Publications

Publications

Originalarbeiten / Original Papers

2023

  • Gil-Moles M., O’Beirne C., Esarev I. V., Lippmann P., Tacke M., Cinatl Jr. J., Bojkova D., Ott I., Silver N-heterocyclic carbene complexes are potent uncompetitive inhibitors of the papain-like protease with antiviral activity against SARS-CoV-2. RSC MedChem (2023), 14, 1260-1271. DOI: 10.1039/D3MD00067B
  • Thaler R., Kopacka H., Wurst K., Müller T., Neururer F. R., Hohloch S., Lippmann P., Ott I., Bildstein B., Clathrochelate complexes containing axial cymantrene and tromancenium moieties. Eur. J. Inorg.Chem. (2023), 26, e2023003. doi.org/10.1002/ejic.202300368
  • König P., Zhulenko R., Suparman E., Hoffmeister H., Bückreiß N., Ott I., Bendas G., A biscarbene gold(I)-NHC-complex overcomes cisplatin-resistance in A2780 and W1 ovarian cancer cells highlighting pERK as regulator of apoptosis. Cancer Chemother. Pharmacol. (2023), 92, 57-69. link.springer.com/article/10.1007/s00280-023-04548-1
  • Müller V. L., Simpson P. V., Peng K., Basu U., Moreth D., Nagel C., Türck S., Oehninger L., Ott I., Schatzschneider U., Taming the biological activity of Pd(II) and Pt(II) complexes with triazolato “protective” groups: 1H, 77Se nuclear magnetic resonance and X-ray crystallographic model studies with selenocysteine to elucidate differential thioredoxin reductase inhibition. Inorg. Chem. (2023), 62, 16203−16214. doi.org/10.1021/acs.inorgchem.3c02701
  • Zhang J.-J., Xu J.-Q., El Maaty, M. A. A., Song J., Yu C., Zhou J., Han K., Sun H., Casini A., Ott I., Wölfl S., Elucidating the multimodal anticancer mechanism of an organometallic terpyridine platinum(II) N‑heterocyclic carbene complex against triple-negative breast cancer in vitro and in vivo. J. Med. Chem. (2023), 66, 3995−4008. pubs.acs.org/doi/10.1021/acs.jmedchem.2c01925
  • Babu T., Ghareeb H., Basu U., Schueffl H., Theiner S., Heffeter P., Koellensperger G., Metanis N., Gandin V., Ott I., Schmidt C., Gibson D., Oral anticancer heterobimetallic PtIV-AuI complexes show high in vivo activity and low toxicity. Angew. Chem. Int. Ed. (2023), 62(10), e202217233. https://onlinelibrary.wiley.com/doi/10.1002/anie.202217233
  • Wilke N. L., Burmeister H., Frias C., Ott I., Prokop A., Ruthenium complex HB324 induces apoptosis via mitochondrial pathway with an upregulation of Harakiri and overcomes cisplatin resistance in neuroblastoma cells in vitro. Int. J. Mol. Sci. (2023), 24, 952. https://doi.org/10.3390/ijms24020952

2022

  • Schmidt J., Wölker J., Lippmann P., Ott I., Microwave assisted synthesis of rhodium(I) N-heterocyclic carbene complexes and their cytotoxicity against tumor cell lines. J. Organomet. Chem. (2022), 964, 122300.
    https://doi.org/10.1016/j.jorganchem.2022.122300
  • Scattolin T., Lippmann P., Beliš M., van Hecke K., Ott I., Nolan S. P., A simple synthetic entryway into (N-heterocyclic carbene)gold-steroidyl complexes and their anticancer activity. Appl Organomet Chem. (2022), e6624.
    https://doi.org/10.1002/aoc.6624
  • Senges C. H. R., Warmuth H. L., Vázquez-Hernández M., Uzun H. D., Sagurna L., Dietze P., Schmidt C., Mücher B., Herlitze A., Krämer U., Ott I., Pomorski T. G., Bandow J. E., Effects of 4-Br-A23187 on Bacillus subtilis cells and unilamellar vesicles reveal it to be a potent copper ionophore. Proteomics (2022), 17, 2200061. DOI: 10.1002/pmic.202200061
  • Chen Q., Cuello-Garibo J.-A., Bretin L., Zhang L., Ramu V., Aydar Y., Batsiun Y., Bronkhorst S., Husiev Y., Betzsinna N., Chen L., Zhou X.-Q., Schmidt C., Ott I., Jager M. J., Brouwer A. M., Snaar-Jagalska B. E., Bonnet S., Photosubstitution in a trisheteroleptic ruthenium complex inhibits conjunctival melanoma growth in a zebrafish orthotopic xenograft model. Chem. Sci. (2022), 13(23), 6899-6919. doi.org/10.1039/D2SC01646J

2021

  • Gil-Moles M., Türck S., Basu U., Pettenuzzo A., Bhattacharya S., Rajan A., Ma, X., Büssing R., Wölker J., Burmeister H., Hoffmeister H., Schneeberg P., Prause A., Lippmann P., Kusi-Nimarko J., Hassell-Hart S., McGown A., Guest D., Lin Y., Notaro A., Vinck R., Karges J., Cariou K., Peng K., Qin X., Wang X., Skiba J., Szczupak Ł., Kowalski K., Schatzschneider U., Hemmert C., Gornitzka H., Milaeva E. R., Nazarov A. A., Gasser G., Spencer J., Ronconi L., Kortz U., Cinatl J., Bojkova D., Ott I., Metallodrug profiling against SARS-CoV-2 target proteins identifies highly potent inhibitors of the S/ACE2 interaction and the papain-like protease PLpro. Chem. Eur. J. (2021), 27, 17928-17940.
    https://doi.org/10.1002/chem.202103258
  • Filho M. S., Scattolin T., Dao P., Tzouras N. V., Benhida R., Saab M., Van Hecke K., Lippmann P., Martin A. R., Ott I., Nolan S. P., Straightforward synthetic route to gold(I)-thiolato glycoconjugate complexes bearing NHC ligands (NHC = N-heterocyclic carbene) and their promising anticancer activity. New J. Chem. (2021), 45, 9995-10001.
    https://doi.org/10.1039/D1NJ02117F
  • Shutkov I. A., Okulova Y. N., Tyurin V. Y., Sokolova E. V., Babkov D. A., Spasov A. A., Gracheva Y. A., Schmidt C., Kirsanov K. I., Shtil A. A., Redkozubova O. M., Shevtsova E. F., Milaeva E. R., Ott I., Nazarov A. A., Ru(III) complexes with lonidamine-modified ligands. Int. J. Mol. Sci. (2021), 22, 13468.
    www.mdpi.com/1422-0067/22/24/13468
  • Büssing R., Ott I., Jones P. G., Crystal structures of the gold NHC complex bis(4-bromo-1,3-diethylimidazol-2-ylidene)gold(I)iodide and its 1:1 adduct with trans-bis(4-bromo-1,3-diethyl-imidazol-2-ylidene)diiodidogold(III)iodide. Acta Cryst. (2021). E77, 1249-1252.
    doi.org/10.1107/S2056989021011488
  • Büssing R., Karge B., Lippmann P., Jones P.G., Brönstrup M., Ott I., Gold(I) and gold(III) N-heterocyclic carbene complexes as antibacterial agents and inhibitors of bacterial thioredoxin reductase. ChemMedChem (2021), 16, 3402-3409.
    https://doi.org/10.1002/cmdc.202100381
  • Khodjoyan S., Remadna E., Dossmann H., Lesage D., Gontard G., Forté J., Hoffmeister H., Basu U., Ott I., Spence P., Waller Z. A. E., Salmain M., Bertrand B., [(CC)Au(NN)]+ complexes as a new family of anticancer candidates: synthesis, characterization and exploration of the antiproliferative properties. Chem. Eur. J. (2021), 27, 15773-15785.
    https://doi.org/10.1002/chem.202102751
  • Busemann A., Flaspohler I., Zhou X.-Q., Schmidt C., Goetzfried S.K., van Rixel V.H.S, Ott I., Siegler M. A., Bonnet S., Ruthenium‑based PACT agents based on bisquinoline chelates: synthesis, photochemistry, and cytotoxicity. J. Biol. Inorg. Chem. (2021), 26, 667-674.
    doi.org/10.1007/s00775-021-01882-8
  • Schmidt C., Babu T., Kostrhunova H., Timm A., Basu U., Ott I., Gandin V., Brabec V., Gibson D., Are Pt(IV) prodrugs that release Combretastatin A4 true multi-action prodrugs? J. Med. Chem. (2021), 64, 11364-11378. doi.org/10.1021/acs.jmedchem.1c00706
  • Burmeister H., Dietze P., Preu L., Bandow J.E., Ott I., Evaluation of ruthenium(II) N-heterocyclic carbene complexes as antibacterial agents and inhibitors of bacterial thioredoxin reductase. Molecules (2021), 26, 4282.
    https://doi.org/10.3390/molecules26144282
  • Menia D., Kopacka H., Wurst K., Müller T., Lippmann P., Ott I., Bildstein B., Cobaltoceniumselenolate gold(I) complexes: synthesis, spectroscopic, structural and anticancer properties. Eur. J. Inorg. Chem. (2021), 2784–2786.
    https://doi.org/10.1002/ejic.202100379
  • Kladnik J., Coverdale J.P.C., Kljun J., Burmeister H., Lippman P., Ellis F.G., Jones A.M., Ott I., Romero-Canelón I., Turel I., Organoruthenium complexes with benzo-fused pyrithiones overcome platinum resistance in ovarian cancer cells. Cancers (2021), 13, 2493.
    https://doi.org/10.3390/cancers13102493
  • Butsch K., Haseloer A., Schmitz S., Ott I., Schur J., Klein A., FeIII, CuII and ZnII Complexes of the rigid 9-oxido-phenalenone ligand — spectroscopy, electrochemistry, and cytotoxic properties. Int. J. Mol. Sci. (2021), 22, 3976.
    doi.org/10.3390/ijms22083976
  • Zhou X.-Q., Carbo-Bague I., Siegler M.A., Hilgendorf J., Basu U., Ott I., Liu R., Zhang L., Vadde R., IJzerman A.P, Bonnet S., Rollover cyclometalation vs nitrogen coordination in tetrapyridyl anticancer gold(III) complexes: Effect on protein interaction and toxicity. JACS Au (2021), 1, 380-395.
    pubs.acs.org/doi/10.1021/jacsau.0c00104
  • Brüning D., Hatlapatka K., Lier-Glaubitz V., Andermark V., Scherneck S., Ott I., Rustenbeck I., Pharmacological inhibition of thioredoxin reductase increases insulin 7 secretion and diminishes beta cell viability. Naunyn-Schmiedeberg's Arch. Pharmacol. (2021), 394, 1133-1142.
    doi.org/10.1007/s00210-020-02046-2

