Publications

Schrödter, D., Mozafari, M., Fichtner, J., von Trotha, J. W., Köster, R. W., Dietzel, A. (2024). A 3D tailored monolithic glass chip for stimulating and recording zebrafish neuronal activity with a commercial light sheet microscope. Frontiers Lab. Chip Technol. 3. https://doi.org/10.3389/frlct.2024.1346439.

Pose-Méndez, S., Rehbock, M., Wolf-Asseburg, A., Köster R: W. (2024). In vivo monitoring of Fabp7 expression in transgenic zebrafish. Cells 13:1138.

Zhang, H., Papadaki, S., Sun, X., Wang, X., Drobizhev, M., Yao, L., Rehbock, M., Köster, R. W., Wu, L., Namikawa, K., Piatkevich, K. D. (2023). Quantitative assessment of near-infrared fluorescent proteins. Nature Methods 20:1605-1616.

Pose-Méndez, S., Schramm, P., Valishetti, K., Köster, R. W. (2023). Development, circuitry and function of the zebrafish cerebellum. Cellular and Molecular Life Sciences 80: 227.

Pose-Méndez, S., Schramm, P., Winter, B., Meier, J. C., Ampatzis, K., Köster, R. W. (2023). Lifelong regeneration of cerebellar Purkinje cells after induced cell ablation in zebrafish. Elife 12:e79672.

Dorigo, A., Valishetti, K., Hetsch, F., Matsui, H., Meier, J. C., Namikawa, K., Köster, R. W. (2023). Functional regionalization of the differentiating cerebellar Purkinje cell population occurs in an activity-dependent manner. Front. Neurosci. 16:1166900.

Hassan, K., Kemkuignou, B. M., Kirchenwitz, M., Wittstein, K., Rascher, M., Chepkirui, C., Matasyoh, J. C., Decock, C., Köster, R. W., Stradal, T. E. B., Stadler, M. (2022). Neurotrophic and immunomodulatory lanostane triterpenoids from wood-inhabiting Basidiomycota. International Journal of Molecular Sciences 23: 13593. Doi: 10.3390/ijms232113593.

Jaron, M., Lehky, M., Zarà, M., Zaydowicz, C. N., Lak, A., Ballmann, R., Heine, P. A., Wenzel, E. V., Schneider, K.-T., Bertoglio, F. Kempter, S. Köster, R. W., Barbieri, S. S., Van den Heuvel, J., Hust, M., Dübel, S., Schubert, M. (2022). Baculovirus-Free SARS-CoV-2 Virus Like Particle Production in Insect Cells for Rapid Neutralization Assessment. Viruses 14: 2087.

Korte, M., Köster, R. W. (2022). Opening the Box of PANTHORA in Alzheimer's Disease. Signal Transduction and Targeted Therapy 7: 344.

Lindemann, N., Kalix, L., Possiel, J., Stasch, R., Kusian, T., Köster, R. W., v. Trotha, J. W. (2022). A comparative analysis of Danionella cerebrum and zebrafish (Danio rerio) larval locomotor activity in a light-dark test. Frontiers in Behavioral Neuroscience doi.org/10.3389/fnbeh.2022.885775.

Papdaki, S., Wang, X., Wang, Y., Zhang, H., Jia, S., Liu, S., Yang, M., Li, D., Jia, J., Köster, R. W., Namikawa, K., Piatkevich, K. D. (2022). Dual-Expression System for Blue Fluorescent Protein Optimization. Scientific Reports 12: 10190.

Babakhanova, S., Jung, E. E., Namikawa, K., Zhang, H., Wang, Y., Subach, O. M., Korzhenevskiy, D. A., Rakitina, T. V., Xiao, X., Wang, W., Shi, J., Drobizhev, M., Park, D., Eisenhard, L., Tang, H., Köster, R. W., Subach, F. V., Boyden, E. S., Piatkevich, K. D. (2022). Rapid directed molecular evolution of fluorescent proteins in mammalian cells. Protein Sciences 31: 728-751.

