Lower Saxony doctoral programme "Drug Discovery and Cheminformatics for New Anti-Infectives (iCA)"
Antibiotics are drugs that reduce the proliferation of bacteria and have been used very successfully for decades in the treatment of bacterial infections. In earlier times fatal infectious diseases can often be treated with very few side effects with these drugs. However, more and more resistant bacteria occur, which can only be fought insufficiently with the available antibiotics. Multi-resistant pathogens in particular now pose a serious threat to the health of the population, even in Western industrial nations. The situation with diseases caused by parasitic single-cell organisms, which include many of the so-called neglected tropical diseases, is similarly dramatic as with bacterial infections.
The development of new effective drugs against bacterial and parasitic infectious diseases (anti-infectives) requires on the one hand the development of innovative active compounds that differ chemically from the previously used drugs, and on the other hand the identification of new biological targets that are not yet addressed by the established drugs. Both goals can already be supported today with digitalization techniques. Based on such innovative methods, the iCA PhD program is working on new anti-infectives that are introduced through cooperation between Technische Universität Braunschweig, Helmholtz Centre for Infection Research and Ostfalia Hochschule. The combination of drug research with digital methods can provide important impulses for the identification of substantially new drugs and new targets. Through the extensive use of digital technologies (especially from chemistry, bioinformatics and theoretical chemistry) in all areas of the PhD program, a significant added value will be achieved, which should enable significant advances in the treatment of infectious diseases.
Participating Working Groups
The following groups of Technische Universität Braunschweig, Helmholtz-Centre for Infection Research (HZI) and Ostfalia Hochschule are participating:
Prof. Dr. Knut Baumann, Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig
https://www.tu-braunschweig.de/en/pharmchem/forschung/baumann
Prof. Dr. Ludger Beerhues, Institute of Pharmaceutical Biology, TU Braunschweig
https://www.tu-braunschweig.de/pharmbiol/mitarbeiter
Prof. Dr. Wulf Blankenfeldt, Department Structure and Function of Proteins, Helmholtz Centre for Infection Research (HZI)
www.helmholtz-hzi.de/sfpr
Prof. Dr. Mark Brönstrup, Department Chemical Biology, Helmholtz Centre for Infection Research (HZI)
www.helmholtz-hzi.de/en/research/research-topics/anti-infectives/chemical-biology/mark-broenstrup/
Prof. Dr. Heike Bunjes, Department of Pharmaceutics, TU Braunschweig
www.tu-braunschweig.de/pharmtech/institut/arbeitsgruppen/bunjes
Prof. Dr. Christoph Jacob, Institute of Physical and Theoretical Chemistry, TU Braunschweig
https://www.tu-braunschweig.de/pci/agjacob
Prof. Dr. Frank Klawonn, Institute for Information Engineering, Ostfalia
https://www.ostfalia.de/cms/de/pws/klawonn/index.html
Prof. Dr. Reinhard Köster, Zoological Institute, TU Braunschweig
www.tu-braunschweig.de/zoology/forschung/cellularmolecularneurobiology
Prof. Dr. Conrad Kunick, Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig
www.tu-braunschweig.de/en/pharmchem/forschung/kunick
Prof. Dr. Alice McHardy, Department Computational Biology of Infection Research, Helmholtz Centre for Infection Research (HZI)
https://www.helmholtz-hzi.de/en/research/research-topics/bacterial-and-viral-pathogens/computational-biology-of-infection-research/alice-mchardy/
Prof. Dr. Ingo Ott, Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig
https://www.tu-braunschweig.de/en/pharmchem/forschung/ott
PD Dr. Gabriele Raabe, Institute for Thermodynamics Thermal Science Lab, TU Braunschweig
https://www.tu-braunschweig.de/ift/institut/mitarbeiter/raabe-gabriele
Prof. Dr. Stephan Reichl, Department of Pharmaceutics, TU Braunschweig
https://www.tu-braunschweig.de/en/pharmtech/institut/arbeitsgruppen/reichl
Prof. Dr. Marc Stadler, Department Microbial Drugs, Helmholtz Centre for Infection Research (HZI)
www.helmholtz-hzi.de/en/research/research_topics/antiinfectives/microbial_drugs
Prof. Dr. Matthias Tamm, Institute of Inorganic and Analytical Chemistry, TU Braunschweig
https://www.tu-braunschweig.de/iaac/personal/prof-dr-m-tamm
Associated Participants
Prof. Dr. Anna K. H. Hirsch, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
Speaker
Prof. Dr. Ingo Ott
Technische Universität Braunschweig,
Institute of Medicinal and Pharmaceutical Chemistry
Beethovenstraße 55, 38106 Braunschweig
Phone : +49 (0)531 391 2743, email: ingo.ott@tu-braunschweig.de