2020

  • Gil-Moles M., Basu U., Büssing R., Hoffmeister H., Türck S., Varchmin A., Ott I., Gold metallodrugs to target coronavirus proteins: Inhibitory effects on the spike-ACE2 interaction and on PLpro protease activity by Auranofin and gold organometallics. Chem. Eur. J. (2020), 26, 15140-15144.
    DOI: 10.1002/chem.202004112
  • Zhang J.-J., Abu el Maaty, M. A., Hoffmeister H., Schmidt C., Münzner J. K., Schobert R., Wölfl S., Ott I., A multi-target gold(I) complex induces cytotoxicity related to aneuploidy in HCT-116 colorectal carcinoma cells. Angew. Chem. Int. Ed. (2020), 59, 16795-16800.
    DOI: 10.1002/anie.202006212
  • Walther W., Dhiyaa A., Danielle C., O’Beirne C., Mc Carthy C., Ott I., Basu U., Büttner B., Sterner-Kock A., Müller-Bunz H., Sánchez-Sanz G., Zhu X., Tacke M., In-vitro and in-vivo investigations into the carbene-gold anticancer drug candidates NHC*-Au-SCSNMe2 and NHC*-Au-S-GLUC against advanced prostate cancer PC3. Anticancer-Drugs (2020), 31, 672-683.
    DOI: 10.1097/CAD.0000000000000930
  • Cheng X., Haeberle S., Shytaj I. L., Gama-Brambila R. A., Theobald J., Ghafoory S., Wölker J., Basu U., Schmidt C., Timm A., Taškova K., Bauer A. S., Hoheisel J., Tsopoulidis N., Fackler O. T., Savarino A., Andrade-Navarro M. A., Ott I., Lusic M., Hadaschik E. N., Wölfl S., NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice. Commun. Biol. (2020), 3, 10.
    DOI: 10.1038/s42003-019-0716-8
  • Serebryanskaya T. V., Kinzhalov M. A., Bakulev V., Alekseev G., Andreeva A., Gushchin P. V., Protas A. V., Smirnov A. S., Panikorovskii T. L., Lippmann P., Ott I., Verbilo C. M., Zuraev A. V., Bunev A. S., Boyarskiy V. P., Kasyanenko N. A., Water soluble palladium(II) and platinum(II) acyclic diaminocarbene complexes: solution behavior, DNA binding, and antiproliferative activity. New J. Chem. (2020), 44, 5762-5773.
    DOI: 10.1039/d0nj00060d
  • Garbe S., Krause M., Klimpel A., Neundorf I., Lippmann P., Ott I., Brünink D., Strassert C. A., Doltsinis N. L., Klein A., Cyclometalated Pt complexes of CNC pincer ligands: luminescence and cytotoxic evaluation. Organometallics (2020), 39, 746-756. 
    DOI: 10.1021/acs.organomet.0c00015
  • Truong D., Sullivan M. P., Tong K. K. H., Steel T. R., Prause A., Lovett J. H., Andersen J. W., Jamieson S. M. F., Harris H. H., Ott I., Weekley C. M., Hummitzsch K., Söhnel T., Hanif M., Metzler-Nolte N., Goldstone D. C., Hartinger C. G., Potent inhibition of thioredoxin reductase by the Rh derivatives of anticancer M(arene/Cp*)(NHC)Cl2 complexes. Inorg. Chem. (2020), 59, 3281−3289. 
    DOI: 10.1021/acs.inorgchem.9b03640
  • Ortega E., Zamora A., Basu U., Lippmann P., Rodríguez V., Janiak C., Ott I. Ruiz J., An Erlotinib gold(I) conjugate for combating triple-negative breast cancer. J. Inorg. Biochem. (2020), 203, 110910.
    DOI: 10.1016/j.jinorgbio.2019.110910​​​​​​​

2019

  • Kladnik J., Kljun J., Burmeister H., Ott I., Romero-Canelón I., Turel I., Towards identification of essential structural elements of organoruthenium(II)-pyrithionato complexes for anticancer activity. Chem. Eur. J. (2019), 25, 14169-14182.
    DOI: 10.1002/chem.201903109
  • Schur J., Lüning A., Klein A., Köster R. W., Ott I., Platinum alkynyl complexes: Cellular uptake, inhibition of thioredoxin reductase and toxicity in zebrafish embryos. Inorg. Chim. Acta (2019), 495, 118982. doi.org/10.1016/j.ica.2019.118982
    DOI: 10.1016/j.ica.2019.118982
  • Singh K., Jana A., Lippmann P., Ott I., Das N., Isomeric platinum organometallics derived from pyrimidine, pyridazine or pyrazine and their potential as antitumor drugs. Inorg. Chim. Acta (2019), 493, 112-117.
    DOI: 10.1016/j.ica.2019.04.028

  • Singh K., Jana A., Lippmann P., Ott I., Das N., Pyrimidine derivatives with terminal pyridyl heterocycles: Facile synthesis and their antiproliferative activities.
     J. Heterocyclic Chem. (2019), 56, 1866-1872.
    DOI: 10.1002/jhet.3547

  • Schmidt C., Albrecht L., Balasupramaniam S., Misgeld R., Karge B., Brönstrup M., Prokop A., Baumann K., Reich S., Ott I., A gold(I) biscarbene complex with improved activity as a TrxR inhibitor and cytotoxic drug: comparative studies with different gold metallodrugs. Metallomics (2019), 11, 533-545. 
    DOI: 10.1039/C8MT00306H

  • Dalmases M., Pinto A., Lippmann P., Ott I., Rodríguez L., Figuerola A., Preparation and antitumoral activity of Au-based inorganic-organometallic nanocomposites. Front. Chem. (2019), 7, 60.
    DOI: 10.3389%2Ffchem.2019.00060
  • Dabiri Y., Abu el Maaty M. A., Chan H. Y., Wölker J., Ott I., Wölfl S., Cheng X., p53-Dependent anti-proliferative and pro-apoptotic effects of a gold(I) N-heterocyclic carbene (NHC) complex in colorectal cancer cells. Front. Oncol. (2019), 9, 438. DOI:10.3389/fonc.2019.00438