Vauti, F., Vögele, V., Deppe, I., Hahnenstein, S. T., Köster, R. W. (2021). Structural analysis and spatiotemporal expression of atxn1 genes in zebrafish embryos and larvae. International Journal of Molecular Sciences 22: 11348.

Chang, W., Pedroni, A., Köster, R. W., Giacomello, S., Ampatzis, K. (2021). Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses. Scientific Reports 11: 18408.

Elsaey, M. A., Namikawa, K., Köster, R. W. (2021). Genetic modeling of neurodegenerative disease Spinocerebellar Ataxia Type 1 in zebrafish. International Journal of Molecular Sciences 22: 7351.

Buchberger, A., Schepergerdes, L., Flaßhoff, M., Kunick, C., Köster, R. W. (2021). A novel inhibitor rescues cerebellar defects in a zebrafish model of Down Syndrome-associated kinase Dyrk1A overexpression. Journal of Biological Chemistry 297: 100853.

Schramm, P., Hetsch, F., Meier, J. C., Köster, R. W. (2021). In vivo imaging of fully active brain tissue in awake zebrafish larvae and juveniles by skull and skin removal. Journal of Visualized Experiments e62166.

Rascher, M., Wittstein, K., Winter, B., Rupcic, Z., Wolf-Asseburg, A., Stadler, M., Köster, R. W. (2020). Erinacine C activates transcription from a consensus ETS DNA binding site in astrocytic cells in addition to NGF induction. Biomolecules 10: 1440.

Vauti, F., Stegemann, L. A., Vögele, V., Köster, R. W. (2020). All-age whole mount in situ hybridization to reveal larval and juvenile expression patterns in zebrafish. PLoS ONE 15: e0237167.

Theisen, U., Ernst, A. U., Heyne, R. L. S., Ring, T. P., Thorn-Seshold, O., Köster, R. W. (2020). Microtubules and motor proteins support zebrafish neuronal migration by directing cargo. Journal of Cell Biology 219: e201908040.

Chang, W., Pedroni, A., Hohendorf, V., Giacomello, S., Hibi, M., Köster, R. W., Ampatzis, K. (2020). Functionally-distinct Purkinje cell types show temporal precision in encoding locomotion. Proceedings of the National Academy of Sciences USA (PNAS) 117: 17330-17337.

Mattern*, K., von Trotha*, J. P., Erfle, P., Köster, R. W., Dietzel, A. (2020). NeuroExaminer: an all-glass microfluidic device for whole-brain in vivo imaging. Communications Biology 3: 311. * equally contributing authors

Li, J., Ünal, C. M., Namikawa, K., Steinert, M., Köster R. W. (2020). Development of a Larval Zebrafish Infection Model for Clostridioides difficile. Journal of Visualized Experiments 156 doi: 10.3791/60793

Namikawa, K., Dorigo, A., Köster, R. W. (2019). Neurological Disease Modelling for Spinocerebellar Ataxia Using Zebrafish. Journal of Experimental Neuroscience. 13: 1179069519880515.

Namikawa, K., Dorigo, A., Zagrebelsky, M., Russo, G., Kirmann, T., Fahr, W., Dübel, S., Korte, M., Köster, R.W. (2019). Modeling neurodegenerative spinocerebellar ataxia type 13 in zebrafish using a purkinje neuron specific tunable coexpression system. Journal of Neuroscience. 39: 3948-3969.

Jagau, H., Behrens, I. K., Lahme, K., Lorz, G., Köster, R.W., Schneppenheim, R., Obser, T., Brehm, M.A., König, G., Kohler, T.P., Rohde, M., Frank, R., Tegge, W., Fulde, M., Hammerschmidt, S., Steinert, M., Bergmann, S. (2019). Von Willebrand factor mediates pneumococcal aggregation and adhesion in blood flow. Frontiers in Microbiology. 10: 511.

Plate, J., Sassen, W. A., Hassan, A. H., Lehne, F., Köster, R. W. (2019). S-Sulfocysteine induces seizure-like behaviors in zebrafish. Frontiers in Pharmacology. 10: 122.

