Rebecca Sack, M. Sc.

My research area

DFG Project: „Sensitive mix-and-measure magnetic immunoassay for SARS-CoV-2 virus detection: towards benchtop point-of-need diagnostics“

■ Development of magnetic immunoassays for the detection of nucleic acids.
■ Optimization and standardization of processes

Rebecca Sack

516

+49 531 391 3858

rebecca.sack(at)tu-braunschweig.de

2024

Amplification- and Enzyme-Free Magnetic Diagnostics Circuit for Whole-Genome Detection of SARS-CoV-2 RNA
Enja Laureen Rösch, Rebecca Sack, Mohammad Suman Chowdhury, Florian Wolgast, Margarete Zaborski, Frank Ludwig, Meinhard Schilling, Thilo Viereck, Ulfert Rand, Aidin Lak
Chembiochem. 2024 May 6:e202400251
doi: 10.1002/cbic.202400251

2023

Functional magnetic nanoparticles: from synthesis design to in-depth characterization and nano-labelling for ultrasensitive magnetic biosensing
Rebecca Sack, Mayiz Zgheib, Mohammad Suman Chowdhury, Yihao Wang, Frank Ludwig, Meinhard Schilling, Thilo Viereck, Aidin Lak
IEEE International Magnetic Conference - Short Papers (INTERMAG Short Papers), Sendai, Japan, 2023, pp. 1-2
doi: 10.1109/INTERMAGShortPapers58606.2023.10228506

2022

Amplification and extraction free quantitative detection of viral nucleic acids and single-base mismatches using magnetic signal amplification circuit
Enja Laureen Rösch, Rebecca Sack, Mohammad Suman Chowdhury, Florian Wolgast, Meinhard Schilling, Thilo Viereck, Aidin Lak
bioRxiv, 2022.12. 24.521858 - 2022
doi: 10.1101/2022.12.24.521858

Theses

Established methods for the diagnosis of diseases such as real-time PCR require many sophisticated sample preparation steps. The DNA assays developed at emg are based on the resizing of a system of magnetic nanoparticles (MNPs) when a specific target sequence is present in the sample. DNA nanotechnologies are used to initially separate connected MNPs (clusters) from each other, which can be detected by magnetic sensors. Since biological elements do not contribute to the magnetic measurement signal, the magnetic assays are promising for "mix and measure" detection, which significantly simplifies the performance of the tests.

Current research questions:

Realising viral detection without complex extraction steps
Ensuring the specificity of the magnetic assays
Adaptation to alternative RNA targets

Keywords: DNA/RNA detection, magnetism

Rebecca Sack, M. Sc.

My research area

Theses

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