2018

  • Lam, N. Y. S., Truong D., Burmeister H., Babak M. V., Holtkamp H. U., Movassaghi S., Ayine-Tora D. M., Zafar A., Kubanik M., Oehninger L., Söhnel T., Reynisson J., Jamieson S. M. F, Gaiddon C., Ott I., Hartinger C. G., From catalysis to cancer: Toward structure-activity relationships for benzimidazol-2-ylidene-derived N-heterocyclic-carbene complexes as anticancer agents. Inorg. Chem. (2018), 57, 14427-14434.
    DOI: 10.1021/acs.inorgchem.8b02634

  • Streciwilk W., Terenzi A., Cheng X., Hager L., Dabiri Y., Prochnow P., Bandow J. E., Wölfl S., Keppler B., Ott I., Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction. Eur. J. Med. Chem. (2018), 156, 148-161.
    DOI: 10.1016/j.ejmech.2018.06.056

  • Dabiri Y., Schmid A., Theobald J., Blagojevic B., Streciwilk W., Ott I., Wölfl S., Cheng X., A ruthenium(II) N-heterocyclic carbene (NHC) complex with naphthalimide ligand triggers apoptosis in colorectal cancer cells via activating the ROS-p38 MAPK pathway. Int. J. Mol. Sci. (2018), 19, 3964;
    DOI: 10.3390/ijms19123964

  • Walther W., Dada O., Ott I., Prochnicka A., Büttner B., Zhu X., Tacke M., In vivo investigations into the carbene gold anticancer drug candidates NHC*-Au-SCN and NHC*-Au-Scyclo. Trends Cancer Res. (2018), 13, 63-70.
    researchtrends

  • Williams M. R. M., Bertrand B., Hughes D. L., Zoe A. E., Waller Z. A. E., Schmidt C., Ott I., O'Connell M., Searcey M., Bochmann M., Cyclometallated Au(III) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies. Metallomics (2018), 10, 1655-1666.
    DOI: 10.1039/c8mt00225h

  • Streciwilk W., Terenzi A., Lo Nardo F., Prochnow P., Bandow J. E., Keppler B. K., Ott I., Synthesis and biological evaluation of organometallic complexes bearing bis-1,8-naphthalimide ligands. Eur. J. Inorg. Chem. (2018), 3104-3112.
    DOI: 10.1002/ejic.201800384

  • Walter A., Chaikuad A., Helmer R., Loaëc N., Preu L., Ott I.,Knapp S., Meijer L., Kunick C. Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. PLoS ONE (2018), 13, e0196761.
    DOI: 10.1371/journal.pone.0196761

  • Hormann J., Malina J., Lemke O., Hülsey M. J.; Wedepohl S., Potthoff J., Schmidt C., Ott I., Keller B., Brabec V., Kulak N., Multiply intercalator-substituted Cu(II) cyclen complexes as DNA condensers and DNA/RNA synthesis inhibitors. Inorg. Chem. (2018), 57, 5004-5012.
    DOI: 10.1021/acs.inorgchem.8b00027

  • Protas A. V., Popova E. A., Mikolaichuk O. V., Porozov Y. B., Mehtief A. R., Ott I., Alekseev G. V., Kasyanenko N. A., Trifonov R. E., Synthesis, DNA and BSA binding of Pd(II) and Pt(II) complexes featuring tetrazolylacetic acids and their esters. Inorg. Chimica Acta (2018), 473, 133-144.
    DOI: 10.1016/j.ica.2017.12.040

  • Shpakovsky D. B., Shtil A.A., Kharitonashvili E. V., Tyurin V. Y., Antonenko T. A., Nazarov A. A., Osipova V. P., Berberova N. T., Foteeva L. S., Schmidt C., Ott I., Milaeva E. R., The antioxidant 2,6-di-tert-butylphenol moiety attenuates the pro-oxidant properties of the auranofin analogue. Dalton Trans. (2018), 10, 406-413.
    DOI: 10.1039/C7MT00286F

  • Jana A., Lippmann P., Ott I., Das N., Self-Assembly of Flexible [2 + 2] Ionic Metallamacrocycles and Their Cytotoxicity Potency. Inorg. Chimica Acta (2018), 471, 223-227.
    DOI: 10.1016/j.ica.2017.11.002

  • Vanicek S., Podewitz M., Stubbe J., Schulze D., Kopacka H., Wurst K., Meller T., Lippmann P., Haslinger S., Schottenberger H., Liedl K. R., Ott I., Sarkar B., Bildstein B., Highly Electrophilic, Catalytically Active and Redox-Responsive Cobaltoceniumyl and Ferrocenyl Triazolylidene Coinage Metal Complexes. Chem Eur. J. (2018), 24, 3742 - 3753.
    DOI: 10.1002/chem.201705051

  • Cullinane C., Deacon G. B., Drago P. R., Erven A. P., Junk P. C., Luu J., Meyer G., Schmitz S., Ott I., Schur J., Webster L. K., Klein A., Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes. Dalton Trans. (2018), 4, 1918-1932.
    DOI: 10.1039/c7dt04615d

2017

  • Schmidt C., Karge B., Misgeld R., Prokop, A., Brönstrup, M., Ott, I., Biscarbene gold(I) complexes: structure-activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability. Med. Chem. Commun. (2017), 8, 1681-1689. DOI: 10.1039/c7md00269f
  • Bertrand B., Romanov A. S., Brooks M., Davis J., Schmidt C., Ott I., O'Connell M., Bochmann M., Synthesis, structure and cytotoxicity of cyclic (alkyl)(amino) carbene and acyclic carbene complexes of group 11 metals. Dalton Trans. (2017), 46, 5875-15887.
    DOI: 10.1039/c7dt03189k
  • Schmidt C., Karge B., Misgeld R., Prokop A., Franke R., Brönstrup M., Ott I., Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram-positive directed Antibacterial Effects.
    Chem. Eur. J. (2017), 23, 1869-1880.
    DOI: 10.1002/chem.201604512

  • Appold M., Mari C., Lederle C., Elbert J., Schmidt C., Ott I., Stühn B., Gasser G., Gallei M., Multi-stimuli responsive block coplolymers as a smart release platform for a polypyridyl ruthenium complex.
    Polym. Chem. (2017), 8, 890-900.
    DOI: 10.1039/c6py02026g

  • Streciwilk W., Terenzi A., Misgeld R., Frias C., Jones P. G., Prokop A., Keppler B. K., Ott I., Metal NHC complexes with naphthalimide ligands as DNA-interacting antiproliferative agents.
    ChemMedChem (2017), 12, 214-225.
    DOI: 10.1002/cmdc.201600557

  • Walther W., Dada O., O'Beirne C., Ott I., Sánchez-Sanz G., Schmidt C., Werner C., Zhu X., Tacke M., In Vitro and In Vivo Investigations into the Carbene Gold Chloride and Thioglucoside Anticancer Drug Candidates NHC-AuCl and NHC-AuSR.
    Letters Drug Des. Drug Disc. (2017), 14, 125-134.
    DOI: 10.2174/1570180813666160826100158

  • Skiba J., Schmidt C., Lippmann P., Ensslen P., Wagenknecht H.-A., Czerwieniec R., Brandl F., Ott I., Bernaś T., Krawczyk B., Szczukocki D., Kowalski K., Substitution of metallocenes with [2.2]paracyclophane to enable confocal microscopy imaging in living cells.
    Eur. J. Inorg. Chem. (2017), 297-305.
    DOI: 10.1002/ejic.201600281

2016

  • Muenzner J. K., Biersack B., Albrecht A., Rehm T., Lacher U., Milius W., Casini A., Zhang J.-J., Ott I., Brabec V., Stuchlikova O., Andronache I. C., Kaps L., Schuppan D., Schobert R., Ferrocenyl-Coupled N-Heterocyclic Carbene Complexes of Gold(I): A Successful Approach to Multinuclear Anticancer Drugs.
    Chem. Eur. J. (2016), 22, 18953 -18962.
    DOI: 10.1002/chem.201604246

  • Popova E., Serebryanskaya T. V., Selivanov S. I., Haukka M., Panikorovsky T. L., Gurzhiy V. V., Ott I., Trifonov R. E., Kukushkin V. Y., Water-Soluble Platinum(II) Complexes Featuring 2-Alkyl-2Htetrazol-5-ylacetic Acids: Synthesis, Characterization, and Antiproliferative Activity.
    Eur. J. Inorg. Chem. (2016), 4659-4667.
    DOI: 10.1002/ejic.201600626

  • Zhang J.-J., Muenzner J. K., Abu el Maaty M. A., Karge B., Schobert R., Wölfl S., Ott I., A multi-target caffeine derived rhodium(I) N-heterocyclic carbene complex: evaluation of the mechanism of action.
    Dalton Trans. (2016), 45, 13161-13168.
    DOI: 10.1039/c6dt02025a

