A Parallel Perifusion Slide From Glass for the Functional and Morphological Analysis of Pancreatic Islets
Alshafei, Mohammed; Schulze, Torben; Morsi, Mai; Panten, Uwe; Rustenbeck, Ingo (2023): Short-Term Inhibition of Translation by Cycloheximide Concurrently Affects Mitochondrial Function and Insulin Secretion in Islets from Female Mice. In: International Journal of Molecular Sciences 24 (20). DOI: 10.3390/ijms242015464.
Asmari, Mufarreh; Michalcová, Lenka; Ibrahim, Adel Ehab; Glatz, Zdeněk; Wätzig, Hermann; El Deeb, Sami (2023): Studying molecular interactions via capillary electrophoresis and microscale thermophoresis: A review. In: Electrophoresis 44 (13-14), S. 1114–1142. DOI: 10.1002/elps.202200275.
Ballmann, Rico; Schneider, Kai-Thomas; Roth, Kristian Daniel Ralph; Dübel, Stefan (2023): Antibody Batch Cloning. In: Methods in Molecular Biology 2702, S. 411–417. DOI: 10.1007/978-1-0716-3381-6_21.
Balters, Leon; Reichl, Stephan (2023): 3D bioprinting of corneal models: A review of the current state and future outlook. In: Journal of Tissue Engineering 14. DOI: 10.1177/20417314231197793.
Bendas, Sebastian; Koch, Eugen Viktor; Nehlsen, Kristina; May, Tobias; Dietzel, Andreas; Reichl, Stephan (2023): The Path from Nasal Tissue to Nasal Mucosa on Chip: Part 1—Establishing a Nasal In Vitro Model for Drug Delivery Testing Based on a Novel Cell Line. In: Pharmaceutics 15 (9). DOI: 10.3390/pharmaceutics15092245.
Benselfelt, Tobias; Shakya, Jyoti; Rothemund, Philipp; Lindström, Stefan B.; Piper, Andrew Winkler, , Thomas E., Hajian, Alireza, Wågberg, Lars; Keplinger, Christoph; Max Hamedi, Mahiar (2023): Electrochemically Controlled Hydrogels with Electrotunable Permeability and Uniaxial Actuation. In: Adavnced Materials 35 (45). DOI: 10.1002/adma.202303255
Berten-Schunk, Leonie; Roger, Yvonne; Bunjes, Heike; Hoffmann, Andrea (2023): Release of TGF-β3 from Surface-Modified PCL Fiber Mats Triggers a Dose-Dependent Chondrogenic Differentiation of Human Mesenchymal Stromal Cells. In: Pharmaceutics 15 (4). DOI: 10.3390/pharmaceutics15041303.
Brepohl, Esther; Paschetag, Mandy; Scholl, Stephan (2023): Monomer Recycling as Complementary Technology in a Circular Economy. In: Chemie-Ingenieur-Technik 95 (8), S. 1282–1289. DOI: 10.1002/cite.202300052.
Brune, Sarah E.; Hoppenreijs, Loes J.G.; Kühl, Toni; Lautenbach, Vanessa; Walter, Johannes; Peukert, Wolfgang et al. (2023): Precision fermentation as a route to modify β-lactoglobulin structure through substitution of specific cysteine residues. In: International Dairy Journal 147. DOI: 10.1016/j.idairyj.2023.105772.
Busnena, Belnaser A.; Beerhues, Ludger; Liu, Benye (2023): Biphenyls and dibenzofurans of the rosaceous subtribe Malinae and their role as phytoalexins. In: Planta 258 (4). DOI: 10.1007/s00425-023-04228-7.
Christ, Henrik-Alexander; Daniel, Nils Peter; Solarczek, Jennifer; Fresenborg, Leonard Sebastian; Schallmey, Anett; Menzel, Henning (2023): Application of electrospun chitosan-based nanofibers as immobilization matrix for biomolecules. In: Applied Microbiology and Biotechnology 107 (23), S. 7071–7087. DOI: 10.1007/s00253-023-12777-w.
Christ, Henrik-Alexander; Menzel, Henning (2023): Electrospinning and Photocrosslinking of Highly Modified Fungal Chitosan. In: Macromolecular Materials and Engineering 308 (1). DOI: 10.1002/mame.202200430.
Conrad, M., Proll, G., Builes-Münden, E., Dietzel, A.Wagner, S., Gauglitz, G., Tools to compare antibody gold nanoparticle conjugates for a small molecule immunoassay, Microchimica Acta, 2023, 190(2), 62
Constantinou, Iordania; Bastounis, Effie E. (2023): Cell-stretching devices: advances and challenges in biomedical research and live-cell imaging. In: Trends in Biotechnology 41 (7), S. 939–950. DOI: 10.1016/j.tibtech.2022.12.009.
Dinius, A., Schrinner, K., Schrader, M., Kozanecka, Z.J., Brauns, H., Klose, L., Weiß, H., Kwade, A., Krull, R., 2023. Morphology engineering for novel antibiotics: Effect of glass microparticles and soy lecithin on rebeccamycin production and cellular morphology of filamentous actinomycete Lentzea aerocolonigenes. Frontiers in bioengineering and biotechnology 11, 1171055. doi.org/10.3389/fbioe.2023.1171055.
Dutschmann, Thomas-Martin; Kinzel, Lennart; Laak, Antonius ter; Baumann, Knut (2023): Large-scale evaluation of k-fold cross-validation ensembles for uncertainty estimation. In: Journal of Cheminformatics 15 (1). DOI: 10.1186/s13321-023-00709-9.
Finck, Laura; Hagemann, Valentin; Behrens, Peter; Menzel, Henning (2023): Temperature-triggered liquefication of hydrogels for intentional implant removal. In: Current Directions in Biomedical Engineering 9 (1), S. 158–161. DOI: 10.1515/cdbme-2023-1040.
Franco, Renan Louro Cardoso; Eichert, Carsten; Lücking, Charlotte; Biermann, Lars; Paschetag, Mandy; Scholl, Stephan (2023): revolPET®: An Innovative “Back-to-Monomer” Recycling Technology for the Open Loop Value Chain of PET and Polyester Composite Packaging and Textiles. In: Lecture Notes in Mechanical Engineering, S. 175–183. DOI: 10.1007/978-3-031-28839-5_20.
Giannis, Kostas; Kwade, Arno; Finke, Jan Henrik; Schilde, Carsten (2023): The Effect of Particle Shape on the Compaction of Realistic Non-Spherical Particles—A Multi-Contact DEM Study. In: Pharmaceutics 15 (3). DOI: 10.3390/pharmaceutics15030909.
Glaser, Sarah; Zarmandili, Omid; Stammen, Elisabeth; Dilger, Klaus (2023): Characterization of adhesive curing reactions using rapid heat rheology. In: Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering 237 (1), S. 4–13. DOI: 10.1177/09544089221100354.
Grupe, Katharina; Scherneck, Stephan (2023): Mouse Models of Gestational Diabetes Mellitus and Its Subtypes: Recent Insights and Pitfalls. In: International Journal of Molecular Sciences 24 (6). DOI: 10.3390/ijms24065982.
Hagemann, Valentin; Klodwig, Florian; Herrmann, Timo; Ehlert, Nina; Finck, Laura; Menzel, Henning (2023): Core-Shell-Nanoparticles with Superparamagnetic Properties for Novel Applications as Biomaterials. In: Current Directions in Biomedical Engineering 9 (1), S. 666–669. DOI: 10.1515/cdbme-2023-1167.
Hartung, Sophie; Minkner, Robert; Olabi, Mais; Wätzig, Hermann (2023): Performance of capillary electrophoresis instruments – State of the art and outlook. In: TrAC - Trends in Analytical Chemistry 163. DOI: 10.1016/j.trac.2023.117056.
Heyn, T.R., Schrader, M., Kampen, I., Kwade, A., Schwarz, K., Keppler, J.K., 2023. Glass beads increase the formation kinetics of beta-lactoglobulin amyloid fibrils. Food Hydrocolloids 139, 108511. doi.org/10.1016/j.foodhyd.2023.108511.
Hoffstedt, Marc; Stein, Matthias Oliver; Baumann, Knut; Wätzig, Hermann (2023): Experimentally Observed Conformational Changes in Antibodies Due to Binding and Paratope-epitope Asymmetries. In: Journal of Pharmaceutical Sciences 112 (9), S. 2404–2411. DOI: 10.1016/j.xphs.2023.06.003.
Hoppenreijs, Loes J.G.; Brune, Sarah E.; Biedendieck, Rebekka; Krull, Rainer; Boom, Remko M.; Keppler, Julia K. (2023): Fibrillation of β-lactoglobulin at pH 2.0: Impact of cysteine substitution and disulfide bond reduction. In: Food Hydrocolloids 141. DOI: 10.1016/j.foodhyd.2023.108727.
Hoppenreijs, Loes J.G.; Overbeck, Achim; Brune, Sarah E.; Biedendieck, Rebekka; Kwade, Arno; Krull, Rainer et al. (2023): Amyloid-like aggregation of recombinant β-lactoglobulin at pH 3.5 and 7.0: Is disulfide bond removal the key to fibrillation? In: International Journal of Biological Macromolecules 242. DOI: 10.1016/j.ijbiomac.2023.124855.
Ihnatenko, Irina; Müller, Marco J.; Orban, Oliver C.F.; Lindhof, Jens C.; Benítez, Diego; Ortíz, Cecilia; Dibello, Estefanía; Seidl, Leonardo L.; Comini, Marcelo A.; Kunick, Conrad (2023): The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones. In: PLoS ONE 18. DOI: 10.1371/journal.pone.0292946
Jäger, Luca; Scholl, Stephan (2023): Experimental characterization and mixing modeling of a horizontally rotating disc reactor. In: Chemical Engineering Science 280. DOI: 10.1016/j.ces.2023.118995.
Jarmatz, Niklas; Augustin, Wolfgang; Scholl, Stephan (2023): Comprehensive Parameter Screening for the Investigation of Particulate Fouling in Pipe Fittings. In: Chemie-Ingenieur-Technik 95 (5), S. 708–716. DOI: 10.1002/cite.202200208.
Jarmatz, Niklas; Augustin, Wolfgang; Scholl, Stephan (2023): Generation of experimental data for model training to optimize fouling prediction. In: Heat and Mass Transfer/Waerme- und Stoffuebertragung. DOI: 10.1007/s00231-023-03393-5.
Kara, Sami; Herrmann, Christoph; Hauschild, Michael (2023): Operationalization of life cycle engineering. In: Resources, Conservation and Recycling 190. DOI: 10.1016/j.resconrec.2022.106836.
Klemm, Lisa; Seydewitz, Robert; Siebert, Tobias; Böl, Markus (2023): Three-dimensional multi-field modelling of gastric arrhythmias and their effects on antral contractions. In: Computers in Biology and Medicine 153. DOI: 10.1016/j.compbiomed.2022.106488.
Klodwig, Florian; Ehlert, Nina; Herrmann, Timo; Menzel, Henning (2023): Mechanical Adaptive Silicone Composites for UV-triggered Facilitated Cochlear-Implant Removal. In: Current Directions in Biomedical Engineering 9 (1), S. 670–673. DOI: 10.1515/cdbme-2023-1168.
Koch, Eugen Viktor; Bendas, Sebastian; Nehlsen, Kristina; May, Tobias; Reichl, Stephan; Dietzel, Andreas (2023): The Path from Nasal Tissue to Nasal Mucosa on Chip: Part 2—Advanced Microfluidic Nasal In Vitro Model for Drug Absorption Testing. In: Pharmaceutics 15 (10). DOI: 10.3390/pharmaceutics15102439.
König, Philipp; Zhulenko, Roman; Suparman, Eloy; Hoffmeister, Henrik; Bückreiß, Nico; Ott, Ingo; Bendas, Gerd (2023): A biscarbene gold(I)-NHC-complex overcomes cisplatin-resistance in A2780 and W1 ovarian cancer cells highlighting pERK as regulator of apoptosis. In: Cancer Chemotherapy and Pharmacology 92 (1), S. 57–69. DOI: 10.1007/s00280-023-04548-1.
Kutluk, Hazal; Bastounis, Effie E.; Constantinou, Iordania (2023): Integration of Extracellular Matrices into Organ-on-Chip Systems. In: Advanced Healthcare Materials 12 (20). DOI: 10.1002/adhm.202203256.
Kwiecień, Inga; Miceli, Natalizia; Kędzia, Elżbieta; Cavò, Emilia; Taviano, Maria Fernanda; Beerhues, Ludger; Ekiert, Halina (2023): Different Types of Hypericum perforatum cvs. (Elixir, Helos, Topas) In Vitro Cultures: A Rich Source of Bioactive Metabolites and Biological Activities of Biomass Extracts. In: Molecules 28 (5). DOI: 10.3390/molecules28052376.
Ledwig, Verena; Reichl, Stephan (2023): Isolation and Cultivation of Porcine Endothelial Cells, Pericytes and Astrocytes to Develop an In Vitro Blood–Brain Barrier Model for Drug Permeation Testing. In: Pharmaceutics 15 (6). DOI: 10.3390/pharmaceutics15061688.
Lindhof, Jens C.; Ihnatenko, Irina; Müller, Marco J.; Orban, Oliver C. F.; Ortíz, Cecilia; Benítez, Diego; Dibello, Estefanía; Seidl, Leonardo L.; Comini (2023): Discovery of antitrypanosomal indolylacetamides by a deconstruction–optimization strategy applied to paullones. In: ChemMedChem 18 (10). e202300036. doi: 10.1002/cmdc.202300036.
Lu, Yan; Hammerschmidt, Jochen; Falk, Herbert; Scholl, Stephan; Jasch, Katharina (2023): Simulation of a pillow plate thermosiphon reboiler using an equivalent tube bundle geometry. In: Case Studies in Thermal Engineering 49. DOI: 10.1016/j.csite.2023.103194.
Lu, Yan; Jasch, Katharina; Scholl, Stephan (2023): Simulation of Thermosiphon Reboilers Using Wire Matrix Inserts at Lower Operating Range. In: Heat Transfer Engineering 44 (3), S. 246–258. DOI: 10.1080/01457632.2022.2049542.
Mann, Jil; Garnweitner, Georg; Schilde, Carsten (2023): Preparation of Self-Assembled Nanoparticle–Polymer Hybrids from Modified Silica Nanoparticles and Polystyrene-Block-Polyacrylic Acid Vesicles via the Co-Precipitation Method. In: Polymers 15 (2). DOI: 10.3390/polym15020444.
Mann, Jil; Mayer, Julian K.; Garnweitner, Georg; Schilde, Carsten (2023): Influence of Process Parameters on the Kinetics of the Micelle-to-Vesicle Transition and Ripening of Polystyrene-Block-Polyacrylic Acid. In: Polymers 15 (7). DOI: 10.3390/polym15071695.
Matthiesen, Isabelle; Jury, Michael; Rasti Boroojeni, Fatemeh; Ludwig, Saskia L.; Holzreuter, Muriel; Buchmann, Sebastian; Åman Träger, Andrea; Selegård, Robert (2023): Astrocyte 3D culture and bioprinting using peptide functionalized hyaluronan hydrogels. In: Science and Technology of Advanced Materials 24 (1). DOI: 10.1080/14686996.2023.2165871
Minkner, Robert; Burger, Udo; Malz, Louis; Doerks, Susanne; Wätzig, Hermann (2023): Efficient and reliable CE-SDS separations by the high-speed turbo CE-SDS® cartridge. In: Journal of Liquid Chromatography and Related Technologies 46 (16-20), S. 293–301. DOI: 10.1080/10826076.2023.2269233.
