[1] Bendas, S.; Koch, E.V.; Nehlsen, K.; May, T.; Dietzel, A.; Reichl, S. The Path from Nasal Tissue to Nasal Mucosa on Chip: Part 1—Establishing a Nasal In Vitro Model for Drug Delivery Testing Based on a Novel Cell Line. Pharmaceutics 2023, 15, 2245. https://doi.org/10.3390/pharmaceutics15092245