  • Lingen V., Lüning A., Krest A., Deacon G. B., Schur J., Ott I., Pantenburg I., Meyer G., Klein A., Labile Pd-sulphur and Pt-sulphur bonds in organometallic palladium and platinum complexes [(COD)M(alkyl)(S-ligand)]n+-A speciation study.
    J. Inorg. Biochem. (2016), 165, 119-127.
    DOI: 10.1016/j.jinorgbio.2016.06.009

  • Gavara R., Aguilo E., Schur J., Llorca J., Ott I., Rodriguez L., Study of the effect of the chromophore and nuclearity on the aggregation and potential biological activity of gold(I) alkynyl complexes.
    Inorg. Chim. Acta (2016), 446, 189-197.
    DOI: 10.1016/j.ica.2016.03.012

  • Andermark V., Göke K., Kokoschka M., Abu el Maaty M. A., Lum C. T., Zou T., Sun R. W.-Y., Aguilo E., Oehninger L., Rodriguez L., Bunjes H., Wölfl S., Che CM, Ott I., Alkynyl gold(I) phosphane complexes: evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex.
    J. Inorg. Biochem. (2016), 160, 140-148.
    DOI: 10.1016/j.jinorgbio.2015.12.020

  • Vanicek S., Kopacka H., Wurst K., Vergeiner S., Kankowski S., Schur J., Bildstein B. Ott I., Cobaltoceniumethynyl gold(I) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynylgold complexes.
    Dalton Trans. (2016), 45, 1345-1348.
    DOI: 10.1039/c5dt04796j

  • Rodrigues M., Russo L.,Aguilo E., Rodriguez L., Ott I., Perez-Garcia L., Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles.
    RSC Adv. (2016), 6, 2202-2209.
    DOI: 10.1039/c5ra21621d

2015

  • Oehninger L., Spreckelmeyer S., Holenya P., Meier S. M., Can S., Alborzinia H., Schur J., Keppler B. K., Wölfl S., Ott I., Rhodium(I) N‑Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling.
    J. Med. Chem. (2015), 58, 9591-9600.
    DOI: 10.1021/acs.jmedchem.5b01159

  • Hikisz P., Szczupak L., Koceva-Chyła A., Guśpiel A., Oehninger L., Ott I., Therrien B., Solecka J., Kowalski K, Anticancer and Antibacterial Activity Studies of Gold(I)-Alkynyl Chromones.
    Molecules, (2015), 20, 19647-19672.
    DOI: 10.3390/molecules201119647

  • Serebryanskaya T.V., Zolotarev A., Ott I., A novel aminotriazole-based NHC complex for the design of gold(I) anti-cancer agents: synthesis and biological evaluation.
    Med. Chem. Commun. (2015), 6, 1186-1189.
    DOI: 10.1039/c5md00185d, open access

  • Vanicek S., Kopacka H., Wurst K., Vergeiner S., Oehninger L., Ott I., Bildstein B., Cobaltocenium carboxylate transition metal complexes: synthesis, structure, reactivity, and cytotoxicity.
    Z. Anorg. Allg. Chem. (2015), 641, 1282-1292.
    DOI: 10.1002/zaac.201500033

  • Skiba J., Kowalski K., Prochnicka A., Ott I., Solecka J., Rajnisz A., Therrien B., Metallocene-uracil conjugates: synthesis and biological evaluation of novel mono-, di- and tri-nuclear systems.
    J. Organomet. Chem., (2015), 782, 52-61.
    DOI: 10.1016/j.jorganchem.2014.11.017

  • Lüning A., Neugebauer M., Lingen V., Krest A., Stirnat K., Deacon G. B., Drago P. R., Ott I., Schur J., Pantenburg I., Meyer G., Klein A., Platinum diolefin complexes - Synthesis, structures, and cytotoxicity.
    Eur. J. Inorg. Chem., (2015), 226-239.
    DOI:10.1002/ejic.201402954

  • Zhang J., Che C.M., Ott I., Caffeine derived platinum(II) N-heterocyclic carbene complexes with multiple anti-cancer activities.
    J. Organomet. Chem., (2015), 782, 37-41.
    DOI: 10.1016/j.jorganchem.2014.10.041

2014

  • Serebryanskaya T.V., Lyakhov A. S., Ivashkevich L. S., Schur J., Frias C., Prokop A., Ott I., Gold(I) thiotetrazolates as thioredoxin reductase inhibitors and antiproliferative agents.
    Dalton Trans. (2014), 44, 1161-1169.
    DOI: 10.1039/c4dt03105a, open access

  • Arcau J., Andermark V., Rodrigues M., Giannicchi I., Pérez-Garcia L., Ott I., Rodriguez L., Synthesis and biological activity of gold(I) NHC complexes with long aliphatic side chains.
    Eur. J. Inorg. Chem. (2014), 6117-6125.
    DOI: 10.1002/ejic.201402819

  • Navakoski de Oliveira K., Andermark V., Onambele L. A., Dahl G., Prokop A., Ott I., Organotin complexes containing carboxylate ligands with maleimide and naphthalimide derived partial structures: TrxR inhibition, cytotoxicity and activity in resistant cancer cells.
    Eur. J. Med. Chem. (2014), 87, 794-800.
    DOI: 10.1016/j.ejmech.2014.09.075

  • Spincemaille P., Alborzinia H., Dekervel J., Windmolders P., van Pelt J., Cassiman D., Cheneval O., Craik D. J., Schur J., Ott I., Wölfl S., Cammue B. P. A., Thevissen K., The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells.
    Molecules (2014), 19, 15088-15102.
    DOI: 10.3390/molecules190915088

  • Cheng X., Holenya P., Can S., Alborzinia H., Rubbiani R., Ott I., Wölfl S., A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells.
    Mol. Cancer (2014), 13, 221.
    DOI: 10.1186/1476-4598-13-221

  • Kowalski K., Szczupak L., Oehninger L., Ott I., Hikisz P., Koceva-Chyla A., Therrien B., Ferrocenyl derivatives of pterocarpene and coumestan: synthesis, structure and anticancer activity studies.
    J. Organomet. Chem. (2014), 772-773, 49-59.
    DOI: 10.1016/j.jorganchem.2014.08.027

  • Mari C., Pierroz V., Rubbiani R., Patra M., Hess J., Spingler B., Oehninger L., Schur J., Ott I., Salassa L., Ferrari S., Gasser G., DNA intercalating Ru(II) polypyridyl complexes as effective photosensitizers in photodynamic therapy.
    Chem. Eur. J. (2014), 20, 14421 - 14436.
    DOI: 10.1002/chem.201402796

  • Holenya P., Can S., Rubbiani R., Alborzinia H., Jünger A., Cheng X., Ott I., Wölfl S., Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene-gold(I) complex.
    Metallomics (2014), 6, 1591-1601.
    DOI: 10.1039/c4mt00075g

  • Rubbiani R., Wahrig B., Ott I., Historical and biochemical aspects of a seventeenth century gold-based aurum vitae recipe.
    J. Biol. Inorg. Chem. (2014), 19, 961-965.
    DOI: 10.1007/s00775-014-1135-4

  • Parrilha G. L., Ferraz K. S. O., Lessa J. A., Navakoski de Oliveira K., Rodrigues B. L., Ramos J. P., Souza-Fagundes E. M., Ott I., Beraldo H., Metal complexes with 2-acetylpyridine-N(4)-orthochlorophenylthiosemicarbazone: Cytotoxicity and effect on the enzymatic activity of thioredoxin reductase and glutathione reductase.
    Eur. J. Med. Chem. (2014), 84, 537-544.
    DOI: 10.1016/j.ejmech.2014.07.055

  • Meyer A., Oehninger L., Geldmacher Y., Alborzinia H., Wölfl S., Sheldrick W. S., Ott I., Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators.
    ChemMedChem (2014), 9, 1794-1800.
    DOI: 10.1002/cmdc.201402049