Müller, Clemens; Heck, Carina A.; Stephan, Luca; Paschetag, Mandy; Scholl, Stephan (2023): Precipitation of Terephthalic Acid from Alkaline Solution: Influence of Temperature and Precipitation Acid. In: Industrial and Engineering Chemistry Research 62 (30), S. 12029–12040. DOI: 10.1021/acs.iecr.2c04451.
Müller, Michael; Walkling, Jonas; Seemann, Nele; Rustenbeck, Ingo (2023): The Dynamics of Calcium Signaling in Beta Cells—A Discussion on the Comparison of Experimental and Modelling Data. In: International Journal of Molecular Sciences 24 (4). DOI: 10.3390/ijms24043206.
Nachtmann, Marcel; Feger, Daniel; Wühler, Felix; Rädle, Matthias; Scholl, Stephan (2023): Liquid Mixing on Falling Films: Marker-Free, Molecule-Sensitive 3D Mapping Using Raman Imaging. In: Sensors 23 (13). DOI: 10.3390/s23135846.
Olabi, Mais; Wätzig, Hermann (2023): Quantitation of native and forced degraded collagens by capillary zone electrophoresis: Method development and validation. In: Journal of Separation Science 46 (24). DOI: 10.1002/jssc.202300516.
Panten, Uwe; Brüning, Dennis; Rustenbeck, Ingo (2023): Regulation of insulin secretion in mouse islets: metabolic amplification by alpha-ketoisocaproate coincides with rapid and sustained increase in acetyl-CoA content. In: Naunyn-Schmiedeberg’s Archives of Pharmacology 396 (2), S. 353–364. DOI: 10.1007/s00210-022-02290-8.
Puckhaber, D., Kwade, A., Finke, J.H., 2023. Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical Strength of MCC Tablets. Pharmaceutical research. https://doi.org/10.1007/s11095-023-03602-0.
Puckhaber, D., Voges, A.-L., Rane, S., David, S., Gururajan, B., Henrik Finke, J., Kwade, A., 2023. Enhanced multi-component model to consider the lubricant effect on compressibility and compactibility. European journal of pharmaceutics and biopharmaceutics. doi.org/10.1016/j.ejpb.2023.04.004.
Ritters, Lena; Reichl, Stephan (2023): Spray-dried paracetamol/polyvinylpyrrolidone amorphous solid dispersions: Part II – Solubility and in vitro drug permeation behavior. In: International Journal of Pharmaceutics 639. DOI: 10.1016/j.ijpharm.2023.122939.
Rösemeier-Scheumann, R., Wagner, L., Bobe, U., Bozon, A., Kwade, A., Finke, J.H., 2024. Structural and functional analysis of a new co-processed tableting excipient for food compaction processes. Journal of Food Engineering 363, 111624. https://doi.org/10.1016/j.jfoodeng.2023.111624.
Ruatta, Santiago M.; Prada Gori, Denis N.; Fló Díaz, Martín; Lorenzelli, Franca; Perelmuter, Karen; Alberca, Lucas N.; Bellera, Carolina L.; Medeiros, Andrea; López, Gloria V.; Ingold, Mariana; Porcal, Williams; Dibello, Estefanía; Ihnatenko, Irina; Kunick, Conrad; Incerti, Marcelo; Luzardo, Martín; Colobbio, Maximiliano; Ramos, Juan Carlos; Manta, Eduardo; Minini, Lucía; Lavaggi, María Laura; Hernández, Paola; Šarlauskas, Jonas; Huerta García, César Sebastian; Castillo, Rafael; Hernández-Campos, Alicia; Ribaudo, Giovanni; Zagotto, Giuseppe; Carlucci, Renzo; Medrán, Noelia S.; Labadie, Guillermo R.; Martinez-Amezaga, Maitena; Delpiccolo, Carina M. L.; Mata, Ernesto G.; Scarone, Laura; Posada, Laura; Serra, Gloria; Calogeropoulou, Theodora; Prousis, Kyriakos; Detsi, Anastasia; Cabrera, Mauricio; Alvarez, Guzmán; Aicardo, Adrián; Araújo, Verena; Chavarría, Cecilia; Mašič, Lucija Peterlin; Gantner, Melisa E.; Llanos, Manuel A.; Rodríguez, Santiago; Gavernet, Luciana; Park, Soonju; Heo, Jinyeong; Lee, Honggun; Paul Park, Kyu-Ho; Bollati-Fogolín, Mariela; Pritsch, Otto; Shum, David; Talevi, Alan; Comini, Marcelo A. (2023): Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARS-CoV-2 Mpro. In: Frontiers in Pharmacology 14. DOI: 10.3389/fphar.2023.1193282
Sang Bastian, Samira; Rechberger, Felix; Zellmer, Sabrina; Niederberger, Markus; Garnweitner, Georg (2023): Conducting ITO Nanoparticle-Based Aerogels—Nonaqueous One-Pot Synthesis vs. Particle Assembly Routes. In: Gels 9 (4). DOI: 10.3390/gels9040272.
Sayed, Hesham M.B.; Nassar, Sara; Kaufholdt, David; Beerhues, Ludger; Liu, Benye; El-Awaad, Islam (2023): Biosynthesis of polyprenylated xanthones in Hypericum perforatum roots involves 4-prenyltransferase. In: Plant Physiology 192 (4), S. 2971–2988. DOI: 10.1093/plphys/kiad219.
Schomberg, A.K., Kwade, A., Finke, J.H., 2023. Modeling gravity filling of dies on a rotary tablet press. Powder Technology 413, 117998. https://doi.org/10.1016/j.powtec.2022.117998.
Schomberg, A.K., Kwade, A., Finke, J.H., 2023. Modeling die filling under gravity for different scales of rotary tablet presses. Powder Technology 424, 118550. https://doi.org/10.1016/j.powtec.2023.118550.
Schömig, Oliver; Arafat, Robar; Abraham, Tim; Herrmann, Christoph (2023): Biologicalisation of manufacturing on a factory scale - Taking a wider approach to envision a biologically transformed pulp-factory. In: Procedia CIRP 120. DOI: 10.1016/j.procir.2023.09.001.
Schrader, Marcel; Schrinner, Kathrin; Polomsky, Laura; Ivanov, Dimitri; Kampen, Ingo; Schilde, Carsten et al. (2023): Quantification and modeling of macroparticle-induced mechanical stress for varying shake flask cultivation conditions. In: Frontiers in Bioengineering and Biotechnology 11. DOI: 10.3389/fbioe.2023.1254136.
Schwerdtfeger, Natalie; Schulte, Annalena; Jasch, Katharina; Scholl, Stephan (2023): Spatially Resolved Temperature Measurements during Condensation in Presence of a Non-Condensable Gas. In: Chemie-Ingenieur-Technik 95 (5), S. 675–680. DOI: 10.1002/cite.202200227.
Sprick, Miriam; Raabe, Gabriele (2023): Prediction of toluene/water partition coefficients of SAMPL9 compounds: comparison of the molecular dynamics force fields GAFF/RESP and GAFF/IPolQ-Mod + LJ-fit. In: Physical Chemistry Chemical Physics 26 (4), S. 3126–3138. DOI: 10.1039/d3cp04149b.
Staar, Marcel; Schallmey, Anett (2023): Performance of cross-linked enzyme crystals of engineered halohydrin dehalogenase HheG in different chemical reactor systems. In: Biotechnology and Bioengineering 120 (11), S. 3210–3223. DOI: 10.1002/bit.28528.
Staud, Rolf; Sun, Zhenlong; Xu, Shaoyou; Scholl, Stephan; Jasch, Katharina (2023): Fluid dynamic and separation performance of foam loaded packed distillation columns. In: Chemical Engineering Research and Design 193, S. 801–809. DOI: 10.1016/j.cherd.2023.04.006.
Steiner, D., Tidau, M., Finke, J.H., 2023. Embedding of Poorly Water-Soluble Drugs in Orodispersible Films—Comparison of Five Formulation Strategies. Pharmaceutics 15, 17. doi.org/10.3390/pharmaceutics15010017.
Strodtmann, Laura; Gebauer, Maike; Vetter, Anna; Scholl, Stephan; Jasch, Katharina (2023): Influence of surfactants on thermosiphon reboiling. In: Chemical Engineering Research and Design 194, S. 105–114. DOI: 10.1016/j.cherd.2023.04.015.
Tang, Bo; Liu, Mengxi; Dietzel, Andreas (2023): Low-Cost Impedance Camera for Cell Distribution Monitoring. In: Biosensors 13 (2). DOI: 10.3390/bios13020281.
Tappe, Aike Aline; Selvarajan, Subiksha; Heiduk, Caroline; Scholl, Stephan; Schenkendorf, René (2023): PINN-based Design of Experiment Concept for Process Model Parameter Identification. In: Computer Aided Chemical Engineering 52, S. 837–842. DOI: 10.1016/B978-0-443-15274-0.50134-7.
Tidau, M., Finke, J.H., (2023). Opinion: Basic 3D printing design methodology for individual combinative dosage forms. Annals of 3D Printed Medicine 9, 100089. https://doi.org/10.1016/j.stlm.2022.100089.
van der Burg, Debbie; Wätzig, Hermann; Sänger – van de Griend, Cari E. (2023): Design of experiments for micellar electrokinetic chromatography method development for the monitoring of water-soluble vitamins in cell culture medium. In: Electrophoresis 44 (19-20), S. 1548–1558. DOI: 10.1002/elps.202300032.
van der Burg, Debbie; Wätzig, Hermann; Sänger-van de Griend, Cari E. (2023): Method development for quantitative monitoring of monoclonal antibodies in upstream cell-culture process samples with limited sample preparation – An evaluation of various capillary coatings. In: Electrophoresis 44 (1-2), S. 96–106. DOI: 10.1002/elps.202200144.
Vorländer, K., Bahlmann, L., Kwade, A., Finke, J.H., Kampen, I., (2023): Effect of Process Parameters, Protectants and Carrier Materials on the Survival of Yeast Cells during Fluidized Bed Granulation for Tableting. Pharmaceutics 15, 884. https://doi.org/10.3390/pharmaceutics15030884.
Vorländer, K., Bahlmann, L., Kwade, A., Finke, J.H., Kampen, I., 2023. Tableting of Fluidized Bed Granules Containing Living Microorganisms. European journal of pharmaceutics and biopharmaceutics. https://doi.org/10.1016/j.ejpb.2023.03.011.
Vorländer, K., Bahlmann, L., Kwade, A., Henrik Finke, J., Kampen, I., 2023. Influence of compression kinetics during tableting of fluidized bed-granulated microorganisms on microbiological and physical-mechanical tablet properties. European journal of pharmaceutics and biopharmaceutics. doi.org/10.1016/j.ejpb.2023.05.012.
Voß, Silja; Behrmann, Till; Reichl, Stephan (2023): Development of In Vitro Dry Eye Models to Study Proliferative and Anti-Inflammatory Effects of Allogeneic Serum Eye Drops. In: International Journal of Molecular Sciences 24 (2). DOI: 10.3390/ijms24021567.
Walter, Fabian; Seydewitz, Robert; Mitterbach, Philipp; Siebert, Tobias; Böl, Markus (2023): On a three–dimensional model for the description of the passive characteristics of skeletal muscle tissue. In: Biomechanics and Modeling in Mechanobiology 22 (5), S. 1499–1514. DOI: 10.1007/s10237-022-01664-4.
Wiese, H.; Geißler, H.; Augustin, W.; Scholl, S. (2023): Diffusive mass transfer and protein removal in the alkaline cleaning of a jellylike whey protein fouling layer. In: Heat and Mass Transfer/Waerme- und Stoffuebertragung. DOI: 10.1007/s00231-023-03391-7.
Wilke, Nicola L.; Burmeister, Hilke; Frias, Corazon; Ott, Ingo; Prokop, Aram (2023): Ruthenium Complex HB324 Induces Apoptosis via Mitochondrial Pathway with an Upregulation of Harakiri and Overcomes Cisplatin Resistance in Neuroblastoma Cells In Vitro. In: International Journal of Molecular Sciences 24 (2). DOI: 10.3390/ijms24020952.
Wullenweber, Maike S.; Kottmeier, Jonathan; Kampen, Ingo; Dietzel, Andreas; Kwade, Arno (2023): Numerical Study on High Throughput and High Solid Particle Separation in Deterministic Lateral Displacement Microarrays. In: Processes 11 (8). DOI: 10.3390/pr11082438.
Yogev, David; Goldberg, Tomer; Arami, Amir; Tejman-Yarden, Shai; Winkler, Thomas E.; Maoz, Ben M. (2023): Capillary Zone Electrophoresis with Light-Emitting Diode-Induced Fluorescence Detection for the Analysis of Monoclonal Antibodies: Detector Optimization through Design of Experiments and Comparison to UV Detection. In: APL Bioengineering 7 (3). DOI: 10.1063/5.0152290
Zagst, Holger; Hartung, Sophie; Menges, Dina-Mareike; Wittmann, Antonia; Wätzig, Hermann (2023): Capillary Zone Electrophoresis with Light-Emitting Diode-Induced Fluorescence Detection for the Analysis of Monoclonal Antibodies: Detector Optimization through Design of Experiments and Comparison to UV Detection. In: Separations 10 (5). DOI: 10.3390/separatio
Adams, R. D., Schatzschneider, U., Ott, I., Adams, R. D., Schatzschneider, U. & Ott, I. Special issue on International Symposium on Bioorganometallic Chemistry (ISBOMC21). Journal of Organometallic Chemistry 973-974, 122393; 10.1016/j.jorganchem.2022.122393 (2022).
Ballmann, R., Hotop, S.-K., Bertoglio, F., Steinke, S., Heine, P. A., Chaudhry, M. Z., Jahn, D., Pucker, B., Baldanti, F., Piralla, A., Schubert, M., Čičin-Šain, L., Brönstrup, M., Hust, M. & Dübel, S. ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike Protein. Viruses 14; 10.3390/v14061326 (2022).
Barasinski, M., Schilde, C., Melzig, S., Hübner, M., Garnweitner, G. & Zellmer, S. Micromechanical properties of spray-dried core-shell silica aggregates along with drug release tests. JCIS Open 6; 10.1016/j.jciso.2022.100052 (2022).
Böttcher, A.-C., Beusen, D., Lüddecke, A., Overbeck, A., Schilde, C. & Kwade, A. Single and multiple breakage events in fine particle breakage testing with a rigidly-mounted roll mill. Minerals Engineering 178; 10.1016/j.mineng.2021.107390 (2022).
Brüning, D., Morsi, M., Früh, E., Scherneck, S. & Rustenbeck, I. Metabolic Regulation of Hormone Secretion in Beta-Cells and Alpha-Cells of Female Mice: Fundamental Differences. Endocrinology 163; 10.1210/endocr/bqac125 (2022).
Cai, S., Erfle, P. & Dietzel, A. A Digital Twin of the Coaxial Lamination Mixer for the Systematic Study of Mixing Performance and the Prediction of Precipitated Nanoparticle Properties. Micromachines 13; 10.3390/mi13122076 (2022).
Christ, H.-A., Ang, P. Y., Li, F., Johannes, H.-H., Kowalsky, W. & Menzel, H. Production of highly aligned microfiber bundles from polymethyl methacrylate via stable jet electrospinning for organic solid-state lasers. Journal of Polymer Science 60, 715–725; 10.1002/pol.20210747 (2022).
Christ, H.-A. & Menzel, H. Electrospinning and Photocrosslinking of Highly Modified Fungal Chitosan. Macromolecular Materials and Engineering; 10.1002/mame.202200430 (2022).
