Uwe Siegner was born in Kassel in 1963. After studying physics at the University of Marburg, he received his doctorate in 1992 from the Department of Physics at the University of Marburg with a thesis entitled "Photon echo experiments to investigate the short-term dynamics of optical excitations in disordered semiconductors". After a two-year postdoctoral stay at the Lawrence Berkeley National Laboratory, he moved to the Swiss Federal Institute of Technology in Zurich in 1995, where he qualified as a professor of experimental physics in 1999. In the same year, Uwe Siegner moved to the Physikalisch-Technische Bundesanstalt (PTB) in Braunschweig. There he headed the "Semiconductor Physics and Magnetism" department from 2003 to 2009. Since 2009, he has headed the PTB's Electricity Department.
Uwe Siegner has been a private lecturer at the TU Braunschweig since 2001. His scientific interests include electrical quantum metrology, electromagnetic metrology, ultrafast optics and terahertz optoelectronics. He was appointed honorary professor in 2018.