  • Rubbiani R., Salassa L., Andreia de Almeida, Casini A., Ott I., Cytotoxic Gold(I) N-heterocyclic carbene complexes with phosphane ligands as potent enzyme inhibitors.
    ChemMedChem (2014), 9, 1205-1210.
    DOI: 10.1002/cmdc.201400056
  • Jortzik E., Farhadi M., Ahmadi R., Toth K., Lohr J., Helmke B. M., Kehr S., Unterberg A., Ott I., Gust R., Deborde V., Davioud-Charvet D., Reau R., Becker K., Herold-Mende C., Antiglioma activity of GoPI-sugar, a novel gold(I)-phosphole inhibitor: Chemical synthesis, mechanistic studies, and effectiveness in vivo.
    Biochim. Biophys. Acta (2014), 1844, 1415-14-26.
    DOI: 10.1016/j.bbapap.2014.01.006
  • Pratesi A., Gabbiani C., Michelucci E., Ginanneschi M., Papini A. M., Rubbiani R., Ott I., Messori L., Insights on the mechanism of thioredoxin reductase inhibition by Gold N-heterocyclic carbene compounds using the synthetic linear selenocysteine containing C-terminal peptide hTrxR(488-499): An ESI-MS investigation.
    J. Inorg. Biochem. (2014), 136, 161-169.
    DOI: 10.1016/j.jinorgbio.2014.01.009
  • Pittracher M., Frisch U., Kopacka H., Wurst K., Müller T., Oehninger L., Ott I., Wuttke E., Scheerer S., Winter R.F., Bildstein B., π‑Complexes of tropolone and Its N‑derivatives: Ambi-dentate [O,O]/[N,O]/[N,N]-cycloheptatrienyl pentamethylcyclopentadienyl ruthenium sandwich complexes.
    Organometallics (2014), 33, 1630-1643.
    DOI: 10.1021/om401200t
  • Schur J., Manna C. M., E. Y. Tshuva, Ott I., Quantification of the titanium content in metallodrug exposed tumor cells using HR-CS AAS.
    Metallodrugs (2014), 1, 1-9.
    DOI: 10.2478/medr-2014-0001
  • Arcau J., Andermark V., Aguilo E., Gandioso A., Moro A., Cetina M., Lima J. C., Rissanen K., Ott I., Rodriguez L., Luminescent gold(I)-alkynyl coumarin complexes and their biological activity.,
    Dalton Trans. (2014), 43, 4426-4436.
    DOI: 10.1039/C3DT52594E

2013

  • Oehninger L., Küster N., Schmidt C., Munoz-Castro A., Prokop A., Ott I., A chemical-biological evaluation of rhodium(I) N-heterocyclic carbene complexes as prospective anticancer drugs.,
    Chem. Eur. J. (2013), 19, 17871-17880.
    DOI: 10.1002/chem.201302819
  • Simpson P. V., Schmidt C., Ott I., Bruhn H., Schatzschneider U., Synthesis, cellular uptake and biological activity against pathogenic microorganisms and cancer cells of rhodium and iridium N-heterocyclic carbene complexes bearing charged substituents.
    Eur. J. Inorg. Chem. (2013), 5547-5554.
    DOI: 10.1002/ejic.201300820
  • Kowalski K., Skiba J., Oehninger L., Ott I., Solecka J., Rajnisz A., Therrien B., Metallocene-modified uracils: Synthesis, structure, and biological activity.
    Organometallics (2013), 32, 5766-5773.
    DOI: 10.1021/om400294s
  • Wenzel M., Patra M., Senges C. H. R., Ott I., Stepanek J. J., Pinto A., Prochnow P., Vuong C., Langklotz S., Metzler-Nolte N., Bandow J. E., Analysis of the mechanism of action of potent antibacterial hetero-tri-organometallic compounds - a structurally new class of antibiotics.
    ACS Chem. Biol. (2013), 8, 1442-1450.
    DOI: 10.1021/cb4000844
  • Lüning A., Schur J., Hamel L., Ott I., Klein A., Strong Cytotoxicity of Organometallic Platinum Complexes with Alkynyl Ligands.
    Organometallics (2013), 32, 3662-3672.
    DOI: 10.1021/om400293u
  • Rubbiani R., Schuh E., Meyer A., Lemke J., Wimberg J., Metzler-Nolte N., Meyer F., Mohr F., Ott I.*, TrxR inhibition and antiproliferative activities of structurally diverse gold N-heterocyclic carbene complexes.
    Med. Chem. Commun. (2013), 4, 942-948.
    DOI: 10.1039/C3MD00076A
  • Schur J., Manna C. M., Deally A., Köster R. W., Tacke M., Tshuva E., Ott I.*, A comparative chemical-biological evaluation of titanium(IV) complexes with a salan or cyclopentadienyl ligand.
    Chem. Commun. (2013), 49, 4785-4787.
    DOI: 10.1039/C3CC38604J
  • Meyer A., Gutierrez A., Ott I.*, Rodriguez L., Phosphine-bridged dinuclear gold(I) alkynyl complexes: thioredoxin reductase inhibition and cytotoxicity.
    Inorg. Chim. Acta (2013), 398, 72-76.
    DOI: 10.1016/j.ica.2012.12.013
  • Navakoski de Oliveira K., Andermark V., von Grafenstein S., Onambele L. A., Dahl G., Rubbiani R., Wolber G., Gabbiani C., Messori L., Prokop A. Ott I.*, Butyltin(IV) benzoates: inhibition of thioredoxin reductase, tumor cell growth inhibition and interactions with proteins.
    ChemMedChem (2013), 8, 256-264.
    DOI: 10.1002/cmdc.201200505
  • Oehninger L., Stefanopoulou M., Alborzinia H., Schur J., Ludewig S., Namikawa K., Muñoz-Castro A., W. Köster R. W., Baumann K., Wölfl S., Sheldrick W.S., Ott I.*, Evaluation of Arene Ruthenium(II) N-heterocyclic Carbene Complexes as Organometallics Interacting with Thiol and Selenol Containing Biomolecules.
    Dalton Trans. (2013), 42, 1657-1666.
    DOI: 10.1039/C2DT32319B

2012

  • Pierroz V., Joshi T, Leonidova A., Mari C., Schur J., Ott I., Spiccia L., Ferrari S., Gasser G., Molecular and cellular Characterisation of the biological effects of ruthenium(II) complexes incorporating 2-pyridyl-2-pyrimidine-4-carboxylic acid.
    J. Am. Chem. Soc. (2012), 134, 20376-20387.
    DOI: 10.1021/ja307288s
  • Skiba J., Rajnisz J., Navakoski de Oliveira K., Ott I., Solecka J., Kowalski K., Ferrocenyl bioconjugates of ampicillin and 6-aminopenicillinic acid - synthesis, electrochemistry and biological activity.
    Eur. J. Med. Chem. (2012), 57, 234-239.
    DOI: 10.1016/j.ejmech.2012.09.023
  • Meyer A., Bagowski C. P., Kokoschka M., Stefanopoulou M., Alborzinia H., Can S., Vlecken D. H., Sheldrick W. S., Wölfl S., Ott I.*, On the Biological Properties of Alkynyl Phosphine Gold(I) Complexes.
    Angew. Chem. Int. Ed. (2012), 51, 8895-8899.
    DOI: 10.1002/anie.201202939
  • Gross A., Hüsken N., Schur J., Raszeja L., Ott I., Metzler-Nolte N., A ruthenocene-PNA bioconjugate - synthesis, characterization, cytotoxicity, and AAS-detected cellular uptake.
    Bioconjugate Chem. (2012), 23, 1764-1774.
    DOI: 10.1021/bc200692g
  • Meyer A., Grotefend S., Gross A., Wätzig H., Ott I.*, Total reflection X-ray fluorescence spectrometry as a tool for the quantification of gold and platinum metallodrugs: Determination of recovery rates and precision in the ppb concentration range.
    J. Pharm. Biomed. Anal. (2012), 70, 713-717.
    DOI: 10.1016/j.jpba.2012.07.019

  • Köster S. D., Alborzinia H., Can S., Kitanovic I., Wölfl S., Rubbiani R., Ott I., Riesterer P., Prokop A., Merz K., Metzler-Nolte N., A spontaneous gold(I)-azide alkyne cycloaddition reaction yields gold-peptide bioconjugates which overcome cisplatin resistance in a p53-mutant cancer cell line.
    Chem. Sci. (2012), 3, 2062-2072.
    DOI: 10.1039/C2SC01127A

  • Nazif M. A., Rubbiani R., Alborzinia H., Kitanovic I., Wölfl S., Ott I., Sheldrick W. S., Cytotoxicity and cellular impact of dinuclear organoiridium DNA intercalators and nucleases with long rigid bridging ligands.
    Dalton Trans. (2012), 41, 5587-5598.
    DOI: 10.1039/C2DT00011 C

  • Krüger M., Huang M., Becker-Roβ H., Florek S., Ott I., Gust R., Quantification of the fluorine containing drug 5-fluorouracil in cancer cells by GaF molecular absorption via high-resolution continuum source molecular absorption spectrometry.
    Spectrochim. Acta, part B (2012), 69, 50-55.
    DOI: 10.1016/j.sab.2012.02.004