Chroston, E., Hielscher, A., Strieker, M. & Wittstock, U. The Impact of Nitrile-Specifier Proteins on Indolic Carbinol and Nitrile Formation in Homogenates of Arabidopsis thaliana. Molecules 27; 10.3390/molecules27228042 (2022).
Constantinou, I. Microsystems for Cell Cultures. Biosensors 12; 10.3390/bios12040190 (2022).
Doll-Nikutta, K., Winkel, A., Yang, I., Grote, A. J., Meier, N., Habib, M., Menzel, H., Behrens, P. & Stiesch, M. Adhesion Forces of Oral Bacteria to Titanium and the Correlation with Biophysical Cellular Characteristics. Bioengineering 9; 10.3390/bioengineering9100567 (2022).
Erfle, P., Riewe, J., Cai, S., Bunjes, H. & Dietzel, A. Horseshoe lamination mixer (HLM) sets new standards in the production of monodisperse lipid nanoparticles. Lab on a Chip 22, 3025–3044; 10.1039/d2lc00240j (2022).
Finke, B., Schrader, M., Kwade, A. & Schilde, C. Stress- and process model for dispersing of nanoparticulate suspensions in laminar shear flow. Advanced Powder Technology 33; 10.1016/j.apt.2022.103574 (2022).
Frey, L. J. & Krull, R. Microbioreactors for Process Development and Cell-Based Screening Studies. Advances in Biochemical Engineering/Biotechnology 179, 67–100; 10.1007/10_2020_130 (2022).
Früh, E., Bütefisch, S., Gursky, B., Brüning, D., Leester‐schädel, M., Dietzel, A. & Rustenbeck, I. An Immersible Microgripper for Pancreatic Islet and Organoid Research. Bioengineering 9; 10.3390/bioengineering9020067 (2022).
Gaus, B., Brüning, D., Groß, S., Müller, M. & Rustenbeck, I. The changing view of insulin granule mobility: From conveyor belt to signaling hub. Frontiers in Endocrinology 13; 10.3389/fendo.2022.983152 (2022).
Gutperl, S., Wolke, M., Jasch, K. & Scholl, S. Separation Efficiency Measurements with Non-Volatile Components and Elevated Feed Viscosities. Chemical Engineering and Technology 45, 1414–1423; 10.1002/ceat.202200063 (2022).
Hagen, J., Arafat, R., Abraham, T. & Herrmann, C. Function oriented biological transformation of a lubrication process system. Procedia CIRP 110; 10.1016/j.procir.2022.06.007 (2022).
Jury, M., Matthiesen, I., Rasti Boroojeni, F., Ludwig, S. L., Civitelli, L., Winkler, T. E., Selegård, R., Herland, A. & Aili, D. Bioorthogonally Cross-Linked Hyaluronan–Laminin Hydrogels for 3D Neuronal Cell Culture and Biofabrication. Advanced Healthcare Materials 11; 10.1002/adhm.202102097 (2022).
Kaspar, F. & Schallmey, A. Chemo-enzymatic synthesis of natural products and their analogs. Current Opinion in Biotechnology 77; 10.1016/j.copbio.2022.102759 (2022).
Kempfert, M., Willbold, E., Loewner, S., Blume, C., Pitts, J., Menzel, H., Roger, Y., Hoffmann, A., Angrisani, N. & Reifenrath, J. Polycaprolactone-Based 3D-Printed Scaffolds as Potential Implant Materials for Tendon-Defect Repair. Journal of Functional Biomaterials 13; 10.3390/jfb13040160 (2022).
Klein, A.-K. & Dietzel, A. A Primer on Microfluidics: From Basic Principles to Microfabrication. Advances in Biochemical Engineering/Biotechnology 179, 17–35; 10.1007/10_2020_156 (2022).
Klein, A.-K. & Dietzel, A. Microfluidic Systems for Antimicrobial Susceptibility Testing. Advances in Biochemical Engineering/Biotechnology 179, 291–309; 10.1007/10_2021_164 (2022).
Koch, E. V., Ledwig, V., Bendas, S., Reichl, S. & Dietzel, A. Tissue Barrier-on-Chip: A Technology for Reproducible Practice in Drug Testing. Pharmaceutics 14; 10.3390/pharmaceutics14071451 (2022).
Krebs, F., Burger, U., Dörks, S., Kramer, M. & Wätzig, H. Two quality and stability indicating imaged CIEF methods for mRNA vaccines. Electrophoresis 43, 1971–1983; 10.1002/elps.202200123 (2022).
Kubannek, F., Block, J., Munirathinam, B. & Krull, R. Reaction kinetics of anodic biofilms under changing substrate concentrations: Uncovering shifts in Nernst-Monod curves via substrate pulses. Engineering in Life Sciences 22, 152–164; 10.1002/elsc.202100088 (2022).
Kubiak, M., Kampen, I. & Schilde, C. Structure-Based Modeling of the Mechanical Behavior of Cross-Linked Enzyme Crystals. Crystals 12; 10.3390/cryst12040441 (2022).
Kurzbach, E., Strieker, M. & Wittstock, U. Production of benzylglucosinolate in genetically engineered carrot suspension cultures. Plant Biotechnology 39, 241–250; 10.5511/plantbiotechnology.22.0509a (2022).
Laible, A. R., Dinius, A., Schrader, M., Krull, R., Kwade, A., Briesen, H. & Schmideder, S. Effects and interactions of metal oxides in microparticle-enhanced cultivation of filamentous microorganisms. Engineering in Life Sciences 22, 725–743; 10.1002/elsc.202100075 (2022).
Last, T. S., Winkler, T. E., Stemme, G. & Roxhed, N. Self-sealing MEMS spray-nozzles to prevent bacterial contamination of portable inhalers for aqueous drug delivery. Biomedical Microdevices 24; 10.1007/s10544-022-00628-w (2022).
Lenz, J., Fuest, F., Finke, J. H., Bunjes, H., Kwade, A. & Juhnke, M. Tablet Disintegration and Dispersion under In Vivo-like Hydrodynamic Conditions. Pharmaceutics 14; 10.3390/pharmaceutics14010208 (2022).
Liebmann, M., Grupe, K., Asuaje Pfeifer, M., Rustenbeck, I. & Scherneck, S. Differences in lipid metabolism in acquired versus preexisting glucose intolerance during gestation: role of free fatty acids and sphingosine-1-phosphate. Lipids in Health and Disease 21; 10.1186/s12944-022-01706-x (2022).
Liebmann, M., Pfeifer, M. A., Grupe, K. & Scherneck, S. Estradiol (E2) Improves Glucose‐Stimulated Insulin Secretion and Stabilizes GDM Progression in a Prediabetic Mouse Model. International Journal of Molecular Sciences 23; 10.3390/ijms23126693 (2022).
Mareczek, L., Riehl, C., Harms, M. & Reichl, S. Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol Powders. Pharmaceutics 14; 10.3390/pharmaceutics14102128 (2022).
Martin, N. L., Kononova, N., Cerdas, F. & Herrmann, C. LCA-based framework to support planning of centralized vs. decentralized production of solid pharmaceuticals. Procedia CIRP 105; 10.1016/j.procir.2022.02.022 (2022).
Matthiesen, I., Nasiri, R., Tamashiro Orrego, A., Winkler, T. E. & Herland, A. Metabolic Assessment of Human Induced Pluripotent Stem Cells-Derived Astrocytes and Fetal Primary Astrocytes: Lactate and Glucose Turnover. Biosensors 12; 10.3390/bios12100839 (2022).
Maurer, V., Zarinwall, A., Wang, Z., Wundrack, S., Wundrack, N., Ag Seleci, D., Helm, V., Otenko, D., Frank, C., Schaper, F., Stosch, R. & Garnweitner, G. All-in-one superparamagnetic and SERS-active niosomes for dual-targeted in vitro detection of breast cancer cells. Sens. Diagn. 1, 469–484; 10.1039/D2SD00020B (2022).
Minkner, R., Boonyakida, J., Park, E. Y. & Wätzig, H. Oligonucleotide separation techniques for purification and analysis: What can we learn for today’s tasks? Electrophoresis 43, 2402–2427; 10.1002/elps.202200079 (2022).
Mokrus, M. & Menzel, H. Thermoresponsive Glycopolypeptide Containing Block Copolymers, Particle Formation, and Lectin Interaction. Macromolecular Bioscience 22; 10.1002/mabi.202100518 (2022).
Ouazzou, A. A., Harshe, Y. M., Meunier, V., Finke, J. H. & Heinrich, S. Influence of Process Parameters and Particle Size Distribution on Mechanical Properties of Tablets. Chemie-Ingenieur-Technik; 10.1002/cite.202200157 (2022).
Panten, U., Brüning, D. & Rustenbeck, I. Regulation of insulin secretion in mouse islets: metabolic amplification by alpha-ketoisocaproate coincides with rapid and sustained increase in acetyl-CoA content. Naunyn-Schmiedeberg’s Archives of Pharmacology; 10.1007/s00210-022-02290-8 (2022).
Pfeifer, M. A., Liebmann, M., Beuerle, T., Grupe, K. & Scherneck, S. Role of Serotonin (5-HT) in GDM Prediction Considering Islet and Liver Interplay in Prediabetic Mice during Gestation. International Journal of Molecular Sciences 23; 10.3390/ijms23126434 (2022).
Puckhaber, D., Finke, J. H., David, S., Serratoni, M., Zafar, U., John, E., Juhnke, M. & Kwade, A. Prediction of the impact of lubrication on tablet compactibility. International Journal of Pharmaceutics 617; 10.1016/j.ijpharm.2022.121557 (2022).
Puckhaber, D., Kathrin Schomberg, A., Kwade, A. & Henrik Finke, J. A compactibility-based lubricant dispersion model describing the effect of formulation and paddle speed. International Journal of Pharmaceutics 628; 10.1016/j.ijpharm.2022.122300 (2022).
Russo, G., Unkauf, T., Meier, D., Wenzel, E. V., Langreder, N., Schneider, K.-T., Wiesner, R., Bischoff, R., Stadler, V. & Dübel, S. In vitro evolution of myc-tag antibodies: In-depth specificity and affinity analysis of Myc1-9E10 and Hyper-Myc. Biological Chemistry 403, 479–494; 10.1515/hsz-2021-0405 (2022).
Schmidt, J., Wölker, J., Lippmann, P. & Ott, I. Microwave assisted synthesis of rhodium(Ⅰ) N-heterocyclic carbene complexes and their cytotoxicity against tumor cell lines. Journal of Organometallic Chemistry 964; 10.1016/j.jorganchem.2022.122300 (2022).
Schwab, R. & Reichl, S. Dexamethasone-loaded keratin films for ocular surface reconstruction. Journal of Materials Science: Materials in Medicine 33; 10.1007/s10856-021-06638-z (2022).
Solarczek, J., Kaspar, F., Bauer, P. & Schallmey, A. G-type Halohydrin Dehalogenases Catalyze Ring Opening Reactions of Cyclic Epoxides with Diverse Anionic Nucleophiles**. Chemistry - A European Journal 28; 10.1002/chem.202202343 (2022).
Spiegel, C., Aselmeyer, F., Augustin, W. & Scholl, S. Quantification method for cleaning-in-place procedures in micro structured equipment. Food and Bioproducts Processing 134, 150–162; 10.1016/j.fbp.2022.05.010 (2022).
Staar, M., Henke, S., Blankenfeldt, W. & Schallmey, A. Biocatalytically Active and Stable Cross-Linked Enzyme Crystals of Halohydrin Dehalogenase HheG by Protein Engineering. ChemCatChem 14; 10.1002/cctc.202200145 (2022).
Staar, M., Staar, S. & Schallmey, A. Crystal Contact Engineering for Enhanced Cross-Linking Efficiency of HheG Crystals. Catalysts 12; 10.3390/catal12121553 (2022).
Staud, R., Heller, D., Knüpfer, L., Heitkam, S., Einfalt, D., Jasch, K. & Scholl, S. Minimal-Invasive Method for the Evaluation of Liquid Fractions in Foams with a Point Level Sensor. Chemical Engineering and Technology 45, 1397–1403; 10.1002/ceat.202200072 (2022).
Steiner, D., Schumann, L. V. & Bunjes, H. Processing of Lipid Nanodispersions into Solid Powders by Spray Drying. Pharmaceutics 14; 10.3390/pharmaceutics14112464 (2022).
Sundermann, J., Sydow, S., Burmeister, L., Hoffmann, A., Menzel, H. & Bunjes, H. Spatially and Temporally Controllable BMP-2 and TGF-β3Double Release from Polycaprolactone Fiber Scaffolds via Chitosan-Based Polyelectrolyte Coatings. ACS Biomaterials Science and Engineering; 10.1021/acsbiomaterials.1c01585 (2021).
Tang, B., Bendas, S., Krajka, V., May, T., Moritz, A., Constantinou, I., Reichl, S. & Dietzel, A. Self-loading microfluidic platform with ultra-thin nanoporous membrane for organ-on-chip by wafer-level processing. Front. Sens. 3, 30; 10.3389/fsens.2022.974895 (2022).
Thon, C., Böttcher, A.-C., Möhlen, F., Yu, M., Kwade, A. & Schilde, C. Multi-modal framework to model wet milling through numerical simulations and artificial intelligence (part 1). Chemical Engineering Journal 449; 10.1016/j.cej.2022.137794 (2022).
Thon, C., Böttcher, A.-C., Möhlen, F., Yu, M., Kwade, A. & Schilde, C. Multi-modal framework to model wet milling through numerical simulations and artificial intelligence (part 2). Chemical Engineering Journal 450; 10.1016/j.cej.2022.137947 (2022).
Tidau, M. & Finke, J. H. Modified release kinetics in dual filament 3D printed individualized oral dosage forms. European Journal of Pharmaceutical Sciences 175; 10.1016/j.ejps.2022.106221 (2022).
Viebrock, K., Rabl, D., Meinen, S., Wunder, P., Meyer, J.-A., Frey, L. J., Rasch, D., Dietzel, A., Mayr, T. & Krull, R. Microsensor in Microbioreactors: Full Bioprocess Characterization in a Novel Capillary-Wave Microbioreactor. Biosensors 12; 10.3390/bios12070512 (2022).
Wewers, M., Finke, J. H., Czyz, S., van Eerdenbrugh, B., John, E., Büch, G., Juhnke, M., Bunjes, H. & Kwade, A. Evaluation of the Formulation Parameter-Dependent Redispersibility of API Nanoparticles from Fluid Bed Granules. Pharmaceutics 14; 10.3390/pharmaceutics14081688 (2022).
Winkler, C. M., Kuhn, A. I., Hentschel, G. & Glasmacher, B. A Review on Novel Channel Materials for Particle Image Velocimetry Measurements—Usability of Hydrogels in Cardiovascular Applications. Gels 8; 10.3390/gels8080502 (2022).
Wullenweber, M. S., Kottmeier, J., Kampen, I., Dietzel, A. & Kwade, A. Simulative Investigation of Different DLD Microsystem Designs with Increased Reynolds Numbers Using a Two-Way Coupled IBM-CFD/6-DOF Approach. Processes 10; 10.3390/pr10020403 (2022).
Wünsch, I., Finke, J. H., John, E., Juhnke, M. & Kwade, A. Influence of the drug deformation behaviour on the predictability of compressibility and compactibility of binary mixtures. International Journal of Pharmaceutics 626; 10.1016/j.ijpharm.2022.122117 (2022).