Theisen, U., Hey, S., Henning, C. D., Schnabel, R., Köster, R. W. (2018). Glycine is able to induce both a motility speed in- und decrease during zebrafish neuronal migration. Communicative & Integrative Biology 11: 1-7.

Russo, G., Lehne, F., Pose Mendez, S. M., Dübel, S., Köster, R. W., Sassen W. A. (2018). Culture and transfection ob zebrafish primary cells. Journal of Visualized Experiments 138: e57872

Rupcic*, Z., Rascher*, M., Kanaki, S., Köster, R. W., Stadler, M., Wittstein, K. (2018). Two new cyathane diterpenoids from mycelial cultures of the medicinal mushroom Hericium erinaceus and of the rare species, Hericium flagellum. International. Journal of Molecular Sciences 19: 740. * equally contributing authors

Theisen, U., Hennig, C., Ring, T., Schnabel, R., Köster, R. W. (2018). Neurotransmitter-mediated activity spatially controls neuronal migration in the zebrafish cerebellum. PLoS Biology 16: e2002226.

Russo, G., Theisen, U., Fahr, W., Helmsing, S., Hust, M., Köster, R. W., Dübel, S. (2018). Sequence defined antibodies improve the detection of Cadherin 2 (N-Cadherin) during zebrafish development. New Biotechnology PMID: 29289749.

Sassen, W. A., Lehne, F., Russo, G., Wargenau, S., Dübel, S., Köster, R. W. (2017). Embryonic zebrafish primary cell culture for transfection and live cellular and subcellular imaging. Developmental Biology 430: 18-31.

Weber, T., Namikawa, K., Winter, B., Müller-Brown, K., Kühn, R., Wurst, W., Köster, R. W. (2016). Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons. Development 143: 4279-4287.

Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. W., Stadler, M. (2016). Corallocins A-C, Nerve Growth and Brain-Derived Neurotrophic Factor inducing metabolites from the mushroom Hericium coralloides. Journal of Natural Products 79: 2264-2269.

Biechl, D., Dorigo, A., Köster, R. W., Grothe, B., Wullimann, F. (2016). EppurSi Muove: Evidence for an external granular layer and possibly transit amplification in the teleostean cerebellum. Frontiers in Neuroanatomy 10: 49.

Matsui, H., Dorigo, A., Buchberger, A., Hocking, J. C., Distel, M., Köster, R. W. (2015). Zebrafish jam-b2 Gal4-enhancer trap line recapitulates endogenous jam-b2 expression in extraocular muscles. Developmental Dynamics 244: 1574-1580.

Sassen, W. A., Köster, R. W. (2015). A molecular toolbox for genetic manipulation of zebrafish. Advances in Genomics and Genetics 5: 151-163. (Review Article)

Matsui, H., Namikawa, K., Köster R. W. (2014). Identification of the zebrafish red nucleus using Wheat Germ Agglutinin transneuronal tracing. Communicative & Integrative Biology 7: e994383.

Schoetz, U., Deliolanis, N. C., Ng, D., Pauli, J., Resch-Genger, U., Kühn, E., Heuer, S., Beisker, W., Köster, R. W., Zitzelsberger, H., Caldwell, R. B. (2014). Usefulness of a Darwinian System in a Biotechnological Application: Evolution of Optical Window Fluorescent Protein Variants under Selective Pressure. PLoS One 9: e107069.

Matsui, H., Namikawa, K., Babaryka, A., Köster R. W. (2014). Functional regionalization of the teleost cerebellum analyzed in vivo. Proceedings of the National Academy of Sciences USA (PNAS) 111: 11846-11851. (Accompanying Commentary)

Flinn, L. J., Keatinge, M., Bretaud, S., Mortiboys, H., Matsui, H., De Felice, E., Woodroof, H. I., Brown, L., McTighe, A., Söllner, R., Allen, C. E., Heath, P. R., Milo, M., Muqit, M. M., Reichert, A. S., Köster, R. W., Ingham, P. W., Bandmann, O. (2013). TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency. Annals of Neurology 74: 837-847.