  • Geldmacher Y., Splith K., Kitanovic I., Alborzinia H., Can S., Rubbiani R., Nazif M. A., Wefelmeyer P., Prokop A., Ott I., Wölfl S., Neundorf I., Sheldrick W. S., Cellular impact and selectivity of half-sandwich organorhodium(III) anticancer complexes and their organoiridium(III) and trichloridorhodium(III) counterparts.
    J. Biol. Inorg. Chem. (2012), 17, 631-636.
    DOI: 10.1007/s00775-012-0883-2

  • Osowole A. A., Ott I., Ogunlana O. M., Synthesis, spectroscopic, anticancer, and antimicrobial properties of some metal(II) complexes of (substituted) nitrophenol schiff base.
    Int. J. Inorg. Chem. (2012), ID 206417.
    DOI: 10.1155/2012/206417

  • Kasper C., Alborzinia H., Can S., Kitanovic I., Meyer A., Geldmacher Y., Oleszak M., Ott I., Wölfl S., Sheldrick W. S., Synthesis and cellular impact of diene-ruthenium(II) complexes: A new class of organoruthenium anticancer agents.
    J. Inorg. Biochem. (2012), 106, 126-133.
    DOI: 10.1016/j.jinorgbio.2011.08.027

2011

  • Rubbiani R., Can S., Kitanovic I., Alborzinia H., Stefanopoulou M., Kokoschka M., Mönchgesang S., Sheldrick W. S., Wölfl S., Ott I., Comparative in vitro evaluation of N-heterocyclic carbene gold(I) complexes of the benzimidazolylidene type.
    J. Med. Chem. (2011), 54, 8646-8657.
    DOI: 10.1021/jm201220n

  • Gasser G., Neumann S., Ott I., Seitz M., Heumann R., Metzler-Nolte N. Preparation and biological evaluation of di-hetero organometallic-containing PNA bioconjugates.
    Eur. J. Inorg. Chem. (2011), 5471-5478.
    DOI: 10.1002/ejic.201100734

  • Oehninger L., Alborzinia H., Ludewig S., Baumann K., Wölfl S., Ott I., From catalysts to bioactive organometallics: do Grubbs catalysts trigger biological effects?
    ChemMedChem (2011), 6, 2142-2145.
    DOI: 10.1002/cmdc.201100308

  • Ott I., Xu Y., Qian X., Fluorescence properties and antiproliferative effects of mono-, bis-, and tris thiophenylnaphthalimides: results of a comparative pilot study.
    J. Photochem. Photobiol. B (2011), 105, 75-80.
    DOI: 10.1016/j.jphotobiol.2011.06.012

  • Wetzel C., Kunz P. C., Kassack M. U., Hamacher A., Böhler, P., Wätjen, W., Ott I., Rubbiani, R., Spingler B., Gold(I) complexes of water-soluble diphos-type ligands: Synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition.
    Dalton Trans. (2011), 40, 9212-9220.
    DOI: 10.1039/C1DT10368G

  • Tolle N., Dunkel U., Oehninger L., Ott I., Preu L., Haase T., Behrends S., Jones P. G., Totzke F., Schächtele C., Kubbutat M. H. G., Kunick C., Synthesis and structure of fluorescent chelate boron complexes of 4-anilinomethylidene-1-benzazepine-2,5-dione ligands.
    Synthesis (2011), 17, 2848-2858.
    DOI: 10.1055/s-0030-1260165
  • Hackenberg F., Oehninger L., Alborzinia H., Can S., Kitanovic I., Geldmacher Y., Kokoschka M., Wölfl S., Ott I., Sheldrick W. S., Highly cytotoxic substitutionally inert rhodium(III) tris(chelate) complexes: DNA binding modes and biological impact on human cancer cells.
    J. Inorg. Biochem. (2011), 105, 991-999.
    DOI: 10.1016/j.jinorgbio.2011.04.006
  • Bieda R., Kitanovic I., Alborzinia H., Meyer A., Ott I., Wölfl S., Sheldrick W. S., Antileukemic activity and cellular effects of rhodium(III) crown thiaether complexes.
    Biometals (2011), 24, 645-661.
    DOI: 10.1007/s10534-011-9414-9

  • Geldmacher Y., Rubbiani R., Wefelmeier P., Prokop A., Ott I., Sheldrick W. S., Synthesis and DNA-binding properties of apoptosis-inducing cytotoxic half-sandwich rhodium(III) complexes with methyl-substituted polypyridyl ligands,
    J. Organomet. Chem. (2011), 696, 1023-1031.
    DOI: 10.1016/j.jorganchem.2010.10.034

  • Geldmacher Y., Kitanovic I., Alborzinia H., Bergerhoff K., Rubbiani R., Wefelmeier P., Prokop A., Gust R., Ott I., Wölfl S., Sheldrick W.S., Cellular selectivity and biological impact of cytotoxic rhodium(III) and iridium(III) complexes containing methyl-substituted phenanthroline ligands.
    ChemMedChem(2011), 6, 429-439.
    DOI: 10.1002/cmdc.201000517

  • Hille A., Wolf T., Schumacher P., Ott I., Gust R., Kircher B., Effects of metal salophene and saldach complexes on lymphoma and leukemia cells.
    Arch. Pharm. Chem. Life Sci. (2011), 344, 217-223.
    DOI: 10.1002/ardp.201000237

2010

  • Rubbiani R., Kitanovic I., Alborzinia H., Can S., Kitanovic A., Onambele L. A., Stefanopoulou M., Geldmacher Y., Sheldrick W. S., Wolber G., Prokop A., Wölfl S., Ott I., Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties.
    J. Med. Chem.(2010), 53, 8608-8618.
    DOI: 10.1021/jm100801e

  • Rubner G., Bensdorf K., Wellner A., Bergemann S., Ott I., Gust R., [Cyclopentadienyl] metalcarbonyl complexes of acetylsalicylic acid as neo-anticancer agents.
    Eur. J. Med. Chem. (2010), 45, 5157-5163.
    DOI: 10.1016/j.ejmech.2010.08.028

  • Rubner G., Bensdorf K., Wellner A., Kircher B., Bergemann S., Ott I., Gust R., Synthesis and biological activities of transition metal complexes based on acetylsalicylic acid as neo-anticancer agents.
    J. Med. Chem. (2010), 53, 6889-6898.
    DOI: 10.1021/jm101019j

  • Splith K., Hu W., Schatzschneider U., Gust R., Ott I., Onambele L.A., Prokop A., Neundorf I., Protease-activatable organometal-peptidebioconjugates with enhanced cytotoxicity on cancer cells.
    Bioconjug. Chem.(2010),21, 1288-1296.
    DOI: 10.1021/bc100089z

  • Klein A., Lüning A., Ott I., Hamel L., Neugebauer M., Butsch K., Lingen V., Heinrich F., Elmas S., Organometallic palladium and platinum complexes with strongly donating alkyl coligands - Synthesis, structures, chemical and cytotoxic properties.
    J. Organomet. Chem. (2010), 695, 1898-1905.
    DOI: 10.1016/j.jorganchem.2010.04.027

  • Bieda R., Dobroschke M., Triller A., Ott I., Spehr M., Gust R., Prokop A., Sheldrick W. S., Cell selective, apoptosis-inducing rhodium(III) crown thiaether complexes.
    ChemMedChem(2010), 5, 1123-1133.
    DOI: 10.1002/cmdc.201000129

  • Butsch K., Gust R., Klein A., Ott I., Romanski M., Tuning the electronic properties of dppz-ligands and their palladium(II) complexes.
    Dalton Trans.(2010), 39, 4331-4340.
    DOI: 10.1039/B926233D

  • Ott I., Kowalski K., Gust R., Maurer J., Mücke P., Winter R. F., Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species,
    Bioorg. Med. Chem. Lett. (2010), 20, 866-869.
    DOI: 10.1016/j.bmcl.2009.12.080

  • Scheffler H., You Y., Ott I., Comparative studies on the cytotoxicity, cellular and nuclear uptake of a series of chloro gold(I) phosphine complexes.
    Polyhedron(2010), 29, 66-69.
    DOI: 10.1016/j.poly.2009.06.007

2009

  • Bagowski C. P., You Y., Scheffler H., Vlecken D. H., Schmitz D. J., Ott I., Naphthalimide gold(I) phosphine complexes as anticancer metallodrugs.
    Dalton Trans.(2009), 10799-10805.
    DOI: 10.1039/B912378D

  • Patra M., Gasser G., Pinto A., Merz K., Ott I., Bandow E.J., Metzler-Nolte N., Synthesis and biological evaluation of chromium bioorganometallics based on the antibiotic platensimycin lead structure,
    ChemMedChem (2009), 4, 1930-1938.
    DOI: 10.1002/cmdc.200900347