Zagst, H., Elgert, C., Behrends, S. & Wätzig, H. Combination of strong anion exchange liquid chromatography with microchip capillary electrophoresis sodium dodecyl sulfate for rapid two-dimensional separations of complex protein mixtures. Analytical and Bioanalytical Chemistry 414, 1699–1712; 10.1007/s00216-021-03797-4 (2022).
Zarinwall, A., Maurer, V., Pierick, J., Oldhues, V. M., Porsiel, J. C., Finke, J. H. & Garnweitner, G. Amorphization and modified release of ibuprofen by post-synthetic and solvent-free loading into tailored silica aerogels. Drug Delivery 29, 2086–2099; 10.1080/10717544.2022.2092237 (2022).
Zhou, M., Heide, C. von der & Dietzel, A. Four-Level micro-Via Technology (4LμV) for ASIC Integration in Active Flexible Sensor Arrays. Sensors 22; 10.3390/s22134723 (2022).
Ag Seleci, D., Maurer, V., Barlas, F. B., Porsiel, J. C., Temel, B., Ceylan, E., Timur, S., Stahl, F., Scheper, T. & Garnweitner, G. Transferrin-Decorated Niosomes with Integrated InP/ZnS Quantum Dots and Magnetic Iron Oxide Nanoparticles: Dual Targeting and Imaging of Glioma 22; 10.3390/ijms22094556 (2021).
Bertoglio, F., Fühner, V., Ruschig, M., Heine, P. A., Abassi, L., Klünemann, T., Rand, U., Meier, D., Langreder, N., Steinke, S., Ballmann, R., Schneider, K.-T., Roth, K. D. R., Kuhn, P., Riese, P., Schäckermann, D., Korn, J., Koch, A., Chaudhry, M. Z., Eschke, K., Kim, Y., Zock-Emmenthal, S., Becker, M., Scholz, M., Moreira, G. M. S. G., Wenzel, E. V., Russo, G., Garritsen, H. S. P., Casu, S., Gerstner, A., Roth, G., Adler, J., Trimpert, J., Hermann, A., Schirrmann, T., Dübel, S., Frenzel, A., van den Heuvel, J., Čičin-Šain, L., Schubert, M. & Hust, M. A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2-RBD interface and is tolerant to most known RBD mutations. Cell Reports 36; 10.1016/j.celrep.2021.109433 (2021).
Bertoglio, F., Meier, D., Langreder, N., Steinke, S., Rand, U., Simonelli, L., Heine, P. A., Ballmann, R., Schneider, K.-T., Roth, K. D. R., Ruschig, M., Riese, P., Eschke, K., Kim, Y., Schäckermann, D., Pedotti, M., Kuhn, P., Zock-Emmenthal, S., Wöhrle, J., Kilb, N., Herz, T., Becker, M., Grasshoff, M., Wenzel, E. V., Russo, G., Kröger, A., Brunotte, L., Ludwig, S., Fühner, V., Krämer, S. D., Dübel, S., Varani, L., Roth, G., Čičin-Šain, L., Schubert, M. & Hust, M. SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface. Nature Communications 12; 10.1038/s41467-021-21609-2 (2021).
Bode, T., Höltje, K., Leal-Marin, S., Müller, M. & Glasmacher, B. Evaluation and Implementation of Biocompatible Methods for the Cross-linking of Plasma Proteins. Current Directions in Biomedical Engineering 7, 187–190; 10.1515/cdbme-2021-2048 (2021).
Böl, M., Schrinner, K., Tesche, S. & Krull, R. Challenges of influencing cellular morphology by morphology engineering techniques and mechanical induced stress on filamentous pellet systems - A critical review. Engineering in Life Sciences 21, 51–67; 10.1002/elsc.202000060 (2021).
Bolze, H., Riewe, J., Bunjes, H., Dietzel, A. & Burg, T. P. Continuous Production of Lipid Nanoparticles by Ultrasound-Assisted Microfluidic Antisolvent Precipitation. Chemical Engineering and Technology 44, 1641–1650; 10.1002/ceat.202100149 (2021).
Bolze, H., Riewe, J., Bunjes, H., Dietzel, A. & Burg, T. P. Protective Filtration for Microfluidic Nanoparticle Precipitation for Pharmaceutical Applications. Chemical Engineering and Technology 44, 457–464; 10.1002/ceat.202000475 (2021).
Böttcher, A.-C., Schilde, C. & Kwade, A. Experimental assessment of grinding bead velocity distributions and stressing conditions in stirred media mills. Advanced Powder Technology 32, 413–423; 10.1016/j.apt.2020.12.022 (2021).
Böttcher, A.-C., Thon, C., Fragnière, G., Chagas, A., Schilde, C. & Kwade, A. Rigidly-mounted roll mill as breakage tester for characterizing fine particle breakage. Powder Technology 383, 554–563; 10.1016/j.powtec.2021.01.055 (2021).
Bourgat, Y., Mikolai, C., Stiesch, M., Klahn, P. & Menzel, H. Enzyme-responsive nanoparticles and coatings made from alginate/peptide ciprofloxacin conjugates as drug release system. Antibiotics 10; 10.3390/antibiotics10060653 (2021).
Bourgat, Y., Tiersch, B., Koetz, J. & Menzel, H. Enzyme Degradable Polymersomes from Chitosan-g-[poly-l-lysine-block-ε-caprolactone] Copolymer. Macromolecular Bioscience 21; 10.1002/mabi.202000259 (2021).
Brüning, D., Hatlapatka, K., Lier-Glaubitz, V., Andermark, V., Scherneck, S., Ott, I. & Rustenbeck, I. Pharmacological inhibition of thioredoxin reductase increases insulin secretion and diminishes beta cell viability. Naunyn-Schmiedeberg's Archives of Pharmacology 394, 1133–1142; 10.1007/s00210-020-02046-2 (2021).
Buchberger, A., Schepergerdes, L., Flaβhoff, M., Kunick, C. & Köster, R. W. A novel inhibitor rescues cerebellar defects in a zebrafish model of down syndrome-associated kinase Dyrk1A overexpression. Journal of Biological Chemistry 297; 10.1016/j.jbc.2021.100853 (2021).
Burmeister, H., Dietze, P., Preu, L., Bandow, J. E. & Ott, I. Evaluation of ruthenium(Ii) n-heterocyclic carbene complexes as antibacterial agents and inhibitors of bacterial thioredoxin reductase. Molecules 26; 10.3390/molecules26144282 (2021).
Büssing, R., Karge, B., Lippmann, P., Jones, P. G., Brönstrup, M. & Ott, I. Gold(I) and Gold(III) N-Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase. ChemMedChem 16, 3402–3409; 10.1002/cmdc.202100381 (2021).
Büssing, R., Ott, I. & Jonesb, P. G. Crystal structures of the gold NHC complex bis (4-bromo-1,3-di ethyl imidazol-2-yl idene)gold(I) iodide and its 1:1 adduct with trans-bis (4-bromo-1,3-diethyl-imidazol-2-yl idene)di iodido gold(III) iodide. Acta Crystallographica Section E: Crystallographic Communications 77, 1249–1252; 10.1107/S2056989021011488 (2021).
Cabiscol, R., Finke, J. H. & Kwade, A. A bi-directional DEM-PBM coupling to evaluate chipping and abrasion of pharmaceutical tablets. Advanced Powder Technology 32, 2839–2855; 10.1016/j.apt.2021.06.002 (2021).
Dübel, S., Herrmann, A., Schirrmann, T., Frenzel, A. & Hust, M. COR-101, a human antibody against COVID-19. BioSpektrum 27, 46–48; 10.1007/s12268-021-1512-x (2021).
El-Hawari, L. & Bunjes, H. Premix membrane emulsification: Preparation and stability of medium-chain triglyceride emulsions with droplet sizes below 100 nm. Molecules 26; 10.3390/molecules26196029 (2021).
Erfle, P., Riewe, J., Bunjes, H. & Dietzel, A. Goodbye fouling: a unique coaxial lamination mixer (CLM) enabled by two-photon polymerization for the stable production of monodisperse drug carrier nanoparticles. Lab on a Chip 21, 2178–2193; 10.1039/d1lc00047k (2021).
Finke, J. H. & Kwade, A. Powder processing in pharmaceutical applications—in-depth understanding and modelling. Pharmaceutics 13, 1–3; 10.3390/pharmaceutics13020128 (2021).
Fragnière, G., Naumann, A., Schrader, M., Kwade, A. & Schilde, C. Grinding media motion and collisions in different zones of stirred media mills. Minerals 11, 1–20; 10.3390/min11020185 (2021).
Francke, N. M. & Bunjes, H. Drug localization and its effect on the physical stability of poloxamer 188-stabilized colloidal lipid emulsions. International Journal of Pharmaceutics 599; 10.1016/j.ijpharm.2021.120394 (2021).
Francke, N. M., Schneider, F., Baumann, K. & Bunjes, H. Formulation of cannabidiol in colloidal lipid carriers. Molecules 26; 10.3390/molecules26051469 (2021).
Frey, L. J., Vorländer, D., Ostsieker, H., Rasch, D., Lohse, J.-L., Breitfeld, M., Grosch, J.-H., Wehinger, G. D., Bahnemann, J. & Krull, R. 3D-printed micro bubble column reactor with integrated microsensors for biotechnological applications: From design to evaluation. Scientific Reports 11; 10.1038/s41598-021-86654-9 (2021).
Früh, E., Elgert, C., Eggert, F., Scherneck, S. & Rustenbeck, I. Glucagonotropic and Glucagonostatic Effects of KATPChannel Closure and Potassium Depolarization. Endocrinology (United States) 162; 10.1210/endocr/bqaa136 (2021).
Gaus, B., Brüning, D., Hatlapatka, K. & Rustenbeck, I. Changes in granule mobility and age contribute to changes in insulin secretion after desensitization or rest. BMJ open diabetes research & care 9; 10.1136/bmjdrc-2021-002394 (2021).
Giannis, K., Schilde, C., Finke, J. H. & Kwade, A. Modeling of high-density compaction of pharmaceutical tablets using multi-contact discrete element method. Pharmaceutics 13; 10.3390/pharmaceutics13122194 (2021).
Giannis, K., Schilde, C., Finke, J. H., Kwade, A., Celigueta, M. A., Taghizadeh, K. & Luding, S. Stress based multi-contact model for discrete-element simulations. Granular Matter 23; 10.1007/s10035-020-01060-8 (2021).
Gil-Moles, M., Türck, S., Basu, U., Pettenuzzo, A., Bhattacharya, S., Rajan, A., Ma, X., Büssing, R., Wölker, J., Burmeister, H., Hoffmeister, H., Schneeberg, P., Prause, A., Lippmann, P., Kusi-Nimarko, J., Hassell-Hart, S., McGown, A., Guest, D., Lin, Y., Notaro, A., Vinck, R., Karges, J., Cariou, K., Peng, K., Qin, X., Wang, X., Skiba, J., Szczupak, ┼., Kowalski, K., Schatzschneider, U., Hemmert, C., Gornitzka, H., Milaeva, E. R., Nazarov, A. A., Gasser, G., Spencer, J., Ronconi, L., Kortz, U., Cinatl, J., Bojkova, D. & Ott, I. Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain-like Protease PLpro. Chemistry - A European Journal 27, 17928–17940; 10.1002/chem.202103258 (2021).
Gryshkov, O., Mutsenko, V., Tarusin, D., Khayyat, D., Naujok, O., Riabchenko, E., Nemirovska, Y., Danilov, A., Petrenko, A. Y. & Glasmacher, B. Coaxial Alginate Hydrogels. From Self-Assembled 3D Cellular Constructs to Long-Term Storage. International Journal of Molecular Sciences; 10.15488/11206 (2021).
Guo, Y., Nassar, S., Ma, L., Feng, G., Li, X., Chen, M., Chai, T., Abdel-Rahman, I. A. M., Beuerle, T., Beerhues, L., Wang, H. & Liu, B. Octaketide Synthase from Polygonum cuspidatum Implements Emodin Biosynthesis in Arabidopsis thaliana. Plant & cell physiology 62, 424–435; 10.1093/pcp/pcaa135 (2021).
Hildebrand, T., Nogueira, L., Sunde, P. T., Ørstavik, D., Glasmacher, B. & Haugen, H. J. Contrast-enhanced nano-CT reveals soft dental tissues and cellular layers. International Endodontic Journal 54, 1275–1288; 10.1111/iej.13527 (2021).
Ihnatenko, I., Jones, P. G. & Kunick, C. (E)-5-(methoxyimino)-1,3,4,5-tetrahydro-2h-benzo[b]azepin-2-one. MolBank 2021; 10.3390/M1293 (2021).
Karatas, M., Chaikuad, A., Berger, B., Kubbutat, M. H. G., Totzke, F., Knapp, S. & Kunick, C. 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a “Cut and Glue” Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors. Molecules 26; 10.3390/molecules26061611 (2021).
Keppler, J. K., Heyse, A., Scheidler, E., Uttinger, M. J., Fitzner, L., Jandt, U., Heyn, T. R., Lautenbach, V., Loch, J. I., Lohr, J., Kieserling, H., Günther, G., Kempf, E., Grosch, J.-H., Lewiński, K., Jahn, D., Lübbert, C., Peukert, W., Kulozik, U., Drusch, S., Krull, R., Schwarz, K. & Biedendieck, R. Towards recombinantly produced milk proteins: Physicochemical and emulsifying properties of engineered whey protein beta-lactoglobulin variants. Food Hydrocolloids 110; 10.1016/j.foodhyd.2020.106132 (2021).
Knoke, S. & Bunjes, H. Transfer investigations of lipophilic drugs from lipid nanoemulsions to lipophilic acceptors: Contributing effects of cholesteryl esters and albumin as acceptor structures. Pharmaceuticals 14; 10.3390/PH14090865 (2021).
Knoke, S. & Bunjes, H. Transfer of lipophilic drugs from nanoemulsions into lipid-containing alginate microspheres. Pharmaceutics 13, 1–16; 10.3390/pharmaceutics13020173 (2021).
Krebs, F., Scheller, C., Grove-Heike, K., Pohl, L. & Wätzig, H. Isoelectric point determination by imaged CIEF of commercially available SARS-CoV-2 proteins and the hACE2 receptor. Electrophoresis 42, 687–692; 10.1002/elps.202100015 (2021).
Kubiak, M., Mayer, J., Kampen, I., Schilde, C. & Biedendieck, R. Structure-properties correlation of cross-linked penicillin G acylase crystals. Crystals 11; 10.3390/cryst11040451 (2021).
Kubiak, M., Staar, M., Kampen, I., Schallmey, A. & Schilde, C. The depth-dependent mechanical behavior of anisotropic native and cross-linked hheg enzyme crystals. Crystals 11; 10.3390/cryst11070718 (2021).
Laible, A. R., Dinius, A., Schrader, M., Krull, R., Kwade, A., Briesen, H. & Schmideder, S. Effects and interactions of metal oxides in microparticle-enhanced cultivation of filamentous microorganisms. Engineering in Life Sciences; 10.1002/elsc.202100075 (2021).
Lande, D. H., Nasereddin, A., Alder, A., Gilberger, T. W., Dzikowski, R., Grünefeld, J. & Kunick, C. Synthesis and antiplasmodial activity of bisindolylcyclobutenediones. Molecules 26; 10.3390/molecules26164739 (2021).
Lenz, J., Bunjes, H., Kwade, A. & Juhnke, M. An improved method for the simultaneous determination of water uptake and swelling of tablets. International Journal of Pharmaceutics 595; 10.1016/j.ijpharm.2021.120229 (2021).
