Florian Wolgast, M. Sc.

2024

Amplification- and Enzyme-Free Magnetic Diagnostics Circuit for Whole-Genome Detection of SARS-CoV-2 RNA
Enja Laureen Rösch, Rebecca Sack, Mohammad Suman Chowdhury, Florian Wolgast, Margarete Zaborski, Frank Ludwig, Meinhard Schilling, Thilo Viereck, Ulfert Rand, Aidin Lak
Chembiochem. 2024 May 6:e202400251
doi: 10.1002/cbic.202400251

Improvements of magnetic nanoparticle assays for SARS-CoV-2 detection using a mimic virus approach
Tamara Kahmann, Florian Wolgast, Thilo Viereck, Meinhard Schilling, Frank Ludwig
Sensing and Bio-Sensing Research, Volume 44, id.100654 - 2024
doi: 10.1016/j.sbsr.2024.100654

Towards sensitive Magnetic Particle Spectroscopy-based immunoassays with adjustable DC offset fields
Florian Wolgast, Eike Wendt, Frank Ludwig, Meinhard Schilling, Thilo Viereck
International Journal on Magnetic Particle Imaging IJMPI, Vol. 10 No. 1 Suppl - 2024
https://www.journal.iwmpi.org/index.php/iwmpi/article/view/732

2023

Decoupling the Characteristics of Magnetic Nanoparticles for Ultrahigh Sensitivity
Mohammad Suman Chowdhury, Enja Laureen Rösch, Daniel Arenas Esteban, Klaas-Julian Janssen, Florian Wolgast, Frank Ludwig, Meinhard Schilling, Sara Bals, Thilo Viereck, and Aidin Lak
Nano Letters 2023 23 (1), 58-65
doi: 10.1021/acs.nanolett.2c03568

Low-cost standalone magnetic particle spectroscopy device for fast and sensitive immunoassays
Florian Wolgast, Tamara Kahmann, Meinhard Schilling, Frank Ludwig, Thilo Viereck
International Journal on Magnetic Particle Imaging IJMPI 9 (1 Suppl 1) - 2023

2022

Amplification and extraction free quantitative detection of viral nucleic acids and single-base mismatches using magnetic signal amplification circuit
Enja Laureen Rösch, Rebecca Sack, Mohammad Suman Chowdhury, Florian Wolgast, Meinhard Schilling, Thilo Viereck, Aidin Lak
bioRxiv, 2022.12. 24.521858 - 2022
doi: 10.1101/2022.12.24.521858

A wide variety of magnetic measurement methods are available for the characterisation of magnetic nanoparticles (MNPs), e.g. (field-dependent) AC susceptibility or magnetic particle spectroscopy (MPS). What they have in common is that they must first generate a magnetic field in order to excite the nanoparticles. The power required for this is provided by a power amplifier, which must fulfil high linearity requirements in order to obtain a spectrally pure magnetic field. These requirements cannot be met by a single amplifier, which is why a combined approach is necessary.

The aim of this thesis is to develop a composite amplifier consisting of an arrangement of two individual amplifiers in order to benefit from the advantages of both amplifiers, such as high linearity and low noise.

Previous knowledge: Hardware hobbyist, measurement electronics, operational amplifiers, independence

Keywords: Magnetic nanoparticles, magnetic measurement methods, circuit board layout

In our interdisciplinary group for magnetic nanoparticles, we are developing a highly sensitive and specific detection method based on magnetic particle spectroscopy (MPS), which enables us, for example, to detect virus fragments and DNA.For this we need support in our hardware team.As part of the Master's thesis, existing hardware concepts are to be taken up and further developed.The focus is on the integration of the hardware in order to build a highly sensitive, compact and easy-to-use MPS table-top device to further improve the detection limit of biological analytes.

Previous knowledge: Hardware hobbyist, measurement electronics, programming skills (C, C++, C#)

Keywords: Magnetic nanoparticles, detection of DNA, viruses & DNA