  • Bieda R., Ott I., Gust R., Sheldrick W.S.,Cytotoxic rhodium(III) polypyridyl complexes containing the tris(pyrazolyl)methane coligand: synthesis, DNA-binding properties and structure-activity relationships.,
    Eur. J. Inorg. Chem. (2009), 25, 3821-3831.
    DOI: 10.1002/ejic.200900373

  • Nazif A., Bangert J. A., Ott I., Gust R., Stoll R., Sheldrick W.S., Dinuclear organoiridium(III) mono- and bis-intercalators with rigid bridging ligands: synthesis, cytotoxicity and DNA binding.
    J. Inorg. Biochem.(2009), 103, 1405-1414.
    DOI: 10.1016/j.jinorgbio.2009.08.003

  • Walther C., Ott I., Gust R., Neundorf I., Specific labeling with potent radionuclides alters the uptake of cell-penetrating peptides.
    Biopolymers(2009), 92, 445-451.
    DOI: 10.1002/bip.21218

  • Kappert K., Tsuprykov O., Kaufmann J., Fritzsche J., Ott I., Goebel M., Bahr I. N., Hassle P. L., Gust R., Fleck E., Unger T., Stawowy P., Kintscher U., Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation.
    Hypertension(2009), 54, 738-743.
    DOI: 10.1161/HYPERTENSIONAHA.109.132886

  • Butsch K., Elmas S., Gupta N. S., Gust R., Heinrich F., Klein A., von Mering Y., Neugebauer M., Ott I., Schäfer M., Scherer H., Schurr T., Organoplatinum(II) and -palladium(II) complexes of nucleobases and their derivatives.
    Organometallics(2009), 28, 3906-3915.
    DOI: 10.1021/om900208r

  • Hille A., Ott I., Kitanovic A., Kitanovic I., Alborzinia H., Lederer E., Wölfl S., Metzler-Nolte N., Schäfer S., Sheldrick W.S., Bischof C., Schatzschneider U., Gust R., [N,N'-Bis(salicylidene)-1,2-phenylenediamine] metal complexes with cell death promoting properties.
    J. Biol. Inorg. Chem. (2009), 14, 711-725.
    DOI: 10.1007/s00775-009-0485-9

  • Bieda R., Ott I., Dobroschke M., Prokop A., Gust R., Sheldrick W.S., Structure-activity relationships and DNA binding properties of apoptosis inducing rhodium(III) polypyridyl complexes containing the cyclic thioether [9]aneS3.
    J. Inorg. Biochem. (2009), 103, 698-708.
    DOI: 10.1016/j.jinorgbio.2009.01.008

  • Ott I., Qian X., Xu Y., Vlecken D. H., Marques I. J., Kubat D., Will J., Sheldrick W. S., Jesse P., Prokop A., Bagowski C. P., A gold(I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor.
    J. Med. Chem.(2009), 53, 763-770.
    DOI: 10.1021/jm8012135

  • Ott I., Kircher B., Bagowski C. P., Vlecken D. H. W., Ott E. B., Will J., Bensdorf K., Sheldrick W. S., Gust R., Modulation of the biological properties of aspirin by bioorganometallic derivatisation.
    Angew. Chem. Int. Ed.(2009), 48, 1160-1163.
    DOI: 10.1002/anie.200803347

  • Dobroschke M., Geldmacher Y., Ott I., Harlos M., Kater L., Wagner L., Gust R., Sheldrick W. S., Prokop A., Cytotoxic rhodium(III) and iridium(III) polypyridyl complexes: structure-activity relationships, antileukemic activity, and apoptosis induction.
    ChemMedChem (2009), 4, 177-187.
    DOI: 10.1002/cmdc.200800311
  • N'Dongo H. W. P.,Ott I., Gust R.,Schatzschneider U., Microwave-assisted solid-phase synthesis, cellular uptake, and cytotoxicity studies of cymantrene-peptide bioconjugates.
    J. Organomet. Chem.(2009), 694, 823-827.
    DOI: 10.1016/j.jorganchem.2008.07.031

2008

  • Sinning C., B. Watzer, Coste O., Nüsing R. M., Ott I., Ligresti A., Di Marzo V., Imming P., New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide.
    J. Med. Chem. (2008), 51, 7800-7805.
    DOI: 10.1021/jm800807k
  • Schlenk M., Ott I., Gust R., Cobalt-alkyne complexes with imidazoline ligands as estrogenic carriers.
    J. Med. Chem.(2008), 51, 7318-7322.
    DOI: 10.1021/jm8008376
  • Ott I., Xu Y., Liu J., Kokoschka M., Harlos M., Sheldrick W.S., Qian X., Sulfur substituted naphthalimides as photoactivatable anticancer agents: DNA interaction, fluorescence imaging and phototoxic effects in cultured tumor cells.
    Bioorg. Med. Chem. (2008), 16, 1707-1716.
    DOI: 10.1016/j.bmc.2008.06.052
  • Schatzschneider U., Niesel J., Ott I., Gust R., Alborzinia H., Wölfl S., Cellular uptake, cytotoxicity and metabolic profiling, of human cancer cells treated with ruthenium(II) polypyridyl complexes.
    ChemMedChem (2008), 3, 1104-1109.
    DOI: 10.1002/cmdc.200800039

  • Scharwitz M. A., Ott I., Gust R., Kromm A., Sheldrick W.S., Synthesis, cellular uptake and structure-activity relationships for potent cytotoxic trichlorididoiridium(III) polypyridyl complexes.
    J. Inorg. Biochem. (2008), 102, 1623.
    DOI: 10.1016/j.jinorgbio.2008.03.001

  • Harlos M., Ott I., Gust R., Alborzinia H., Wölfl S., Kromm A., Sheldrick W. S., Synthesis, biological activity and structure activity relationships for potent cytotoxic rhodium (III) polypyridyl complexes.
    J. Med. Chem.(2008), 51, 3924-3933.
    DOI: 10.1021/jm800173s

  • Ott I., Scharwitz M., Scheffler H., Sheldrick W. S., Gust R., Atomic absorption spectrometric determination of the iridium content of tumor cells exposed to an iridium metallodrug.
    J. Pharm. Biomed. Anal. (2008), 47, 938-942.
    DOI: 10.1016/j.jpba.2008.02.027

  • Kirin S. I., Ott I., Gust R., Mier W., Weyhermüller T., Metzler-Nolte N., Cellular uptake quantification of metallated peptide and peptide nucleic acid bioconjugates by atomic absorption spectroscopy.
    Angew. Chem., Int. Ed. (2008), 47, 955-959.
    DOI: 10.1002/anie.200703994

  • Niesel J., Pinto A., Peindy N`Dongo H. W., Merz K., Ott I., Gust R., Schatzschneider U. Photoinduced CO-release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex.
    Chem. Commun. (2008), 1798-1800.
    DOI: 10.1039/B719075A

  • Sergeant C. D., Ott I., Sniady A., Meneni, S., Gust R., Rheingold A. L., Dembinski R., Metallo-nucleosides: synthesis and biological evaluation of hexacarbonyl dicobalt 5-alkynyl-2'-deoxyuridines.
    Org. Biomol. Chem. (2008), 6, 73-80.
    DOI: 10.1039/B713371E

  • Kapp T., Krüger M., Ott I., Steiner S., Schumacher P., Nachbaur D., Gastl G., Gust R., Kircher B., Biological effect of mono- and dinuclear alkylamine platinum(II) compounds on human lymphoma cells.
    J. Inorg. Biochem.(2008), 102, 713-720.
    DOI: 10.1016/j.jinorgbio.2007.10.014

  • Scharwitz M. A., Ott I., Geldmacher Y., Gust R., Sheldrick W.S. Cytotoxic half-sandwich rhodium(III) complexes: polypyridyl ligand influence on their DNA binding properties and cellular uptake.
    J. Organomet. Chem.(2008), 693, 2299-2309.
    DOI: 10.1016/j.jorganchem.2008.04.002

2007

  • Schäfer S., Ott I., Gust R., Sheldrick W. S., Influence of the polypyridyl (pp) ligand size on the DNA binding properties, cytotoxicity and cellular uptake of organoruthenium(II) complexes of the types [(η6-C6Me6)Ru(L)(pp)]n+ (L=Cl, n=1; L= (NH2)2CS, n=2).
    Eur. J. Inorg. Chem. (2007), 3034-3046.
    DOI: 10.1002/ejic.200700206

  • Ott I., Scheffler H., Gust R., Development of a method for the quantification of the molar gold concentration in tumor cells exposed to gold containing drugs.
    ChemMedChem (2007), 2, 702-707.
    DOI: 10.1002/cmdc.200600275