Lenz, J., Finke, J. H., Bunjes, H., Kwade, A. & Juhnke, M. Tablet formulation development focusing on the functional behaviour of water uptake and swelling. International Journal of Pharmaceutics: X 3; 10.1016/j.ijpx.2021.100103 (2021).
Lorenz, T., Kirschke, M., Ledwig, V., Reichl, S. & Dietzel, A. Microfluidic system for in vivo-like drug permeation studies with dynamic dilution profiles. Bioengineering 8; 10.3390/bioengineering8050058 (2021).
Martin, N. L., Schomberg, A. K., Finke, J. H., Abraham, T. G. -M., Kwade, A. & Herrmann, C. Process modeling and simulation of tableting - an agent-based simulation methodology for direct compression. Pharmaceutics 13; 10.3390/pharmaceutics13070996 (2021).
Maurer, V., Altin, S., Ag Seleci, Didem, Zarinwall, A., Temel, B., Vogt, P. M., Strauß, S., Stahl, F., Scheper, T., Bucan, V. & Garnweitner, G. In-Vitro Application of Magnetic Hybrid Niosomes: Targeted siRNA-Delivery for Enhanced Breast Cancer Therapy. Pharmaceutics 13, 394; 10.3390/pharmaceutics13030394 (2021).
Meyer, V., Cairns, T., Barthel, L., King, R., Kunz, P., Schmideder, S., Müller, H., Briesen, H., Dinius, A. & Krull, R. Understanding and controlling filamentous growth of fungal cell factories: novel tools and opportunities for targeted morphology engineering. Fungal Biology and Biotechnology 8; 10.1186/s40694-021-00115-6 (2021).
Miethke, L., Prziwara, P., Finke, J. H. & Breitung-Faes, S. Opposing Effects of Additives in Dry Milling and Tableting of Organic Particles. Pharmaceutics 13, 1434; 10.3390/pharmaceutics13091434 (2021).
Müller, J. P., Scholl, S., Kunick, C. & Klempnauer, K.-H. Expression of protein kinase HIPK2 is subject to a quality control mechanism that acts during translation and requires its kinase activity to prevent degradation of nascent HIPK2. Biochimica et Biophysica Acta - Molecular Cell Research 1868; 10.1016/j.bbamcr.2020.118894 (2021).
Onugwu, A. L., Agbo, C. P., Nwagwu, C. S., Uzondu, S. E., Echezona, A. C., Nwabueze Ogbonna, J. D., Kenechukwu, F. C., Umeyor, C. E., Uronnachi, E. M., Akpa, P. A., Momoh, M. A., Nnamani, P. O., Müller-Goymann, C. C. & Attama, A. A. Development of lipid-based microsuspensions for improved ophthalmic delivery of gentamicin sulphate. Therapeutic Delivery 12, 671–683; 10.4155/tde-2021-0039 (2021).
Ritters, L., Tian, Y. & Reichl, S. Spray-Dried Paracetamol/Polyvinylpyrrolidone Amorphous Solid Dispersions: Part I-Stability of Powders and Tablets. Pharmaceutics 13; 10.3390/pharmaceutics13111938 (2021).
Roth, K. D. R., Wenzel, E. V., Ruschig, M., Steinke, S., Langreder, N., Heine, P. A., Schneider, K.-T., Ballmann, R., Fühner, V., Kuhn, P., Schirrmann, T., Frenzel, A., Dübel, S., Schubert, M., Moreira, G. M. S. G., Bertoglio, F., Russo, G. & Hust, M. Developing Recombinant Antibodies by Phage Display Against Infectious Diseases and Toxins for Diagnostics and Therapy. Frontiers in Cellular and Infection Microbiology 11; 10.3389/fcimb.2021.697876 (2021).
Rustenbeck, I., Schulze, T., Morsi, M., Alshafei, M. & Panten, U. What is the metabolic amplification of insulin secretion and is it (Still) relevant? Metabolites 11; 10.3390/metabo11060355 (2021).
Scheller, C., Krebs, F., Wiesner, R., Wätzig, H. & Oltmann-Norden, I. A comparative study of CE-SDS, SDS-PAGE, and Simple Western-Precision, repeatability, and apparent molecular mass shifts by glycosylation. Electrophoresis 42, 1521–1531; 10.1002/elps.202100068 (2021).
Schneider, K.-T., Kirmann, T., Wenzel, E. V., Grosch, J.-H., Polten, S., Meier, D., Becker, M., Matejtschuk, P., Hust, M., Russo, G. & Dübel, S. Shelf-Life Extension of Fc-Fused Single Chain Fragment Variable Antibodies by Lyophilization. Frontiers in Cellular and Infection Microbiology 11; 10.3389/fcimb.2021.717689 (2021).
Schomberg, A. K., Diener, A., Wünsch, I., Finke, J. H. & Kwade, A. The use of X-ray microtomography to investigate the microstructure of pharmaceutical tablets: Potentials and comparison to common physical methods. International Journal of Pharmaceutics: X 3; 10.1016/j.ijpx.2021.100090 (2021).
Schrinner, K., Althof, K., Ebersbach, A. T., Grosch, J.-H. & Krull, R. XAD Resins for Increased Rebeccamycin Productivity in Cultivations of Lentzea aerocolonigenes. Chemie-Ingenieur-Technik 93, 282–288; 10.1002/cite.202000131 (2021).
Schrinner, K., Schrader, M., Niebusch, J., Althof, K., Schwarzer, F. A., Nowka, P.-F., Dinius, A., Kwade, A. & Krull, R. Macroparticle-enhanced cultivation of Lentzea aerocolonigenes: Variation of mechanical stress and combination with lecithin supplementation for a significantly increased rebeccamycin production. Biotechnology and Bioengineering 118, 3984–3995; 10.1002/bit.27875 (2021).
Schulze, T., Mattern, K., Erfle, P., Brüning, D., Scherneck, S., Dietzel, A. & Rustenbeck, I. A Parallel Perifusion Slide From Glass for the Functional and Morphological Analysis of Pancreatic Islets. Frontiers in Bioengineering and Biotechnology 9; 10.3389/fbioe.2021.615639 (2021).
Singh, P., Kaufholdt, D., Awadalah, M., Hänsch, R., Beerhues, L. & Gaid, M. Cytosolic aromatic aldehyde dehydrogenase provides benzoic acid for xanthone biosynthesis in Hypericum. Plant Physiology and Biochemistry 160, 82–93; 10.1016/j.plaphy.2021.01.011 (2021).
Steiner, D. & Bunjes, H. Influence of process and formulation parameters on the preparation of solid lipid nanoparticles by dual centrifugation. International Journal of Pharmaceutics: X 3; 10.1016/j.ijpx.2021.100085 (2021).
Steiner, D., Emmendörffer, J. F. & Bunjes, H. Orodispersible films: A delivery platform for solid lipid nanoparticles? Pharmaceutics 13; 10.3390/pharmaceutics13122162 (2021).
Sundermann, J., Oehmichen, S., Sydow, S., Burmeister, L., Quaas, B., Hänsch, R., Rinas, U., Hoffmann, A., Menzel, H. & Bunjes, H. Varying the sustained release of BMP-2 from chitosan nanogel-functionalized polycaprolactone fiber mats by different polycaprolactone surface modifications. Journal of Biomedical Materials Research - Part A 109, 600–614; 10.1002/jbm.a.37045 (2021).
Sundermann, J., Sydow, S., Burmeister, L., Hoffmann, A., Menzel, H. & Bunjes, H. Elisa-and activity assay-based quantification of bmp-2 released in vitro can be biased by solubility "physiological" buffers and an interfering effect of chitosan. Pharmaceutics 13; 10.3390/pharmaceutics13040582 (2021).
Tesche, S. & Krull, R. An image analysis method to quantify heterogeneous filamentous biomass based on pixel intensity values ÔÇô Interrelation of macro- and micro-morphology in Actinomadura namibiensis. Biochemical Engineering Journal 166; 10.1016/j.bej.2020.107865 (2021).
Triemer, S., Schulze, M., Wriedt, B., Schenkendorf, R., Ziegenbalg, D., Krewer, U. & Seidel-Morgenstern, A. Kinetic analysis of the partial synthesis of artemisinin: Photooxygenation to the intermediate hydroperoxide. Journal of Flow Chemistry 11, 641–659; 10.1007/s41981-021-00181-2 (2021).
van der Burg, D., Josefsson, L., Mikkonen, S., Chotteau, V., Emmer, Å., Wätzig, H. & Sänger-van de Griend, C. E. Method development for mono- and disaccharides monitoring in cell culture medium by capillary and microchip electrophoresis. Electrophoresis; 10.1002/elps.202100213 (2021).
Wätzig, H., Hoffstedt, M., Krebs, F., Minkner, R., Scheller, C. & Zagst, H. Protein analysis and stability: Overcoming trial-and-error by grouping according to physicochemical properties. Journal of Chromatography A 1649; 10.1016/j.chroma.2021.462234 (2021).
Wiesner, R., Scheller, C., Krebs, F., Wätzig, H. & Oltmann-Norden, I. A comparative study of CE-SDS, SDS-PAGE, and Simple Western: Influences of sample preparation on molecular weight determination of proteins. Electrophoresis 42, 206–218; 10.1002/elps.202000199 (2021).
Wünsch, I., Finke, J. H., John, E., Juhnke, M. & Kwade, A. The influence of particle size on the application of compression and compaction models for tableting. International Journal of Pharmaceutics 599; 10.1016/j.ijpharm.2021.120424 (2021).
Wünsch, I., Michel, S., Finke, J. H., John, E., Juhnke, M. & Kwade, A. How can single particle compression and nanoindentation contribute to the understanding of pharmaceutical powder compression? European Journal of Pharmaceutics and Biopharmaceutics 165, 203–218; 10.1016/j.ejpb.2021.05.009 (2021).
Xiang, L., Kaspar, F., Schallmey, A. & Constantinou, I. Two-phase biocatalysis in microfluidic droplets. Biosensors 11; 10.3390/bios11110407 (2021).
Zarinwall, A., Asadian-Birjand, M., Seleci, D. A., Maurer, V., Trautner, A., Garnweitner, G. & Fuchs, H. Magnetic nanoparticle-based dianthin targeting for controlled drug release using the endosomal escape enhancer SO1861. Nanomaterials 11; 10.3390/nano11041057 (2021).
Al-Halhouli, A., Doofesh, Z., Albagdady, A. & Dietzel, A. High-Efficiency small sample microparticle fractionation on a femtosecond laser-machined microfluidic disc. Micromachines 11; 10.3390/mi11020151 (2020).
Benninger, G. & Scholl, S. Forschung vernetzen hilft Mehrwert erzielen. CITplus 23, 14–16; 10.1002/citp.202001109 (2020).
Bliatsiou, C., Schrinner, K., Waldherr, P., Tesche, S., Böhm, L., Kraume, M. & Krull, R. Rheological characteristics of filamentous cultivation broths and suitable model fluids. Biochemical Engineering Journal 163; 10.1016/j.bej.2020.107746 (2020).
Böl, M., Iyer, R., Garcés-Schröder, M., Kohn, S. & Dietzel, A. Mechano-geometrical skeletal muscle fibre characterisation under cyclic and relaxation loading. Journal of the Mechanical Behavior of Biomedical Materials 110; 10.1016/j.jmbbm.2020.104001 (2020).
Brammann, C., Bornemann, C., Kannewurf, R. & Müller-Goymann, C. C. Solid lipid microparticles for hair follicle targeting of adapalene and benzoyl peroxide - Release through targeted erosion. Journal of Drug Delivery Science and Technology 60; 10.1016/j.jddst.2020.101990 (2020).
Brammann, C. & Müller-Goymann, C. C. An update on formulation strategies of benzoyl peroxide in efficient acne therapy with special focus on minimizing undesired effects. International Journal of Pharmaceutics 578; 10.1016/j.ijpharm.2020.119074 (2020).
Busche, J. F., Möller, S., Klein, A.-K., Stehr, M., Purr, F., Bassu, M., Burg, T. P. & Dietzel, A. Nanofluidic immobilization and growth detection of escherichia coli in a chip for antibiotic susceptibility testing. Biosensors 10; 10.3390/BIOS10100135 (2020).
Cabiscol, R., Shi, H., Wünsch, I., Magnanimo, V., Finke, J. H., Luding, S. & Kwade, A. Effect of particle size on powder compaction and tablet strength using limestone. Advanced Powder Technology 31, 1280–1289; 10.1016/j.apt.2019.12.033 (2020).
Cheng, X., Haeberle, S., Luca Shytaj, I., Gama-Brambila, R. A., Theobald, J., Ghafoory, S., Wölker, J., Basu, U., Schmidt, C., Timm, A., Taškova, K., Bauer, A. S., Hoheisel, J., Tsopoulidis, N., Fackler, O. T., Savarino, A., Andrade-Navarro, M. A., Ott, I., Lusic, M., Hadaschik, E. N. & Wölfl, S. NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice. Communications Biology 3; 10.1038/s42003-019-0716-8 (2020).
Czyz, S., Wewers, M., Finke, J. H., Kwade, A., van Eerdenbrugh, B., Juhnke, M. & Bunjes, H. Spray drying of API nanosuspensions: Importance of drying temperature, type and content of matrix former and particle size for successful formulation and process development. European Journal of Pharmaceutics and Biopharmaceutics 152, 63–71; 10.1016/j.ejpb.2020.04.021 (2020).
Francke, N. M. & Bunjes, H. Influence of drug loading on the physical stability of phospholipid-stabilised colloidal lipid emulsions. International Journal of Pharmaceutics: X 2; 10.1016/j.ijpx.2020.100060 (2020).
Frey, L. J., Vorländer, D., Rasch, D., Meinen, S., Müller, B., Mayr, T., Dietzel, A., Grosch, J.-H. & Krull, R. Defining mass transfer in a capillary wave micro-bioreactor for dose-response and other cell-based assays. Biochemical Engineering Journal 161; 10.1016/j.bej.2020.107667 (2020).
Gaid, M., Singh, P., El-Awaad, I., Nagia, M. & Beerhues, L. (eds.). Biotechnological production of prenylated xanthones for pharmaceutical use. In: Pharmaceutical Biocatalysis: Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients (Jenny Stanford Publishing, Singapore, 2020).
Gelker, M., Müller-Goymann, C. C. & Viöl, W. Plasma Permeabilization of Human Excised Full-Thickness Skin by μs-and ns-pulsed DBD. Skin Pharmacology and Physiology 33, 69–76; 10.1159/000505195 (2020).
Godard, T., Zühlke, D., Richter, G., Wall, M., Rohde, M., Riedel, K., Poblete-Castro, I., Krull, R. & Biedendieck, R. Metabolic Rearrangements Causing Elevated Proline and Polyhydroxybutyrate Accumulation During the Osmotic Adaptation Response of Bacillus megaterium. Frontiers in Bioengineering and Biotechnology 8; 10.3389/fbioe.2020.00047 (2020).
Grüne, L. & Bunjes, H. Self-dispersing formulations for the delivery of poorly soluble drugs – Miscibility of phosphatidylcholines with oils and fats. European Journal of Pharmaceutics and Biopharmaceutics 151, 209–219; 10.1016/j.ejpb.2020.04.013 (2020).
Grüne, L. & Bunjes, H. Suitability of phosphatidylcholine-based formulations for liquid filling in hard capsules. European Journal of Pharmaceutical Sciences 153; 10.1016/j.ejps.2020.105470 (2020).
Hamdallah, S. I., Zoqlam, R., Erfle, P., Blyth, M., Alkilany, A. M., Dietzel, A. & Qi, S. Microfluidics for pharmaceutical nanoparticle fabrication: The truth and the myth. International Journal of Pharmaceutics 584; 10.1016/j.ijpharm.2020.119408 (2020).
