The development and optimization of innovative methods for the cost-effective and efficient production of biomolecular drugs is based on integrated operations for a holistic approach of upstream processing, cultivation and downstream processing. The most important challenge is the development and optimization of highly productive pharmaceutical cell factories for labile and poorly soluble ingredients in active shape and high concentration. Analyzing the effects of changes in the product spectrum is important for the development of efficient downstream strategies.
Using miniaturized systems, early process decisions reduce development times. For patient-friendly and personalized biopharmaceuticals, reliable methods for flexible, demand-driven, reproducible and procedural concepts have to be developed. Synthetic biotechnology will help generate cost-effective personalized drug production in miniaturized systems, i.e. tailor-made cell factories with optimal power of synthesis.
left: Bioreactor with growth medium for large-scale cultivation; right: Delight about the growing bacterial culture.
Heads of Department:
Prof. Dr. rer. nat. Ludger Beerhues | TU Braunschweig
Institute of Pharmaceutical Biology (ipb)
Mendelssohnstraße 1 | 38106 Braunschweig
E-Mail: l.beerhues(at)tu-braunschweig.de | Phone: +49(0)531 391-5689
Prof. Dr. habil. Rainer Krull | TU Braunschweig
Institute of Biochemical Engineering (ibvt)
Rebenring 56, Raum 339 | 38106 Braunschweig
E-Mail: r.krull(at)tu-braunschweig.de | Phone: +49 (0)531 391-55311