  • Meneni S., Ott I., Sergeant C.D., Sniady A., Gust R., Dembinski R., 5-Alkynyl-2'-deoxyuridines: chromatography-free synthesis and cytotoxicity evaluation against human breast cancer.
    Bioorg. Med. Chem. (2007), 15, 3082-3088.
    DOI: 10.1016/j.bmc.2007.01.048

  • Banekovich C., Ott I., Koch T., Matuszczak B., Gust R., Synthesis and biological activities of novel dexibuprofen tetraacetylriboflavin conjugates.
    Bioorg. Med. Chem. Lett. (2007), 17, 683-687.
    DOI: 10.1016/j.bmcl.2006.10.087

2006

  • Ott I., Abraham A., Schumacher P., Shorafa H., Gastl G., Gust R., Kircher B., Synergistic and additive antiproliferative effects on human leukemia cell lines induced by combining acetylenehexacarbonyldicobalt complexes with the tyrosine kinase inhibitor imatinib.
    J. Inorg. Biochem. (2006), 100, 1903-1906.
    DOI: 10.1016/j.jinorgbio.2006.06.013

2005

  • Ott I., Schmidt K., Kircher B., Schumacher P., Wiglenda T., Gust R., Antitumoractive cobalt-alkyne complexes derived from acetylsalicylic acid: studies on the mode of drug action.,
    J. Med. Chem. (2005), 48, 622-629.
    DOI: 10.1021/jm049326z

  • Wiglenda T., Ott I., Kircher B., Schumacher P., Schuster D., Langer T., Gust R., Synthesis and pharmacological evaluation of 1H-imidazoles as ligands for the estrogen receptor and cytotoxic inhibitors of the cyclooxygenase.
    J. Med. Chem. (2005), 48, 6516-6521.
    DOI: 10.1021/jm050190u
  • Ott I., Koch T., Shorafa H., Bai Z., Pöckel D., Steinhilber D., Gust R. Synthesis, cytotoxicity, cellular uptake and influence on eicosanoid metabolism of cobalt-alkyne modified fructoses in comparison to auranofin and the cytotoxic COX inhibitor Co-ASS.
    Org. Biomol. Chem. (2005), 3, 2282-2286.
    DOI: 10.1039/B504294C
  • Ott I., Gust R., Stability, protein binding and thiol interaction studies on [2-acetoxy-(2-propynyl)benzoate]hexacarbonyldicobalt.,
    Biometals (2005), 18, 171-177.
    DOI: 10.1007/s10534-004-6252-z

2004 - 2001

  • Gust R., Ott I., Posselt D., Sommer K., Development of cobalt(3,4-diarylsalen)complexes as tumor therapeutics.,
    J. Med. Chem. (2004), 47, 5837-5846.
    DOI: 10.1021/jm040763n
  • Ott I., Kircher B., Heinisch G., Matuszczak B., Substituted pyridazino[3,4-b][1,5]benzoxazepin-5(6H)ones as multidrug resistance modulating agents.,
    J. Med. Chem. (2004), 47, 4627-4630.
    DOI: 10.1021/jm040803n
  • Ott I., Kircher B., Gust R., Investigations on the effects of cobalt-alkyne complexes on leukemia and lymphoma cells: cytotoxicity and cellular uptake.,
    J. Inorg. Biochem. (2004), 98, 485-489.
    DOI: 10.1016/j.jinorgbio.2003.12.008
  • Amann A., Decristoforo C., Ott I., Wenger M., Bader D., Alberto R., Putz G., Surfactant protein B labelled with [99mTc(CO)3(H2O)3]+ retains biological activity in vitro.,
    Nucl. Med. Biol. (2001), 28, 243-250.
    DOI: 10.1016/S0969-8051(01)00192-5

Übersichtsartikel und andere Beiträge / Reviews and other reports

  • Schur J., Ott I., Neuerungen in der Spurenelementanalytik,
    GIT Labor-Fachzeitschrift (2013), 3, 154.
  • Oehninger L., Rubbiani R., Ott I., N-heterocyclic carbene metal complexes in medicinal chemistry.
    Dalton Trans. (2013), 42, 3269-3284.
    DOI: 10.1039/C2DT32617E
  • Gasser G., Ott I., Metzler-Nolte N., Organometallic anticancer compounds,
    J. Med. Chem. (2011), 54, 3-25.
    DOI: 10.1021/jm100020w
  • Kunick C., Ott I., Metal complexes as protein kinase inhibitors,
    Angew. Chem. Int. Ed. (2010), 49, 5226-5227.
    DOI: 10.1002/anie.201002062
  • Ott I., Kircher B., Dembinski R., Gust R. Alkyne hexacarbonyl dicobalt complexes in medicinal chemistry and drug development.
    Expert Opin. Ther. Patents (2008), 18, 327-337.
    DOI: 10.1517/13543776.18.3.327
  • Ott I., Gust R., Organometallverbindungen: Hilfreich in der Therapie von Tumor-erkrankungen.
    Pharmazeutische Zeitung (2007), 32, 74-76.
  • Ott I., Gust R., Non platinum metal complexes as anti-cancer agents.
    Arch. Pharm. Chem. Life Sci. (2007), 340, 117-126.
    DOI: 10.1002/ardp.200600151
  • Ott I., Gust R., Preclinical and clinical studies on the use of platinum complexes for breast cancer treatment.
    Anti-Cancer Agents Med. Chem. (2007), 7, 95-110.
    DOI: 10.2174/187152007779314071
  • Ott I., Gust R., Medizinische Chemie der Platinkomplexe. (written in German)
    Pharm. Unserer Zeit (2006), 35, 124-133.
    DOI: 10.1002/pauz.200500161
  • Adams R. D., Schatzschneider U., Ott I., Special issue on International Symposium on Bioorganometallic Chemistry (ISBOMC21), J. Organomet. Chem. (2022), 973-974, 122393 doi.org/10.1016/j.jorganchem.2022.122393

Patente / Patents

  • Bagowski C., Ott I., Meyer A., Wölfl S., Kitanovic I., Can S., Alborzinia H., Goldverbindungen mit Alkinyl-Liganden und deren Therapeutische Verwendung. DE102011054972 (A1) WO2013064594 (A1)
  • Gust R., Ott I., Sheldrick W. S., Harlos M., Octahedral metal(III) polypyridyl complexes and their use in prevention and treatment of cancer. EP 2072521 (A1), WO2009080482 (A1)

Buchkapitel / Book Chapters

  • Gil-Moles M., Ott I., Transition Metal-Based Antiviral Agents against SARS-COV-2 and other Pathogenic Viruses, in Targeted Metallo-Drugs: Design, Development, and Modes of Action, Vol. 24 of Metal Ions in Life Sciences, Eds. Marmion C. J., Farkas E., CRC Press, 2023, ISBN 9781032223308
  • Ott I., Metal N-heterocyclic Carbene Complexes in Medicinal Chemistry, in Advances in Inorganic Chemistry, Volume 75 (Medicinal Chemistry), Eds. Sadler P.J., van Eldik R., Elsevier, 2020, doi.org/10.1016/bs.adioch.2019.10.008
  • Casini A., Sun R. W.-Y., Ott I., Medicinal Chemistry of Gold Anticancer Metallodrugs, in "Metallo-Drugs: Development and Action of Anticancer Agents", Vol. 18 of Metal Ions in Life Sciences, Eds A. Sigel, H. Sigel, E. Freisinger, R. K. O. Sigel, Walter de Gruyter, GmbH, Berlin, Germany, 2018, ISBN 978-3-11-046984-4
  • Ott I., Medicinal Chemistry of Metal N-Heterocyclic Carbene (NHC) Complexes, In: Inorganic and Organometallic Transition Metal Complexes: Interactions, Fundamentals, and Applications with Biological Molecules and Living Cells, Elsevier, 2017, ISBN 9780128038147
  • Cinellu M. A., Ott I., Casini A., Gold organometallics with biological properties, chapter in Bioorganometallic Chemistry, Wiley-VCH, Weinheim, 2015, ISBN 978-3-527-33527-5; p.117-135.
  • Ott I., Biot C., Hartinger C., AAS, XRF and MS Methods in Chemical Biology of Metal Complexes. In: Inorganic Chemical Biology: Principles, Techniques and Applications, John Wiley & Sons, Ltd, UK, 2014, ISBN: 978-1-11851-002-5
  • Ott I. Biodistribution of Metals and Metallodrugs. In: Jan Reedijk and Kenneth Poeppelmeier, editors. Comprehensive Inorganic Chemistry II, Vol 3. Oxford: Elsevier; 2013. p. 933-949.