Hertweck, D., Emenike, V. N., Spiess, A. C. & Schenkendorf, R. Rigorous model-based design and experimental verification of enzyme-catalyzed carboligation under enzyme inactivation. Catalysts 10; 10.3390/catal10010096 (2020).
Lladó Maldonado, S., Krull, J., Rasch, D., Panjan, P., Sesay, A. M., Marques, M., Szita, N. & Krull, R. Correction to: Application of a multiphase microreactor chemostat for the determination of reaction kinetics of Staphylococcus carnosus (Bioprocess and Biosystems Engineering, (2019), 42, 6, (953-961), 10.1007/s00449-019-02095-9). Bioprocess and Biosystems Engineering 43, 359; 10.1007/s00449-019-02225-3 (2020).
Mattern, K., Trotha, J. W., Erfle, P., Köster, R. W. & Dietzel, A. NeuroExaminer: an all-glass microfluidic device for whole-brain in vivo imaging in zebrafish. Communications Biology 3; 10.1038/s42003-020-1029-7 (2020).
Maurer, V., Frank, C., Porsiel, J. C., Zellmer, S., Garnweitner, G. & Stosch, R. Step-by-step monitoring of a magnetic and SERS-active immunosensor assembly for purification and detection of tau protein. Journal of Biophotonics 13; 10.1002/jbio.201960090 (2020).
Mayr, J. C., Rosa, L., Klinger, N., Grosch, J.-H., Harnisch, F. & Spiess, A. C. Response-Surface-Optimized and Scaled-Up Microbial Electrosynthesis of Chiral Alcohols. ChemSusChem 13, 1808–1816; 10.1002/cssc.201903428 (2020).
Mecklenfeld, A. & Raabe, G. Applicability of a thermodynamic cycle approach for a force field parametrization targeting non-aqueous solvation free energies. Journal of Computer-Aided Molecular Design 34, 71–82; 10.1007/s10822-019-00261-5 (2020).
Mecklenfeld, A. & Raabe, G. GAFF/IPolQ-Mod+LJ-Fit: Optimized force field parameters for solvation free energy predictions. ADMET and DMPK 8, 274–296; 10.5599/admet.837 (2020).
Medeiros, A., Benítez, D., Korn, R. S., Ferreira, V. C., Barrera, E., Carrión, F., Pritsch, O., Pantano, S., Kunick, C., Oliveira, C. I. de, Orban, O. & Comini, M. A. Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania. Journal of Enzyme Inhibition and Medicinal Chemistry 35, 1345–1358; 10.1080/14756366.2020.1780227 (2020).
Meise, M., Jäger, L., Wilk, A., Heitmann, T. & Scholl, S. Residence Time Characteristics of the Novel Archimedean Screw Crystallizer/Reactor. Chemie-Ingenieur-Technik 92, 1074–1082; 10.1002/cite.202000092 (2020).
Müller, J. P., Scholl, S., Kunick, C. & Klempnauer, K.-H. Expression of protein kinase HIPK2 is subject to a quality control mechanism that acts during translation and requires its kinase activity to prevent degradation of nascent HIPK2. Biochimica et biophysica acta. Molecular cell research 1868, 118894; 10.1016/j.bbamcr.2020.118894 (2021).
Puckhaber, D., Eichler, S., Kwade, A. & Finke, J. H. Impact of particle and equipment properties on residence time distribution of pharmaceutical excipients in rotary tablet presses. Pharmaceutics 12; 10.3390/pharmaceutics12030283 (2020).
Purr, F., Lowe, R. D., Stehr, M., Singh, M., Burg, T. P. & Dietzel, A. Biosensing based on optimized asymmetric optofluidic nanochannel gratings. Micro and Nano Engineering 8; 10.1016/j.mne.2020.100056 (2020).
Riewe, J., Erfle, P., Melzig, S., Kwade, A., Dietzel, A. & Bunjes, H. Antisolvent precipitation of lipid nanoparticles in microfluidic systems – A comparative study. International Journal of Pharmaceutics 579; 10.1016/j.ijpharm.2020.119167 (2020).
Schomberg, A. K., Kwade, A. & Finke, J. H. The challenge of die filling in rotary presses—a systematic study of material properties and process parameters. Pharmaceutics 12; 10.3390/pharmaceutics12030248 (2020).
Schrinner, K., Veiter, L., Schmideder, S., Doppler, P., Schrader, M., Münch, N., Althof, K., Kwade, A., Briesen, H., Herwig, C. & Krull, R. Morphological and physiological characterization of filamentous Lentzea aerocolonigenes: Comparison of biopellets by microscopy and flow cytometry. PLoS ONE 15; 10.1371/journal.pone.0234125 (2020).
Schulze, M. & Schenkendorf, R. Robust model selection: Flatness-based optimal experimental design for a biocatalytic reaction. Processes 8; 10.3390/pr8020190 (2020).
Schwarz, M., Jendrusch, M. & Constantinou, I. Spatially resolved electrical impedance methods for cell and particle characterization. Electrophoresis 41, 65–80; 10.1002/elps.201900286 (2020).
Schweda, S. I., Alder, A., Gilberger, T. & Kunick, C. 4-Arylthieno[2,3-b]pyridine-2-carboxamides Are a New Class of Antiplasmodial Agents. Molecules 25; 10.3390/molecules25143187 (2020).
Singh, P., Preu, L., Beuerle, T., Kaufholdt, D., Hänsch, R., Beerhues, L. & Gaid, M. A promiscuous coenzyme A ligase provides benzoyl-coenzyme A for xanthone biosynthesis in Hypericum. Plant Journal 104, 1472–1490; 10.1111/tpj.15012 (2020).
Steiner, D., Massing, U. & Bunjes, H. Solid lipid nanoparticles for the application of insoluble active pharmaceutical ingredients. BioSpektrum 26, 520–521; 10.1007/s12268-020-1437-8 (2020).
Stosch, M. von, Schenkendorf, R., Geldhof, G., Varsakelis, C., Mariti, M., Dessoy, S., Vandercammen, A., Pysik, A. & Sanders, M. Working within the design space: Do our static process characterization methods suffice? Pharmaceutics 12, 1–15; 10.3390/pharmaceutics12060562 (2020).
Sundermann, J., Zagst, H., Kuntsche, J., Wätzig, H. & Bunjes, H. Bone morphogenetic protein 2 (BMP-2) aggregates can be solubilized by albumin—investigation of BMP-2 aggregation by light scattering and electrophoresis. Pharmaceutics 12, 1–20; 10.3390/pharmaceutics12121143 (2020).
Tidau, M. & Finke, J. H. Additive Fertigung in der Arzneimittelproduktion. TechnoPharm 10, Nr. 3, 164–171 (2020).
Vorländer, K., Kampen, I., Finke, J. H. & Kwade, A. Along the process chain to probiotic tablets: Evaluation of mechanical impacts on microbial viability. Pharmaceutics 12; 10.3390/pharmaceutics12010066 (2020).
Wagner, S., Sánchez, J., Leester-Schädel, M., Dietzel, A., Hutterer, J., Proll, G. & Gauglitz, G. 8th GMM-Workshop:. Micro-Nano-Integration, 74–79 (2020).
Wewers, M., Czyz, S., Finke, J. H., John, E., van Eerdenbrugh, B., Juhnke, M., Bunjes, H. & Kwade, A. Influence of formulation parameters on redispersibility of naproxen nanoparticles from granules produced in a fluidized bed process. Pharmaceutics 12; 10.3390/pharmaceutics12040363 (2020).
Wünsch, I., Friesen, I., Puckhaber, D., Schlegel, T. & Finke, J. H. Scaling tableting processes from compaction simulator to rotary presses—mind the sub-processes. Pharmaceutics 12; 10.3390/pharmaceutics12040310 (2020).
Department 1: Pharmaceutical-biological Process Technology
Dittmann, J., Tesche, S., Krull, R. & Böl, M. The influence of salt-enhanced cultivation on the micromechanical behaviour of filamentous pellets. Biochemical Engineering Journal 148, 65–76; 10.1016/j.bej.2019.04.023 (2019).
Frey, L. J., Vorländer, D., Rasch, D., Ostsieker, H., Müller, B., Schulze, M., Schenkendorf, R., Mayr, T., Grosch, J.-H. & Krull, R. Novel electrodynamic oscillation technique enables enhanced mass transfer and mixing for cultivation in micro-bioreactor. Biotechnology Progress 35; 10.1002/btpr.2827 (2019).
Gaid, M., Füller, J. & Müller-Goymann, C. The Petroleum Ether Extract from Hypericum perforatum Root Cultures Exhibits Potent Antiproliferative Activity in Human Keratinocytes and Fibroblasts. Planta Medica 85, 591–598; 10.1055/a-0806-7735 (2019).
Gaid, M., Grosch, J.-H., Möller, S., Beerhues, L. & Krull, R. Toward enhanced hyperforin production in St. John's wort root cultures. Engineering in Life Sciences 19, 916–930; 10.1002/elsc.201900043 (2019).
Kleinfeldt, L., Gädke, J., Biedendieck, R., Krull, R. & Garnweitner, G. Spray-Dried Hierarchical Aggregates of Iron Oxide Nanoparticles and Their Functionalization for Downstream Processing in Biotechnology. ACS Omega 4, 16300–16308; 10.1021/acsomega.9b01549 (2019).
Lladó Maldonado, S., Panjan, P., Sun, S., Rasch, D., Sesay, A. M., Mayr, T. & Krull, R. A fully online sensor-equipped, disposable multiphase microbioreactor as a screening platform for biotechnological applications. Biotechnology and Bioengineering 116, 65–75; 10.1002/bit.26831 (2019).
Maldonado, S. L., Krull, J., Rasch, D., Panjan, P., Sesay, A. M., Marques, M., Szita, N. & Krull, R. Application of a multiphase microreactor chemostat for the determination of reaction kinetics of Staphylococcus carnosus. Bioprocess and Biosystems Engineering 42, 953–961; 10.1007/s00449-019-02095-9 (2019).
Mayr, J. C., Grosch, J.-H., Hartmann, L., Rosa, L., Spiess, A. C. & Harnisch, F. Resting Escherichia coli as Chassis for Microbial Electrosynthesis: Production of Chiral Alcohols. ChemSusChem 12, 1631–1634; 10.1002/cssc.201900413 (2019).
Nagia, M., Gaid, M., Biedermann, E., Fiesel, T., El-Awaad, I., Hänsch, R., Wittstock, U. & Beerhues, L. Sequential regiospecific gem-diprenylation of tetrahydroxyxanthone by prenyltransferases from Hypericum sp. New Phytologist 222, 318–334; 10.1111/nph.15611 (2019).
Pommerehne, K., Walisko, J., Ebersbach, A. & Krull, R. The antitumor antibiotic rebeccamycin—challenges and advanced approaches in production processes. Applied Microbiology and Biotechnology; 10.1007/s00253-019-09741-y (2019).
Tesche, S., Rösemeier-Scheumann, R., Lohr, J., Hanke, R., Büchs, J. & Krull, R. Salt-enhanced cultivation as a morphology engineering tool for filamentous actinomycetes: Increased production of labyrinthopeptin A1 in Actinomadura namibiensis. Engineering in Life Sciences 19, 781–794; 10.1002/elsc.201900036 (2019).
Department 2: Pharmaceutical-chemical Process Technology
Kahle, J., Zagst, H., Wiesner, R. & Wätzig, H. Comparative charge-based separation study with various capillary electrophoresis (CE) modes and cation exchange chromatography (CEX) for the analysis of monoclonal antibodies. Journal of Pharmaceutical and Biomedical Analysis 174, 460–470; 10.1016/j.jpba.2019.05.058 (2019).
Lechner, C., Flaßhoff, M., Falke, H., Preu, L., Loaëc, N., Meijer, L., Knapp, S., Chaikuad, A. & Kunick, C. [b]-annulated halogen-substituted indoles as potential DYRK1A inhibitors. Molecules 24; 10.3390/molecules24224090 (2019).
Masch, A., Nasereddin, A., Alder, A., Bird, M. J., Schweda, S. I., Preu, L., Doerig, C., Dzikowski, R., Gilberger, T. W. & Kunick, C. Structure-activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines. Malaria Journal 18; 10.1186/s12936-019-2725-y (2019).
Puschmann, J., Evers, D.-H., Müller-Goymann, C. C. & Herbig, M. E. Development of a design of experiments optimized method for quantification of polysorbate 80 based on oleic acid using UHPLC-MS. Journal of Chromatography A 1599, 136–143; 10.1016/j.chroma.2019.04.015 (2019).
Puschmann, J., Herbig, M. E. & Müller-Goymann, C. C. Influence of emulsifier concentration on partition behavior and chemical stability of betamethasone dipropionate in emulsion gels. International Journal of Pharmaceutics 562, 105–112; 10.1016/j.ijpharm.2019.02.044 (2019).
Rehbein, M. C., Wolters, J., Kunick, C. & Scholl, S. Continuous high-pressure operation of a pharmaceutically relevant Krapcho dealkoxycarbonylation reaction. Journal of Flow Chemistry 9, 123–131; 10.1007/s41981-019-00031-2 (2019).
Sauk, T., Henke, L., Xiao, C., Hartig, D. & Scholl, S. Continuous-Flow Di-N-Alkylation of 1H-Benzimidazole in a Fixed-Bed Reactor. Chemical Engineering and Technology 42, 2215–2222; 10.1002/ceat.201900114 (2019).
Department 3: Formulation and Packaging Technology
Ag Seleci, D., Maurer, V., Stahl, F., Scheper, T. & Garnweitner, G. Rapid Microfluidic Preparation of Niosomes for Targeted Drug Delivery. International Journal of Molecular Sciences 20; 10.3390/ijms20194696 (2019).
Brammann, C. & Mueller-Goymann, C. C. Incorporation of benzoyl peroxide nanocrystals into adapalene-loaded solid lipid microparticles: Part I – Nanocrystalline benzoyl peroxide. International Journal of Pharmaceutics 564, 171–179; 10.1016/j.ijpharm.2019.04.031 (2019).
Brammann, C. & Müller-Goymann, C. C. Incorporation of benzoyl peroxide nanocrystals into adapalene-loaded solid lipid microparticles: Part II – Solid-in-Oil dispersion of nanoparticulate benzoyl peroxide. International Journal of Pharmaceutics 572; 10.1016/j.ijpharm.2019.118792 (2019).
Cabiscol, R., Finke, J. H. & Kwade, A. Assessment of particle rearrangement and anisotropy in high-load tableting with a DEM-based elasto-plastic cohesive model. Granular Matter 21; 10.1007/s10035-019-0953-z (2019).
Gelker, M., Mrotzek, J., Ichter, A., Müller-Goymann, C. C. & Viöl, W. Influence of pulse characteristics and power density on stratum corneum permeabilization by dielectric barrier discharge. Biochimica et Biophysica Acta - General Subjects 1863, 1513–1523; 10.1016/j.bbagen.2019.05.014 (2019).
Groot, C. de, Müsken, M. & Müller-Goymann, C. C. The bidesmosidic triterpene saponins hederacoside C and ginsenoside Rb1 exhibit low affinity to cholesterol in liposomal membranes. Journal of Drug Delivery Science and Technology 53; 10.1016/j.jddst.2019.101127 (2019).
Melzig, S., Finke, J. H., Schilde, C., Vierheller, A., Dietzel, A. & Kwade, A. Fluid mechanics and process design of high-pressure antisolvent precipitation of fenofibrate nanoparticles using a customized microsystem. Chemical Engineering Journal 371, 554–564; 10.1016/j.cej.2019.04.051 (2019).