Weber, T., Köster, R. W. (2013). Genetic tools for multicolor imaging in zebrafish larvae. Methods 62: 279-291. (Review Article)

Schur, J., Manna, C. M., Deally, A., Köster, R. W., Tacke, M., Tshuva, E. Y., Ott, I. (2013). A comparative chemical-biological evaluation of titanium(iv) complexes with a salan or cyclopentadienyl ligand. Chemical Communications 49: 4785-4787.

Hocking, J. C., Distel, M., Köster, R. W. (2013). Studying cellular and subcellular dynamics in the developing zebrafish nervous system. Experimental Neurology 242: 1-10. (Review Article)

Oehninger, L., Stefanopoulou, M., Alborzinia, H., Schur, J., Ludewig, S., Namikawa, K., Munoz-Castro, A., Köster, R. W., Baumann, K., Wölfl, S., Sheldrick, W. S., Ott, I. (2013). Evaluation of arene ruthenium(II) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules. Dalton Transactions 42: 1657-1666.

Xie, X,. Mathias, J. R., Smith, M.-A., Walker, S. L., Teng, Y., Distel, M., Köster, R. W., Sirotkin, H. I., Saxena, M. T., Mumm, J. S. (2012). Silencer-delimited transgenesis: NRSE/RE1 sequences promote neural-specific transgen expression in a NRSF/REST-dependent manner. BMC Biology 10: 93. doi: 10.1186/1741-7007-10-93.

Sasmal, P. K., Carregal-Romero, S., Streu, C. N., Lin, Z., Namikawa, K., Elliott, S. L., Köster, R. W., Parak, W. J., Meggers, E. (2012). Catalytic azide reduction in biological environments. ChemBioChem 13: 1116-1120.

Walker, S. L., Ariga, J., Mathias, J. R., Coothankaswamy, V., Xie, X., Distel, M., Köster, R. W., Parsons, M. J., Bhalla, K. N., Saxena, M. T., Mumm, J. S. (2012). Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish. PLoS One 7: e29916. doi:10.1371/journal.pone.0029916.

Oberoi, T. K., Dogan, T., Hocking, J. C., Scholz, R. P., Mooz, J., Anderson, C. L., Karreman, C., Meyer zu Heringdorf, D., Schmidt, G., Ruonala, M., Namikawa, K., Harms, G. S., Carpy, A., Macek, B., Köster, R. W., Rajalingam, K. (2012). IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO Journal 31: 14-28.

Hoegler, K. J., Distel, M., Köster, R. W., Horne, J. H. (2011). Targeting Olfactory Bulb Neurons Using Combined In Vivo Electroporation and Gal4-Based Enhancer Trap Zebrafish Lines. Journal of Visualized Experiments 54: doi: 10.3791/2964. (Summarizing Video)

Distel, M., Hocking, J. C., Köster, R. W. (2011). In vivo cell biology using Gal4-mediated multicolor subcellular labeling in zebrafish. Communicative & Integrative Biology 4: doi: 10.4151/cib.4.3.15037.

Wullimann, M. F., Mueller, T., Distel, M., Babaryka, A., Grothe, B., Köster, R. W. (2011). The adventurous journey of rhombic lip cells in jawed vertebrates: a comparative developmental analysis. Frontiers in Neuroanatomy 5: 27. doi: 10.3389/fnana.2011.00027. (Review Article)

Santoriello, C., Gennaro, E., Anelli, V., Distel, M., Köster, R. W., Hurlstone, A., Mione, M. (2010). Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish. PLoS ONE 5: e15170.

