Nanoparticular drug delivery systems and their application for graded implants

Whenever a drug delivery system and their release kinetics are shown, a so called “burst-release” is observed. This means most of the drug is “gone” within the first hours. In some cases, this might be good but mostly a more liner release is wished. Therefore, it is important to develop a way for optimizing this release kinetics. Also for our research group (“Gradierte Implantate”) where we are developing a graded implant to regenerate the rotator cuff, a “burst release” from the functionalized scaffold is taken place. We are trying to change this behavior by using biopolymers and other bio-compatible compounds as “blocking-layers”, which are applied in a Layer-by-Layer process. Furthermore, the processes will be investigated and new innovative release systems will be created.