Melzig, S., Purr, F., Lorenz, T., Yan, Z., Finke, J. H., Schilde, C., Kwade, A. & Dietzel, A. Microfluidic spray drying device for process-oriented product development with low sample consumption. Microfluidics and Nanofluidics 23; 10.1007/s10404-019-2296-9 (2019).
Steiner, D., Finke, J. H. & Kwade, A. Model-based description of disintegration time and dissolution rate of nanoparticle-loaded orodispersible films. European Journal of Pharmaceutical Sciences 132, 18–26; 10.1016/j.ejps.2019.02.029 (2019).
Steiner, D., Finke, J. H. & Kwade, A. SOFTs – Structured orodispersible film templates. European Journal of Pharmaceutics and Biopharmaceutics 137, 209–217; 10.1016/j.ejpb.2019.03.001 (2019).
Tidau, M., Kwade, A. & Finke, J. H. Influence of high, disperse api load on properties along the fused-layer modeling process chain of solid dosage forms. Pharmaceutics 11; 10.3390/pharmaceutics11040194 (2019).
Wünsch, I., Finke, J. H., John, E., Juhnke, M. & Kwade, A. A mathematical approach to consider solid compressibility in the compression of pharmaceutical powders. Pharmaceutics 11; 10.3390/pharmaceutics11030121 (2019).
Department 4: Microdevices and Analytics
Al-Halhouli, A., Albagdady, A., Al-Faqheri, W., Kottmeier, J., Meinen, S., Frey, L. J., Krull, R. & Dietzel, A. Enhanced inertial focusing of microparticles and cells by integrating trapezoidal microchambers in spiral microfluidic channels. RSC Advances 9, 19197–19204; 10.1039/c9ra03587g (2019).
Bolze, H., Erfle, P., Riewe, J., Bunjes, H., Dietzel, A. & Burg, T. P. A microfluidic split-flow technology for product characterization in continuous low-volume nanoparticle synthesis. Micromachines 10; 10.3390/mi10030179 (2019).
Constantinou, I., Jendrusch, M., Aspert, T., Görlitz, F., Schulze, A., Charvin, G. & Knop, M. Self-learning microfluidic platform for single-cell imaging and classification in flow. Micromachines 10; 10.3390/mi10050311 (2019).
Erfle, P., Riewe, J., Bunjes, H. & Dietzel, A. Stabilized production of lipid nanoparticles of tunable size in Taylor flow glass devices with high-surface-quality 3D microchannels. Micromachines 10; 10.3390/mi10040220 (2019).
Hinkel, S., Mattern, K., Dietzel, A., Reichl, S. & Müller-Goymann, C. C. Parametric investigation of static and dynamic cell culture conditions and their impact on hCMEC/D3 barrier properties. International Journal of Pharmaceutics 566, 434–444; 10.1016/j.ijpharm.2019.05.074 (2019).
Kottmeier, J., Wullenweber, M., Blahout, S., Hussong, J., Kampen, I., Kwade, A. & Dietzel, A. Accelerated particle separation in a DLD device at Re > 1 investigated by means of μPIV. Micromachines 10; 10.3390/mi10110768 (2019).
Meinen, S., Frey, L. J., Krull, R. & Dietzel, A. Resonant mixing in glass bowl microbioreactor investigated by microparticle image velocimetry. Micromachines 10; 10.3390/mi10050284 (2019).
Cross-sectional group 5: Multi-scale Simulations of Pharmaceutical Processes
Emenike, V. N., Xie, X., Krewer, U. & Schenkendorf, R. A point estimate method-based back-off approach to robust optimization: application to pharmaceutical processes. Computer Aided Chemical Engineering 46, 223-228; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069637459&doi=10.1016%2fB978-0-12-818634-3.50038-2&partnerID=40&md5=2f1b38fb5ff2b8d67cbdd1ca8b41fd19 (2019).
Emenike, V. N., Xie, X., Schenkendorf, R., Spiess, A. C. & Krewer, U. Robust dynamic optimization of enzyme-catalyzed carboligation: A point estimate-based back-off approach. Computers and Chemical Engineering 121, 232–247; 10.1016/j.compchemeng.2018.10.006 (2019).
Schenkendorf, R., Xie, X. & Krewer, U. An efficient polynomial chaos expansion strategy for active fault identification of chemical processes. Computers and Chemical Engineering 122, 228–237; 10.1016/j.compchemeng.2018.08.022 (2019).
Schrader, M., Pommerehne, K., Wolf, S., Finke, B., Schilde, C., Kampen, I., Lichtenegger, T., Krull, R. & Kwade, A. Design of a CFD-DEM-based method for mechanical stress calculation and its application to glass bead-enhanced cultivations of filamentous Lentzea aerocolonigenes. Biochemical Engineering Journal 148, 116–130; 10.1016/j.bej.2019.04.014 (2019).
Xie, X. & Schenkendorf, R. Robust optimization of a pharmaceutical freeze-drying process under non-Gaussian parameter uncertainties. Chemical Engineering Science 207, 805–819; 10.1016/j.ces.2019.06.023 (2019).
Xie, X. & Schenkendorf, R. Stochastic back-off-based robust process design for continuous crystallization of ibuprofen. Computers and Chemical Engineering 124, 80–92; 10.1016/j.compchemeng.2019.02.009 (2019).
Xie, X., Schenkendorf, R. & Krewer, U. Efficient sensitivity analysis and interpretation of parameter correlations in chemical engineering. Reliability Engineering and System Safety 187, 159–173; 10.1016/j.ress.2018.06.010 (2019).
Xie, X., Schenkendorf, R. & Krewer, U. The Effect of Correlated Kinetic Parameters on (Bio)Chemical Reaction Networks. Chemie-Ingenieur-Technik 91, 632–636; 10.1002/cite.201800201 (2019).
Füller, J. & Müller-Goymann, C. C. Anti-proliferative and anti-migratory effects of hyperforin in 2D and 3D artificial constructs of human dermal fibroblasts – A new option for hypertrophic scar treatment? Eur. J. Pharm. Biopharm. 126, 108–114 (2018).
Mattern, K., Beißner, N., Reichl, S. & Dietzel, A. DynaMiTES – A dynamic cell culture platform for in vitro drug testing PART 1 – Engineering of microfluidic system and technical simulations. Eur. J. Pharm. Biopharm. 126, 159–165 (2018).
Meise, M., Niggemann, M., Dunens, A., Schoenitz, M., Kuschnerow, J. C., Kunick, C. & Scholl, S. Early process development of API applied to poorly water-soluble TBID. Eur. J. Pharm. Biopharm. 126, 2–9 (2018).
Melzig, S., Niedbalka, D., Schilde, C. & Kwade, A. Spray drying of amorphous ibuprofen nanoparticles for the production of granules with enhanced drug release. Colloids Surfaces A Physicochem. Eng. Asp. 536, 133–141 (2018).
Haas, P., Gaid, M., Zarinwall, A., Beerhues, L. & Scholl, S. Downstream processing of hyperforin from Hypericum perforatum root cultures. Eur. J. Pharm. Biopharm. 126, 104–107 (2018).
Steiner, D., Finke, J. H. & Kwade, A. Instant ODFs – Development of an intermediate, nanoparticle-based product platform for individualized medication. Eur. J. Pharm. Biopharm. 126, 149–158 (2018).
Schenkendorf, R., Xie, X., Rehbein, M., Scholl, S. & Krewer, U. The impact of global sensitivities and design measures in model-based optimal experimental design. Processes 6, (2018).
Füller, J., Kellner, T., Gaid, M., Beerhues, L. & Müller-Goymann, C. C. Stabilization of hyperforin dicyclohexylammonium salt with dissolved albumin and albumin nanoparticles for studying hyperforin effects on 2D cultivation of keratinocytes in vitro. Eur. J. Pharm. Biopharm. 126, 115–122 (2018).
Beinert, S., Fragnière, G., Schilde, C. & Kwade, A. Multiscale simulation of fine grinding and dispersing processes: Stressing probability, stressing energy and resultant breakage rate. Adv. Powder Technol. 29, 573–583 (2018).
Kahle, J., Maul, K. J. & Wätzig, H. The next generation of capillary electrophoresis instruments: Performance of CE-SDS protein analysis. Electrophoresis 39, 311–325 (2018).
Gädke, J., Thies, J.-W., Kleinfeldt, L., Schulze, T., Biedendieck, R., Rustenbeck, I., Garnweitner, G., Krull, R. & Dietzel, A. Selective manipulation of superparamagnetic nanoparticles for product purification and microfluidic diagnostics. Eur. J. Pharm. Biopharm. 126, 67–74 (2018).
Beiβner, N., Mattern, K., Dietzel, A. & Reichl, S. DynaMiTES – A dynamic cell culture platform for in vitro drug testing PART 2 – Ocular DynaMiTES for drug absorption studies of the anterior eye. Eur. J. Pharm. Biopharm. 126, 166–176 (2018).
Schlütke, L., Immer, M., Preu, L., Totzke, F., Schächtele, C., Kubbutat, M. H. G. & Kunick, C. Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors. Eur. J. Pharm. Biopharm. 126, 89–94 (2018).
Lakowitz, A., Godard, T., Biedendieck, R. & Krull, R. Mini review: Recombinant production of tailored bio-pharmaceuticals in different Bacillus strains and future perspectives. Eur. J. Pharm. Biopharm. 126, 27–39 (2018).
Cabiscol, R., Finke, J. H. & Kwade, A. Calibration and interpretation of DEM parameters for simulations of cylindrical tablets with multi-sphere approach. Powder Technol. 327, 232–245 (2018).
Gaid, M., Biedermann, E., Füller, J., Haas, P., Behrends, S., Krull, R., Scholl, S., Wittstock, U., Müller-Goymann, C. & Beerhues, L. Biotechnological production of hyperforin for pharmaceutical formulation. Eur. J. Pharm. Biopharm. 126, 10–26 (2018).
Rehbein, M. C., Husmann, S., Lechner, C., Kunick, C. & Scholl, S. Fast and calibration free determination of first order reaction kinetics in API synthesis using in-situ ATR-FTIR. Eur. J. Pharm. Biopharm. 126, 95–100 (2018).
Meine, R., Becker, W., Falke, H., Preu, L., Loaëc, N., Meijer, L. & Kunick, C. Indole-3-carbonitriles as DYRK1A inhibitors by fragment-based drug design. Molecules 23, (2018).
Kahle, J. & Wätzig, H. Interlaced Size Exclusion Chromatography for faster protein analysis. Eur. J. Pharm. Biopharm. 126, 101–103 (2018).
Gelker, M., Müller-Goymann, C. C. & Viöl, W. Permeabilization of human stratum corneum and full-thickness skin samples by a direct dielectric barrier discharge. Clin. Plasma Med. 9, 34–40 (2018).
Beißner, N., Zorn-Kruppa, M. & Reichl, S. Parameter study of shipping conditions for the ready-to-use application of a 3D human hemicornea construct in drug absorption studies. Int. J. Pharm. 536, 377–387 (2018).
Füller, J. & Müller-Goymann, C. C. Anti-proliferative and anti-migratory effects of hyperforin in 2D and 3D artificial constructs of human dermal fibroblasts – A new option for hypertrophic scar treatment? Eur. J. Pharm. Biopharm. 126, 108–114 (2018).
Mattern, K., Beißner, N., Reichl, S. & Dietzel, A. DynaMiTES – A dynamic cell culture platform for in vitro drug testing PART 1 – Engineering of microfluidic system and technical simulations. Eur. J. Pharm. Biopharm. 126, 159–165 (2018).
Beiβner, N., Mattern, K., Dietzel, A. & Reichl, S. DynaMiTES – A dynamic cell culture platform for in vitro drug testing PART 2 – Ocular DynaMiTES for drug absorption studies of the anterior eye. Eur. J. Pharm. Biopharm. 126, 166–176 (2018).
Kahle, J. & Wätzig, H. Interlaced Size Exclusion Chromatography for faster protein analysis. Eur. J. Pharm. Biopharm. 126, 101–103 (2018).
Gädke, J., Thies, J.-W., Kleinfeldt, L., Schulze, T., Biedendieck, R., Rustenbeck, I., Garnweitner, G., Krull, R. & Dietzel, A. Selective manipulation of superparamagnetic nanoparticles for product purification and microfluidic diagnostics. Eur. J. Pharm. Biopharm. 126, 67–74 (2018).
Steiner, D., Finke, J. H. & Kwade, A. Instant ODFs – Development of an intermediate, nanoparticle-based product platform for individualized medication. Eur. J. Pharm. Biopharm. 126, 149–158 (2018).
Lakowitz, A., Godard, T., Biedendieck, R. & Krull, R. Mini review: Recombinant production of tailored bio-pharmaceuticals in different Bacillus strains and future perspectives. Eur. J. Pharm. Biopharm. 126, 27–39 (2018).
Schlütke, L., Immer, M., Preu, L., Totzke, F., Schächtele, C., Kubbutat, M. H. G. & Kunick, C. Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors. Eur. J. Pharm. Biopharm. 126, 89–94 (2018).
de Groot, C., Müsken, M. & Müller-Goymann, C. Novel Colloidal Microstructures of β-Escin and the Liposomal Components Cholesterol and DPPC. Planta Med. 84, 1219–1227 (2018).
Lladó Maldonado, S., Rasch, D., Kasjanow, A., Bouwes, D., Krühne, U. & Krull, R. Multiphase microreactors with intensification of oxygen mass transfer rate and mixing performance for bioprocess development. Biochem. Eng. J. 139, 57–67 (2018).
Melzig, S., Finke, J. H., Schilde, C. & Kwade, A. Formation of long-term stable amorphous ibuprofen nanoparticles via antisolvent melt precipitation (AMP). Eur. J. Pharm. Biopharm. 131, 224–231 (2018).
Cabiscol, R., Finke, J., Zetzener, H. & Kwade, A. Characterization of Mechanical Property Distributions on Tablet Surfaces. Pharmaceutics 10, 184 (2018).
Xie, X., Schenkendorf, R. & Krewer, U. Toward a Comprehensive and Efficient Robust Optimization Framework for (Bio)chemical Processes. Processes 6, 183 (2018).
Puschmann, J., Herbig, M. E. & Müller-Goymann, C. C. Correlation of antimicrobial effects of phenoxyethanol with its free concentration in the water phase of o/w-emulsion gels. Eur. J. Pharm. Biopharm. 131, 152–161 (2018).
Emenike, V. N., Schenkendorf, R. & Krewer, U. Model-based optimization of biopharmaceutical manufacturing in Pichia pastoris based on dynamic flux balance analysis. Comput. Chem. Eng. 118, 1–13 (2018).
Abt, V., Barz, T., Cruz-Bournazou, M. N., Herwig, C., Kroll, P., Möller, J., Pörtner, R. & Schenkendorf, R. Model-based tools for optimal experiments in bioprocess engineering. Curr. Opin. Chem. Eng. 22, 244–252 (2018).
Peters, F., Gelker, M., Fleckenstein, M., Militz, H., Ohms, G. & Viöl, W. Decrease of the surface pH of maple and the production of nitrate by three pulsed dielectric barrier discharges. Wood Sci. Technol. 52, 1495–1510 (2018).
Mecklenfeld, A. & Raabe, G. Comparison of RESP and IPolQ-Mod Partial Charges for Solvation Free Energy Calculations of Various Solute/Solvent Pairs. J. Chem. Theory Comput. 13, 6266–6274 (2017).