Distel, M., Hocking, J., Volkmann, K., Köster, R. W. (2010). The centrosome neither persistently leads migration nor determines the site of axonogenesis in migrating neurons in vivo. Journal of Cell Biology 191: 875-890. (Summarizing Biosights Video)

Distel, M., Hocking, J., Köster, R. W. (2010). Imaging the cell biology of neuronal migration in zebrafish. In "Live imaging in Zebrafish: Insights into Development and Disease" World Scientific Publishing, Singapore, 35-69. (Book Chapter)

Volkmann, K., Chen, Y.-Y., Harris, M., Wullimann, M. F., Köster, R. W. (2010). The zebrafish cerebellar upper rhombic lip generates tegmental hindbrain nuclei by long-distance migration in an evolutionary conserved manner. Journal of Comparative Neurology 518: 2794-2817.

Kühn, E., Köster, R. W. (2010) Analysis of gene expression by in situ hybridization on adult zebrafish brain sections. Cold Spring Harbor Protocols Vol. 2010. doi: 10.1101/pdb.prot5382.

Anelli, V., Santoriello, C., Distel, M., Köster, R. W., Ciccarelli, F., Mione, M. (2009). Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation. Zebrafish 6: 417-424.

Rieger, S., Senghaas, N., Walch, A., Köster, R. W. (2009). Cadherin-2 controls directional chain migration of cerebellar granule neurons. PLoS Biology 7: e1000240. doi:10.1371/journal.pbio.1000240.

Distel, M., Wullimann, M. F., Köster, R. W. (2009). Optimized Gal4-genetics for permanent gene expression mapping in zebrafish. Proceedings of the National Academy of Sciences USA (PNAS) 106: 13365-13370.

Razansky, D., Distel, M., Vinegoni, C., Ma, R., Perrimon, N., Köster, R. W., Ntziachristos, V. (2009). Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo. Nature Photonics 3: 412-417.

Nikolaou, N., Watanabe-Asaka, T., Gerety, S., Distel, M., Köster, R. W., Wilkinson, D. G. (2009). Lunatic fringe promotes the lateral inhibition of neurogenesis in the zebrafish hindbrain. Development 136: 2523-2533.

Köster, R. W., Fraser, S. E. (2009). Time-lapse microscopy of brain development. In "Essential Zebrafish Methods" Elsevier Press, Philadelphia, USA, 293-323. (Book Chapter)

Senghaas, N., Köster, R. W. (2009). Culturing and transfecting Pac2 zebrafish fibroblast cells. Cold Spring Harbor Protocols 4: doi:10.1101/pdb.prot5235.

Flinn, L., Mortiboys, H., Volkmann, K., Köster, R. W., Bandmann, O. (2009). Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio). Brain 132: 1613-1623.

Paquet, D., Bhat, R., Mandelkow, E.-M., Berg, S., Hellberg, S., Lindquist, J., Distel, M., Köster, R. W., Schmid, B., Haass, C. (2009). A novel Tau transgenic zebrafish model for drug discovery. Journal of Clinical Investigations 119: 1382-1395.

Babaryka, A., Kühn, E., Köster, R. W. (2009). In vivo synthesis of meganuclease results in efficient transgenesis in zebrafish. Journal of Fish Biology 74: 452-457.

Chu, Y., Senghaas, N., Köster, R. W., Wurst, W., Kühn, R. (2008). Novel Caspase-suicide proteins for tamoxifen-inducible apoptosis. Genesis 46: 530-536.

Volkmann, K., Rieger, S., Babaryka, A., Köster, R. W. (2008). The zebrafish cerebellar rhombic lip is spatially subdivided in producing granule cell populations of different functional compartments. Developmental Biology 313: 167-180.

Rieger, S., Volkmann, K., Köster, R. W. (2008). Polysialyltransferase expression is linked to neuronal migration in the developing and adult zebrafish. Developmental Dynamics 237: 276-285.

Volkmann, K., Köster, R. W. (2007). In vivo retrograde labeling of neurons in the zebrafish embryo or larvae with rhodamine dextrane. Cold Spring Harbor Protocols 2: doi:10.1101/pdb.prot4832.

Distel, M., Köster, R. W. (2007). In vivo time-lapse imaging of zebrafish embryonic development. Cold Spring Harbor Protocols 2: doi:10.1101/pdb.prot4816.

