The low entropy of mixing of block copolymers and the resulting self aggregation behaviour in solution leads to new possibilities for drug delivery, drug encapsulation and the use of target-molecules.[1-3] Biodegradable and biocompatible[4,5] glycopolypeptides can undergo conformational changes due to external stimuli. Combining the self aggregation behaviour of block copolymers with stimuli responsive polypeptides results in an interesting field of research. The influence of different parameters on self aggregation behavior, lectin interaction and drug encapsulation is the main topic.
Literature
[1] H. Kukula, Dissertation: Lineare und verzweigte Blockcopolymere aus Polypeptiden und synthetischen Polymeren, Universität Potzdam, Potsdam, 2001.
[2] J. Lin, S. Zhang, T. Chen, S. Lin, H. Jin, International journal of pharmaceutics 2007, 336, 49.
[3] H.-A. Klok, S. Lecommandoux in Advances in Polymer Science (Hrsg.: H.-A. Klok, H. Schlaad), Springer-Verlag, Berlin/Heidelberg, 2006, S. 75–111.
[4] Z. Song, H. Fu, R. Wang, L. A. Pacheco, X. Wang, Y. Lin, J. Cheng, Chemical Society reviews, 2018, 47, 7401.
[5] G. Gaucher, M.-H. Dufresne, V. P. Sant, N. Kang, D. Maysinger, J.-C. Leroux, Journal of controlled release: official journal of the Controlled Release Society, 2005, 109, 169.