Structured Light Microscopy (NL2)

Welcome to the website of our junior research group „Structured Light Microscopy“!

We are working within the research cluster NanoLight inside of QUANOMET. Currently, we are composed of scientific staff from the Institute of Semiconductor Technology, the Institute of Pharmacology, Toxicology and Clinical Pharmacy and the Institute of Mathematical Physics. We have close collaborations with the Institute of Microtechnology and ec2 (epitaxy competence center).

In the institutes we are carrying out research on the following topics:

Institute of Semiconductor Technology

• Epitaxy of 3D GaN/InGaN LEDs
• Processing of LED arrays
• Lensless microscopy and holography

Institute of Pharmacology, Toxicology and Clinical Pharmacy

• Typ 2 diabetes with the focus on micro physiology of the pancreatic islets
• Investigation of stimulus-secretion coupling in the beta-cell

Institute of Mathematical Physics

• Theoretical description of quantum transport in low dimensional systems
• Detection and manipulation of charge, spin and photonic quantum degree of freedom

Institute of Microtechnology

• Lab-on-Chip, Organ-on-Chip
• Sensor microfabrication
• Structuring by ultra-short pulse lasers

Within our interdisciplinary collaboration we combine our expertise to accomplish methodological progress by direct application on relevant biomedical systems.

Within our research group we will develop new techniques in the field of structured illumination for optical microscopy. By the help of structured illumination, more information about the analysed objects can be detected, e.g. by an increased local resolution. The relevance of this additional information will be illustrated by the functional analysis of pancreatic islets. These pancreatic islets are three-dimensional aggregates of endocrine active cells which are of major significance for the energy metabolism of humans. The insufficient production of the hormone insulin in the beta-cells of the pancreatic islets leads to the disease diabetes mellitus. By the novel microscope setup, we want not only to investigate these cells with higher local resolution, but also understand their behaviour in dependence of different parameters in more detail.

Therefore, we are currently developing and testing various possibilities to immobilize and specifically illuminate the pancreatic islets or single cells of them. Specially driven LED arrays and a time-resolved interpretation of photodetector signals should enhance the local resolution of the living cells. In a first step, a lensless microscope was developed, which has a field of view of 10.1 mm2 and a resolution below 2.46 µm. Due to the compact size of this lensless microscope (see image below) it can be even integrated in incubator setups. In the future, we will gain new insights into the functionality of the pancreatic islets by combining this setup with the local measurement of oxygen, glucose and insulin concentrations and the detection of fluorescence.

Head

M. Sc. Mayra Garcés-Schröder
Halbleitertechnik
m.garces-schroeder@tu-bs.de

 

Staff

Dr. Torben Schulze
Pharmakologie, Toxikologie und Klinische Pharmazie
to.schulze(at)tu-bs.de

M. Sc. Gregor Scholz
Halbleitertechnik
gregor.scholz@tu-bs.de

M. Sc. Lena Bittermann
Mathematische Physik
l.bittermann@tu-bs.de

 

Cooperating Researchers

Dipl.-Ing. Kai Mattern
Mikrotechnik
k.mattern(at)tu-bs.de

M. Sc. Agus Budi Dharmawan
Halbleitertechnik
A.Dharmawan(at)tu-bs.de

Dr. Hutomo Suryo Wasisto
Halbleitertechnik
H.Wasisto(at)tu-bs.de

Dr. Thorben Dammeyer
LENA
T.Dammeyer(at)tu-bs.de

» Conference Proceeding

Gregor Scholz, Qifeng Xu, Torben Schulze, Heidi Boht, Kai Mattern, Jana Hartmann, Andreas Dietzel, Stephan Scherneck, Ingo Rustenbeck, Joan Daniel Prades, Sönke Fündling, Hutomo Suryo Wasisto, Andreas Waag
LED-Based Tomographic Imaging for Live-Cell Monitoring of Pancreatic Islets in Microfluidic Channels
Proceedings (Eurosensors 2017)

Contact Research Group "Structured Light Microscopy"

M. Sc. Mayra Garcés-Schröder

Technische Universität Braunschweig,
Laboratory for Emerging Nanometrology (LENA),
Institut für Halbleitertechnik (IHT),
epitaxy competence center ec²,
NL2 Nachwuchsgruppe „Structured Light Microscopy“

Hans-Sommer-Str. 66, D-38106 Braunschweig,
Phone: +49 (0) 531 391-0
m.garces-schroeder(at)tu-braunschweig.de