Rieger, S., Köster, R. W. (2007) Preparation of zebrafish embryos for transmission electron microscopy. Cold Spring Harbor Protocols 2: doi:10.1101/pdb.prot4772.

Köster, R. W., Fraser, S. E. (2006). FGF-signaling mediates regeneration of the differentiating zebrafish cerebellum through repatterning of the anterior hindbrain and reinitiation of neuronal migration. Journal of Neuroscience 26: 7293-7304.

Distel, M., Babaryka, A., Köster, R. W. (2006) Multicolor in vivo time-lapse imgaging at cellular resolution by stereomicroscopy. Developmental Dynamics 235: 843-845.

Rieger S., Kulkarni, R. P., Darcy, D., Fraser, S. E., Köster, R. W. (2005). Quantum Dots are powerful multipurpose vital labeling agents in zebrafish embryos. Developmental Dynamics 234: 670-681.

Köster, R. W., Fraser, S. E. (2004). Time-lapse microscopy of brain development. Methods in Cell Biology 76: 207-235. (Book Chapter)

Wagner, T. U., Renn, J., Riemensperger, T., Volff, J.-N., Köster, R. W., Göhrlich, R., Schartl, M., Winkler, C. (2003). The teleost fish medaka (Oryzias latipes) as genetic model to study gravity dependent bone homeostasis in vivo. Advances in Space Research 32: 1459-1465.

Hove*, J. R., Köster*, R. W., Forouhar, A. S., Acevedo-Bolton, G., Fraser, S. E. Gharib, M. (2003). Intracardiac fluid forces are an essential epigenetics factor for embryonic cardiogenesis. Nature 421: 172-177. * equally contributing first authors

Köster, R. W., Fraser, S. E. (2001). Direct imaging of in vivo neuronal migration in the developing cerebellum. Current Biology 11: 1858-1863.

Köster, R. W., Fraser, S. E. (2001). Tracing transgene expression in living zebrafish embryos. Developmental Biology 233: 329-346.

Udvadja, A. J., Köster, R. W., Skene, J. H. P. (2001). GAP-43 promoter elements in transgenic zebrafish reveal a difference in signals for axon growth during CNS development and regeneration. Development 128: 1175-1182.

Loosli*, F., Köster*, R. W., Carl, M., Kühnlein, R., Henrich, T., Mücke, M., Krone, A., Wittbrodt J. (2000). A genetic screen for mutations affecting embryonic development in medaka fish (Oryzias latipes). Mechanisms of Development 97: 133-139. * equally contributing first authors

Köster, R. W., Kühnlein, R. P., Wittbrodt, J. (2000). Ectopic Sox3 activity elicits sensory placode formation. Mechanisms of Development 95: 175-187.

Loosli*, F., Köster*, R. W., Carl, M., Krone, A., Wittbrodt, J. (1998). Six3, a medaka homologue of the Drosophila homeobox gene sine oculis is expressed in the anterior embryonic shield and the developing eye. Mechanisms of Development 74: 159-164. * equally contributing first authors

Köster, R., Stick, R., Loosli, F., Wittbrodt, J. (1997). Medaka spalt acts as a target gene of hedgehog signaling. Development 124: 3147-3156.

Oliver, G., Loosli, F., Köster, R., Wittbrodt, J., Gruss, P. (1996). Ectopic lens induction in fish in response to the murine homeobox gene Six3. Mechanisms of Development 60: 233-239.

Köster, R., Götz, R., Altschmied, J., Sendtner, M., Schartl, M. (1996). Comparison of monocistronic and bicistronic constructs for neurotrophin transgene and reporter gene expression in fish cells. Molecular Marine Biology and Biotechnology 5: 1-8.

Götz, R., Köster, R., Winkler, C., Raulf, F., Lottspeich, F., Schartl, M., Thoenen, H. (1994). Neurotrophin-6 is a new member of the nerve growth factor family. Nature 372: 266-269.