Erfle, P., Riewe, J., Bunjes, H. & Dietzel, A. Optically monitored segmented flow for controlled ultra-fast mixing and nanoparticle precipitation. Microfluid. Nanofluidics 21, (2017).
Beißner, S., Thies, J.-W., Bechthold, C., Kuhn, P., Thürmann, B., Dübel, S. & Dietzel, A. Low-cost, in-liquid measuring system using a novel compact oscillation circuit and quartz-crystal microbalances (QCMs) as a versatile biosensor platform. J. Sensors Sens. Syst. 6, 341–350 (2017).
Xie, X., Schenkendorf, R. & Krewer, U. Robust Design of Chemical Processes Based on a One-Shot Sparse Polynomial Chaos Expansion Concept. Comput. Aided Chem. Eng. 40, 613–618 (2017).
Schenkendorf, R., Xie, X. & Krewer, U. An Efficient Polynomial Chaos Expansion Strategy for Active Fault Identification of Chemical Processes. Comput. Aided Chem. Eng. 40, 1675–1680 (2017).
Göke, K., Lorenz, T., Repanas, A., Schneider, F., Steiner, D., Baumann, K., Bunjes, H., Dietzel, A., Finke, J. H., Glasmacher, B., Kwade, A. Novel strategies for the formulation and processing of poorly water-soluble drugs. Eur. J. Pharm. Biopharm. (2017).
Göke, K., Bunjes, H. Parameters influencing the course of passive drug loading into lipid nanoemulsions. Eur. J. Pharm. Biopharm. (2017).
Overbeck, A., Günther, S., Kampen, I. & Kwade, A. Compression Testing and Modeling of Spherical Cells – Comparison of Yeast and Algae. Chem. Eng. Technol. 40, (2017).
Thies, J.-W., Kuhn, P., Thürmann, B., Dübel, S. & Dietzel, A. Microfluidic quartz-crystal-microbalance (QCM) sensors with specialized immunoassays for extended measurement range and improved reusability. Microelectron. Eng. 179, (2017).
Steiner, D., Finke, J. H., Kwade, A. Redispersion of Nanoparticle-Loaded Orodispersible Films: Preservation of Particle Fineness. Chemie-Ingenieur-Technik 89, (2017).
Schulze, T., Mattern, K., Früh, E., Hecht, L., Rustenbeck, I., Dietzel, A. A 3D microfluidic perfusion system made from glass for multiparametric analysis of stimulus-secretioncoupling in pancreatic islets. Biomed. Microdevices 19, (2017).
Haas, P., Gaid, M., Zarinwall, A., Beerhues, L., Scholl, S. Downstream processing of hyperforin from Hypericum perforatum root cultures. Eur. J. Pharm. Biopharm. (2017).
Weidner, T., Lucantoni, L., Nasereddin, A., Preu, L., Jones, P. G., Dzikowski, R., Avery, V. M., Kunick, C. Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages. Malaria J. (2017), 16, 192 (1-10).
Meine, R., Blech, M., Lindhof, J., Kunick, C., 7-Bromo-1-methyl-2-phenyl-1H-indole-3-carbonitrile. Molbank (2017), M941.
K. Mattern, N. Beissner, S. Reichl, A. Dietzel, DynaMiTES - a dynamic cell culture platform for in vitro drug testing PART 1- Engineering of microfluidic system and technical simulations. Eur. J. Pharm. Biopharm. (2017).
N. Beissner, K. Mattern, A. Dietzel, S. Reichl, DynaMiTES - a dynamic cell culture platform for in vitro drug testing PART 2- Ocular DynaMiTES for drug absorption studies of the anterior eye. Eur. J. Pharm. Biopharm. (2017).
Gaid, M., Wucherpfennig, T., Scholl, S., Beerhues, L., Krull, R., Challenges for the cultivation of plant cells on the example of Hypericum perforatum and Taxus chinensis, in: A. Pavlov, T. Bley (Eds), Bioprocessing of plant in vitro systems, Reference Series in Phytochemistry, Springer, (2017) 1-26.
Füller J., Kellner T., Gaid M., Beerhues L., Müller-Goymann C.C. Stabilization of hyperforin dicyclohexylammonium salt with dissolved albumin and albumin nanoparticles for studying hyperforin effects on 2D cultivation of keratinocytes in vitro. Eur. J. Pharm. Biopharm. (2017).
Göke, K., Lorenz, T., Repanas, A., Schneider, F., Steiner, D., Baumann, K., Bunjes, H., Dietzel, A., Finke, J. H., Glasmacher, B., Kwade, A. Novel strategies for the formulation and processing of poorly water-soluble drugs. Eur. J. Pharm. Biopharm. (2017).
Göke, K., Bunjes, H. Parameters influencing the course of passive drug loading into lipid nanoemulsions. Eur. J. Pharm. Biopharm. (2017).
Overbeck, A., Günther, S., Kampen, I. & Kwade, A. Compression Testing and Modeling of Spherical Cells – Comparison of Yeast and Algae. Chem. Eng. Technol. 40, (2017).
Thies, J.-W., Kuhn, P., Thürmann, B., Dübel, S. & Dietzel, A. Microfluidic quartz-crystal-microbalance (QCM) sensors with specialized immunoassays for extended measurement range and improved reusability. Microelectron. Eng. 179, (2017).
Steiner, D., Finke, J. H., Kwade, A. Redispersion of Nanoparticle-Loaded Orodispersible Films: Preservation of Particle Fineness. Chemie-Ingenieur-Technik 89, (2017).
Schulze, T., Mattern, K., Früh, E., Hecht, L., Rustenbeck, I., Dietzel, A. A 3D microfluidic perfusion system made from glass for multiparametric analysis of stimulus-secretioncoupling in pancreatic islets. Biomed. Microdevices 19, (2017).
Haas, P., Gaid, M., Zarinwall, A., Beerhues, L., Scholl, S. Downstream processing of hyperforin from Hypericum perforatum root cultures. Eur. J. Pharm. Biopharm. (2017).
Weidner, T., Lucantoni, L., Nasereddin, A., Preu, L., Jones, P. G., Dzikowski, R., Avery, V. M., Kunick, C. Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages. Malaria J. (2017), 16, 192 (1-10).
Meine, R., Blech, M., Lindhof, J., Kunick, C., 7-Bromo-1-methyl-2-phenyl-1H-indole-3-carbonitrile. Molbank (2017), M941.
K. Mattern, N. Beissner, S. Reichl, A. Dietzel, DynaMiTES - a dynamic cell culture platform for in vitro drug testing PART 1- Engineering of microfluidic system and technical simulations. Eur. J. Pharm. Biopharm. (2017).
N. Beissner, K. Mattern, A. Dietzel, S. Reichl, DynaMiTES - a dynamic cell culture platform for in vitro drug testing PART 2- Ocular DynaMiTES for drug absorption studies of the anterior eye. Eur. J. Pharm. Biopharm. (2017).
Gaid, M., Wucherpfennig, T., Scholl, S., Beerhues, L., Krull, R., Challenges for the cultivation of plant cells on the example of Hypericum perforatum and Taxus chinensis, in: A. Pavlov, T. Bley (Eds), Bioprocessing of plant in vitro systems, Reference Series in Phytochemistry, Springer, (2017) 1-26.
Füller, J. & Müller-Goymann, C. C. Anti-proliferative and anti-migratory effects of hyperforin in 2D and 3D artificial constructs of human dermal fibroblasts - A new option for hypertrophic scar treatment? Eur. J. Pharm. Biopharm. (2017).
Gaid, M., Biedermann, E., Füller, J., Haas, P., Behrends, S., Krull, R., Scholl, S., Wittstock, U., Müller-Goymann, C. & Beerhues, L. Biotechnological production of hyperforin for pharmaceutical formulation. Eur. J. Pharm. Biopharm. (2017).
Schlütke, L., Immer, M., Preu, L., Totzke, F., Schächtele, C., Kubbutat, M. H. G. & Kunick, C. Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors. Eur. J. Pharm. Biopharm. (2017).
Gädke, J., Kleinfeldt, L., Schubert, C., Rohde, M., Biedendieck, R., Garnweitner, G. & Krull, R. In situ affinity purification of his-tagged protein A from Bacillus megaterium cultivation using recyclable superparamagnetic iron oxide nanoparticles. J. Biotechnol. 242, (2017).
Walisko, J., Vernen, F., Pommerehne, K., Richter, G., Terfehr, J., Kaden, D., Dähne, L., Holtmann, D. & Krull, R. Particle-based production of antibiotic rebeccamycin with Lechevalieria aerocolonigenes. Process Biochem. 53, (2017).
Lakowitz, A., Krull, R. & Biedendieck, R. Recombinant production of the antibody fragment D1.3 scFv with different Bacillus strains. Microb. Cell Fact. 16, (2017).
Mecklenfeld, A. & Raabe, G. Efficient solvation free energy simulations: impact of soft-core potential and a new adaptive λ-spacing method. Mol. Phys. (2017).
Göke K., Roese E., Arnold A., Kuntsche J., Bunjes H., Control over particle size distribution by autoclaving poloxamer-stabilized trimyristin nanodispersions, Mol. Pharmaceutics 13 (2016) 3187–3195.
Emenike, V. N. & Krewer, U. Model-Based Optimal Design of Continuous-Flow Reactors for the Synthesis of Active Pharmaceutical Ingredients. Chemie-Ingenieur-Technik 88, (2016).
Gehrmann S., Bunjes H., Instrumented small scale extruder to investigate the influence of process parameters during premix membrane emulsification, Chem. Eng. J. 284 (2016) 716–723.
Schenkendorf, R. Supporting the shift towards continuous pharmaceutical manufacturing by condition monitoring. in Conference on Control and Fault-Tolerant Systems, SysTol (2016).
Steiner, D., Finke, J. H., Breitung-Faes, S. & Kwade, A. Breakage, temperature dependency and contamination of Lactose during ball milling in ethanol. Adv. Powder Technol. 27, (2016).
Steiner, D., Finke, J. H. & Kwade, A. Instant ODFs - Development of an intermediate, nanoparticle-based product platform for individualized medication. Eur. J. Pharm. Biopharm. (2016).
Orban, O. C. F., Korn, R. S., Benítez, D., Medeiros, A., Preu, L., Loaëc, N., Meijer, L., Koch, O., Comini, M. A. & Kunick, C. 5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms. Bioorganic Med. Chem. 24, (2016).
Dietzel, A. Microsystems for pharmatechnology: Manipulation of fluids, particles, droplets, and cells. (2016).
Andermark, V., Göke, K., Kokoschka, M., Abu El Maaty, M. A., Lum, C. T., Zou, T., Sun, R. W.-Y., Aguiló, E., Oehninger, L., Rodríguez, L., Bunjes, H., Wölfl, S., Che, C.-M. & Ott, I. Alkynyl gold(I) phosphane complexes: Evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex. J. Inorg. Biochem. 160, (2016).
Weidner, T., Nasereddin, A., Preu, L., Grünefeld, J., Dzikowski, R., Kunick, C. Novel 2-phenoxyanilide congeners derived from a hit structure of the TCAMS: Synthesis and evaluation of their in vitro activity against plasmodium falciparum. Molecules 21, (2016).
Gaid, M., Haas, P., Beuerle, T., Scholl, S. & Beerhues, L. Hyperforin production in Hypericum perforatum root cultures. J. Biotechnol. 222, (2016).
Dietzel, A. Preface. Microsystems Pharmatechnology Manip. Fluids, Part. Droplets, Cells (2016).
Schulze, T., Morsi, M., Brüning, D., Schumacher, K. & Rustenbeck, I. Different responses of mouse islets and MIN6 pseudo-islets to metabolic stimulation: a note of caution. Endocrine 51, (2016).
El-Awaad, I., Bocola, M., Beuerle, T., Liu, B. & Beerhues, L. Bifunctional CYP81AA proteins catalyse identical hydroxylations but alternative regioselective phenol couplings in plant xanthone biosynthesis. Nat. Commun. 7, (2016).
Eugen, K., Thies, J.-W. J.-W., Andreas, D., Koch, E., Thies, J.-W. J.-W. & Dietzel, A. Periodic convection of superparamagnetic beads within a microfluidic channel by interlocked, electroplated structures activated by a static field. Microelectron. Eng. 158, 46–51 (2016).
Dietzel, A. A brief introduction to microfluidics. Microsystems for Pharmatechnology: Manipulation of Fluids, Particles, Droplets, and Cells (2016).
Beißner, N., Reichl, S. & Lorenz, T. Organ on chip. Microsystems for Pharmatechnology: Manipulation of Fluids, Particles, Droplets, and Cells (2016).
Steiner, D., Finke, J. H. & Kwade, A. Efficient production of nanoparticle-loaded orodispersible films by process integration in a stirred media mill. Int. J. Pharm. 511, (2016).
Schilde, C., Gothsch, T., Beinert, S. & Kwade, A. Microsystems for dispersing nanoparticles. Microsystems for Pharmatechnology: Manipulation of Fluids, Particles, Droplets, and Cells (2016).
Bunjes, H. & Müller-Goymann, C. C. Microsystems for emulsification. Microsystems for Pharmatechnology: Manipulation of Fluids, Particles, Droplets, and Cells (2016).
Eichler, M., Lachmann, K. & Klages, C.-P. Surface functionalization of microfluidic devices. Microsystems for Pharmatechnology: Manipulation of Fluids, Particles, Droplets, and Cells (2016).
Joseph S., Rappolt M., Schoenitz M., Huzhalska V., Augustin W., Scholl S., Bunjes H., Stability of the metastable α-polymorph in solid triglyceride drug carrier nanoparticles, Langmuir 31 (2015) 6663–6674.
Fiesel, T., Gaid, M., Müller, A., Bartels, J., El-Awaad, I., Beuerle, T., Ernst, L., Behrends, S. & Beerhues, L. Molecular cloning and characterization of a xanthone prenyltransferase from hypericum calycinum cell cultures. Molecules 20, (2015).
Meine, R., Falke, H., Kötz, J., Schweda, S. I. & Kunick, C. 7-iodo-1H-indole-3-carbonitrile. Molbank 2015, (2015).
Joseph S., Bunjes H., Evaluation of Shirasu Porous Glass (SPG) membrane emulsification for the preparation of colloidal lipid drug carrier dispersions, Eur. J. Pharm. Biopharm. 87 (2014) 176–186.
Wilkins, M. R., Aldashev, A. A., Wharton, J., Rhodes, C. J., Vandrovcova, J., Kasperaviciute, D., Bhosle, S. G., Mueller, M., Geschka, S., Rison, S., Kojonazarov, B., Morrell, N. W., Neidhardt, I., Surmeli, N. B., Aitman, T. J., Stasch, J.-P., Behrends, S. & Marletta, M. A. α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among kyrgyz highlanders. Circ. Cardiovasc. Genet. 7, (2014).
Wöhl-Bruhn S., Bertz A., Kuntsche J., Menzel H., Bunjes H., Variations in polyethylene glycol brands and their influence on the preparation process of hydrogel microspheres, Eur. J. Pharm. Biopharm. 85 (2013) 1215–1218.
Kupetz E., Preu L., Kunick C., Bunjes H., Parenteral formulation of an antileishmanial drug candidate – Tackling poor solubility, chemical instability, and polymorphism, Eur. J. Pharm. Biopharm. 85 (2013) 511–520.
Ryczak, J., Papini, M., Lader, A., Nasereddin, A., Kopelyanskiy, D., Preu, L., Jaffe, C. L. & Kunick, C. 2-Arylpaullones are selective antitrypanosomal agents. Eur. J. Med. Chem. 64, (2013).
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