In the context of interdisciplinary research in biology, pharmacy and metrology, the Institute of Semiconductor Technology investigates the generation of partially coherent light using miniaturized LEDs.
For the imaging of small intracellular structures, the properties of the light of an LED provide specific advantages depending on the application. Conventional lensless microscopy uses lasers with high spatial coherence, which generate artefacts ('speckles') in the reconstructed image, making it difficult to image subcellular structures [1].
The lensless microscopy approach pursued at the Institute of Semiconductor Technology provides a cost-effective, robust and small microscope with a large field of view, which for example enables the continuous observation of cell cultures inside an incubator.
Publications:
Scholz, Gregor; Mariana, Shinta; Dharmawan, Agus Budi; Syamsu, Iqbal; Hörmann, Philipp; Reuse, Carsten et al. (2019): Continuous Live-Cell Culture Imaging and Single-Cell Tracking by Computational Lensfree LED Microscopy. In: Sensors (Basel, Switzerland) 19 (5). DOI: 10.3390/s19051234.
Funded projects:
Research line Quantum and Nanometrology (QUANOMET): Junior Research Group "Structured Light Microscopy (NL2)", 11/2016 –10/2021
Contact: Mayra Garcés-Schröder
[1] Deng, Yuanbo; Chu, Daping (2017): Coherence properties of different light sources and their effect on the image sharpness and speckle of holographic displays. In: Scientific reports 7 (1), S. 5893. DOI: 10.1038/s41598-017-06215-x.
[2] Scholz, Gregor; Mariana, Shinta; Dharmawan, Agus Budi; Syamsu, Iqbal; Hörmann, Philipp; Reuse, Carsten et al. (2019): Continuous Live-Cell Culture Imaging and Single-Cell Tracking by Computational Lensfree LED Microscopy. In: Sensors (Basel, Switzerland) 19 (5). DOI: 10.3390/s19051234.
